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Liposomes are cellular structures made up of lipid molecules, which are water insoluble organic molecules and the basis of biological membranes. Important as a cellular model in the study of basic biology, liposomes are also used in clinical applications such as drug delivery and virus studies. Liposomes Part F is a continuation of previous MIE Liposome volumes A through E. One of the most highly respected publications in the field of biochemistry since 1955 Frequently consulted and praised by researchers and reviewers alike Truly an essential publication for anyone in any field of the life sciences

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This volume of The Enzymes features high-caliber thematic articles on the topic of glycosylphosphatidylinositol (GPI) anchoring of proteins. Contributions from leading authorities Informs and updates on all the latest developments in the field

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Anant Kumar Menon, Taroh Kinoshita, Peter A Orlean, Fuyuhiko Tamanoi

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Endogenous and Exogenous Control of Gametogenesis and Spawning in Echinoderms

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Advances in Marine Biology was first published in 1963. Now edited by A.J. Southward (Marine Biological Association, UK), P.A. Tyler (Southampton Oceanography Association, UK), C.M. Young (Harbor Branch Oceanographic Institution, USA) and L.A. Fuiman (University of Texas, USA), the serial publishes in-depth and up-to-date reviews on a wide range of topics which will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, oceanography. Eclectic volumes in the series are supplemented by thematic volumes on such topics as The Biology of Calanoid Copepods. Rated "Number 1" in the highly competitive category of Marine and Freshwater Biology by ISI in the 2000 ISI journals citation report Maintains an Impact Factor of 3.37, the highest in the field Series features over 35 years of coverage of research

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Handbook of Assessment in Clinical Gerontology

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New trends in mental healthcare practice and a rapid increase in the aged population are causing an explosion in the fields of clinical gerontology and geropsychology today. This comprehensive second edition handbook offers clinicians and graduate students clear guidelines and reliable tools for assessing general mental health, cognitive functioning, functional age, psychosocial health, comorbidity, behavior deficits, and more. Psychopathology, behavioral disorders, changes in cognition, and changes in everyday functioning are addressed in full, and a wide range of conditions and disorders common to this patient population are covered. Each chapter provides an empirical review of assessment instruments, assessment scales in their totality, a review of how these instruments are used with and adapted for different cultural groups, illustration of assessments through case studies, and information on how to utilize ongoing assessment in treatment and/or treatment planning. This combination of elements will make the volume the definitive assessment source for clinicians working with elderly patients. The most comprehensive source of up-to-date data on gerontological assessment, with review articles covering: psychopathology, behavioral disorders, changes in cognition, and changes in everyday functioning Consolidates broadly distributed literature into single source, saving researchers and clinicians time in obtaining and translating information and improving the level of further research and care they can provide Chapters directly address the range of conditions and disorders most common for this patient population - i.e. driving ability, mental competency, sleep, nutrition, sexual functioning, demntias, elder abuse, depression, anxiety disorders, etc Fully informs readers regarding conditions most commonly encountered in real world treatment of an elderly patient population Each chapter cites case studies to illustrate assessment techniques Exposes reader to real-world application of each assessment discussed

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Advances in Marine Biology has been providing in-depth and up-to-date reviews on all aspects of marine biology since 1963 -- over 40 years of outstanding coverage! The series is well-known for both its excellence of reviews and editing. Now edited by D.W. Sims (Marine Biological Association Laboratory, Plymouth, UK), with an internationally renowned Editorial Board, the serial publishes in-depth and up-to-date content on a wide range of topics that will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, and biological oceanography.
Rated "Number 1" in the highly competitive category of Marine and Freshwater Biology by ISI in the 2000 ISI journals citation report Maintains an Impact Factor of 3.37, the highest in the field Series features over 35 years of coverage of the research

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Single Molecule Tools, Part A: Fluorescence Based Approaches

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Single molecule tools have begun to revolutionize the molecular sciences, from biophysics to chemistry to cell biology. They hold the promise to be able to directly observe previously unseen molecular heterogeneities, quantitatively dissect complex reaction kinetics, ultimately miniaturize enzyme assays, image components of spatially distributed samples, probe the mechanical properties of single molecules in their native environment, and "just look at the thing" as anticipated by the visionary Richard Feynman already half a century ago. Single Molecule Tools, Part A: Fluorescence Based Approaches captures a snapshot of this vibrant, rapidly expanding field, presenting articles from pioneers in the field intended to guide both the newcomer and the expert through the intricacies of getting single molecule tools. Includes time-tested core methods and new innovations applicable to any researcher employing single molecule tools Methods included are useful to both established researchers and newcomers to the field Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines

