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The rapidly expanding field of food safety includes many new developments in the understanding of the entire range of toxic compounds found in foods -- whether naturally occurring or having been introduced by industry or food processing methods.  This 2e of Introduction to Food Toxicology explores these developments while continuing to provide a core understanding of the basic principles of food toxicology. Solid-phase extraction, immunoassay, and LC/MS Mechanisms of regulation of xenobiotic activation and deactivation Developments in the modes of action and impact of natural toxins in food plants A comprehensive review of the issues surrounding dioxins The function of antioxidants and their toxicological aspects Acrylamide, its occurrence, toxicity and regulation on its use Phytochemicals, their beneficial effects and the modes of action of this growing group of nutraceuticals from food plants Diet and drug interactions

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Takayuki Shibamoto, Leonard F. Bjeldanes

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Forest Management and Planning provides a focused understanding of contemporary forest management issues through real life examples to engage students.

The methodology for the development of quantitatively-derived forest management plans from gathering information to the implementation of plans at the forest level are clearly explained. Emphasis is placed on the development of traditional commodity production forest plans using linear programming, the development of alternative forest plans, and problem resolution in planning.

The authors have developed this book based on their personal experience in teaching forest management courses and the review of ten forestry programs (Auburn University, University of Georgia, Iowa State University, Louisiana State University, Northern Arizona University, Ohio State University, Pennsylvania State University, University of Florida, Virginia Tech, and Oregon State University). The integration of extended case studies of a variety of scenarios as well as the inclusion of a section on report writing will engage students. Acknowledgement and integration of various software packages for forest management provide the most useful tools for those studying forest management and distinguish this book from the competition.

This book is an ideal resource for students of Forest Management primarily an upper-level course in forestry, and natural resource management, wildlife, and recreation programs.
Real-life examples illustrated mathematically and graphically End-of-chapter questions Modern coverage of the planning and management of US Forest timber production Case study analysis Expansive applications drawn for examples in the western US, the Lake States, the northeastern US, the southern US and Canada Detailed descriptions of models and solution methods for integrating a variety of wildlife habitat constraints

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Pete Bettinger, Kevin Boston, Jacek P. Siry, Donald L. Grebner, Pete Bettinger

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Forensic Science, Computers, and the Internet

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Digital Evidence and Computer Crime, Third Edition, provides the knowledge necessary to uncover and use digital evidence effectively in any kind of investigation.

It offers a thorough explanation of how computer networks function, how they can be involved in crimes, and how they can be used as a source of evidence. In particular, it addresses the abuse of computer networks as well as privacy and security issues on computer networks.

This updated edition is organized into five parts. Part 1 is about digital forensics and covers topics ranging from the use of digital evidence in the courtroom to cybercrime law. Part 2 explores topics such as how digital investigations are conducted, handling a digital crime scene, and investigative reconstruction with digital evidence. Part 3 deals with apprehending offenders, whereas Part 4 focuses on the use of computers in digital investigation. The book concludes with Part 5, which includes the application of forensic science to networks.

New to this edition are updated information on dedicated to networked Windows, Unix, and Macintosh computers, as well as Personal Digital Assistants; coverage of developments in related technology and tools; updated language for search warrant and coverage of legal developments in the US impacting computer forensics; and discussion of legislation from other countries to provide international scope. There are detailed case examples that demonstrate key concepts and give students a practical/applied understanding of the topics, along with ancillary materials that include an Instructor's Manual and PowerPoint slides.

This book will prove valuable to computer forensic students and professionals, lawyers, law enforcement, and government agencies (IRS, FBI, CIA, CCIPS, etc.).
Named The 2011 Best Digital Forensics Book by InfoSec Reviews Provides a thorough explanation of how computers & networks function, how they can be involved in crimes, and how they can be used as evidence Features coverage of the abuse of computer networks and privacy and security issues on computer networks

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The field of gender-specific medicine examines how normal human biology and physiology differ between men and women and how the diagnosis and treatment of disease differs as a function of gender. This revealing research covers various conditions that predominantly occur in men as well conditions that predominantly occur in women. Among the areas of greatest difference are cardiovascular disease, mood disorders, the immune system, lung cancer as a consequence of smoking, osteoporosis, diabetes, obesity, and infectious diseases.

