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Principles and Applications of Semi-Batch Bioreactors

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Many, if not most, industrially important fermentation and bioreactor operations are carried out in fed-batch mode, producing a wide variety of products. In spite of this, there is no single book that deals with fed-batch operations. This is the first book that presents all the necessary background material regarding the 'what, why and how' of optimal and sub-optimal fed-batch operations. Numerous examples are provided to illustrate the application of optimal fed-batch cultures. This unique book, by world experts with decades of research and industrial experience, is a must for researchers and industrial practitioners of fed-batch processes (modeling, control and optimization) in biotechnology, fermentation, food, pharmaceuticals and waste treatment industries.

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Introduction to Statistical Methods for Biosurveillance

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With an Emphasis on Syndromic Surveillance

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Bioterrorism is not a new threat, but in an increasingly interconnected world, the potential for catastrophic outcomes is greater today than ever. The medical and public health communities are establishing biosurveillance systems designed to proactively monitor populations for possible disease outbreaks as a first line of defense. The ideal biosurveillance system should identify trends not visible to individual physicians and clinicians in near-real time. Many of these systems use statistical algorithms to look for anomalies and to trigger epidemiologic investigation, quantification, localization and outbreak management. This book discusses the design and evaluation of statistical methods for effective biosurveillance for readers with minimal statistical training. Weaving public health and statistics together, it presents basic and more advanced methods, with a focus on empirically demonstrating added value. Although the emphasis is on epidemiologic and syndromic surveillance, the statistical methods can be applied to a broad class of public health surveillance problems.

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More Nuts and Bolts for the Social Sciences

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This book is an expanded and revised edition of the author's critically acclaimed volume Nuts and Bolts for the Social Sciences. In twenty-six succinct chapters, Jon Elster provides an account of the nature of explanation in the social sciences. He offers an overview of key explanatory mechanisms in the social sciences, relying on hundreds of examples and drawing on a large variety of sources - psychology, behavioral economics, biology, political science, historical writings, philosophy and fiction. Written in accessible and jargon-free language, Elster aims at accuracy and clarity while eschewing formal models. In a provocative conclusion, Elster defends the centrality of qualitative social sciences in a two-front war against soft (literary) and hard (mathematical) forms of obscurantism.

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There are over 600 neuromuscular disorders and the variability of these syndromes can leave clinicians feeling as if they are lost in a maze as they seek to diagnose and manage patients. This book addresses this problem by using the case-history and symptom manifestation as a starting point for the diagnostic process in adult patients, mimicking the situation in the consultation room. For each case, diagnostic tools, disease pathogenesis, prognosis and treatment options are discussed, along with rare manifestations and differential diagnoses. Symptoms, signs and syndromes are cross-linked to help the reader navigate the variety of disorders. Accompanying tables give a broader picture of the manifestations of a particular disease within the landscape of neuromuscular disorders. This highly-illustrated book, with accompanying videos, will aid neurologists at all levels, internists, geneticists, rehabilitation physicians and researchers in the field, as they seek to familiarize themselves with this complex range of disorders.

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John H. J. Wokke, Pieter A. van Doorn, Jessica E. Hoogendijk, Marianne de Visser

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The fundamental principles of the scientific method are essential for enhancing perspective, increasing productivity, and stimulating innovation. These principles include deductive and inductive logic, probability, parsimony and hypothesis testing, as well as science's presuppositions, limitations, ethics and bold claims of rationality and truth. The examples and case studies drawn upon in this book span the physical, biological and social sciences; include applications in agriculture, engineering and medicine; and also explore science's interrelationships with disciplines in the humanities such as philosophy and law. Informed by position papers on science from the American Association for the Advancement of Science, National Academy of Sciences and National Science Foundation, this book aligns with a distinctively mainstream vision of science. It is an ideal resource for anyone undertaking a systematic study of scientific method for the first time, from undergraduates to professionals in both the sciences and the humanities.

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An incredible wealth of scientific data on global warming has been collected in the last few decades. The history of the Earth's climate has been probed by drilling into polar ice sheets and sediment layers of the oceans' vast depths, and great advances have been made in computer modelling of our climate. This book provides a concise and accessible overview of what we know about ongoing climate change and its impacts, and what we can do to confront the climate crisis. Using clear and simple graphics in full colour, it lucidly highlights information contained in the Intergovernmental Panel on Climate Change reports, and brings the subject completely up-to-date with current science and policy. The book makes essential scientific information on this critical topic accessible to a broad audience. Obtaining sound information is the first step in preventing a serious, long-lasting degradation of our planet's climate, helping to ensure our future survival.

