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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The volume covers ghrelin, and has chapters on such topics as orphan gpcrs and methods for identifying their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice.
Contains quality chapters authored by leaders in the field Has chapters on such topics as orphan gpcrs and methods for identifying their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice

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A classic nephrology reference for over 25years, Seldin and Giebischs The Kidney, is the acknowledged authority on renal physiology and pathophysiology. In this 5th edition, such new and powerful disciplines as genetics and cell biology have been deployed to deepen and widen further the explanatory framework. Not only have previous chapters been extensively updated, but new chapters have been added to incorporate additional disciplines. Individual chapters, for example, now provide detailed treatment of the significance of cilia; the role of stem cells is now given special consideration. Finally, there has been a significant expansion of the section of pathophysiology, incorporating the newer findings of cell biology and genetics. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin and Giebischs The Kidney is your number one source for information. Offers the most comprehensive coverage on the market of fluid and electrolyte regulation and dysregulation in 85 completely revised chapters and 10 new chapters Includes 4sections, 62 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation Includes foreword by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology and editors of the previous three editions

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Robert J. Alpern, Michael J. Caplan, Orson W. Moe

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Flow Processes, Scaling, Equations of Motion, and Solutions to Environmental Flows

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Environmental Fluid Dynamics provides an introduction to the principles of environmental fluid dynamics, i.e., natures use of air and water to transport and transform waste into nutrients for various organisms.

The author, a Professor of Environmental Engineering and the Director of the Centre for Water Research at the University of Western Australia, is careful to include the appropriate mathematical expressions for the fundamentals of fluid dynamics without overburdening the reader with difficult or extensive notation.

Starting with a discussion of the basics of fluid dynamics for undergraduates, the book moves on to more detailed material for graduate students and specialists in environmental engineering and/or science, physical limnology, estuarine dynamics, and coastal oceanography. Topics covered include equations of motion, fluid viscosity, environmental hydraulics, mixing and dispersion, surface waves, and environmental flows. The materials presented are based on the authors 40 years of teaching fluid dynamics at Berkeley, Caltech, Karlsruhe, Padova, and Western Australia.

The book provides a basic overview, while specialists needing more in-depth information can to turn to advanced texts in their specific areas of interest.
Introduces the principles of fluid dynamics, follows with simple applications, and builds to more complex applications experienced in the field Offers a unique, authoritative, and accessible treatment of the subject Includes appropriate mathematical expressions without overburdening the reader with difficult or extensive notation

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The 3rd edition of Hormones offers a comprehensive treatment of the hormones of humans all viewed from the context of current theories of their action in the framework of our current understanding their physiological actions as well as their molecular structures, and those of their receptors. This new edition of Hormones is intended to be used by advanced undergraduates and graduate students in the biological sciences. It will also provide useful background information for first year medical students as they engage in studies which are increasingly problem-based rather than discipline-focused. As the field of endocrinology itself has expanded so much in the past two decades, the up to date presentation of the basics presented in this book will be a solid foundation on which more specialized considerations can be based.

New to this Edition: Hormones, 3rd Edition is organized with two introductory chapters followed by 15 chapters on selected topics of the molecular biology of the major endocrine systems operative in humans. Coverage, for the first time of the following hormones; ghrelin, oxyntomodulin, kisspeptin, adrenomedullin, FGF23, erythropoietin, VIP and extended coverage of NO. Coverage of the hypothalamus has been integrated with the anterior pituitary because of the intimate functional and relationship between the two. Consideration of the role of hormones in cancer has been integrated into the chapters on the relevant hormones. Each of these areas occupies a unique niche in our understanding of the biological world and is part of the universality of signaling systems and how they govern biological systems.
Organized with two introductory chapters, followed by 15 chapters on selected topics of the molecular biology of the major human endocrine systems New full color format includes over 300 full color, completely redrawn images Companion web site will host all images from the book as PPT slides and .jpeg files All chapters have been completely updated and revitalized. Coverage of the hypothalamus has been integrated into the anterior pituitary chapter and coverage of the thymus has been eliminated and left to immunology textbooks Provides essential basics for advanced undergraduates and graduate students in the biological sciences, as well as first year medical students as they engage in studies which are increasingly problem-based rather than discipline-focused

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Handbook of Environmental Engineering Assessment

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This is one of the most comprehensive books on complex subjects of environmental engineering assessment and planning. Addressing these issues requires an understanding of technical, economic, and policy perspectives; based upon extensive research and practical experience of the authors, these perspectives are thoughtfully and clearly presented.