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This fully revised second edition provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the readers understanding.
More than 25% new content, particularly expanding the scope to include new findings in translational research. Unique in its depth of coverage of molecular and cellular mechanisms Extensive cross-referencing to Comprehensive Learning and Memory Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples

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Molecular Mechanisms of Hormone Actions on Behavior

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A single volume of 31 articles, Mechanisms of Hormone Actions on Behavior is an authoritative selection of relevant chapters from the Hormones Brain and Behavior 2e MRW, the most comprehensive source of neuroendocrinological information assembled to date (AP June 2009). The study of hormones as they impact the brain and, subsequently, behavior is a central topic in neuroscience, endocrinology and psychiatry. This volume offers an overview of neuroendocrinological topics, approaching the subject from the perspective of the mechanisms which control hormone actions on behavior. Female, male and stress hormones are discussed at the cellular, behavioral and developmental level, and sexual differentiation of the development of hormone-dependent neuronal systems, neuropeptides/neuromodulators, and steroid-inducedneuroplasticity are addressed. There is simply no other current single-volume reference with such comprehensive coverage and depth.Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 175 figures (over 50 in color). A collection of articles reviewing our fundamental knowledge of the mechanisms of neuroendocrinology, the book provides an essential, affordable reference for researchers, clinicians and graduate students in the area. The most comprehensive single-volume source of up-to-date data on the mechanisms behind neuroendocrinology, with review articles covering x,y z Chapters synthesize information otherwise dispersed across a number of journal articles and book chapters, thus saving researchers the time consuming process of finding and integrating this information themselves Offering outstanding scholarship, each chapter is written by an expert in the topic area and approximately 35% of chapters are written by international contributors Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions Heavily illustrated with 175 figures, approximately 54 in color Presents material in most visually useful form for the reader

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Principles of Molecular, Cellular, and Medical Neurobiology

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Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences.

The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology.
Completely updated text with new authors and material, and many entirely new chapters Over 400 fully revised figures in splendid color 61 chapters covering the range of cellular, molecular and medical neuroscience Translational science boxes emphasizing the connections between basic and clinical neuroscience Companion website at http://elsevierdirect.com/companions/9780123749475

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R. Wayne Albers, Donald L. Price, Scott Brady, George Siegel

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Bioactive Foods in Promoting Health: Probiotics and Prebiotics brings together experts working on the different aspects of supplementation, foods, and bacterial preparations, in health promotion and disease prevention, to provide current scientific information, as well as providing a framework upon which to build clinical disease treatment studies. Since common dietary bacterial preparations are over-the-counter and readily available, this book will be useful to the growing nutrition, food science, and natural product community that will use it as a resource in identifying dietary behavioral modifications in pursuit of improved health as well as for treatment of specific disease, as it focuses on the growing body of knowledge of the role of various bacteria in reducing disease risk and disease.

Probiotics are now a multi-billion-dollar, dietary supplement business which is built upon extremely little research data. In order to follow the 1994 ruling, the U.S. Food and Drug Administration with the support of Congress is currently pushing this industry to base its claims and products on scientific research. Research as shown that dietary habits need to be altered for most people whether for continued or improved good health. The conclusions and recommendations from the various chapters in this book will provide a basis for those important factors of change by industry with new uses. Animal studies and early clinical ones will lead to new uses and studies. Particularly the cutting edge experimental and clinical studies from Europe will provide novel approaches to clinical uses through their innovative new studies.
Heavy emphasis on clinical applications (benefits and/or lack thereof) as well as future biomedical therapeutic uses identified in animal model studies Focused on therapies and data supporting them for application in clinical medicine as complementary and alternative medicines Key insights into gut flora and the potential health benefits thereof Health scientists and nutritionists will use this information to map out key areas of research. Food scientists will use it in product development Information on pre-and probiotics as important sources of micro-and macronutrients Aids in the development of methods of bio-modification of dietary plant molecules for health promotion Coverage of a broad range of bacterial consituents Nutritionists will use the information to identify which of these constituents should be used as dietary supplements based on health status of an individual Science-based information on the health promoting characteristics of pre-and probiotics Provides defense of food selections for individual consumption based on health needs and current status Diverse international authoring team experienced in studying prebiotics and probiotics for medical practice Unusally broad range of experiences and newly completed clinical and animal studies provides extended access to latest information