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How to Prepare a Scientific Doctoral Dissertation Based on Research Articles

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The article-based thesis is becoming increasingly common, especially in the 'hard' sciences such as biology, medicine and technology, and is beginning to replace the traditional monograph. Format guidelines vary among universities. This is the first book to summarise the main features, showing the PhD student how to prepare a thesis in such a format. The suggestions are highly practical; both its good and bad examples from published theses support the author's wise advice on all aspects of such theses. Poor figures are not only scrutinised in detail but also redrawn for comparison. Guidance also covers the issues of reprint permissions and copyright. This informative and accessible book, from the author of How to Write and Illustrate a Scientific Paper, has been developed through the author's extensive teaching experience in scientific writing and also his experience as a journal editor. It is therefore an indispensable guide to article-based thesis success.

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An Introduction via Difference and Differential Equations

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Mathematical Modelling in One Dimension demonstrates the universality of mathematical techniques through a wide variety of applications. Learn how the same mathematical idea governs loan repayments, drug accumulation in tissues or growth of a population, or how the same argument can be used to find the trajectory of a dog pursuing a hare, the trajectory of a self-guided missile or the shape of a satellite dish. The author places equal importance on difference and differential equations, showing how they complement and intertwine in describing natural phenomena.

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What is the impact of three decades of neoliberal narratives and policies on communities and individual lives? What are the sources of social resilience? This book offers a sweeping assessment of the effects of neoliberalism, the dominant feature of our times. It analyzes the ideology in unusually wide-ranging terms as a movement that not only opened markets but also introduced new logics into social life, integrating macro-level analyses of the ways in which neoliberal narratives made their way into international policy regimes with micro-level analyses of the ways in which individuals responded to the challenges of the neoliberal era. The product of ten years of collaboration among a distinguished group of scholars, it integrates institutional and cultural analysis in new ways to understand neoliberalism as a syncretic social process and to explore the sources of social resilience across communities in the developed and developing worlds.

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A First Course in Computational Algebraic Geometry

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A First Course in Computational Algebraic Geometry is designed for young students with some background in algebra who wish to perform their first experiments in computational geometry. Originating from a course taught at the African Institute for Mathematical Sciences, the book gives a compact presentation of the basic theory, with particular emphasis on explicit computational examples using the freely available computer algebra system, Singular. Readers will quickly gain the confidence to begin performing their own experiments.

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A Course in Mathematical Analysis: Volume 1, Foundations and Elementary Real Analysis

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The three volumes of A Course in Mathematical Analysis provide a full and detailed account of all those elements of real and complex analysis that an undergraduate mathematics student can expect to encounter in their first two or three years of study. Containing hundreds of exercises, examples and applications, these books will become an invaluable resource for both students and instructors. This first volume focuses on the analysis of real-valued functions of a real variable. Besides developing the basic theory it describes many applications, including a chapter on Fourier series. It also includes a Prologue in which the author introduces the axioms of set theory and uses them to construct the real number system. Volume 2 goes on to consider metric and topological spaces and functions of several variables. Volume 3 covers complex analysis and the theory of measure and integration.

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Elster proposes a normative theory of collective decision making, inspired by Jeremy Bentham but not including his utilitarian philosophy. The central proposal is that in designing democratic institutions one should reduce as much as possible the impact of self-interest, passion, prejudice and bias on the decision makers, and then let the chips fall where they may. There is no independently defined good outcome that institutions can track, nor is there any way of reliably selecting good decision makers. In addition to a long initial chapter that surveys theories of collective decision making, notably social choice theory, and a chapter expounding and discussing Bentham's views, historical chapters on the jury, constituent assemblies and electoral systems develop and illustrate the main ideas. This work draws on a welter of case studies and historical episodes, from Thucydides and Plutarch to the present. It is also grounded in psychology, behavioral economics and law.

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Preventing and Treating Missing Data in Longitudinal Clinical Trials

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Recent decades have brought advances in statistical theory for missing data, which, combined with advances in computing ability, have allowed implementation of a wide array of analyses. In fact, so many methods are available that it can be difficult to ascertain when to use which method. This book focuses on the prevention and treatment of missing data in longitudinal clinical trials. Based on his extensive experience with missing data, the author offers advice on choosing analysis methods and on ways to prevent missing data through appropriate trial design and conduct. He offers a practical guide to key principles and explains analytic methods for the non-statistician using limited statistical notation and jargon. The book's goal is to present a comprehensive strategy for preventing and treating missing data, and to make available the programs used to conduct the analyses of the example dataset.

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The Bush Administration and the Israeli-Palestinian Conflict

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This book tells the full inside story of the Bush Administration and the Israeli-Palestinian conflict. Written by a top National Security Council officer who worked at the White House with Bush, Cheney, and Rice and attended dozens of meetings with figures like Sharon, Mubarak, the kings of Jordan and Saudi Arabia, and Palestinian leaders, it brings the reader inside the White House and the palaces of Middle Eastern officials. How did 9/11 change American policy toward Arafat and Sharon's tough efforts against the Second Intifada? What influence did the Saudis have on President Bush? Did the American approach change when Arafat died? How did Sharon decide to get out of Gaza, and why did the peace negotiations fail? In the first book by an administration official to focus on Bush and the Middle East, Elliott Abrams brings the story of Bush, the Israelis, and the Palestinians to life.

