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In fields such as biology, medical sciences, sociology, and economics researchers often face the situation where the number of available observations, or the amount of available information, is sufficiently small that approximations based on the normal distribution may be unreliable. Theoretical work over the last quarter-century has led to new likelihood-based methods that lead to very accurate approximations in finite samples, but this work has had limited impact on statistical practice. This book illustrates by means of realistic examples and case studies how to use the new theory, and investigates how and when it makes a difference to the resulting inference. The treatment is oriented towards practice and comes with code in the R language (available from the web)  which enables the methods to be applied in a range of situations of interest to practitioners. The analysis includes some comparisons of higher order likelihood inference with bootstrap or Bayesian methods.

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The global spread of English has resulted in the emergence of a diverse range of postcolonial varieties around the world. Postcolonial English provides a clear and original account of the evolution of these varieties, exploring the historical, social and ecological factors that have shaped all levels of their structure. It argues that while these Englishes have developed new and unique properties which differ greatly from one location to another, their spread and diversification can in fact be explained by a single underlying process, which builds upon the constant relationships and communication needs of the colonizers, the colonized, and other parties. Outlining the stages and characteristics of this process, it applies them in detail to English in sixteen different countries across all continents as well as, in a separate chapter, to a  history of American English. Of key interest to sociolinguists, dialectologists, historical linguists and syntacticians alike, this book provides a fascinating new picture of the growth and evolution of English around the globe.

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Debating Immigration, first published in 2007, presents 18 original essays, written by some of the world's leading experts and pre-eminent academics, that explore the nuances of contemporary immigration and citizenship affecting the United States and Europe. The volume is organized around the following themes: religion and philosophy, law and policy, economics and demographics, race and ethnicity, and cosmopolitanism. Critical questions addressed include: What accounts for the disconnect between public attitudes about immigration and the policies produced by elected officials? Why has the United States not developed a well-articulated public philosophy of immigration? What does the Christian Bible have to say about immigration policy? What are our moral and social obligations to our fellow citizens, and do these trump our obligations to the world's poor? How does the European experience differ from the American situation?

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An Introduction to Public Health Genetics

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Genetics, Health Care and Public Policy is an introduction to the new discipline of public health genetics. It brings together the insights of genetic and molecular science as a means of protecting and improving the health of the population. Its scope is wide and requires an understanding of genetics, epidemiology, public health and the principles of ethics, law and the social sciences. This book sets out the basic principles of public health genetics for a wide audience from those providing health care to those involved in establishing policy. The emphasis throughout the text is on providing an accessible introduction to the field. The content moves from the basic concepts, including definitions and history, through chapters on genetics, genetic technology, epidemiology, genetics in medicine, genetics in health services, ethical, legal and social implications, to the implications for health policy. It provides one-stop, introductory coverage of this rapidly developing and multidisciplinary field.

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Alison Stewart, Philippa Brice, Hilary Burton, Paul Pharoah, Simon Sanderson, Ron Zimmern

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The Comparative Histories of Slavery in Brazil, Cuba, and the United States

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This 2007 book is an introductory history of racial slavery in the Americas. Brazil and Cuba were among the first colonial societies to establish slavery in the early sixteenth century. Approximately a century later British colonial Virginia was founded, and slavery became an integral part of local culture and society. In all three nations, slavery spread to nearly every region, and in many areas it was the principal labor system utilized by rural and urban elites. Yet long after it had been abolished elsewhere in the Americas, slavery stubbornly persisted in the three nations. It took a destructive Civil War in the United States to bring an end to racial slavery in the southern states in 1865. In 1866 slavery was officially ended in Cuba, and in 1888 Brazil finally abolished this dreadful institution, and legalized slavery in the Americas came to an end.

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Atrocity, Punishment, and International Law

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This book argues that accountability for extraordinary atrocity crimes should not uncritically adopt the methods and assumptions of ordinary liberal criminal law. Criminal punishment designed for common criminals is a response to mass atrocity and a device to promote justice in its aftermath. This book comes to this conclusion after reviewing the sentencing practices of international, national, and local courts and tribunals that punish atrocity perpetrators.  Sentencing practices of these institutions fail to attain the goals that international criminal law ascribes to punishment, in particular retribution and deterrence. Fresh thinking is necessary to confront the collective nature of mass atrocity and the disturbing reality that individual membership in group-based killings is often not maladaptive or deviant behavior but, rather, adaptive or conformist behavior. This book turns to a modern, and adventurously pluralist, application of classical notions of cosmopolitanism to advance the frame of international criminal law to a broader construction of atrocity law and towards an interdisciplinary, contextual, and multicultural conception of justice.