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Evidence-Based Counseling and Psychotherapy for an Aging Population

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At a time when the mental health difficulties/disorders of the elderly are coming to the fore of many practitioners' patient rosters, naming and treating those problems is still too often handled as an art as much as a science. Inconsistent practices based on clinical experience and intuition rather than hard scientific evidence of efficacy have for too long been the basis of much treatment. Evidence-based practices help to alleviate some of the confusion, allowing the practitioner to develop quality practice guidelines that can be applied to the client, identify appropriate literature that can be shared with the client, communicate with other professionals from a knowledge-guided frame of reference, and continue a process of self-learning that results in the best possible treatment for clients.

The proposed volume will provide practitioners with a state-of-the-art compilation of evidence-based practices in the assessment and treatment of elderly clients. As such it will be more clinically useful than anything currently on the market and will better enable practitioners to meet the demands faced in private and institutional practice. Focusing on the most current research and best evidence regarding assessment, diagnosis, and treatment, the volume covers difficulties including, but not limited to: social isolation/loneliness, elder abuse/neglect, depression and suicidal inclinations, anxiety disorders, substance abuse, dementias, prolonged bereavement, patients with terminal illnesses.

Because concrete research evidence is so often not used as the basis for practice, this book provides a timely guide for clinicians, social workers, and advanced students to a research-oriented approach to serving the mental health needs of elderly adults.
Fully covers assessment, diagnosis & treatment of the elderly, focusing on evidence-based practicesConsolidates broadly distributed literature into single source and specifically relates evidence-based tools to practical treatment, saving clinicians time in obtaining and translating information and improving the level of care they can provide Detailed how-to explanation of practical evidence-based treatment techniques Gives reader firm grasp of how to more effectively treat patients Chapters directly address the range of conditions and disorders most common for this patient population - i.e. social isolation, elder abuse/neglect, depression, anxiety disorders, terminal illnesses/disabilites, bereavement, substance abuse, and dementias Prepares readers for the conditions they will encounter in real world treamtent of an elderly patient population Cites numerous case studies and provides integrative questions at the end of each chapter Exposes reader to real-world application of each treatment discussed Offers reader easy base for further study of subject, saving clinicians time

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Essentials of Genomic and Personalized Medicine

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Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. Full color throughout Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practic Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

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Geoffrey S. Ginsburg, Huntington F Willard

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Autophagy in Disease and Clinical Applications, Part C

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The third and final installment of Daniel J. Klionsky's new three-volume treatment of autophagy, this volume focuses on monitoring autophagy with regard to disease connections, and presents methods that can be used to analyze autophagy in clinical samples. Edited by one of the leading authorities in the field, this volume and its companion volumes, Autophagy: Lower Eukaryotes and Autophagy in Mammalian Systems, provide a comprehensive overview of the techniques involved in studying autophagy in eukaryotes and simple animal systems, mammalian cells and non-human animals, and humans.

Particularly in times of stress, like starvation and disease, higher organisms have an internal mechanism in their cells for chewing up and recycling parts of themselves. The process of internal house cleaning in the cell is called autophagy literally self-eating. In the future, research in this field will help to design clinical approaches that can turn on autophagy and halt tumor growth. Provides an overview of autophagy in regards to humans, specifically regarding disease connections and clinical samples Includes methods to evaluate the role of autophagy in the drug-induced cell death of cancer cells in culture Presents reliable methods that, in this relatively new field, allow the reader to find appropriate techniques to identify, monitor, and quantify autophagic processes

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Hormones and Reproduction of Vertebrates, Volume 2

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This series of volumes represents a comprehensive and integrated treatment of reproduction in vertebrates from fishes of all sorts through mammals. It is designed to provide a readable, coordinated description of reproductive basics in each group of vertebrates as well as an introduction to the latest trends in reproductive research and our understanding of reproductive events. Whereas each chapter and each volume is intended to stand alone as a review of that topic or vertebrate group, respectively, the volumes are prepared so as to provide a thorough topical treatment across the vertebrates. Terminology has been standardized across the volumes to reduce confusion where multiple names exist in the literature, and a comprehensive glossary of these terms and their alternative names is provided. A complete, essential and up to date reference for research scientists working on vertebrate hormones and reproduction - and on animlals as models in human reproductive research Covers the endocrinology, neuroendocrinology, physiology, behaviour and anatomy of vertebrate reproduction Structured coverage of the major themes for all five vertebrate groups allows a consistent treatment for all Special chapters elaborate on features specific to individual vertebrate groups and to comparative aspects, similarities and differences between them