The Second Edition of Principles of Gender-Specific Medicine focuses on the essentials of gender-specific medicine and the current study of sex and gender differences in human physiology and pathophysiology. New section editors, new chapter authors, and new chapters have been added to reflect the most up-to-date clinical research and practice.
Offers insight into how the gender-specific risks of one organ systems disease affects the health of other organ systems Outlines the sex-specific differences of normal anatomy and physiology Illustrates the gender-specific features and quantifies "gender" and "sex" as risk factors across all major diseases Qualifies and analyzes the results of new drug therapies designed with gender-specific differences in mind: ex, hormone therapy in men and women for the prevention and treatment of cardiovascular disease All chapters progress translationally from the basic science to the clinical applications of gender-specific therapies, drugs, or treatments Sections on drug metabolism, aging, and meta-analysis of data incorporated into all disease-specific chapters

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Clinical Psychology is a graduate-level introduction to the field of clinical psychology. While most textbooks focus on either assessment, treatment, or research, this textbook covers all three together specifically for the introductory level graduate course.

Chapter coverage is diverse and contributors come from both PhD and PsyD programs and a variety of theoretical orientations. Chapter topics cover the major activities of the contemporary clinical psychologist with an introduction focusing on training models. The book has a mentoring style designed to highlight the relevance of the topics discussed to clinicians in training. Assessment and treatment chapters focus on evidence-based practice, comparing and contrasting different options, the basis for clinical choice between them, and efficacy of same. It will also introduce the business and ethical aspects of the clinical career that current introductory books do not include, such ethics in assessment, treatment, and research; third party payers; technological developments; dissemination of research findings; cross-cultural issues; and the future of the profession.

The text is designed for students in their first year of clinical psychology graduate training.
Includes assessment, treatment, and practice issues Compares and contrasts different therapeutic styles Exemplifies practical application through case studies Focuses on evidence-based practice Orients future clinicians to contemporary issues facing psychological practices

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Handbook of Digital Forensics and Investigation

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Handbook of Digital Forensics and Investigation builds on the success of the Handbook of Computer Crime Investigation, bringing together renowned experts in all areas of digital forensics and investigation to provide the consummate resource for practitioners in the field. It is also designed as an accompanying text to Digital Evidence and Computer Crime.

This unique collection details how to conduct digital investigations in both criminal and civil contexts, and how to locate and utilize digital evidence on computers, networks, and embedded systems. Specifically, the Investigative Methodology section of the Handbook provides expert guidance in the three main areas of practice: Forensic Analysis, Electronic Discovery, and Intrusion Investigation. The Technology section is extended and updated to reflect the state of the art in each area of specialization. The main areas of focus in the Technology section are forensic analysis of Windows, Unix, Macintosh, and embedded systems (including cellular telephones and other mobile devices), and investigations involving networks (including enterprise environments and mobile telecommunications technology).

This handbook is an essential technical reference and on-the-job guide that IT professionals, forensic practitioners, law enforcement, and attorneys will rely on when confronted with computer related crime and digital evidence of any kind.
*Provides methodologies proven in practice for conducting digital investigations of all kinds
*Demonstrates how to locate and interpret a wide variety of digital evidence, and how it can be useful in investigations
*Presents tools in the context of the investigative process, including EnCase, FTK, ProDiscover, foremost, XACT, Network Miner, Splunk, flow-tools, and many other specialized utilities and analysis platforms
*Case examples in every chapter give readers a practical understanding of the technical, logistical, and legal challenges that arise in real investigations

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Due to the adverse stress conditions typical of olive cultivation in desert conditions, the olive tree is responding with production of high levels of antioxidant substances. Among these substances are polyphenols, tocopherols, and phytosterols. Studies have shown that saline irrigated varieties of olives have demonstrated advantages over those irrigated with tap water.