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Practical Foundations for Programming Languages

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Types are the central organizing principle of the theory of programming languages. In this innovative book, Professor Robert Harper offers a fresh perspective on the fundamentals of these languages through the use of type theory. Whereas most textbooks on the subject emphasize taxonomy, Harper instead emphasizes genetics, examining the building blocks from which all programming languages are constructed. Language features are manifestations of type structure. The syntax of a language is governed by the constructs that define its types, and its semantics is determined by the interactions among those constructs. The soundness of a language design  the absence of ill-defined programs  follows naturally. Professor Harper's presentation is simultaneously rigorous and intuitive, relying on elementary mathematics. The framework he outlines scales easily to a rich variety of language concepts and is directly applicable to their implementation. The result is a lucid introduction to programming theory that is both accessible and practical.

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Oil is the world's single most important commodity and its political effects are pervasive. Jeff D. Colgan extends the idea of the resource curse into the realm of international relations, exploring how countries form their foreign policy preferences and intentions. Why are some but not all oil-exporting 'petrostates' aggressive? To answer this question, a theory of aggressive foreign policy preferences is developed and then tested, using both quantitative and qualitative methods. Petro-Aggression shows that oil creates incentives that increase a petrostate's aggression, but also incentives for the opposite. The net effect depends critically on its domestic politics, especially the preferences of its leader. Revolutionary leaders are especially significant. Using case studies including Iraq, Iran, Libya, Saudi Arabia and Venezuela, this book offers new insight into why oil politics has a central role in global peace and conflict.

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Race, Caste, and Difference in India and the United States

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This is a book about prejudice and democracy, and the prejudice of democracy. In comparing the historical struggles of two geographically disparate populations - Indian Dalits (once known as Untouchables) and African Americans - Gyanendra Pandey, the leading subaltern historian, examines the multiple dimensions of prejudice in two of the world's leading democracies. The juxtaposition of two very different locations and histories, and within each of them of varying public and private narratives of struggle, allows for an uncommon analysis of the limits of citizenship in modern societies and states. Pandey, with his characteristic delicacy, probes the histories of his protagonists to uncover a shadowy world where intolerance and discrimination are part of both public and private lives. This unusual and sobering book is revelatory in its exploration of the contradictory history of promise and denial that is common to the official narratives of nations such as India and the United States and the ideologies of many opposition movements.

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Language and Gender is an introduction to the study of the relation between gender and language use, written by two leading experts in the field. This new edition, thoroughly updated and restructured, brings out more strongly an emphasis on practice and change, while retaining the broad scope of its predecessor and its accessible introductions which explain the key concepts in a non-technical way. The authors integrate issues of sexuality more thoroughly into the discussion, exploring more diverse gendered and sexual identities and practices. The core emphasis is on change, both in linguistic resources and their use and in gender and sexual ideologies and personae. This book explores how change often involves conflict and competing norms, both social and linguistic. Drawing on their own extensive research, as well as other key literature, the authors argue that the connections between language and gender are deep yet fluid, and arise in social practice.

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The Power of Human Rights (published in 1999) was an innovative and influential contribution to the study of international human rights. At its center was a 'spiral model' of human rights change which described the various socialization processes through which international norms were internalized into the domestic practices of various authoritarian states during the Cold War years. The Persistent Power of Human Rights builds on these insights, extending its reach and analysis. It updates our understanding of the various causal mechanisms and conditions which produce behavioural compliance, and expands the range of rights-violating actors examined to include democratic and authoritarian Great Powers, corporations, guerrilla groups, and private actors. Using a unique blend of quantitative and qualitative research and theory, this book yields not only important new academic insights but also a host of useful lessons for policy-makers and practitioners.

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Thomas Risse, Stephen C. Ropp, Kathryn Sikkink

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The Sources of Social Power: Volume 4, Globalizations, 19452011

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Distinguishing four sources of power  ideological, economic, military and political  this series traces their interrelations throughout human history. This fourth volume covers the period from 1945 to the present, focusing on the three major pillars of post-war global order: capitalism, the nation-state system and the sole remaining empire of the world, the United States. In the course of this period, capitalism, nation-states and empires interacted with one another and were transformed. Mann's key argument is that globalization is not just a single process, because there are globalizations of all four sources of social power, each of which has a different rhythm of development. Topics include the rise and beginnings of decline of the American Empire, the fall or transformation of communism (respectively, the Soviet Union and China), the shift from neo-Keynesianism to neoliberalism, and the three great crises emerging in this period  nuclear weapons, the great recession and climate change.