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Esophageal cancer is a relatively uncommon but highly lethal malignancy. The incidence of adenocarcinoma is rapidly increasing and improved survival will depend on prevention, earlier diagnosis, improved staging and appropriate treatment. The multidisciplinary team approach toward patient care is critical in determining the management of patients with esophageal cancer. This volume provides a detailed review of new endoscopic methods of diagnosis, staging using both conventional and functional imaging and assessment of surgical and medical methods of therapy, providing all members of the team with a detailed overview of the diagnosis and management of this malignancy.

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Platelets in Hematologic and Cardiovascular Disorders

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A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the clinical role of platelets in a wide variety of haematologic, cardiovascular and other disorders, providing a practical, clinically relevant handbook for all clinicians and researchers interested in platelets and their role in disease. Covering platelet physiology, bleeding disorders, thrombotic disorders and antithrombotic therapy. Chapters cover all the conventional and less conventional aspects of platelet involvement in disease, with an emphasis on recent clinical developments. Clear take home messages have been included in each chapter to aid clinical practice. With contributions from leading experts across three continents, Platelets in Hematologic and Cardiovascular Disorders is an up-to-date, well illustrated, practical resource for everyone involved in clinical practice with platelet disorders.

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Paolo Gresele, Valentin Fuster, Jose A. Lopez, Clive P. Page, Jos Vermylen

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An Introduction to Many-Valued and Fuzzy Logic

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Semantics, Algebras, and Derivation Systems

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Professor Merrie Bergmann presents an accessible introduction to the subject of many-valued and fuzzy logic designed for use on undergraduate and graduate courses in non-classical logic. Bergmann discusses the philosophical issues that give rise to fuzzy logic - problems arising from vague language - and returns to those issues as logical systems are presented. For historical and pedagogical reasons, three-valued logical systems are presented as useful intermediate systems for studying the principles and theory behind fuzzy logic. The major fuzzy logical systems - Lukasiewicz, Godel, and product logics - are then presented as generalisations of three-valued systems that successfully address the problems of vagueness. A clear presentation of technical concepts, this book includes exercises throughout the text that pose straightforward problems, that ask students to continue proofs begun in the text, and that engage students in the comparison of logical systems.

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White Men's Countries and the International Challenge of Racial Equality

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In 1900 W. E. B. DuBois prophesied that the colour line would be the key problem of the twentieth-century and he later identified one of its key dynamics: the new religion of whiteness that was sweeping the world. Whereas most historians have confined their studies of race-relations to a national framework, this book studies the transnational circulation of people and ideas, racial knowledge and technologies that under-pinned the construction of self-styled white men's countries from South Africa, to North America and Australasia. Marilyn Lake and Henry Reynolds show how in the late nineteenth century and early twentieth century these countries worked in solidarity to exclude those they defined as not-white, actions that provoked a long international struggle for racial equality. Their findings make clear the centrality of struggles around mobility and sovereignty to modern formulations of both race and human rights.

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Intellectual Property Strategies for a Dynamic World

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How does IP balance the exclusive rights of innovators with public demand for access to their innovations? How can organizations manage IP strategically to meet their goals? How do IP strategies play out on the global stage? Driving Innovation reveals the dynamics of intellectual property (IP) as it drives the innovation cycle and shapes global society. The book presents fundamental IP concepts and practical legal and business strategies that apply to all innovation communities, including industry, non-profit institutions, and developing countries. Further, it draws on the author's broad experience, news headlines, and precedent-setting lawsuits relating to patents, trademarks, copyright, and trade secrets - from biotechnology to the open source movement. General readers and students will welcome the lively overview of this complex topic, while executives and practitioners can gain new insights and valuable approaches for putting ideas to work and navigating within or changing the global IP system to expand innovation.

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The developed world has an increasingly aging population, with approximately 10% of the population aged over 65 years. As the incidence and prevalence of blood disorders increases with age, these conditions are a heavy burden on healthcare systems. Blood Disorders in the Elderly will provide hematologists, geriatricians and all clinicians involved in the care of patients with blood disorders with clear clinical advice on the diagnosis and management of these conditions. The introductory section reviews epidemiology of aging and anemia and provides a comprehensive approach to the management of cancer in the aging patient. This is followed by a full discussion of hemopoiesis and changes it undergoes in aging. The remaining sections cover the diagnosis and management of all major disorders: anemia, malignancy, coagulation and platelet disorders and hemophilia. A detailed chapter on antithrombotic therapies is also included.

