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Dental defects may be the physical expression of genetic defects, and so they can often be seen in a variety of syndromes associated with malformations of organs. However, dental defects are often not recognized, identified, nor characterised despite representing a possible diagnostic sign for an undiagnosed condition. This book addresses this gap by providing an understanding of dental genetics and its developmental biology counterpart. With approximately seventy well-illustrated examples, the authors present the clinical oro-facial manifestations accompanying various syndromes, providing the necessary knowledge for diagnostic purposes, as well as giving insight into recent development for each specific condition. The clarity and format of this book make it an ideal support guide both in the clinic and while conducting research.
Comprehensive examination of dento/oro/craniofacial anomalies Well-illustrated examples Presented in a compact, easy to use format

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Agnes Bloch-Zupan, Heddie Sedano, Crispian Scully

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Polyphosphoesters are a multifunctional, environmentally friendly, and cost-efficient material, making them an important subject. The design of this type of material plays a key role in the progress of industry, agriculture, and medicine. This book introduces the chemistry, characterization and application of polyphosphoesters including comprehensive coverage of poly(alkylene H-phosphonate)s, poly(alkylene phosphate)s, poly(alkyl or aryl phosphonate)s, and poly(alkyl phosphite)s and poly(alkyl phosphinite)s. Each polymer is discussed in detail including methods, properties, and applications.

This book is useful for students and practitioners preparing to work, or in the process of working, in the exciting field of polymer chemistry.
Presents a unique look at an important, multifunctional and environmentally friendly material Outlines methods used to prepare different polyphosphoesters Comprehensive examination of the properties of polyphosphoesters

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Cargo Theft, Loss Prevention, and Supply Chain Security

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Cargo Theft, Loss Prevention, and Supply Chain Security outlines steps for identifying the weakest links in the supply chain and customizing a security program to help you prevent thefts and recover losses. Written by one of the worlds leading experts in cargo theft analysis, risk assessment and supply chain security, this is the most comprehensive book available on the topic of cargo theft and loss prevention. Part history of cargo theft, part analysis and part how-to guide, the book is the one source supply chain professionals and students can turn to in order to understand every facet of cargo theft and take steps to prevent losses.This groundbreaking book contains methods of predictive cargo theft modeling, allowing proactive professionals to develop prevention solutions at every step along the supply chain. It provides a complete methodology for use in creating your own customized supply chain security program as well as in-depth analysis of commonly encountered supply chain security problems. It also supplies a massive amount of credible cargo theft statistics and provides solutions and best practices to supply chain professionals who must determine their companys risk and mitigate their losses by adopting customizable security programs. Furthermore, it presents cutting-edge techniques that industry professionals can use to prevent losses and keep their cargo secure at every stage along the supply chain.This book will be of interest to manufacturing, logistics and security professionals including chief security officers, VPs of logistics or supply chain operations, and transportation managers, as well as professionals in any company that manufactures, ships, transports, stores, distributes, secures or is otherwise responsible for bulk product and cargo. Outlines steps you can take to identify the weakest links in the supply chain and customize a security program to help you prevent thefts and recover losses Offers detailed explanations of downstream costs in a way that makes sense - including efficiency losses, customer dissatisfaction, product recalls and more - that dramatically inflate the impact of cargo theft incidents Provides a complete methodology for use in creating your own customized supply chain security program as well as in-depth analysis of commonly encountered supply chain security problems

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Implications and Applications: Animals and Microbes

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This volume on medicinal foods from the sea narrates the bioactive principles of various marine floral (vertebrate and Invertebrate), faunal (Macro and Micro algal) and microbial sources. Contributions from eminent scientists worldwide explain about the latest advance implications in the development and application of marine originated functional foods, as potential pharmaceuticals and medicines for the benefit of humankind by meeting the present nutraceutical demands. The latest important information for food scientists and nutritionists Peer-reviewed articles by a panel of respected scientists The go-to series since 1948

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Nanoparticles in Translational Science and Medicine

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This volume explores some of the most exciting recent advances in basic research on nanoparticles in translational science and medicine and how this knowledge is leading to advances in the various fields. This series provides a forum for discussion of new discoveries, approaches, and ideas Contributions from leading scholars and industry experts Reference guide for researchers involved in molecular biology and related fields

