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The Knowledge Grid is an intelligent and sustainable interaction environment that consists of autonomous individuals, self-organized semantic communities, adaptive networking mechanisms, evolving semantic link networks keeping meaningful connection between individuals, flows for dynamic resource sharing, and mechanisms supporting effective resource management and providing appropriate knowledge services for learning, innovation, teamwork, problem solving, and decision making. This book presents its methodology, theory, models and applications systematically for the first time.Its second edition fulfils the ideal of the Knowledge Grid by includingmany new contents, including: (1) The insight of cyber-physical society; (2) The systematic method of semantic link network that supports uncertainty management, discovery of semantic links and semantic communities, autonomous semantic data model, and cyber-physical-socio semantic link network; (3) Semantic peer-to-peer infrastructures for efficient knowledge sharing; (4) A new centrality measure of network; and (5) The Energy-Knowledge Grid. This new edition will undoubtedly provide inspiring materials for researchers, academics, practitioners and students.

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China has achieved significant socio-economic progress and has become a key player on the international stage after several decades of open-door and reform policy. Looking beyond China's transformation, this book focusses on the theme of governance which is widely regarded as the next most critical element to ensure that China's growth remains sustainable.Today, China is confronted with a host of pressing challenges that call for urgent attention. These include the need to rebalance and restructure the economy, the widening income gaps, the poor integration of migrant populations in the urban areas, insufficient public housing and healthcare coverage, the seeming lack of political reforms and the degree of environmental degradation. In the foreign policy arena, China is likewise under pressure to do more to address global concerns while not appearing to be overly aggressive. The next steps that China takes would have a great deal to do with governance, in terms of how it tackles or fails to address the myriad of challenges, both domestic and foreign.China: Development and Governance, with 57 short chapters in total, is based on up-to-date scholarly research written in a readable and concise style. Besides China's domestic developments, it also covers China's external relations with the United States, Japan, Korea and Taiwan. Non-specialists, in particular, should find this volume accessible and useful in keeping up with fast-changing developments in East Asia.

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Crystallographic groups are groups which act in a nice way and via isometries on some n-dimensional Euclidean space. They got their name, because in three dimensions they occur as the symmetry groups of a crystal (which we imagine to extend to infinity in all directions). The book is divided into two parts. In the first part, the basic theory of crystallographic groups is developed from the very beginning, while in the second part, more advanced and more recent topics are discussed. So the first part of the book should be usable as a textbook, while the second part is more interesting to researchers in the field. There are short introductions to the theme before every chapter. At the end of this book is a list of conjectures and open problems. Moreover there are three appendices. The last one gives an example of the torsion free crystallographic group with a trivial center and a trivial outer automorphism group.This volume omits topics about generalization of crystallographic groups to nilpotent or solvable world and classical crystallography. We want to emphasize that most theorems and facts presented in the second part are from the last two decades. This is after the book of L Charlap Bieberbach groups and flat manifolds was published.

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Advances in Diagnosis and Therapy for Gastrointestinal and Hepatological Diseases

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Inflammation and cancer are two major disorders that cause huge concerns in our society. However, what one may not know is that both diseases are closely associated and, in particular, both occur in the gastrointestinal tract and liver. This book describes the mechanics of how inflammation can progress to cancer in these organs. The authors in this book comprehensively discuss the different biomarkers for early diagnosis, and current therapeutic treatments for these diseases. All of these would allow us to better understand the pathogenesis of both diseases. As such, this book provides comprehensive information concerning the interrelationship between inflammation and cancer in a cohesive manner, and the information derived would benefit not only basic scientists but also clinicians who are working in these fields.

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Oncoplastic breast cancer surgery is one of the fastest-growing domains in breast surgery. This approach is continuing to gain practice acceptance due to increased emphasis on both optimum cosmetic outcome and maintenance of a sound oncologic basis. This book summarizes the basic principles and techniques using evidence-based data. Patient images and comprehensive drawings complete this practical guide for surgeons who treat diseases of the breast.