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Lodovico Balducci, William Ershler, Giovanni de Gaetano

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Equity and Agency in Comparative Constitutional Design

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We live in an era of constitution-making. New constitutions are appearing in historically unprecedented numbers, following regime change in some countries, or a commitment to modernization in others. No democratic constitution today can fail to recognize or provide for gender equality. Constitution-makers need to understand the gendered character of all constitutions, and to recognize the differential impact on women of constitutional provisions, even where these appear gender-neutral. This book confronts what needs to be considered in writing a constitution when gender equity and agency are goals. It examines principles of constitutionalism, constitutional jurisprudence, and history. Its goal is to establish a framework for a 'gender audit' of both new and existing constitutions. It eschews a simple focus on rights and examines constitutional language, interpretation, structures and distribution of power, rules of citizenship, processes of representation, and the constitutional recognition of international and customary law. It discusses equality rights and reproductive rights as distinct issues for constitutional design.

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The last two decades have seen ground-shifting changes in the epidemiology, genetics, diagnosis and management of renal cancer. Advances in diagnosis have led to many tumours being identified at an asymptomatic stage. There have also been parallel advances in treatment, such as nephron sparing procedures and radiologically guided ablative procedures. However, these changes have brought with them dilemmas such as our ability to evaluate the nature and aggressiveness of early stage tumours and how best to identify those patients who will benefit most from early treatment. This practical, clinically-oriented volume focuses on these current diagnostic and clinical challenges, making it relevant to all members of the multidisciplinary cancer care team.

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Recent advances in non-invasive sampling techniques have led to an increase in the study of hormones and behaviour. Behaviour is complex but can be explained to a large degree by interactions between various psychological and physiological components, such as the interplay between hormonal and psychological systems. This new textbook from Nick Neave offers a detailed introduction to the fascinating science of behavioural endocrinology from a psychological perspective, examining the relationships between hormones and behaviour in both humans and animals. Neave explains the endocrine system and the ways in which hormones can influence brain structure and function, and presents a series of examples to demonstrate how hormones can influence specific behaviours, including sexual determination and differentiation, neurological differentiation, parental behaviours, aggressive behaviours and cognition. This introductory textbook will appeal to second and third year social science undergraduate students in psychology and biomedicine.

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An Interdisciplinary Approach to Budget Policy

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Fiscal Challenges: An Interdisciplinary Approach to Budget Policy brings together leading experts from a range of disciplines to explore the problems of budget policy. The authors, including top economists, political scientists, historians, psychologists, and legal scholars, together provide a unique, multidisciplinary introduction to the subject. In addition to in-depth analysis of congressional budget procedures and the economics of federal deficits and debt, Fiscal Challenges explores important recent developments in budget policy at the state level and in the European Union. The goal of the volume is to offer readers wide-ranging perspectives on the many different academic disciplines and perspectives that bear on the evaluation of budgetary procedures and their reform.

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Elizabeth Garrett, Elizabeth A. Graddy, Howell E. Jackson

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Intense interest in past injustice lies at the centre of contemporary world politics. Most scholarly and public attention has focused on truth commissions, trials, lustration, and other related decisions, following political transitions. This book examines the political uses of official apologies in Australia, Canada, New Zealand, and the United States. It explores why minority groups demand such apologies and why governments do or do not offer them. Nobles argues that apologies can help to alter the terms and meanings of national membership. Minority groups demand apologies in order to focus attention on historical injustices. Similarly, state actors support apologies for ideological and moral reasons, driven by their support of group rights, responsiveness to group demands, and belief that acknowledgment is due. Apologies, as employed by political actors, play an important, if underappreciated, role in bringing certain views about history and moral obligation to bear in public life.

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Geochemical and Biogeochemical Reaction Modeling

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This book provides a comprehensive overview of reaction processes in the Earth's crust and on its surface, both in the laboratory and in the field. A clear exposition of the underlying equations and calculation techniques is balanced by a large number of fully worked examples. The book uses The Geochemist's Workbench modeling software, developed by the author and already installed at over 1000 universities and research facilities worldwide. Since publication of the first edition, the field of reaction modeling has continued to grow and find increasingly broad application. In particular, the description of microbial activity, surface chemistry, and redox chemistry within reaction models has become broader and more rigorous. These areas are covered in detail in this new edition, which was originally published in 2007. This text is written for graduate students and academic researchers in the fields of geochemistry, environmental engineering, contaminant hydrology, geomicrobiology, and numerical modeling.

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HR Management and Performance in Practice

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Organizations today are facing heightened challenges in their efforts to perform effectively. These challenges are reflected in the failure of many long-standing organizations and the shortened tenure of senior level executives. There is increasing agreement that the unique competitive advantage organizations have today lies in their people, their human resource management practices and their cultures. All other elements of production can be readily obtained, bought or copied. We are now in the era of human capital; to be successful organizations need to unleash the talents of their people. Fortunately we now have considerable understanding of what high performing organizations look like. However, a large gap still exists between what we know and what managers actually do. With contributions from a team of leading academics and practitioners, Building More Effective Organizations provides an extensive survey of human resource management and the organizational practices associated with the high performance of individuals.