This is just one of the aspects of desert cultivation of olives that is covered in Desert Olive Oil Advanced Biotechnologies. Based on 20 years of research, the book expounds on the appropriate selection of olive varieties with high productivity and oil quality, the impact of foliar nutrition on decreasing alternate bearing and increasing fruit quality, improving efficiency of mechanical harvesting, and increasing efficiency of oil extraction and oil quality regulating analysis.
Addresses olive cultivation methods for semi-arid environments Focuses on intensive cultivation using saline and municipal waste recycled irrigation water and their significant impact on the production and nutritional value of olive oil Integrated and multidisciplinary approaches providing a comprehensive view of the desert olive industry Provides key considerations including ecological, biotechnological, agricultural and political impacts

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A Christopher and Dana Reeve Foundation Text and Atlas

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Many hundreds of thousands suffer spinal cord injuries leading to loss of sensation and motor function in the body below the point of injury. Spinal cord research has made some significant strides towards new treatment methods, and is a focus of many laboratories worldwide. In addition, research on the involvement of the spinal cord in pain and the abilities of nervous tissue in the spine to regenerate has increasingly been on the forefront of biomedical research in the past years. The Spinal Cord, a collaboration with the Christopher and Dana Reeve Foundation, is the first comprehensive book on the anatomy of the mammalian spinal cord. Tens of thousands of articles and dozens of books are published on this subject each year, and a great deal of experimental work has been carried out on the rat spinal cord. Despite this, there is no comprehensive and authoritative atlas of the mammalian spinal cord. Almost all of the fine details of spinal cord anatomy must be searched for in journal articles on particular subjects. This book addresses this need by providing both a comprehensive reference on the mammalian spinal cord and a comparative atlas of both rat and mouse spinal cords in one convenient source. The book provides a descriptive survey of the details of mammalian spinal cord anatomy, focusing on the rat with many illustrations from the leading experts in the field and atlases of the rat and the mouse spinal cord. The rat and mouse spinal cord atlas chapters include photographs of Nissl stained transverse sections from each of the spinal cord segments (obtained from a single unfixed spinal cord), detailed diagrams of each of the spinal cord segments pictured, delineating the laminae of Rexed and all other significant neuronal groupings at each level and photographs of additional sections displaying markers such as acetylcholinesterase (AChE), calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), enkephalin, calcitonin gene-related peptide (CGRP), and neuronal nuclear protein (NeuN). The text provides a detailed account of the anatomy of the mammalian spinal cord and surrounding musculoskeletal elements The major topics addressed are: development of the spinal cord; the gross anatomy of the spinal cord and its meninges; spinal nerves, nerve roots, and dorsal root ganglia; the vertebral column, vertebral joints, and vertebral muscles; blood supply of the spinal cord; cytoarchitecture and chemoarchitecture of the spinal gray matter; musculotopic anatomy of motoneuron groups; tracts connecting the brain and spinal cord; spinospinal pathways; sympathetic and parasympathetic elements in the spinal cord; neuronal groups and pathways that control micturition; the anatomy of spinal cord injury in experimental animals The atlas of the rat and mouse spinal cord has the following features: Photographs of Nissl stained transverse sections from each of 34 spinal segments for the rat and mouse; Detailed diagrams of each of the 34 spinal segments for rat and mouse, delineating the laminae of Rexed and all other significant neuronal groupings at each level. ; Alongside each of the 34 Nissl stained segments, there are additional sections displaying markers such as acetylcholinesterase, calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), and neuronal nuclear protein (NeuN) All the major motoneuron clusters are identified in relation to the individual muscles or muscle groups they supply

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Charles Watson, George Paxinos, Gulgun Kayalioglu