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DIALYSIS : HISTORY,DEVELOPMENT & PROMISE

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This book describes the past, present and future of dialysis and dialysis-related renal replacement therapies so that the reader can acquire a firm grasp of the medical management of acute and chronic renal failure.By becoming thoroughly conversant with the past and present of dialysis, a health care professional will be in a much better position to provide the best standard of care to patients suffering from renal failure. As the book highlights the unsolved operational obstacles in the field of renal replacement therapies, future innovators may be inspired to develop novel solutions to tackle these problems. This remarkable work is a must-read not only for healthcare providers in the dialysis industry, but also for patients, dialysis equipment manufacturers as well as pharmaceutical companies.

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Todd S Ing, Mohamed Rahman, Carl M Kjellstrand

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Missionaries, and in particular the Portuguese Assistancy of the Society of Jesus, played a fundamental role in the dissemination of Western scientific knowledge in East Asia. They also brought to Europe a deeper knowledge of Asian countries. This volume brings together a series of essays analyzing important new data on this significant scientific and cultural exchange, including several in-depth discussions of new sources relevant to Jesuit scientific activities at the Chinese Emperor's Court. It includes major contributions examining various case studies that range from the work of some individual missionaries (Karel Slavicek, Guillaume Bonjour) in Beijing during the reigns of Kangxi and Yongzheng to the cultural exchange between a Korean envoy and the Beijing Jesuits during the early 18th century. Focusing in particular on the relationship between science and the arts, this volume also features articles pertaining to the historical contributions made by Tomas Pereira and Jean-Joseph-Marie Amiot, to the exchange of musical knowledge between China and Europe.

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This book is a collection of speeches and lectures delivered by political luminaries, practitioners and noted scholars on South Asian security at the Institute of South Asian Studies, National University of Singapore.It offers interesting insights on the emerging security dynamics of South Asia. The issues covered are highly topical and include analyses of the conflict in Afghanistan, counter-terrorism in Pakistan, conflict management in Kashmir, post-conflict restructuring in Nepal and militarization in Asia. Some of the chapters provide in-depth analyses of the regional power politics and competing foreign policy priorities, with particular emphasis on India, the major regional power. India's foreign policy and defense relations with Southeast Asia, China and Russia are covered in detail in individual chapters.The book brings together insights from experts who have served at the highest levels of government as well as scholars and experts with firsthand experience in the field. It highlights some of the significant security issues that have a vital bearing on the future of South Asia and will be of interest to policy makers, students and observers of the South Asian security scene.

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CHRONIC HEPATITIS B AND C: BASIC SCIENCE TO CLINICAL APPLN

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The scope of the book is very broad, covering a wide range of areas in HBV/HDV and HCV research, including both basic and clinical science. The selected topics range from epidemiology, immunology, molecular virology and oncology, to clinical therapy.Chronic Hepatitis B and C consists of 14 chapters, each being a review of a special topic on HBV or HCV. While review articles on a special topic can be found in periodical journals, they tend to be more restricted in presentation. Therefore, this book will provide more in-depth coverage of what are presented as unpublished results and data not shown in journal articles. Furthermore, several authors in this book do not write review articles regularly. Some authors wrote reviews on a specific topic regularly, but they tried a new topic in this book (e.g., Dr. YF Liaw on natural course, Dr. Shih on virion release, Dr. Michael Lai on lymphotropism of HCV, etc. ). Overall, the book will offer useful information at the cutting age.Sample Chapter(s)

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Understanding and Exploring Nature as Computation

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This volume, with a foreword by Sir Roger Penrose, discusses the foundations of computation in relation to nature.It focuses on two main questions:The contributors are world-renowned experts who have helped shape a cutting-edge computational understanding of the universe. They discuss computation in the world from a variety of perspectives, ranging from foundational concepts to pragmatic models to ontological conceptions and philosophical implications.The volume provides a state-of-the-art collection of technical papers and non-technical essays, representing a field that assumes information and computation to be key in understanding and explaining the basic structure underpinning physical reality. It also includes a new edition of Konrad Zuse's Calculating Space (the MIT translation), and a panel discussion transcription on the topic, featuring worldwide experts in quantum mechanics, physics, cognition, computation and algorithmic complexity.The volume is dedicated to the memory of Alan M Turing  the inventor of universal computation, on the 100th anniversary of his birth, and is part of the Turing Centenary celebrations.