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Incentives, Competition, and Cost-Benefit Analysis in International Perspective

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The pharmaceutical industry worldwide is a rapidly burgeoning industry contributing to growth of gross domestic product and employment. Technological change in this field has been very rapid, with many new products being introduced. For this reason in part, health care budgets throughout the world have increased dramatically, eliciting growing pressures for cost containment. This book explores four important issues in pharmaceutical innovations: (1) the industry structure of pharmaceutical innovation; (2) incentives for correcting market failures in allocating resources for research and development; (3) competition and marketing; and (4) public evaluation of the benefits and costs of innovation. The lessons are applicable to countries all over the world, at all levels of economic development. By discussing existing evidence this book proposes incentive arrangements to accomplish social objectives.

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This wide ranging but self-contained account of the spectral theory of non-self-adjoint linear operators is ideal for postgraduate students and researchers, and contains many illustrative examples and exercises. Fredholm theory, Hilbert-Schmidt and trace class operators are discussed, as are one-parameter semigroups and perturbations of their generators. Two chapters are devoted to using these tools to analyze Markov semigroups. The text also provides a thorough account of the new theory of pseudospectra, and presents the recent analysis by the author and Barry Simon of the form of the pseudospectra at the boundary of the numerical range. This was a key ingredient in the determination of properties of the zeros of certain orthogonal polynomials on the unit circle. Finally, two methods, both very recent, for obtaining bounds on the eigenvalues of non-self-adjoint Schrodinger operators are described. The text concludes with a description of the surprising spectral properties of the non-self-adjoint harmonic oscillator.

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Security has become a defining feature of contemporary public discourse, permeating the so-called 'war on terror', problems of everyday crime and disorder, the reconstruction of 'weak' or 'failed' states and the dramatic renaissance of the private security industry. But what does it mean for individuals to be secure, and what is the relationship between security and the practices of the modern state? In this timely and important book, Ian Loader and Neil Walker outline and defend the view that security remains a valuable public good. They argue that the state is indispensable to the task of fostering and sustaining liveable political communities in the contemporary world and thus pivotal to the project of civilizing security. This is a major contribution by two leading scholars in the field and will be of interest to anyone wishing to deepen their understanding of one the most significant and pressing issues of our times.

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How Digital Innovations are Changing the World

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Everybody knows that digital technology has revolutionised our economy and our lifestyles. But how many of us really understand the drivers behind the technology - the significance of going digital; the miniaturization of circuit boards; the role of venture capital in financing the revolution; the importance of research and development? How many of us understand what it takes to make money from innovative technologies? Should we worry about manufacturing going offshore? What is the role of India and China in the digital economy? Drawing on a lifetime's experience in the industry, as an engineer, a senior manager and as a partner in a venture capital firm, Henry Kressel offers an expert personalized answer to all these questions. He explains how the technology works, why it matters, how it is financed and what the key lessons are for public policy.

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Sequence Organization in Interaction: Volume 1

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Much of our daily lives are spent talking to one another, in both ordinary conversation and more specialized settings such as meetings, interviews, classrooms, and courtrooms.  It is largely through conversation that the major institutions of our society - economy, religion, politics, family and law - are implemented. This book Emanuel Schegloff, the first in a series and first published in 2007, introduces the findings and theories of conversation analysis. Together, the volumes in the series constitute a complete and authoritative 'primer' in the subject. The topic of this first volume is 'sequence organization' - the ways in which turns-at-talk are ordered and combined to make actions take place in conversation, such as requests, offers, complaints, and announcements. Containing many examples from real-life conversations, it will be invaluable to anyone interested in human interaction and the workings of conversation.

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Completely revised new edition of the premier reference on pediatric liver disease. Liver Disease in Children, 3rd Edition provides authoritative coverage of every aspect of liver disease affecting infants, children, and adolescents. The book offers an integrated approach to the science and clinical practice of pediatric hepatology and charts the substantial progress in understanding and treating these diseases. Chapters are written by international experts and address the unique pathophysiology, manifestations, and management of these disorders in the pediatric population. The third edition has been thoroughly updated and features new contributions on liver development, cholestatic and autoimmune disorders, fatty liver disease, and inborn errors of metabolism. With the continued evolution of pediatric hepatology as a discipline, this text remains an essential reference for all physicians involved in the care of children with liver disease.

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Frederick J. Suchy, Ronald J. Sokol, William F. Balistreri

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The interest in using Bayesian methods in ecology is increasing, however many ecologists have difficulty with conducting the required analyses. McCarthy bridges that gap, using a clear and accessible style. The text also incorporates case studies to demonstrate mark-recapture analysis, development of population models and the use of subjective judgement. The advantages of Bayesian methods, are also described here, for example, the incorporation of any relevant prior information and the ability to assess the evidence in favour of competing hypotheses. Free software is available as well as an accompanying web-site containing the data files and WinBUGS codes. Bayesian Methods for Ecology will appeal to academic researchers, upper undergraduate and graduate students of Ecology.