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This is a comprehensive book addressing steroid disorders from hormonal, genetic, psychological, and surgical perspectives. It is meant to educate adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It will assist these specialists in the diagnosis and treatment of steroid disorders. The book is written for postgraduate and faculty-level physicians. The content consists of steroid disorders, genetic bases for the disorder and case presentations of each disorder.
Provides a common language for professionals to discuss and diagnose genetic steroid disorders Includes the very latest details on genetic tests and diagnoses Offers a strong understanding of the molecular basis for the diseases and therefore correct diagnosis and treatment of steroid disorders Presents insight into which medications to use based on the genetic makeup of a patient Teaches the best strategies and most effective use of genetic information in the patient counseling setting

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Maria I. New, Oksana Lekarev, Alan Parsa, Tony T. Yuen, Bert O'Malley, Gary D. Hammer

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This second edition of a pioneering technical work in biomedical informatics provides a very readable treatment of the deep computational ideas at the foundation of the field. Principles of Biomedical Informatics, 2nd Edition is radically reorganized to make it especially useable as a textbook for courses that move beyond the standard introductory material. It includes exercises at the end of each chapter, ideas for student projects, and a number of new topics, such as: tree structured data, interval trees, and time-oriented medical data and their use On Line Application Processing (OLAP), an old database idea that is only recently coming of age and finding surprising importance in biomedical informatics a discussion of nursing knowledge and an example of encoding nursing advice in a rule-based system X-ray physics and algorithms for cross-sectional medical image reconstruction, recognizing that this area was one of the most central to the origin of biomedical computing an introduction to Markov processes, and an outline of the elements of a hospital IT security program, focusing on fundamental ideas rather than specifics of system vulnerabilities or specific technologies.

It is simultaneously a unified description of the core research concept areas of biomedical data and knowledge representation, biomedical information access, biomedical decision-making, and information and technology use in biomedical contexts, and a pre-eminent teaching reference for the growing number of healthcare and computing professionals embracing computation in health-related fields.

As in the first edition, it includes many worked example programs in Common LISP, the most powerful and accessible modern language for advanced biomedical concept representation and manipulation.

The text also includes humor, history, and anecdotal material to balance the mathematically and computationally intensive development in many of the topic areas. The emphasis, as in the first edition, is on ideas and methods that are likely to be of lasting value, not just the popular topics of the day. Ira Kalet is Professor Emeritus of Radiation Oncology, and of Biomedical Informatics and Medical Education, at the University of Washington. Until retiring in 2011 he was also an Adjunct Professor in Computer Science and Engineering, and Biological Structure. From 2005 to 2010 he served as IT Security Director for the University of Washington School of Medicine and its major teaching hospitals. He has been a member of the American Medical Informatics Association since 1990, and an elected Fellow of the American College of Medical Informatics since 2011. His research interests include simulation systems for design of radiation treatment for cancer, software development methodology, and artificial intelligence applications to medicine, particularly expert systems, ontologies and modeling.
Develops principles and methods for representing biomedical data, using information in context and in decision making, and accessing information to assist the medical community in using data to its full potential Provides a series of principles for expressing biomedical data and ideas in a computable form to integrate biological, clinical, and public health applications Includes a discussion of user interfaces, interactive graphics, and knowledge resources and reference material on programming languages to provide medical informatics programmers with the technical tools to develop systems

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The relatively new technique of solid phase microextraction (SPME) is an important tool to prepare samples both in the lab and on-site. SPME is a "green" technology because it eliminates organic solvents from analytical laboratory and can be used in environmental, food and fragrance, and forensic and drug analysis. This handbook offers a thorough background of the theory and practical implementation of SPME. SPME protocols are presented outlining each stage of the method and providing useful tips and potential pitfalls. In addition, devices and fiber coatings, automated SPME systems, SPME method development, and In Vivo applications are discussed.

This handbook is essential for its discussion of the latest SPME developments as well as its in depth information on the history, theory, and practical application of the method.
Practical application of Solid Phase Microextraction methods including detailed steps Provides history of extraction methods to better understand the process Suitable for all levels, from beginning student to experienced practitioner

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This Expert Guide gives you the techniques and technologies in embedded multicore to optimally design and implement your embedded system. Written by experts with a solutions focus, this encyclopedic reference gives you an indispensable aid to tackling the day-to-day problems when building and managing multicore embedded systems.

Following an embedded system design path from start to finish, our team of experts takes you from architecture, through hardware implementation to software programming and debug.