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After the 1978 Economic Reform, China's economic development has been on a fast track ever since. Later on, the successful accession into the WTO in 2001 accelerated China's economic transformation and made it more integrated with the world. Today, as the second-largest economy in the world, China has earned herself a leading role on the world stage beyond dispute. This book provides readers with answers to why and how China functions as a leader in the world economy.This book surveys China's economy in four parts  economic institutions, economic problems, economic policies and economic analyses. It is based on the author's latest findings from his scholarly research on China's economy, his involvement with China's economic reform and development, and his personal contacts with Chinese academics, entrepreneurs, government officials and ordinary citizens for over thirty years. The book is written in a style accessible to the general readers, since most chapters are based on articles published in three major Chinese newspapers, of which the author is a columnist. It can also serve as a reference book for professionals, an authoritative guide for general readers and a supplementary text for university students. The author uses it as a supplementary text for his course on the Chinese economy at Princeton University.

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Volume 1: Curricular and Teaching and Learning Practices

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This book will introduce the history and practices of mathematics education in Korea. How it has been influenced from Japan, America, and other countries, and has developed into the unique Korean style of mathematics education. The editors have planned to include most of the topics researchers outside Korea want to know mathematics education in Korea.

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Jinho Kim, Joong Kwoen Lee, Mangoo Park, Inki Han

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The Nobel Prizes in natural sciences have developed to become a unique measure of scientific excellence. Using archival documents, which have been released (50 years secrecy) for scholarly work, the author expertly traces the strengths and weaknesses of the Nobel system as exemplified by individual prizes. Surveys of the more than 100 years that the Prizes have been awarded are also presented.This book discusses the most important prize in the world of science and gives unique historical insights into how the laureate selection process has developed to secure optimal choice.No other book has been published which draws from previously classified archival materials to the extent that this book does. It indirectly deals with factors that foster scientific discoveries viz. the role of both individuals and institutions and thus provides invaluable insights for researchers, institutions and anyone interested in science.

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This is the first-ever book on smoothed particle hydrodynamics (SPH) and its variations, covering the theoretical background, numerical techniques, code implementation issues, and many novel and interesting applications.It contains many appealing and practical examples, including free surface flows, high explosive detonation and explosion, underwater explosion and water mitigation of explosive shocks, high velocity impact and penetration, and multiple scale simulations coupled with the molecular dynamics method. An SPH source code is provided, making this a friendly book for readers and SPH users.

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USING ANIMAL MODELS IN BIOMEDICAL RESEARCH: A PRIMER FOR THE INVESTIGATOR

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Animal models play crucial roles in the continuum of experimental activities that make up biomedical research. Such in vivo modes are especially important in proof-of-principle experiments and in establishing the preclinical safety and efficacy data required for progressing to human clinical trials. A practical understanding of the choice, care and use of animal models is thus expected and required of all biomedical researchers. However, while both legislations and the practice of laboratory animal science have made great advances in the last decade and have impacted significantly on the use of animal models, this corpus of knowledge is not readily available in formats easily digestible to the average biomedical researcher. This book fills this gap in knowledge and provides material not easily sourced by the average biomedical researcher, such as current information on bioimaging, occupational health and biosafety, animal protocol design and histological-pathological support.

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Pierce K H Chow, Robert T H Ng, Bryan E Ogden

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This book is unique in covering all important topics of the Chinese economy in depth but written in a language understandable to the layman and yet challenging to the expert. Beginning with entrepreneurship that propels the dynamic economic changes in China today, the book is organized into four broad parts to discuss China's economic development, to analyze significant economic issues, to recommend economic policies and to comment on the timely economic issues in the American economy for comparison.Unlike a textbook, the discussion is original and thought-provoking. It is written by a most distinguished economist who has studied the Chinese economy for thirty years, after making breathtaking contributions to the fields of econometrics, applied economics and dynamic economics and serving as a major adviser to the government of Taiwan during its period of rapid development in the 1960s and 1970s. In the last thirty years, the author has served as a major adviser to the government of China on economic reform and important economic policies and cooperated with the Ministry of Education to introduce and promote the development of modern economics in China, including training hundreds of economists in China and placing many graduate students to pursue a doctoral degrees in economics in leading universities in the US and Canada. These graduates now plays pivotal roles in China and in the US in academics, business or government institutions. The essays, a culmination of the author's expertise in China over five decades, are being widely read in China. When the author became professor emeritus at Princeton, the University named the Econometric Research Program as the Gregory C Chow Econometric Research Program in his honor.

