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The first edition of Theory of Rank Tests (1967) has been the precursor to a unified and theoretically motivated treatise of the basic theory of tests based on ranks of the sample observations. For more than 25 years, it helped raise a generation of statisticians in cultivating their theoretical research in this fertile area, as well as in using these tools in their application oriented research. The present edition not only aims to revive this classical text by updating the findings but also by incorporating several other important areas which were either not properly developed before 1965 or have gone through an evolutionary development during the past 30 years. This edition therefore aims to fulfill the needs of academic as well as professional statisticians who want to pursue nonparametrics in their academic projects, consultation, and applied research works. Asymptotic Methods Nonparametrics Convergence of Probability Measures Statistical Inference

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Zbynek Sidak, Pranab K. Sen, Jaroslav Hajek

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Designed to serve as the first point of reference on the subject, Comprehensive Chemometrics presents an integrated summary of the present state of chemical and biochemical data analysis and manipulation. The work covers all major areas ranging from statistics to data acquisition, analysis, and applications.

This major reference work provides broad-ranging, validated summaries of the major topics in chemometricswith chapter introductions and advanced reviews for each area. The level of material is appropriate for graduate students as well as active researchers seeking a ready reference on obtaining and analyzing scientific data.
Features the contributions of leading experts from 21 countries, under the guidance of the Editors-in-Chief and a team of specialist Section Editors: L. Buydens; D. Coomans; P. Van Espen; A. De Juan; J.H. Kalivas; B.K. Lavine; R. Leardi; R. Phan-Tan-Luu; L.A. Sarabia; and J. Trygg Examines the merits and limitations of each technique through practical examples and extensive visuals: 368 tables and more than 1,300 illustrations (750 in full color) Integrates coverage of chemical and biological methods, allowing readers to consider and test a range of techniques Consists of 2,200 pages and more than 90 review articles, making it the most comprehensive work of its kind Offers print and online purchase options, the latter of which delivers flexibility, accessibility, and usability through the search tools and other productivity-enhancing features of ScienceDirect

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Roma Tauler, Beata Walczak, Steven Brown

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Bioconjugate Techniques is the essential guide to the modification and crosslinking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. Armed with this information and the abundant protocols provided, readers will form unique complexes that can be used for detecting, quantifying, and targeting important analytes. This book helps readers make: high activity antibody-enzymes conjugates, immunotoxins, immunogen complexes, liposome conjugates; as well as biotinylated molecules, avidin or streptavidin conjugates, colloidal gold labeled proteins, PEG or dextran complexes, labeled oligonucleotide probes, and fluorescently tagged or radiolabeled molecules. This book is the first to thoroughly capture the entire field of bioconjugate chemistry in a single volume Serves as a practical guide to modification and cross-linking technology for research, diagnostics, and therapeutics Provides useful, detailed, easy-to-follow, step-by-step protocols Contains easy-to-read, and easy-to-understand key concepts for making bioconjugates of all types Efficiently covers the chemistry of bioconjugation, the major reagents available for modification and cross-linking, and the application of these reagents to the synthesis of highly active conjugates Cites over more than references keyed to concepts covered in the book Uses more than 600 figures to illustrate bioconjugate reagents, their reactions, and applications Suggests sources for all key reagents

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Mims' Pathogenesis of Infectious Disease

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The newly revised edition of this work provides an up-to-date description of the mechanisms of infection and disease production in a clear and logical manner. Dealing in an integrated manner with all microorganisms, the factors common to all infectious diseases are set out. Molecular biology, pathology, and immunology are brought together to explain how an infectious agent causes disease, and how the body reacts to it. Attachment to and entry of microorganisms Events occurring immediately after entry The encounter of the microbe with the phagocytic cell The spread of microbes through the body The immune response to infection Microbial strategies in relation to the immune response Mechanisms of cell and tissue damage Recovery from infection Failure to eliminate the microbe Host and microbial factors influencing susceptibility Vaccines

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Anthony A. Nash, Cedric A. Mims, Nigel J. Dimmock, John Stephen

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Bioconjugate Techniques, 2nd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or cross linking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. A one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates More than 600 figures that visually describe the complex reactions associated with the synthesis of bioconjugates Includes entirely new chapters on the latest areas in the field of bioconjugation as follows: Microparticles and nanoparticlesSilane coupling agentsDendrimers and dendronsChemoselective ligationQuantum dotsLanthanide chelatesCyanine dyesDiscrete PEG compoundsBuckyballs,fullerenes, and carbon nanotubesMass tags and isotope tagsBioconjugation in the study of protein interactions

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The Encyclopedia of Human Behavior, Second Edition, Three Voluime Set is an award-winning three-volume reference on human action and reaction, and the thoughts, feelings, and physiological functions behind those actions. Presented alphabetically by title, 300 articles probe both enduring and exciting new topics in physiological psychology, perception, personality, abnormal and clinical psychology, cognition and learning, social psychology, developmental psychology, language, and applied contexts.