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Allan Hedberg has been in private practice as a psychologist for over 30 years. In Forms for the Therapist, Dr. Hedberg has put together a one-stop source of every imaginable form for the early career therapist. The book is not geared exclusively to psychologists, but to all types of practitioners including psychologists, psychiatrists, social workers, marriage and family counselors, alcohol counselors, rehabilitation, recreational, occupational, physical, and speech therapists. The forms have been provided by experienced, seasoned professionals who have refined their content over the course of many years in practice.In addition to the forms themselves, practical guidelines on their use and helpful information on developing personalized forms is included. The book is written in a concise format and the forms are easy to duplicate or adapt for the busy professional. Forms are designed for early career therapists and obtained from experienced, seasoned therapists Includes all types of forms, including surveys, questionnaires, informal tests, informational ratings sheets, and "homework assignments" to be used between sessions Information is geared toward all types of practitioners, and forms are easily duplicated or adapted, saving professionals valuable time

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Hormones and Reproduction of Vertebrates, Volume 3

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This series of volumes represents a comprehensive and integrated treatment of reproduction in vertebrates from fishes of all sorts through mammals. It is designed to provide a readable, coordinated description of reproductive basics in each group of vertebrates as well as an introduction to the latest trends in reproductive research and our understanding of reproductive events. Whereas each chapter and each volume is intended to stand alone as a review of that topic or vertebrate group, respectively, the volumes are prepared so as to provide a thorough topical treatment across the vertebrates. Terminology has been standardized across the volumes to reduce confusion where multiple names exist in the literature, and a comprehensive glossary of these terms and their alternative names is provided. A complete, essential and up to date reference for research scientists working on vertebrate hormones and reproduction - and on animlals as models in human reproductive research Covers the endocrinology, neuroendocrinology, physiology, behaviour and anatomy of vertebrate reproduction Structured coverage of the major themes for all five vertebrate groups allows a consistent treatment for all Special chapters elaborate on features specific to individual vertebrate groups and to comparative aspects, similarities and differences between them

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Hormones and Reproduction of Vertebrates, Volume 5

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This series of volumes represents a comprehensive and integrated treatment of reproduction in vertebrates from fishes of all sorts through mammals. It is designed to provide a readable, coordinated description of reproductive basics in each group of vertebrates as well as an introduction to the latest trends in reproductive research and our understanding of reproductive events. Whereas each chapter and each volume is intended to stand alone as a review of that topic or vertebrate group, respectively, the volumes are prepared so as to provide a thorough topical treatment across the vertebrates. Terminology has been standardized across the volumes to reduce confusion where multiple names exist in the literature, and a comprehensive glossary of these terms and their alternative names is provided. A complete, essential and up to date reference for research scientists working on vertebrate hormones and reproduction - and on animlals as models in human reproductive research Covers the endocrinology, neuroendocrinology, physiology, behaviour and anatomy of vertebrate reproduction Structured coverage of the major themes for all five vertebrate groups allows a consistent treatment for all Special chapters elaborate on features specific to individual vertebrate groups and to comparative aspects, similarities and differences between them

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Nutritional and Herbal Therapies for Children and Adolescents