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There is an increasing need to construct engineering structures in the Arctic seas. The requirement is principally generated by the oil and gas industry, because of the substantial reserves that are known to exist offshore in the Beaufort Sea, the Caspian Sea, the Barents Sea, the Pacific Ocean off the coast of Sakhalin, the Canadian Arctic, and almost certainly elsewhere. Structures have to withstand the severe environmental forces generated by sea ice, a subject that is developing rapidly but is still far from completely understood. Underwater pipelines have to be safe against ice gouging and strudel scour, but also have to be constructed safely and economically. The social and human environment has to be understood and respected.This important book intentionally takes a broad view, and vividly accounts for the many and often subtle interactions between the different factors. It is illustrated by case studies of actual projects.

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Andrew Clennel Palmer, Kenneth R Croasdale

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Cellular Self-Digestion in Neurons and Neurological Diseases

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What is autophagy? Why would neurons digest parts of themselves through autophagy? How can autophagy save the lives of cells under some conditions, but act as an accomplice to cell death in others? By what mechanisms are autophagy-related processes dysregulated in neurological diseases, and are there therapeutic strategies to correct or compensate for their dysfunction? This book provides an expert view of major concepts in autophagy research with a focus on autophagy in neurons. Experimental evidence for evolutionarily conserved and specialized regulatory mechanisms for autophagy in the mammalian nervous system will be presented, including recent data on braking mechanisms. Areas of intersection with cell death, the ubiquitin-proteasome system, chaperone-mediated autophagy, and the endocytic pathway will be reviewed, along with emerging areas of mitochondrial autophagy (mitophagy) and the autophagic regulation of neuritic/synaptic processes. Advances in delineating mechanisms by which autophagy is involved in the pathophysiology of neurological disorders, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, ischemia/hypoxia and lysosomal storage diseases, will be discussed along with current drug development strategies targeting autophagy.

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The Potential Application of Nanomaterials

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Nanomaterials, with their unique size-dependent physical and chemical properties, have shown promising advantages as drug and gene delivery vehicles, ultra-sensitive intracellular detectors and novel therapeutic drugs. Nanopharmaceutics is one of the disciplines that will benefit the most from this technology.Nanotechnology will have a revolutionary impact on cancer diagnosis and therapy due to the exceptional characteristics of nanopharmaceutics.This book provides an overview of some tools, methods, and materials of nanotechnology that offer potential applications in pharmaceutics, followed by a series of examples showing applications that are already in development. It may very well inspire researchers to develop a new generation of pharmaceutics with inventive non-traditional approach and employ nanoscale science for the benefit of the patient.

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In a relatively brief but masterful recounting, Professor Ulf Lagerkvist traces the origins and seminal developments in the field of chemistry, highlighting the discoveries and personalities of the individuals who transformed the ancient myths of the Greeks, the musings of the alchemists, the mystique of phlogiston into the realities and the laws governing the properties and behavior of the elements; in short, how chemistry became a true science. A centerpiece of this historical journey was the triumph by Dmitri Mendeleev who conceived the Periodic Law of the Elements, the relation between the properties of the elements and their atomic weights but more precisely their atomic number. Aside from providing order to the elements known at the time, the law predicted the existence and atomic order of elements not then known but were discovered soon after.An underlying but explicit intent of Lagerkvist's survey is to address what he believes was a gross injustice in denying Mendeleev the Nobel Prize in Chemistry in 1905 and again in 1906. Delving into the Royal Swedish Academy of Sciences' detailed records concerning the nominations, Lagerkvist reveals the judging criteria and the often heated and prejudicial arguments favoring and demeaning the contributions of the competing contenders of those years. Lagerkvist, who was a member of the Swedish Academy of Sciences and has participated in judging nominations for the chemistry prize, concludes It is in the nature of the Nobel Prize that there will always be a number candidates who obviously deserve to be rewarded but never get the accolade  Mendeleev was one of those.