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This text on contact topology is a comprehensive introduction to the subject, including recent striking applications in geometric and differential topology: Eliashberg's proof of Cerf's theorem via the classification of tight contact structures on the 3-sphere, and the Kronheimer-Mrowka proof of property P for knots via symplectic fillings of contact 3-manifolds. Starting with the basic differential topology of contact manifolds, all aspects of 3-dimensional contact manifolds are treated in this book. One notable feature is a detailed exposition of Eliashberg's classification of overtwisted contact structures. Later chapters also deal with higher-dimensional contact topology. Here the focus is on contact surgery, but other constructions of contact manifolds are described, such as open books or fibre connected sums. This book serves both as a self-contained introduction to the subject for advanced graduate students and as a reference for researchers.

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What is the environment, and how does it figure in an ethical life? This book is an introduction to the philosophical issues involved in this important question, focussing primarily on ethics but also encompassing questions in aesthetics and political philosophy. Topics discussed include the environment as an ethical question, human morality, meta-ethics, normative ethics, humans and other animals, the value of nature, and nature's future. The discussion is accessible and richly illustrated with examples. The book will be valuable for students taking courses in environmental philosophy, and also for a wider audience in courses in ethics, practical ethics, and environmental studies. It will also appeal to general readers who want a reliable and sophisticated introduction to the field.

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Unifying Theory and Integrating Practice

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Drawing together contributions from leading thinkers around the world, this 2007 book reviews developments in the theory and practice of performance measurement and management. Significantly updated and modified from the first edition, the book includes ten additional chapters which review performance measurement from the perspectives of accounting, marketing, operations, public services and supply-chain management. In addition to these functional analyses the book explores performance measurement frameworks and methodologies, practicalities and challenges, and enduring questions and issues. Edited by one of the world's leading experts on performance measurement and management, Business Performance Measurement will be of interest to graduate students, managers and researchers who wish to understand more about the theory and practice of performance measurement and management.

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The Anthropology of Texts, Persons and Publics

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What can texts - both written and oral - tell us about the societies that produce them? How are texts constituted in different cultures, and how do they shape societies and individuals? How can we understand the people who compose them? Drawing on examples from Africa and other countries, this original study sets out to answer these questions, by exploring textuality from a variety of angles. Topics covered include the importance of genre, the ways in which oral genres transcend the here-and-now, and the complex relationship between texts and the material world. Barber considers the ways in which personhood is evoked, both in oral poetry and in written diaries and letters, discusses the audience's role in creating the meaning of texts, and shows textual creativity to be a universal human capacity expressed in myriad forms. Engaging and thought-provoking, this book will be welcomed by anyone interested in anthropology, literature and cultural studies.

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Medieval Jewish intellectuals living in Muslim and Christian lands were strongly concerned to recover what they regarded as a 'lost' Jewish philosophical tradition. As part of this project they transmitted and produced many philosophical and scientific works and commentaries, as well as philosophical commentary on scripture, in Judaeo-Arabic and Hebrew, the principal literary languages of medieval Jewry. This volume presents translations of seven prominent medieval Jewish rationalists: Saadia Gaon, Solomon ibn Gabirol, Moses Maimonides, Isaac Albalag, Moses of Narbonne, Levi Gersonides, Hasdai Crescas and Joseph Albo - including, for the first time in English, the complete Falaquera abridgement of Gabirol's Source of Life. These works range over topics that are both theological (e.g. the creation of the world) and philosophical (e.g. determinism and free choice), but they are characterized by two overarching principles: the unity of truth, and its accessibility to human reason.

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What is real? What can we know? How might we act? This book sets out to answer these fundamental philosophical questions in a radical and original theory of security for our times. Arguing that the concept of security in world politics has long been imprisoned by conservative thinking, Ken Booth explores security as a precious instrumental value which gives individuals and groups the opportunity to pursue the invention of humanity rather than live determined and diminished lives. Booth suggests that human society globally is facing a set of converging historical crises. He looks to critical social theory and radical international theory to develop a comprehensive framework for understanding the historical challenges facing global business-as-usual and for planning to reconstruct a more cosmopolitan future. Theory of World Security is a challenge both to well-established ways of thinking about security and alternative approaches within critical security studies.

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Learning Medicine is a must-read for anyone thinking of a career in medicine, or who is already in the training process and wants to understand and explore the various options and alternatives along the way. Whatever your background, whether you are school-leaver or mature student, if you are interested in finding out more about becoming and being a good doctor, this is the book for you. In continuous publication since 1983, and now in its eighteenth edition, Learning Medicine provides the most current, honest and informative source of essential knowledge combined with pragmatic guidance. Learning Medicine describes medical school courses, explains foundation years and outlines the wide range of speciality choices allowing tomorrow's doctors to decide about their future careers; but it also goes further to consider the privilege and responsibility of being a doctor, providing food for thought and reflection throughout a long and rewarding career.

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Peter Richards, Simon Stockill, Rosalind Foster, Elizabeth Ingall