With this book you will learn:

What motivates multicore

The architectural options and tradeoffs; when to use what

How to deal with the unique hardware challenges that multicore presents

How to manage the software infrastructure in a multicore environment

How to write effective multicore programs

How to port legacy code into a multicore system and partition legacy software

How to optimize both the system and software

The particular challenges of debugging multicore hardware and software
Examples demonstrating timeless implementation details Proven and practical techniques reflecting the authors expertise built from years of experience and key advice on tackling critical issues

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Dimensionless Physical Quantities in Science and Engineering

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Dimensionless quantities, such as p, e, and f are used in mathematics, engineering, physics, and chemistry. In recent years the dimensionless groups, as demonstrated in detail here, have grown in significance and importance in contemporary mathematical and computer modeling as well as the traditional fields of physical modeling. This book offers the most comprehensive and up to date resource for dimensionless quantities, providing not only a summary of the quantities, but also a clarification of their physical principles, areas of use, and other specific properties across multiple relevant fields. Presenting the most complete and clearly explained single resource for dimensionless groups, this book will be essential for students and researchers working across the sciences.
Includes approximately 1,200 dimensionless quantities Features both classic and newly developing fields Easy to use with clear organization and citations to relevant works

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An Interactive History of the Clean Air Act

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The Clean Air Act of 1970 set out for the United States a basic, yet ambitious, objective to reduce pollution to levels that protect health and welfare. The Act set out state and federal regulations to limit emissions and the Environmental Protection Agency was established to help enforce the regulations. The Act has since had several amendments, notably in 1977 and 1990, and has successfully helped to increase air quality. This book reviews the history of the Clean Air Act of 1970 including the political, business, and scientific elements that went into establishing the Act, emphasizing the importance that scientific evidence played in shaping policy. The analysis then extends to examine the effects of the Act over the past forty years including the Environmental Protection Agencys evolving role and the role of states and industry in shaping and implementing policy. Finally, the book offers best practices to guide allocation of respective government and industry roles to guide sustainable development.

The history and analysis of the Clean Air Act presented in this book illustrates the centrality of scientific analysis and technological capacity in driving environmental policy development. It would be useful for policy makers, environmental scientists, and anyone interested in gaining a clearer understand of the interaction of science and policy.
Offers an overview of the 1970 Clean Air Act and its subsequent effects Highlights the relationship between policy and scientific discovery Extracts lessons from the United States to apply to other policy and national contexts

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Resident Stem Cells and Regenerative Therapy

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In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures.

This book will present the main findings to date and the important factors to be considered when considering resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin, and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate.
Highlights basic research in tissue specific stem cells, experiments with animal models and clinical trials that are transforming the field of regeneration Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications

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Regina Coeli dos Santos Goldenberg, Antonio Carlos Campos de Carvalho

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This new volume of Current Topics in Developmental Biology covers the area of gametogenesis, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as germline stem cells, signaling modalities during oogenesis in mammals, and genomic imprinting as a parental effect established in mammalian germ cells.
Covers the area of gametogenesis International board of authors Provides a comprehensive set of reviews covering such topics as germline stem cells, signaling modalities during oogenesis in mammals, and genomic imprinting as a parental effect established in mammalian germ cells

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Structured Parallel Programming offers the simplest way for developers to learn patterns for high-performance parallel programming. Written by parallel computing experts and industry insiders Michael McCool, Arch Robison, and James Reinders, this book explains how to design and implement maintainable and efficient parallel algorithms using a composable, structured, scalable, and machine-independent approach to parallel computing. It presents both theory and practice, and provides detailed concrete examples using multiple programming models.

The examples in this book are presented using two of the most popular and cutting edge programming models for parallel programming: Threading Building Blocks, and Cilk Plus. These architecture-independent models enable easy integration into existing applications, preserve investments in existing code, and speed the development of parallel applications. Examples from realistic contexts illustrate patterns and themes in parallel algorithm design that are widely applicable regardless of implementation technology.

Software developers, computer programmers, and software architects will find this book extremely helpful.
The patterns-based approach offers structure and insight that developers can apply to a variety of parallel programming models Develops a composable, structured, scalable, and machine-independent approach to parallel computing Includes detailed examples in both Cilk Plus and the latest Threading Building Blocks, which support a wide variety of computers

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Michael McCool, James Reinders, Arch Robison

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In Situ Molecular Pathology and Co-Expression Analyses

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In Situ Molecular Pathology and Co-Expression Analyses explains, in easy-to-understand language, simplified ways of understanding and performing in situ hybridization and immunohistochemistry tests. The book also focuses on straightforward protocols used to simultaneously detect two or more proteins/nucleic acids within intact tissue by doing co-expression analyses.