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Neuromodulation will be the first comprehensive and in-depth reference textbook covering all aspects of the rapidly growing field of neuromodulation. This book provides a complete discussion of the fundamental principles of neuromodulation and therapies applied to the brain, spinal cord, peripheral nerves, autonomic nerves and various organs.
The textbook is highly structured and organized into overarching sections that cover chronic pain, movement disorders, psychiatric disorders, epilepsy, functional electrical stimulation, cardiac, gastrointestinal, genitourinary and organ neuromodulation. The fundamental principles of electricity and infusion, neural tissue interface, biomedical engineering, neuromodulation devices, basic science, neuroanatomy, neurophysiology, imaging and mechanisms are emphasized. In addition to providing details pertaining to the state-of-the-art current practice, innovative and emerging applications are discussed in specific chapters. Finally, the textbook provides specific chapters focusing on the technical aspects of the various neuromodulation procedures as well as technical specifications of various implantable devices.
All of the contributors to Neuromodulation represent leading experts in the field. The editors are internationally renowned in their respective fields of neuromodulation, pain management, functional neurosurgery and biomedical engineering. Neuromodulation will be the first and foremost authoritative text on neuromodulation therapies and will establish the gold standard that defines the field for years to come.
Key Features
The first comprehensive reference on the emerging field of Neuromodulation Editors and authors include all leading figures in the field, and the leaders of the International Neuromodulation Society Over 90 chapters on topics ranging from a layout of the fundamentals (e.g. neuroanatomy, plasticity, bioelectrical effects, infusion therapies), solutions for the biomedical engineering challenges (e.g. materials, how to preserve normal function etc.), to a rundown of the existing applications and their future promise Over 1200 pages in splendid full color, richly illustrated Important areas of application include: control of chronic pain delivery of drugs to the nervous system via implanted devices control of epilepsy, Parkinson, etc. functional restoration, e.g. visual, auditory, restoration after stroke, restoration of motor function after traumatic events stimulation of body organs via neural devices (incl. the heart, abdominal organs, genitourinary organs) overview over newly emerging fields - control of obesity, blood pressure, tinnitus, brain injury, neurodegenerative diseases, brain-machine interfaces

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Elliot S. Krames, P. Hunter Peckham, Ali R. Rezai

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HIV/AIDS continues to be the pandemic of our times and there has not been a comprehensive medically based AIDS prevention book published in the last 5 years.  It is estimated that 36 to 45 million people including 2-3 million children already are infected worldwide and an additional 4-7 million more are infected each year. There are about 6,000 new infections daily and about 12 million AIDS orphans.  People receiving AIDS treatments feel well and have no detectable viral load, but still can infect others. And even when a vaccine is found, it will take many years before it can be administered across the developing world. Discusses all aspects of AIDS prevention, from epidemiology, molecular immunology and virology to the principles of broad-based public health prevention interventions Special focus on the array of interventions that have been proven effective through rigorous study Identifies new trends in HIV/AID epidemiology and their impact on creating and implementing prevention interventions Incorporates virology, biology, infectious diseases, vaccinology, microbicides and research methodologies into AIDS prevention

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The previous two editions of the Human Nervous System have been the standard reference for the anatomy of the central and peripheral nervous system of the human. The work has attracted nearly 2,000 citations, demonstrating that it has a major influence in the field of neuroscience. The 3e is a complete and updated revision, with new chapters covering genes and anatomy, gene expression studies, and glia cells. The book continues to be an excellent companion to the Atlas of the Human Brain, and a common nomenclature throughout the book is enforced. Physiological data, functional concepts, and correlates to the neuroanatomy of the major model systems (rat and mouse) as well as brain function round out the new edition.
Adopts standard nomenclature following the new scheme by Paxinos, Watson, and Puelles and aligned with the Mai et al. Atlas of the Human Brain (new edition in 2007) Full color throughout with many new and significantly enhanced illustrations Provides essential reference information for users in conjunction with brain atlases for the identification of brain structures, the connectivity between different areas, and to evaluate data collected in anatomical, physiological, pharmacological, behavioral, and imaging studies

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The purpose of this book is to provide the most comprehensive, easy-to-use, and informative guide on light microscopy. Light and Video Microscopy will prepare the reader for the accurate interpretation of an image and understanding of the living cell. With the presentation of geometrical optics, it will assist the reader in understanding image formation and light movement within the microscope. It also provides an explanation of the basic modes of light microscopy and the components of modern electronic imaging systems and guides the reader in determining the physicochemical information of living and developing cells, which influence interpretation.

* Brings together mathematics, physics, and biology to provide a broad and deep understanding of the light microscope

* Clearly develops all ideas from historical and logical foundations

* Laboratory exercises included to assist the reader with practical applications

* Microscope discussions include: bright field microscope, dark field microscope, oblique illumination, phase-contrast microscope, photomicrography, fluorescence microscope, polarization microscope, interference microscope, differential interference microscope, and modulation contrast microscope

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Complementary and Alternative Therapies and the Aging Population

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The major objective of this book is to review in detail health problems occurring with significant frequency in aging adults which are proposed to be treated or ameliorated using nutriceuticals as foods and dietary supplements as well as other complementary and alternative therapies. Chapters primarily focusing on nutrients have been excluded to maintain a focus on complementary and alternative medicine (CAM).