Written by leading scientists in these disciplines, every article has been peer-reviewed to establish clarity, accuracy, and comprehensiveness. The most comprehensive reference source to provide both depth and breadth to the study of human behavior, the encyclopedia will again be a much-used reference source. This set appeals to public, corporate, university and college libraries, libraries in two-year colleges, and some secondary schools.

Carefully crafted, well written, and thoroughly indexed, the encyclopedia helps userswhether they are students just beginning formal study of the broad field or specialists in a branch of psychologyunderstand the field and how and why humans behave as we do.
Named a 2013 Outstanding Academic Title by the American Library Association's Choice publication Concise entries (ten pages on average) provide foundational knowledge of the field Each article features suggested further readings, a list of related websites, a 5-10 word glossary and a definition paragraph, and cross-references to related articles in the encyclopedi Newly expanded editorial board and a host of international contributors from the United States, Australia, Belgium, Canada, France, Germany, Ireland, Israel, Japan, Sweden, and the United Kingdom

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Hormones and Reproduction of Vertebrates

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This series of volumes represents a comprehensive and integrated treatment of reproduction in vertebrates from fishes of all sorts through mammals. It is designed to provide a readable, coordinated description of reproductive basics in each group of vertebrates as well as an introduction to the latest trends in reproductive research and our understanding of reproductive events. Whereas each chapter and each volume is intended to stand alone as a review of that topic or vertebrate group, respectively, the volumes are prepared so as to provide a thorough topical treatment across the vertebrates. Terminology has been standardized across the volumes to reduce confusion where multiple names exist in the literature, and a comprehensive glossary of these terms and their alternative names is provided. A complete, essential and up to date reference for research scientists working on vertebrate hormones and reproduction - and on animlals as models in human reproductive research Covers the endocrinology, neuroendocrinology, physiology, behaviour and anatomy of vertebrate reproduction Structured coverage of the major themes for all five vertebrate groups allows a consistent treatment for all Special chapters elaborate on features specific to individual vertebrate groups and to comparative aspects, similarities and differences between them

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The first edition of the successful Encyclopedia of Creativity, Two Volume Set served to establish the study of creativity is a field in itself. Now completely updated and revised in its second edition, coverage encompasses the definition of creativity, the development and expression of creativity across the lifespan, the environmental conditions that encourage or discourage creativity, creativity within specific disciplines like music, dance, film, art, literature, etc., the relationship of creativity and mental health, intelligence, and learning styles, and the process of being creative. This reference also appeals to a lay audience with articles specifically on the application of creativity to business settings. Available online via ScienceDirect and in limited print release. Named a 2012 Outstanding Academic Title by the American Library Association's Choice publication Serves as a compendium of reviews of a number of domain-specific areas, such as acting, dance, expressive arts, film, food, music, religion, science, sports, theater, and writing. Creativity and education are examined in articles about thought processes, such as developmental trends in creative abilities and potentials, the enhancement of creativity, intelligence, knowledge, play, prodigies, programs and courses, talent and teaching creativity. Cognitive aspects of creativity can be investigated in articles about altered and transitional states, analogies, attention, cognitive style, divergent thinking, flow and optimal experience, metacognition, metaphors, problem-finding, problem-solving, and remote associates. Covers business and organizational creativity in articles about advertising with art, creative visuals, business/management, creativity coaching, creativity exercises, entrepreneurship, group dynamics, innovation, leadership, organizational culture, organizational development, teams, and training, among others. Explicitly examines the complex interrelationship between society and creativity in articles about awards, conformity and conventionality, the creative sector and class of society, cultural diversity, the dark side of creativity, East vs. West, networking, social psychology, war, zeitgeist, and others. Personal and interpersonal creativity is discussed in articles relating to collaboration, family, life stages, mentors, networking, personal creativity and self-actualization. Focuses on scientific information about creativity, there are also articles that discuss brain and neuropsychology, concepts of creativity, definitions of creativity, expertise, longitudinal studies, researching art, artists and art audiences, research methods, phenomenology research and qualitative research. Online version contains an additional 26 biographies of famously creative people

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Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field

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Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year.