The fields of in situ hybridization and immunohistochemistry have expanded rapidly due to the use of computer-based analysis. To get the most out of these automated platforms, researchers and diagnostic biomedical investigators must have a solid understanding of the basics of in situ-based tests, protocols, and regimens for troubleshooting.

Practicing molecular pathologists, clinical chemists, and toxicologists, as well as clinicians and researchers in training, will benefit from this book's clear presentation of protocols and theoretical framework.
Includes over 200 easy-to-follow experimental protocols Features chapter-ending summaries of "Key Points to Remember" to bring beginners up to speed with any seasoned veteran in the field Offers two chapters written by industry leaders in the fields of in situ hybridization, immunohistochemistry, and computer software for co-expression analyses

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Magnetochemistry is concerned with the study of magnetic properties in materials. It investigates the relationship between the magnetic properties of chemical compounds and their atomic and molecular structure. This rapidly growing field has a number of applications, and the measuring and interpreting of magnetic properties is often conducted by scientists who are not specialists in the field. Magnetochemistry requires complex mathematics and physics and so can be daunting for those who have not previously studied it in depth. Aimed at providing a single source of information on magnetochemistry, this book offers a comprehensive and contemporary review of the mathematical background and formula for predicting or fitting magnetic data, including a summary of the theory behind magnetochemistry to help understand the necessary calculations. Along with tables listing the key formula, there is also a model of the magnetic functions showing the effect of individual magnetic parameters. The clear structure and comprehensive coverage of all aspects of magnetochemistry will make this an essential book for advanced students and practitioners.
Provides comprehensive overview of the mathematical background of magnetochemistry Uses clear and accessible language so scientists in a variety of fields can utilize the information Detailed explanations of equations and formula

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Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. Electrocardiography of Laboratory Animals will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research. Covers safety electrocardiography of large laboratory animals Offers comprehensive analysis of ECGs for practical laboratory use Includes a self-evaluation section for testing of ECG reading and analysis

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Biomedical Optical Phase Microscopy and Nanoscopy

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Written by leading optical phase microscopy experts, this book is a comprehensive reference to phase microscopy and nanoscopy techniques for biomedical applications, including differential interference contrast (DIC) microscopy, phase contrast microscopy, digital holographic microscopy, optical coherence tomography, tomographic phase microscopy, spectral-domain phase detection, and nanoparticle usage for phase nanoscopy The Editors show biomedical and optical engineers how to use phase microscopy for visualizing unstained specimens, and support the theoretical coverage with applied content and examples on designing systems and interpreting results in bio- and nanoscience applications. Provides a comprehensive overview of the principles and techniques of optical phase microscopy and nanoscopy with biomedical applications Tips/advice on building systems and working with advanced imaging biomedical techniques, including interpretation of phase images, and techniques for quantitative analysis based on phase microscopy Interdisciplinary approach that combines optical engineering, nanotechnology, biology and medical aspects of this topic. Each chapter includes practical implementations and worked examples

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Natan T. Shaked, Zeev Zalevsky, Lisa L Satterwhite

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As the embedded world expands, developers must have a strong grasp of many complex topics in order to make faster, more efficient and more powerful microprocessors to meet the publics growing demand. Embedded Software: The Works covers all the key subjects embedded engineers need to understand in order to succeed, including Design and Development, Programming, Languages including C/C++, and UML, Real Time Operating Systems Considerations, Networking, and much more. New material on Linux, Android, and multi-core gives engineers the up-to-date practical know-how they need in order to succeed.

Colin Walls draws upon his experience and insights from working in the industry, and covers the complete cycle of embedded software development: its design, development, management, debugging procedures, licensing, and reuse. For those new to the field, or for experienced engineers looking to expand their skills, Walls provides the reader with detailed tips and techniques, and rigorous explanations of technologies.

Key features include:

New chapters on Linux, Android, and multi-core the cutting edge of embedded software development!
Introductory roadmap guides readers through the book, providing a route through the separate chapters and showing how they are linked
About the Author

Colin Walls has over twenty-five years experience in the electronics industry, largely dedicated to embedded software. A frequent presenter at conferences and seminars and author of numerous technical articles and two books on embedded software, he is a member of the marketing team of the Mentor Graphics Embedded Software Division. He writes a regular blog on the Mentor website (blogs.mentor.com/colinwalls).
New chapters on Linux, Android, and multi-core the cutting edge of embedded software development! Introductory roadmap guides readers through the book, providing a route through the separate chapters and showing how they are linked

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Animal Models for the Study of Human Disease

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Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse.
Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives and animal ethics Covers a broad range of animal models used in research for human disease