The book is divided into three general sections:

1. Nutriceuticals and Botanicals in Health Promotion - including Specific Nutriceuticals Used in Treating Aged; and General Nutraceutical Approaches to Therapy with emphasis on cancer. 2. Non-nutritional CAM Therapies including Mind-mediated Therapies; and Physically Applied CAM Therapies3. Non-dietary Complementary and Alternative Medicine (CAM) Use and Benefits to the Elderly in Health
Identifies the important nutritional requirements of the aging population, and how nutraceuticals and other CAM options affect those Addresses the many disease entities and cancers are found with higher frequency in the aged, including cancer, trauma, or infectious disease that can alter intakes of nutraceutical containing foods and/or requirements for various nutrients. Explores the nutritional materials botanical extracts and components that can have important health promotion benefits and risks, to ensure safe consumption Reviews the frequently used non-traditional and often unproven CAM therapies, beyond nutritional and nutraceutical supplements, including a variety of physical and psychosocial treatments.

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Plant Cell Biology is a semester long course for undergraduates and graduate students which integrates mathematics and physics, two years of chemistry, genetics, biochemistry and evolution disciplines. Having taught this course for over ten years, the author uses his expertise to relate the background established in plant anatomy, plant physiology, plant growth and development, plant taxonomy, plant biochemistry, and plant molecular biology courses to plant cell biology. This integration attempts to break down the barrier so plant cell biology is seen as an entree into higher science.Distinguishing this book from papers that are often used for teaching the subject which use a single plant to demonstrate the techniques of molecular biology, this book covers all aspects of plant cell biology without emphasizing any one plant, organelle, molecule, or technique. Although most examples are biased towards plants, basic similarities between all living eukaryotic cells (animal and plant) are recognized and used to best illustrate for students cell processes. Thoroughly explains the physiological underpinnings of biological processes to bring original insight related to plants Includes examples throughout from physics, chemistry, geology, and biology to bring understanding to plant cell development, growth, chemistry and diseases Provides the essential tools for students to be able to evaluate and assess the mechanisms involved in cell growth, chromosome motion, membrane trafficking, and energy exchange Companion Web site provides support for all plant cell biology courses

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Motor Control is a complex process that involves the brain, muscles, limbs, and often external objects. It underlies motion, balance, stability, coordination, and our interaction with others and technology. This book is a comprehensive introduction to motor control, covering a complex topic in an approachable way encompassing the psychological, physiological, and computational approaches to motor control.

Human Motor Control, 2e cuts across all movement related disciplines: physical education, dance, physical therapy, robotics, etc. This second edition incorporates advances to the field, and integrates throughout the book how research harkens back to four critical questions: how do we select our actions of the many actions possible? How are these behaviors sequenced for appropriate order and timing between them? How does perception integrate with motor control? And how are perceptualmotor skills acquired?

As before, the book retains its signature organization around activity systems. These activity systems include walking, looking, reaching, drawing and writing, keyboarding, speaking and singing, and smiling. Chapters here exemplify rather than encompass all the behaviors related to them. Hence smiling discusses physical and neural control of the face used in other expressions besides smiling, as well as the origins of emotional expression, and the importance of emotion expression in social interaction. These chapters on activity systems are preceded by chapters on basics, with an introduction and information on the physiological and psychological foundations of movement. The last section discusses integration of movements, individual differences, theories of motor control, and the contributions of both genetics and technology to motor control.

Special features of the second edition:Organization by major activity systems New: brain imaging, social action, embodied cognition, advances in genetics and technology Detailed treatment of motor neuroscience Further Readings section added to each chapter
Retains unique organization of first edition: Part 1 on Preliminaries, Part 2 on Activity Systems, Part 3 on Principles and Prospects Emphasizes exciting advances in the field and promising new directions Well-illustrated with entertaining figures