Covered in this book are subjects related to environmental engineering and planning which include environmental laws and regulations, international perspectives on environmental analysis engineering and planning, economic and social impact analysis, public participation, and energy and environmental implications of major public works and private projects. Contemporary issues ranging from climate change to ecorisk and sustainability are covered in a special section as well.

Under Contemporary Challenges are environmental issues that have received considerable public support and concern; they include: climate change, acid rain, deforestation, endangered species, biodiversity, ecorisk, cultural resources, and sustainability. For most of these issues, there are scientific agreements and disagreements; there are many uncertainties, thus views differ widely. These topics are discussed in considerable detail. Notwithstanding uncertainties and differing views on such topics, all of this information is put in a policy context such that progress towards addressing these contemporary challenges can be made while consensus on the nature and extent of the problem and resultant solutions are being developed.

The book provides considerable information about many timeless issues. These issues range from resources needed for sustaining the quality of life on the planet: air resources to natural resources. Specifically covered are: air, water, land, ecology, sound/noise, human aspects, economics, and resources. For each of these areas, some of the key elements are described so that one can effectively manage complex environmental engineering and planning requirements. Each of the elements are clearly defined and other information, such as how human activities affect the element, source of affects, variable to be measured, how such variables can be measured, data sources, and evaluation and interpretation of data, etc. are provided. Material presented provides a rich source of information so the reader can efficiently and effectively use it to make meaningful environmental engineering, planning, and management decisions.
Help with every aspect of analyzing the environmental implications of a project Complete coverage of current approaches, practices, procedures, documentations, regulations, and issues related to environmental engineering and planning Step-by-step directions for preparing environmental impact analysis, and environmental reports Valuable expert advice on international perspectives, public participation, social and environmental impacts A comprehensive write-up on contemporary issues ranging from climate change to sustainability A comprehensive description and analysis of timeless issues ranging from air resources to natural resources

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Ravi Jain, Lloyd Urban, Harold Balbach, M. Diana Webb

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Enological Chemistry is written for the professional enologist tasked with finding the right balance of compounds to create or improve wine products. Related titles lack the appropriate focus for this audience, according to reviewers, failing either to be as comprehensive on the topic of chemistry, to include chemistry as part of the broader science of wine, or targeting a less scientific audience and including social and historical information not directly pertinent to the understanding of the role of chemistry in successful wine production.

The topics in the book have been sequenced identically with the steps of the winemaking process. Thus, the book describes the most salient compounds involved in each vinification process, their properties and their balance; also, theoretical knowledge is matched with its practical application. The primary aim is to enable the reader to identify the specific compounds behind enological properties and processes, their chemical balance and their influence on the analytical and sensory quality of wine, as well as the physical, chemical and microbiological factors that affect their evolution during the winemaking process.
Organized according to the winemaking process, guiding reader clearly to application of knowledge Describes the most salient compounds involved in each step enabling readers to identify the specific compounds behind properties and processes and effectively work with them Provides both theoretical knowledge and practical application providing a strong starting point for further research and development

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A Laboratory and Field Guide of Common North American Animals

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In the forensic context it is quite common for nonhuman bones to be confused with human remains and end up in the medical examiner or coroner system. It is also quite common for skeletal remains (both human and nonhuman) to be discovered in archaeological contexts. While the difference between human and nonhuman bones is often very striking, it can also be quite subtle. Fragmentation only compounds the problem. The ability to differentiate between human and nonhuman bones is dependent on the training of the analyst and the available reference and/or comparative material.

Comparative Osteology is a photographic atlas of common North American animal bones designed for use as a laboratory and field guide by the forensic scientist or archaeologist. The intent of the guide is not to be inclusive of all animals, but rather to present some of the most common species which also have the highest likelihood of being potentially confused with human remains.
An affordably priced, compact laboratory/field manual, comparing human and nonhuman bones Contains almost 600 high-quality black and white images and diagrams, including inch and centimeter scales with each photograph Written by the foremost forensic scientists with decades of experience in the laboratory and as expert witnesses An additional Companion Web site hosts images from the volume the reader can magnify and zoom into to see specific landmarks and features on bones http://booksite.academicpress.com/9780123884374

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How Enterprise Design Bridges the Gap between Business, Technology, and People

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Many organizations struggle with the dynamics and the complexity of today's social ecosystems that connect everyone and everything, everywhere and all the time. Facing challenges at the intersection of business models, technical developments, and human needs, modern enterprises must overcome the siloed thinking and isolated efforts of the past, and instead address their relationships to people holistically. In Intersection, Milan Guenther introduces a Strategic Design approach that aligns the overarching efforts of Branding, Enterprise Architecture, and Experience Design, and sets them on a common course to shape tomorrows enterprises.This book gives designers, entrepreneurs, innovators, and leaders a model and a comprehensive vocabulary for tackling such deep-rooted challenges. The Enterprise Design framework cuts through the complexity of Strategic Design work, showing how to navigate key aspects and bridge diverging viewpoints. In 9 case studies, the author looks at the way companies like SAP, BBVA, IKEA, and Jeppesen (a Boeing Company) apply design thinking and practice to shape their enterprises. Moving from strategy to conceptual design and concrete results, Intersection shows what is relevant at which point, and what expertise to involve. Teaches how to align business strategy with Brand Identity, Customer Experience, and Enterprise Architecture initiatives as part of a consolidated enterprise-wide design practice to achieve stakeholder value Provides a framework for designing systems, products and services as the building blocks of a consistent and coherent experience for all stakeholders in the wider enterprise, joining strategic considerations with the delivery of tangible outcomes Explains how to make results such as websites, apps, objects, platforms, or environments part of a larger system that orchestrates enterprise touchpoints with people

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Principles of Embedded Computing System Design

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Computers as Components: Principles of Embedded Computing System Design, Third Edition, presents essential knowledge on embedded systems technology and techniques. Updated for today's embedded systems design methods, this volume features new examples including digital signal processing, multimedia, and cyber-physical systems. It also covers the latest processors from Texas Instruments, ARM, and Microchip Technology plus software, operating systems, networks, consumer devices, and more.

Like the previous editions, this textbook uses real processors to demonstrate both technology and techniques; shows readers how to apply principles to actual design practice; stresses necessary fundamentals that can be applied to evolving technologies; and helps readers gain facility to design large, complex embedded systems. Updates in this edition include: description of cyber-physical systems; exploration of the PIC and TI OMAP processors; high-level representations of systems using signal flow graphs; enhanced material on interprocess communication and buffering in operating systems; and design examples that include an audio player, digital camera, and cell phone. The author maintains a robust ancillary site at http://www.marilynwolf.us/CaC3e/index.html which includes a variety of support materials for instructors and students, including PowerPoint slides for each chapter; lab assignments developed for multiple systems including the ARM-based BeagleBoard computer; downloadable exercises solutions and source code; and links to resources and additional information on hardware, software, systems, and more.

This book will appeal to students in an embedded systems design course as well as to researchers and savvy professionals schooled in hardware or software design.
Description of cyber-physical systems: physical systems with integrated computation to give new capabilities Exploration of the PIC and TI OMAP multiprocessors High-level representations of systems using signal flow graphs Enhanced material on interprocess communication and buffering in operating systems Design examples include an audio player, digital camera, cell phone, and more

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Approximation and Optimization of Discrete and Differential Inclusions

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Optimal control theory has numerous applications in both science and engineering.
This book presents basic concepts and principles of mathematical programming in terms of set-valued analysis and develops a comprehensive optimality theory of problems described by ordinary and partial differential inclusions.
In addition to including well-recognized results of variational analysis and optimization, the book includes a number of new and important ones Includes practical examples

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Amorphous chalcogenide semiconductors have commercial value and have many uses such as image formation, including x-rays, and high-definition TV pick up tubes. They have widespread application in the microelectronics industry and amorphous metallic alloys also have useful magnetic properties.This book focuses on their imaging applications and related properties. It examines the two groups of amorphous semiconductors that are of most commercial interest:1. the chalcogenide glasses2. the tetrahedrally bonded amorphous solids such as amorphous silicon, germanium and related alloysBoth of these groups may be conveniently prepared in the form of thin/thick films which is of considerable importance in applications where large-area coverage of flat or curved surfaces of rigid or flexible materials is desirable such as in photovoltaic arrays, X-Ray sensors, display screens and photocopier drums. Provides information on the amorphous semiconductors that are of most commercial interest Presents the history of the commercial applications, the latest developments and future possibilities

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As the computer industry retools to leverage massively parallel graphics processing units (GPUs), this book is designed to meet the needs of working software developers who need to understand GPU programming with CUDA and increase efficiency in their projects. CUDA Application Design and Development starts with an introduction to parallel computing concepts for readers with no previous parallel experience, and focuses on issues of immediate importance to working software developers: achieving high performance, maintaining competitiveness, analyzing CUDA benefits versus costs, and determining application lifespan.

The book then details the thought behind CUDA and teaches how to create, analyze, and debug CUDA applications. Throughout, the focus is on software engineering issues: how to use CUDA in the context of existing application code, with existing compilers, languages, software tools, and industry-standard API libraries.

Using an approach refined in a series of well-received articles at Dr Dobb's Journal, author Rob Farber takes the reader step-by-step from fundamentals to implementation, moving from language theory to practical coding.
Includes multiple examples building from simple to more complex applications in four key areas: machine learning, visualization, vision recognition, and mobile computing Addresses the foundational issues for CUDA development: multi-threaded programming and the different memory hierarchy Includes teaching chapters designed to give a full understanding of CUDA tools, techniques and structure. Presents CUDA techniques in the context of the hardware they are implemented on as well as other styles of programming that will help readers bridge into the new material

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Semiconductors and Semimetals has distinguished itself through the careful selection of well-known authors, editors, and contributors. Originally widely known as the "Willardson and Beer" Series, it has succeeded in publishing numerous landmark volumes and chapters. The series publishes timely, highly relevant volumes intended for long-term impact and reflecting the truly interdisciplinary nature of the field. The volumes in Semiconductors and Semimetals have been and will continue to be of great interest to physicists, chemists, materials scientists, and device engineers in academia, scientific laboratories and modern industry.
The series publishes timely, highly relevant volumes intended for long-term impact and reflecting the truly interdisciplinary nature of the field

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Physics in the Arts is a concise, 328-page four-color entry in the Complementary Science Series, designed for science enthusiasts and liberal arts students requiring or desiring a well-developed discussion of physical phenomena, particularly with regard to sound and light. This book offers an alternative route to science literacy for those interested in the arts, music and photography. The material covered is at a level appropriate for self-study or as a complementary textbook.

A typical course on sound and light for non-science majors covers the nature of sound and sound perception as well as important concepts and topics including light and light waves, reflection and refraction; lenses; the eye and the ear; photography; color and color vision; and additive color mixing; subtractive color mixing. There are also discussions on color generating mechanisms; periodic oscillations; simple harmonic motion; damped oscillations and resonance; vibration of strings; Fourier analysis; musical scales; and musical instruments. Problems with solutions are presented. For teaching purposes, all figures in the book as well as hints on how to build labs are provided at http://www.elsevierdirect.com/companion.jsp?ISBN=9780123918789.

This book will be helpful to non-science students in courses related to the study of physics with light and sound.
Offers an alternative route to science literacy for those interested in the arts, music and photography Popular science book with wide readership beyond the classroom at an accessible level Material covered at a level appropriate for self-study or as a complementary textbook For teaching purposes, all figures in the book as well as hints on how to build labs (including seven new labs in March 2012!)

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One of the most pressing tasks in biotechnology today is to unlock the function of each of the thousands of new genes identified every day. Scientists do this by analyzing and interpreting proteins, which are considered the task force of a gene. This single source reference covers all aspects of proteins, explaining fundamentals, synthesizing the latest literature, and demonstrating the most important bioinformatics tools available today for protein analysis, interpretation and prediction. Students and researchers of biotechnology, bioinformatics, proteomics, protein engineering, biophysics, computational biology, molecular modeling, and drug design will find this a ready reference for staying current and productive in this fast evolving interdisciplinary field.
Explains all aspects of proteins including sequence and structure analysis, prediction of protein structures, protein folding, protein stability, and protein interactions Presents a cohesive and accessible overview of the field, using illustrations to explain key concepts and detailed exercises for students.

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Ship Construction, Seventh Edition, offers guidance for ship design and shipbuilding from start to finish. It provides an overview of current shipyard techniques, safety in shipyard practice, materials and strengths, welding and cutting, and ship structure, along with computer-aided design and manufacture, international regulations for ship types, new materials, and fabrication technologies. Comprised of seven sections divided into 32 chapters, the book introduces the reader to shipbuilding, including the basic design of a ship, ship dimensions and category, and development of ship types. It then turns to a discussion of rules and regulations governing ship strength and structural integrity, testing of materials used in ship construction, and welding practices and weld testing. Developments in the layout of a shipyard are also considered, along with development of the initial structural and arrangement design into information usable by production; the processes involved in the preparation and machining of a plate or section; and how a ship structure is assembled. A number of websites containing further information, drawings, and photographs, as well as regulations that apply to ships and their construction, are listed at the end of most chapters. This text is an invaluable resource for students of marine sciences and technology, practicing marine engineers and naval architects, and professionals from other disciplines ranging from law to insurance, accounting, and logistics. Covers the complete ship construction process including the development of ship types, materials and strengths, welding and cutting and ship structure, with numerous clear line diagrams included for ease of understanding  Includes the latest developments in technology and shipyard methods, including a new chapter on computer-aided design and manufacture  Essential for students and professionals, particularly those working in shipyards, supervising ship construction, conversion and maintenance

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This issue of International Review of Neurobiology is split over 2 volumes, bringing together cutting-edge research on Bioinformatics of Behavior. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

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Computational methods are playing an ever increasing role in cell biology. This volume of Methods in Cell Biology focuses on Computational Methods in Cell Biology and consists of two parts: (1) data extraction and analysis to distill models and mechanisms, and (2) developing and simulating models to make predictions and testable hypotheses.
Focuses on computational methods in cell biology Split into 2 parts--data extraction and analysis to distill models and mechanisms, and developing and simulating models to make predictions and testable hypotheses Emphasizes the intimate and necessary connection with interpreting experimental data and proposing the next hypothesis and experiment

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Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the areaone of great importance to organic chemists, polymer chemists and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. Provides up-to-date material on a fast-growing and highly topical subject area Contains the latest research covering a wide variety of heterocyclic topics Written by leading authorities and designed as a handbook for students and industry and academic researchers

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Advances in Planar Lipid Bilayers and Liposomes

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Advances in Planar Lipid Bilayers and Liposomes volumes cover a broad range of topics, including main arrangements of the reconstituted system, namely planar lipid bilayers as well as spherical liposomes. The invited authors present the latest results of their own research groups in this exciting multidisciplinary field.
Incorporates contributions from newcomers and established and experienced researchers Explores the planar lipid bilayer systems and spherical liposomes from both theoretical and experimental perspectives Serves as an indispensable source of information for new scientists