NEW TO THIS EDITION:*Recognizes the critical importance of the Wnt signaling pathway for bone health *Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone *Examines essential updates on estrogen prevention and treatment and the recent results from the WHI *Discusses the controversial topics of screening and clinical trial design for drug registration *Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone * Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere

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Robert Marcus, David Feldman, Dorothy Nelson, Clifford Rosen

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Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases.  It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition

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John P. Bilezikian, Lawrence G. Raisz, T. John Martin

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Encyclopedia of Women and Gender, Two-Volume Set

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Sex Similarities and Differences and the Impact of Society on Gender

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The study of gender differences began in earnest in the 1970s and has since increased dramatically to infiltrate virtually all fields of study in the social and behavioral sciences. Along the way, it was discovered that while women very often think and behave differently than do men, industrialized societies cater to masculine perspectives. The "Psychology of Women" emerged as a field of study focusing on just those areas in which women most often butted against assumed roles. And similarly, in the 1990s, the "Psychology of Men" emerged to focus on the same issues for men.The Encyclopedia of Gender covers all three areas under one cover, discussing psychological differences in personality, cognition, and behavior, as well as biologically based differences and how those differences impact behavior. Coverage includes studies of these differences in applied settings such as education, business, the home, in politics, sports competition, etc.

Key Features* Over 100 In-depth chapters by leading scholars in the psychology of women and gender* Addresses critical questions of similarities and differences in gendering across diverse groups, challenging myths about gender polarization and the "Venus/Mars" distinction* Broad coverage of topics from theory and method to development, personality, violence, sexuality, close relationships, work, health, and social policy* Sensitive attention to multicultural and cross-cultural research* Clearly written, readable, comprehensive, with helpful guides (outline, glossary, reference list)* Raises difficult questions related to power, inequality, ethics, and social justice* Challenges the reader to revise established "truths" and to seek further information* Maintains a feminist and woman-centered focus

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Encyclopedia of Microbiology, Four-Volume Set

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The First Edition of the Encyclopedia of Microbiology was hailed by leading scientists and researchers around the world as "excellent," "outstanding," and "impressive." This Second Edition will serve as an up-to-date version of this reference which has been useful to academic, industrial, and personal libraries for years. The Encyclopedia of Microbiology, Second Edition both challenges and stimulates the reader, and illustrates the importance of microbiology, a field that cannot be over emphasized in this booming biotechnology age.

Key Features* Completely redesigned and revised approach with 65% new material* Contains approximately 300 articles, 1000 illustrations, and 400 tables* New design includes thematic table of contents, combined glossary of terms, and appendix* Provides color plate sections in each volume* 17 subject areas, including exciting coverage of microbes in extreme environments and microbes in emerging infections

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William C. Summers, Martin Alexander, Barry R. Bloom, David A. Hopwood, Roger Hull, Barbara H. Iglewski, Allen I. Laskin, Stephen G. Oliver, Moselio Schaechter, Joshua Lederberg

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The Encyclopedia of Creativity is the sourcebook for individuals seeking specialized information about creativity and motivation. Subjects include theories of creativity, techniques for enhancing creativity, individuals who have made significant contributions to creativity, physiological aspects of creativity, and virtually any topic that touches upon the subject. Entries are placed in alphabetical order with cross-references to other topics and entries where appropriate. Each entry is written in simple easy-to-understand terms summarizing the most important aspects of creative research and writing relating to the specific topic. A bibliography in the back of each article suggests additional sources for more information. The text is visually enhanced throughout by illustrations and photographs. A source-book of specialized information about creativity and motivation Includes virtually any topic dealing with creativity Entries are placed in alphabetical order with cross-references Written in easy-to-understand terms Illustrations and photographs throughout Contains select biographies of internationally renowned creative individuals from throughout history

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Dairy Science, Four Volume Set includes the study of milk and milk-derived food products, examining the biological, chemical, physical, and microbiological aspects of milk itself as well as the technological (processing) aspects of the transformation of milk into its various consumer products, including beverages, fermented products, concentrated and dried products, butter and ice cream.