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Single molecule techniques, including single molecule fluorescence, optical tweezers, and scanning probe microscopy, allow for the manipulation and measurement of single biological molecules within a live cell or in culture. These approaches, amongst the most exciting tools available in biology today, offer powerful new ways to elucidate biological function, both in terms of revealing mechanisms of action on a molecular level as well as tracking the behaviour of molecules in living cells. This book provides the first complete and authoritative treatment of this rapidly emerging field, explicitly from a biological perspective.The contents are organized by biological system or molecule. Each chapter discusses insights that have been revealed about their mechanism, structure or function by single molecule techniques. Among the topics covered are enzymes, motor proteins, membrane channels, DNA, ribozymes, cytoskeletal proteins, and other key molecules of current interest. An introduction by the editor provides a concise review of key principles and an historical overview. The last section discusses applications in molecular diagnostics and drug discovery. Organized by biological system or molecule Each chapter discusses insights into mechanism of action, structure, and function Covers enzymes, motor proteins, membrane channels, DNA, ribozymes, etc Includes an introduction to key principles and an historical overview Discusses applications in molecular diagnostics and drug discovery Provides an expert's perspective on future development

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Chesley's Hypertensive Disorders in Pregnancy

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Hypertensive disorders remain one the major causes of maternal and fetal morbidity and death. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, the hypertensive disorders remain marginally studied, and their management is commonly controversial. Chesleys Hypertensive Disorders in Pregnancy remains one of the beacons to guide this field, recognized for its uniqueness and utility. The Third Edition continues this tradition, focusing on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. Differing from other texts devoted to preeclampsia, it covers the whole gamut of high blood pressure, not just preeclampsia.

NEW TO THE THIRD EDITION:*

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James M. Roberts, Gary F. Cunningham, Marshall D. Lindheimer

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Bridging the Divide between Fundamental Treatise and Industrial Application

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Industrialists developing new food and pharmaceutical products face the challenge of innovation in an increasingly competitive market that must consider incredient cost, product added-value, expectations of a healthy life-style, improved sensory impact, controlled delivery of active compounds and last, but not lease, product stability.  While much work has been done to explore, understand, and address these issues, a gap has emerged between recent advances in fundamental knowledge and its direct application to product situations with a growing need for scientific input.Modern Biopolymer Science matches science to application by first acknowledging the differing viewpoints between those working with low-solids and those working with high-solids, and then sharing the expertise of those two camps under a unified framework of materials science. Real-world utilisation of fundamental science to achieve breakthroughs in product development Includes a wide range of related aspects of low and high-solids systems for foods and pharmaceuticals Covers more than bio-olymer science in foods by including biopolymer interactions with bioactive compounds, issues of importance in drug delivery and medicinal chemistry

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Stefan Kasapis, Ian T. Norton, Johan B Ubbink

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Volume 45 of the Advances in Clinical Chemistry series contains review articles of wide interest to clinical laboratory scientists and diagnostic adventurers. Articles in this volume cover such topics as Inhibins as Diagnostic Markers in Human Reproduction; uPA and PAI-1 in Breast Cancer: Review of Their Clinical Utility and Current Validation in the Prospective NNBC-3 Trial; Advances in Multiple Analyte Profiling; Immune Monitoring of Clinical Trials with Biotherapies; Dietary Modification of Brain Function: Effects on Neuroendocrine and Psychological Determinants of Mental Health and Stress Related Disorders; Menopause, Estrogen and Gonadotropins in Alzheimers Disease; Immunosuppression Routed via the Kynurenine Pathway: A Biochemical and Pathophysiologic Approach; and Pathophysiology of Tumor-associated Macrophages.

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Understanding the causes and contributing factors leading to outbreaks of food-borne illness associated with contamination of fresh produce continues to be a worldwide challenge for everyone from the growers of fresh-cut produce through the entire production and delivery process. Additionally researchers both at universities and in government agencies are facing an increased challenge to develop means of preventing these foodborne illness occurrences. The premise of this book is that when human pathogen contamination of fresh produce occurs, it is extremely difficult to reduce pathogen levels sufficiently to assure microbiological safety with the currently available technologies. A wiser strategy would be to avoid crop production conditions that result in microbial contamination to start.

These critical, problem-oriented chapters have been written by researchers active in the areas of food safety and microbial contamination during production, harvesting, packing and fresh-cut processing of horticultural crops, and were designed to provide methods of contamination avoidance. Coverage includes policy and practices in the US, Mexico and Central America, Europe, and Japan.

*Addresses food-borne contaminations from a prevention view, providing proactive solutions to the problems

*Covers core sources of contamination and methodologies for identifying those sources

*Includes best practice and regulatory information