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One major by-product of the aging baby-boom generation has been a surging interest in cosmetic surgery. Out-patient cosmetic surgery clinics have sprouted up in droves all over the U.S., and the number of cosmetic procedures performed in 2005 increased by over 95% from the previous year. Although procedures like facelifts and abdominoplasties (the 'tummy-tuck') are considered minimally invasive, the anesthetic protocols and regimens here are often overly complex and unnecessarily toxic. Major complications involving anesthesia in this (and any other) surgical milieu can range from severe post-operative nausea and vomiting (PONV) to neuromuscular spasticity to mortality. The mortality spectrum of things may be rare, but there have been many cases in which perfectly healthy cosmetic surgery patients require emergency intervention due to a severe complication involving anesthesia. In recent years, many new anesthetic protocols have been developed to reduce the incidence of PONV and other complications, while ensuring that effective pain management and level of 'un-awareness' during surgery is always maintained.

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Cases and Materials on the English Legal System

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This title, a companion volume to The Law Making Process, is the definitive collection of cases and materials on the workings of the English legal system. Written by the foremost scholar in the field, it surveys how the law functions from the trial process (from pre-trial proceedings to the funding of trials), the role of the jury, and the legal profession. This edition takes account of all recent major legislative and judicial changes and updates the material on the established areas of the law. The book takes a 'law in context' approach, setting out those factors beyond the legal environment which impact on and inform the changes within it. The collection is required reading for all students seeking a thorough knowledge and in-depth understanding of how the English legal system operates.

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The Neuroscience of Psychological Therapies

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The Neuroscience of Psychological Therapies summarizes knowledge of brain function and brain behavior relationships within the context of psychotherapy implementation. It describes how specific locations in the brain carry out specific activities, how the different activities are combined to yield normal and pathological behavior, and how knowledge of brain activities can guide psychological assessment and intervention. Specific topics include the influence of neural networks on discovery and change, the therapist's neuroscience, communicating with patients using the brain as reference, and using neuroscience concepts to compare and integrate traditional schools of psychotherapy. Applying a neuroscience framework to conceptualization and treatment of depression is offered as an example, and specific issues associated with trauma and false memories are discussed. The book is aimed at anyone working within a psychotherapy framework and who wishes to discover more about brain function and brain/behavior relationships.

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Hunting Causes and Using Them argues that causation is not one thing, as commonly assumed, but many. There is a huge variety of causal relations, each with different characterizing features, different methods for discovery and different uses to which it can be put. In this collection of new and previously published essays, Nancy Cartwright provides a critical survey of  philosophical and economic literature on causality, with a special focus on the currently fashionable Bayes-nets and invariance methods - and it exposes a huge gap in that literature. Almost every account treats either exclusively how to hunt causes or how to use them. But where is the bridge between? It's no good knowing how to warrant a causal claim if we don't know what we can do with that claim once we have it. This book will interest philosophers, economists and social scientists.

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In Being and Time Heidegger gives an account of the distinctive features of human existence, in an attempt to answer the question of the meaning of being. He finds that underlying all of these features is what he calls 'original time'. In this clear and straightforward introduction to the text, Paul Gorner takes the reader through the work, examining its detail and explaining the sometimes difficult language which Heidegger uses. The topics which he covers include being-in-the-world, being-with, thrownness and projection, truth, authenticity, time and being, and historicity. His book makes Being and Time accessible to students in a way that conveys the essence of Heidegger's project and remains true to what is distinctive about his thinking.

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Political activity and political thinking began in the cities and other states of ancient Greece, and terms such as tyranny, aristocracy, oligarchy, democracy and politics itself are Greek words for concepts first discussed in Greece. Rhodes presents in translation a selection of texts illustrating the formal mechanisms and informal workings of the Greek states in all their variety. From the states described by Homer out of which the classical Greeks believed their states had developed, through the archaic period which saw the rise and fall of tyrants and the gradual broadening of citizen bodies, to the classical period of the fifth and fourth centuries, Rhodes also looks beyond that to the Hellenistic and Roman periods in which the Greeks tried to preserve their way of life in a world of great powers. For this second edition the book has been thoroughly revised and three new chapters added.

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Progress in Pathology reviews many aspects of pathology, describing issues of everyday diagnostic relevance and the mechanisms underlying some of these processes. Each volume in the series reviews a wide range of topics and recent advances in pathology of relevance to daily practice, keeping consultants, trainees, laboratory staff and researchers abreast of developments as well as providing candidates for the MRCPath and other examinations with answers to some of the questions they will encounter. Highly illustrated in full colour, topics covered in this volume include: Immunohistochemistry as a diagnostic aid in gynaecological pathology, Drug induced liver injury, Childhood lymphoma, Immune responses to tumours, Post-mortem imaging, Understanding the Human Tissue Act 2004 and much more. Volume 7 of Progress in Pathology will be an essential addition to the shelves and laboratory benches of every practising pathologist.