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This volume assists practicing mental health professionals in expanding their knowledge about nutritional and herbal interventions that can be attempted as alternatives to prescription medications. Designed to provide guidance for non-medical caregivers treating children and adolescents who present with emotional and/or behavioral difficulties such as such as depression, anxiety, ADHD, sleep difficulties, impulsivity, distractibility, and other psychological and psychiatric disorders, the volume provides a comprehensive discussion of naturopathic solutions based on existing research. In areas where research is not extensive, conclusions are provided about potentially beneficial effects based on the specific pharmacologic action of the compounds. Dosage for specific age groups, schedules of administration, dietary considerations (i.e., whether or not to take the supplement with food), monitoring for response and adverse effects, signs of dangerous reactions, and the need to control interactions with other compounds (i.e., prescription medications) are thoroughly reviewed with regard to each supplement discussed in the book. Reviews specific psychological disorders (i.e. ADHD, depression, mania, anxiety, sleep difficulties, tic behaviors and autism) and the available data about their treatment with the use of nutritional and herbal supplements Provides rationale for the use of every specific compound with detailed recommendations tailored for each age group with regard to the dosage, frequency of administration, possible dangers and monitoring for side effects Discusses claims of efficacy used to market various products and ground those claims within fully vetted scientific research Discusses neurobiology, pharmacodynamics and pharmokinetics in detailed but accessible language *Non-medical clinicians with limited knowledge of medicine and pharmacology come away with understanding of key issues involved in Fully covers assessment, diagnosis & treatment of children and adolescents, focusing on evidence-based practices  *Consolidates broadly distributed literature into single source and specifically relates evidence-based tools to practical treatment, saving clinicians time in obtaining and translating information and improving the level of care they can provide Detailed how-to explanation of practical evidence-based treatment techniques *Gives reader firm grasp of how to more effectively treat patients Material related to diversity (including race, ethnicity, gender and social class) integrated into each chapter *Prepares readers for treating the wide range of youth they will encounter in practice

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Hormones and Reproduction of Vertebrates, Volume 4

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This series of volumes represents a comprehensive and integrated treatment of reproduction in vertebrates from fishes of all sorts through mammals. It is designed to provide a readable, coordinated description of reproductive basics in each group of vertebrates as well as an introduction to the latest trends in reproductive research and our understanding of reproductive events. Whereas each chapter and each volume is intended to stand alone as a review of that topic or vertebrate group, respectively, the volumes are prepared so as to provide a thorough topical treatment across the vertebrates. Terminology has been standardized across the volumes to reduce confusion where multiple names exist in the literature, and a comprehensive glossary of these terms and their alternative names is provided. A complete, essential and up to date reference for research scientists working on vertebrate hormones and reproduction - and on animlals as models in human reproductive research Covers the endocrinology, neuroendocrinology, physiology, behaviour and anatomy of vertebrate reproduction Structured coverage of the major themes for all five vertebrate groups allows a consistent treatment for all Special chapters elaborate on features specific to individual vertebrate groups and to comparative aspects, similarities and differences between them

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Endocrine Systems Interacting with Brain and Behavior

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A single volume of 41 articles, Hormone/Behavior Relations of Clinical Importance is an authoritative selection of relevant chapters from the Hormones Brain and Behavior 2e MRW, the most comprehensive source of neuroendocrinological information assembled to date (AP July 2009). The study of hormones as they impact the brain and, subsequently, behavior is a central topic in neuroscience, endocrinology and psychiatry. This volume offers an overview of neuroendocrinological topics, approaching the subject from the perspective of hormone-brain function, hormone-behavior relations, sex differences, and the impact on various diseases/pathologies. Many basic human behavioral functions are subject to the influence of hormones - sexual orientation, the experience of pain, fertility, immunity - as are clinical conditions such as diabetes, substance abuse disorder, eating disorders, PTSD, TBI, pain, Alzheimer's, stress/anxiety, affective disorders, and more. There is considerable commercial clinical potential in the study of hormones - drug companies are currently developing a Cholecystokinin (hormonal peptide) booster to reduce appetite in those who suffer from sever obesity, and catamenial epilepsy (features seizure exacerbation in relation to the menstrual cycle) is resistant to treatment by standard antiepileptic medications, but may be hormonally controlled. These issues and more are covered, and there is simply no other current single-volume reference with such comprehensive coverage and depth.Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 150 figures (50 in color). A collection of articles reviewing our fundamental knowledge of neuroendocrinology, the book provides an essential, affordable reference for researchers, clinicians and graduate students in the area. Offering outstanding scholarship, each chapter is written by an expert in the topic area and approximately 25% of chapters are written by international contributors (7 countries represented) Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions Heavily illustrated with 150 figures, approximately 50 in color, presenting the material in the most visually useful form for the reader Fully explores various clinical conditions associated with the hormones and the brain (PTSD, TBI, Stress & Anxiety, eating disorders, diabetes, addictive disorders, Alzheimer's, affective disorders) Broad coverage of disorders makes the volume relevant to clinicians as well as researchers and basic scientists