This new edition includes information on the possible impact of genetic modification of dairy animals, safety concerns of raw milk and raw milk products, peptides in milk, dairy-based allergies, packaging and shelf-life and other topics of importance and interest to those in dairy research and industry.
Fully reviewed, revised and updated with the latest developments in Dairy Science Full color inserts in each volume illustrate key concepts Extended index for easily locating information

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John W. Fuquay, Paul L.H. McSweeney, Patrick F. Fox

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The Adolescent Experience places the college student at the very heart of the book. The authors engage in a dialogue with the reader that is warm, caring, and often humorous as they write and share material about this time of life. The authors emphasize the role that development and society play in the lives of young people. The book has a solid research basis with a historical and multicultural focus. But most important, the book is practical and applied with the strongest prevention/health promotion material available in any basic undergraduate adolescent psychology text currently on the market.

Key Features
* Focuses on health promotion and illness prevention
* Provides not only a U.S. but also a much needed Canadian perspective to this life stage
* Involves students as participants in a long-standing inquiry into the nature of adolescence as they are introduced to the latest research in the field
* Provides students with the latest practical information in subject areas like sexuality, drugs and alcohol, suicide and depression, eating disorders, crime, delinquency, and violent behavior
* List server links student and/or instructor to authors
* Explores the uniqueness of North America's multi-culturalism
* Illustrates important concepts using literature and social history to make them tangible to students

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Thomas P. Gullotta, Gerald R. Adams, Carol A. Markstrom

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Vitamin D, a steroid hormone, has mainly been known for its effects on bone and osteoporosis. The current therapeutic practices expand into such markets as cancer research, pediatrics, nephrology, dermatology, immunology, and genetics. This second edition includes over 100 chapters covering everything from chemistry and metabolism to mechanisms of action, diagnosis and management, new analogs, and emerging therapies. This complete reference works is a must have resource for anyone working in endocrinology, osteology, bone biology, or cancer research.

*Most comprehensive, up-to-date two-volume set on Vitamin D
*New chapters on squamous cell cancer, brain cancer, thyroid cancer and many more
*Further sections on emerging uses for treatments of auto-immune diseases and diabetes
*Over 600 illustrations and figures available on CD

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David Feldman, J. Wesley Pike, Francis H. Glorieux

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In the past decade, enormous strides have been made in understanding the human brain. The advent of sophisticated new imaging techniques (e.g. PET, MRI, MEG, etc.) and new behavioral testing procedures have revolutionized our understanding of the brain, and we now know more about the anatomy, functions, and development of this organ than ever before. However, much of this knowledge is scattered across scientific journals and books in a diverse group of specialties: psychology, neuroscience, medicine, etc. The Encyclopedia of the Human Brain places all information in a single source and contains clearly written summaries on what is known of the human brain.

Covering anatomy, physiology, neuropsychology, clinical neurology, neuropharmacology, evolutionary biology, genetics, and behavioral science, this four-volume encyclopedia contains over 200 peer reviewed signed articles from experts around the world. The Encyclopedia articles range in size from 5-30 printed pages each, and contain a definition paragraph, glossary, outline, and suggested readings, in addition to the body of the article. Lavishly illustrated, the Encyclopedia includes over 1000 figures, many in full color. Managing both breadth and depth, the Encyclopedia is a must-have reference work for life science libraries and researchers investigating the human brain.

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The Encyclopedia of Applied Psychology encompasses applications of psychological knowledge and procedures in all areas of psychology. This compendium is a major source of information for professional practitioners, researchers in psychology, and for anyone interested in applied psychology. The topics included are, but are not limited to, aging (geropsychology), assessment, clinical, cognitive, community, counseling, educational, environmental, family, industrial/organizational, health, school, sports, and transportation psychology. The entries drawn from the above-referenced areas provide a clear definition of topic, a brief review of theoretical basis relevant to the topic, and emphasize major areas of application.Also available online via ScienceDirect  featuring extensive browsing, searching, and internal cross-referencing between articles in the work, plus dynamic linking to journal articles and abstract databases, making navigation flexible and easy. For more information, pricing options and availability visit www.info.sciencedirect.com.

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Principles of Bone Biology is the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology in one convenient source. Written and published in less than one year, it will become an indispensable resource for any scientific or medical library. This, second edition, details countless advances over the past five years, both by updating old chapters and providing additional material. It takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics.

The most current and timely source of information about the biology and pathology of boneProvides succinct coverage of the subjectContributors include over 200 of the most respected researchers in the fieldExtensive table of contents and index for easy referenceEasy-to-read and highly informative to both the newcomer and the initiated to the field Spans the spectrum from molecular biology to in vivo pharmacologyComplete bibliography with each entry fully referenced for additional background reading First edition was selected by Doody Publishing as one of the 250 Best Health Science books published in 1996

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John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan