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Nucleosomes, Histones and Chromatin Part A

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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The first of 2 volumes covering nucleosomes, histones and chromatin, it has chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins. Continues the legacy of this premier serial by containing quality chapters authored by leaders in the field  The first of 2 volumes covering nucleosomes, histones and chromatin  Chapters on methods applied to the study of protein arginine methylation, high-resolution identification of intra- and interchromosomal DNA interactions by 4C technology, and peptide arrays to interrogate the binding specificity of chromatin-binding proteins

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Intermolecular and Surface Forces describes the role of various intermolecular and interparticle forces in determining the properties of simple systems such as gases, liquids and solids, with a special focus on more complex colloidal, polymeric and biological systems. The book provides a thorough foundation in theories and concepts of intermolecular forces, allowing researchers and students to recognize which forces are important in any particular system, as well as how to control these forces. This third edition is expanded into three sections and contains five new chapters over the previous edition. Starts from the basics and builds up to more complex systems Covers all aspects of intermolecular and interparticle forces both at the fundamental and applied levels Multidisciplinary approach: bringing together and unifying phenomena from different fields This new edition has an expanded Part III and new chapters on non-equilibrium (dynamic) interactions, and tribology (friction forces)

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Advanced Analysis Techniques for Windows 7

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Windows Forensic Analysis Toolkit: Advanced Analysis Techniques for Windows 7 provides an overview of live and postmortem response collection and analysis methodologies for Windows 7. It considers the core investigative and analysis concepts that are critical to the work of professionals within the digital forensic analysis community, as well as the need for immediate response once an incident has been identified.  Organized into eight chapters, the book discusses Volume Shadow Copies (VSCs) in the context of digital forensics and explains how analysts can access the wealth of information available in VSCs without interacting with the live system or purchasing expensive solutions. It also describes files and data structures that are new to Windows 7 (or Vista), Windows Registry Forensics, how the presence of malware within an image acquired from a Windows system can be detected, the idea of timeline analysis as applied to digital forensic analysis, and concepts and techniques that are often associated with dynamic malware analysis. Also included are several tools written in the Perl scripting language, accompanied by Windows executables.  This book will prove useful to digital forensic analysts, incident responders, law enforcement officers, students, researchers, system administrators, hobbyists, or anyone with an interest in digital forensic analysis of Windows 7 systems. Timely 3e of a Syngress digital forensic bestseller Updated to cover Windows 7 systems, the newest Windows version New online companion website houses checklists, cheat sheets, free tools, and demos

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Imaging and Spectroscopic Analysis of Living Cells

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This volume of Methods in Enzymology is the first of three parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike.
Expert authors who are leaders in the field Extensively referenced and useful figures and tables Provides hints and tricks to facilitate reproduction of methods

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Real-world Stories to Strengthen Every Interactive Project

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Content is king... and the new kingmaker... and your message needs to align with your model and metrics and other mumbo jumbo, right? Whether youre slogging through theory or buzzwords, theres no denying content strategy is coming of age. But whats in it for you? And if youre not a content strategist, why should you care?

Because even if content strategy isnt your job, contents probably your problemand probably more than you think. You or your business has a message you want to deliver, right? You can deliver that message through various channels and content types, from Tweets to testimonials and photo galleries galore, and your audience has just as many ways of engaging with it. So many ways, so much content... so wheres the problem? That is the problem. And you can measure it in time, creativity, money, lost opportunity, and the sobs you hear equally from creative directors, project managers, and search engine marketing specialists.

The solution is content strategy, and this book offers real-world examples and approaches you can adopt, no matter your role on the team. Put content strategy to work for you by gathering this book into your little hands and gobbling up never-before seen case studies from teams at Johns Hopkins Medicine, MINI, Icebreaker, and more. Content Strategy at Work is a book for designers, information architects, copywriters, project managers, and anyone who works with visual or verbal content. It discusses how you can communicate and forge a plan that will enable you, your company, or your client get that message across and foster better user experiences.
Presents a content strategy framework and ways to implement in both in-house marketing departments and consultancies Includes case studies, interviews, and lessons learned from retail, apparel, network television, business-to-business, automotive, non-profit, and higher ed brands Details practical sales techniques to sell content strategy and use content strategy processes to sell other services and larger projects

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Fluorescence Fluctuation Spectroscopy (FFS), Part A

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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers Fluorescence Fluctuation Spectroscopy<br>Contains chapters on such topics as Time-integrated fluorescence cumulant analysis, Pulsed Interleaved Excitation, and raster image correlation spectroscopy and number and brightness analysis. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers fluorescence fluctuation spectroscopy Contains chapters on such topics as time-integrated fluorescence cumulant analysis, pulsed interleaved excitation, and raster image correlation spectroscopy and number and brightness analysis.

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Strategies and Tactics in Organic Synthesis

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A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, this book vividly demonstrates through first hand accounts how synthesis is really done and how by discovering new reactions, creating new designs and building molecules with atom and step economies, the advancement of the science of organic synthesis is providing solutions through function to create a better world.
Presents state-of-the-art developments in organic synthesis Provides insight and offers new perspective to problem-solving Written by leading experts in the field

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The declared objective of this book is to provide an introductory review of the various theoretical and practical aspects of adsorption by powders and porous solids with particular reference to materials of technological importance. The primary aim is to meet the needs of students and non-specialists who are new to surface science or who wish to use the advanced techniques now available for the determination of surface area, pore size and surface characterization. In addition, a critical account is given of recent work on the adsorptive properties of activated carbons, oxides, clays and zeolites. Provides a comprehensive treatment of adsorption at both the gas/solid interface and the liquid/solid interface Includes chapters dealing with experimental methodology and the interpretation of adsorption data obtained with porous oxides, carbons and zeolites Techniques capture the importance of heterogeneous catalysis, chemical engineering and the production of pigments, cements, agrochemicals, and pharmaceuticals

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Jean Rouquerol, Françoise Rouquerol, Philip Llewellyn, Guillaume Maurin, Kenneth Sing

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Pyridines: From Lab to Production provides a synthetic armory of tools to aid the practicing chemist by reviewing the most reliable historical methods alongside new methods/ Written by scientists who have actually used these in synthesis. By emphasizing tricks and tips to optimize reactions for the best yields and purity, which are often missing from the primary literature, this book provides another dimension for the synthetic chemist. A combined academic and industrial approach evaluates the best methods for different scales of reaction and discusses practical tips (e.g. when to stop a reaction early to maximize purity or when to re-use side products). Chapters also assess whether to make or source starting materials, how to connect them and what are the best synthetic routes. The book is designed to be a stand-alone reference, but also provides cross references to leading reviews and the Comprehensive Heterocyclic Chemistry reference works for those who want to learn more.
Reviews tried and tested practical methods to help the reader select the best method for their research Includes tips, tricks and hints to enable the reader to get the best yield or cleanest product out of their reaction for synthesising or transforming a pyridine derivative Written by both academic researchers and industry leaders this provides a unique view of how to get the most out of a reaction no matter what scale you are running this on

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While there are several books on market that are designed to serve a companys daily shop-floor needs. Their focus is mainly on the physically making specific types of welds on specific types of materials with specific welding processes. There is nearly zero focus on the design, maintenance and troubleshooting of the welding systems and equipment. Applied Welding Engineering: Processes, Codes and Standards is designed to provide a practical in-depth instruction for the selection of the materials incorporated in the joint, joint inspection, and the quality control for the final product. Welding Engineers will also find this book a valuable source for developing new welding processes or procedures for new materials as well as a guide for working closely with design engineers to develop efficient welding designs and fabrication procedures.

Applied Welding Engineering: Processes, Codes and Standards is based on a practical approach. The books four part treatment starts with a clear and rigorous exposition of the science of metallurgy including but not limited to: Alloys, Physical Metallurgy, Structure of Materials, Non-Ferrous Materials, Mechanical Properties and Testing of Metals and Heal Treatment of Steels. This is followed by self-contained sections concerning applications regarding Section 2: Welding Metallurgy & Welding Processes, Section 3: Nondestructive Testing, and Section 4: Codes and Standards. The authors objective is to keep engineers moored in the theory taught in the university and colleges while exploring the real world of practical welding engineering. Other topics include: Mechanical Properties and Testing of Metals, Heat Treatment of Steels, Effect of Heat on Material During Welding, Stresses, Shrinkage and Distortion in Welding, Welding, Corrosion Resistant Alloys-Stainless Steel, Welding Defects and Inspection, Codes, Specifications and Standards.

The book is designed to support welding and joining operations where engineers pass plans and projects to mid-management personnel who must carry out the planning, organization and delivery of manufacturing projects. In this book, the author places emphasis on developing the skills needed to lead projects and interface with engineering and development teams. In writing this book, the book leaned heavily on the authors own experience as well as the American Society of Mechanical Engineers (www.asme.org), American Welding Society (www.aws.org), American Society of Metals (www.asminternational.org), NACE International (www.nace.org), American Petroleum Institute (www.api.org), etc. Other sources includes The Welding Institute, UK (www.twi.co.uk), and Indian Air force training manuals, ASNT (www.asnt.org), the Canadian Standard Association (www.cas.com) and Canadian General Standard Board (CGSB) (www.tpsgc-pwgsc.gc.ca).
Rules for developing efficient welding designs and fabrication procedures
Expert advice for complying with international codes and standards from the American Welding Society, American Society of Mechanical Engineers, and The Welding Institute(UK)
Practical in-depth instruction for the selection of the materials incorporated in the joint, joint inspection, and the quality control for the final product.

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Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines

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Clinical Trials: Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines is a practical guidebook for those engaged in clinical trial design. This book details the organizations and content of clinical trials, including trial design, safety, endpoints, subgroups, HRQoL, consent forms and package inserts. It provides extensive information on both US and international regulatory guidelines and features concrete examples of study design from the medical literature. This book is intended to orient those new to clinical trial design and provide them with a better understanding of how to conduct clinical trials. It will also act as a guide for the more experienced by detailing endpoint selection and illustrating how to avoid unnecessary pitfalls. This book is a straightforward and valuable reference for all those involved in clinical trial design.
Provides extensive coverage of the "study schema" and related features of study design Offers a "hands-on" reference that contains an overview of the process, but more importantly details a step-by-step account of clinical trial design Features examples from the medical literature to highlight how investigators choose the most suitable endpoint(s) for clinical trial and includes graphs from real clinical trials to help explain each concept in study design Integrates clinical trial design, pharmacology, biochemistry, cell biology and legal aspects to provide readers with a comprehensive look at all aspects of clinical trials Includes chapters on core material and important ancillary topics, such as package inserts, consent forms, and safety reporting forms used in the United States, England and Europe For complimentary access to our sample chapter (chapter 24), please copy and paste this link into your browser: http://tinyurl.com/awwutvn

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Imaging and Spectroscopic Analysis of Living Cells

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Live Cell Imaging of Cellular Elements and Functions

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This volume of Methods in Enzymology is the second of three parts looking at current methodology for the imaging and spectroscopic analysis of live cells. The chapters provide hints and tricks not available in primary research publications. It is an invaluable resource for academics, researchers and students alike.
Expert authors who are leaders in the field Extensively referenced and useful figures and tables Provides hints and tricks to facilitate reproduction of methods

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Developing Apps in the New World of Cloud Computing

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Moving to the Cloud provides an in-depth introduction to cloud computing models, cloud platforms, application development paradigms, concepts and technologies. The authors particularly examine cloud platforms that are in use today. They also describe programming APIs and compare the technologies that underlie them. The basic foundations needed for developing both client-side and cloud-side applications covering compute/storage scaling, data parallelism, virtualization, MapReduce, RIA, SaaS and Mashups are covered. Approaches to address key challenges of a cloud infrastructure, such as scalability, availability, multi-tenancy, security and management are addressed. The book also lays out the key open issues and emerging cloud standards that will drive the continuing evolution of cloud computing.
Includes complex case studies of cloud solutions by cloud experts from Yahoo! , Amazon, Microsoft, IBM, Adobe and HP Labs Presents insights and techniques for creating compelling rich client applications that interact with cloud services Demonstrates and distinguishes features of different cloud platforms using simple to complex API programming examples

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This vital reference is the only one-stop resource on how to assess, prevent, and manage severe nuclear accidents in the light water reactors (LWRs) that pose the most risk to the public. LWRs are the predominant nuclear reactor in use around the world today, and they will continue to be the most frequently utilized in the near future. Therefore, accurate determination of the safety issues associated with such reactors is central to a consideration of the risks and benefits of nuclear power. This book emphasizes the prevention and management of severe accidents to teach nuclear professionals how to mitigate potential risks to the public to the maximum extent possible. Organizes and presents all the latest thought on LWR nuclear safety in one consolidated volume, provided by the top experts in the field, ensuring high-quality, credible and easily accessible information Explains how developments in the field of LWR severe accidents have provided more accurate determinations of risk, thereby shedding new light on the debates surrounding nuclear power safety, particularly in light of the recent tragedy in Japan Concentrates on prevention and management of accidents, developing methodologies to estimate the consequences and associated risks

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Learning about Learning Disabilities, Fourth Edition continues to provide equal attention to the intellectual, conceptual, and practical aspects of learning disabilities. The Fourth Edition of this popular title presents 80% new material, keeping the chapters up to date in this fast-moving field. With new contributors, and 11 new chapters, coverage is both comprehensive and thorough, encompassing the classification and identification of learning disabilities, learning disabilities in reading, writing, math, and social studies, interventions, and the issues germane to different age ranges of the learning disabled: children, adolescents, and adults. Readers will find Learning About Learning Disabilities, Fourth Edition suitable for use as a reference source for researchers or as a graduate level text.

Reviews of previous editions:

"This text provides a balanced focus on both the conceptual and practical aspects of learning disabilities. Its research coverage is more comprehensive and of greater depth than any other LD textbook, and it is distinctive in its treatment of such important areas as consultation skills and service delivery." -CHILD ASSESSMENT NEWS "... provides a broad overview of some important issues in relation to the education and development of pupils with learning disabilities... Wong has succeeded in providing detailed descriptions and comments within a book which covers a broad range of topics. Without exception the chapters are clearly written and accessible, and many provide the reader with challenging ideas and practical suggestions." -BRITISH JOURNAL OF SPECIAL EDUCATION
Learning Disabilities occur in 20% of the population. Three million children in the US have a learning disability and receive special education in school 30% of children with learning disabilities drop out of high school, and 48% of those with learning disabilities are out of the workforce or unemployed Discusses different types of learning disabilities including problems with attention, memory, language, math, reading, and writing Encompasses the impact of LD on learning as well as social competence and self-regulation Provides research summaries on most effective ways to teach children with LD Encompasses a lifespan perspective on LD, discussing the impact on children, adolescents, and adults

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The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics reasearch. This thematic volume of Advances in Genetics looks at Socio-Genetics. Includes methods for testing with ethical, legal, and social implications

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Genetics of Bone Biology and Skeletal Disease

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This book identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluations of treatments. The book is aimed at all students of bone biology and genetics, and with this in mind, it includes general introductory chapters on genetics and bone biology and more specific disease-orientated chapters, which comprehensively summarize the clinical, genetic, molecular genetic, animal model, functional and molecular pathology, diagnostic, counselling and treatment aspects of each disorder. Saves academic, medical, and pharma researchers time in quickly accessing the very latest details on a broad range of genetic bone issues, as opposed to searching through thousands of journal articles Provides a common language for bone biologists and geneticists to discuss the development of bone cells and genetics and their interactions in the development of disease Researchers in all areas bone biology and genetics will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays For those clinical researchers who are also MDs, correct diagnosis (and therefore correct treatment) of bone diseases depends on a strong understanding of the molecular basis for the disease

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Rajesh V. Thakker, Michael P. Whyte, John Eisman, Takashi Igarashi

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Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease and autoimmune responses to tumors.
Gives a thorough and an important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications, in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant

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The seminal text Plant Virology is now in its fifth edition. It has been 10 years since the publication of the fourth edition, during which there has been an explosion of conceptual and factual advances. The fifth edition of Plant Virology updates and revises many details of the previous edition while retaining the important earlier results that constitute the field's conceptual foundation. Revamped art, along with fully updated references and increased focus on molecular biology, transgenic resistance, aphid transmission, and new, cutting-edge topics, bring the volume up to date and maintain its value as an essential reference for researchers and students in the field. Thumbnail sketches of each genera and family groups Genome maps of all genera for which they are known Genetic engineered resistance strategies for virus disease control Latest understanding of virus interactions with plants, including gene silencing Interactions between viruses and insect, fungal, and nematode vectors Contains over 300 full-color illustrations

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Electronic publishing and electronic means of text and data presentation have changed enormously since the first edition of this book was published in 1997. The third edition of Scientific Papers and Presentations applies traditional principles to today's modern techniques and the changing needs of up-and-coming academia. Topics include designing visual aids, writing first drafts, reviewing and revising, communicating clearly and concisely, adhering to stylistic principles, presenting data in tables and figures, dealing with ethical and legal issues, and relating science to the lay audience. This successful legacy title is an essential guide to professional communication, provides a wealth of information and detail and is a useful guide.
Covers all aspects of communication for early scientists from research to thesis to presentations. Discusses how to use multi-media effectively in presentations and communication Includes an extensive appendices section with detailed examples for further guidance

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Martha Davis, Kaaron Joann Davis, Marion Dunagan