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Methods and Applications for Risk Assessment

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Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided in this book are based on cutting-edge technologies and set out to stimulate the further development of this promising field to offer rapid, better and more cost-effective answers to major public health concerns.
Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared

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Advances in Carbohydrate Chemistry and Biochemistry

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Since its inception in 1945, this serial has provided critical and integrating articles written by research specialists that integrate industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. The articles provide a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.
Contributions from leading authorities Informs and updates on all the latest developments in the field

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Protein Phosphorylation in Health and Disease

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This volume explores some of the most exciting recent advances in basic research on protein phosphorylation in health and disease and how this knowledge is leading to advances in the various fields. Contributions from leading authorities Informs and updates on all the latest developments in the field

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Control and Optimisation of Process Systems

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Advances in Chemical Engineering was established in 1960 and is the definitive serial in the area. It is one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. This volume focuses on control and optimisation of process systems. Advances in Chemical Engineering was established in 1960 and is the definitive serial in the area. It is one of great importance to organic chemists, polymer chemists, and many biological scientists Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties Focuses on control and optimization of process systems

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Theory of Heavy Ion Collision Physics in Hadron Therapy

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Advances in Quantum Chemistry presents surveys of current topics in this rapidly developing field that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry, and biology. It features detailed reviews written by leading international researchers. This volume focuses on the theory of heavy ion physics in medicine. Presents surveys of current topics in this rapidly developing field Features detailed reviews written by leading international researchers Focuses on the theory of heavy ion physics in medicine

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Understanding Augmented Reality addresses the elements that are required to create augmented reality experiences. The technology that supports augmented reality will come and go, evolve and change. The underlying principles for creating exciting, useful augmented reality experiences are timeless.

Augmented reality designed from a purely technological perspective will lead to an AR experience that is novel and fun for one-time consumption - but is no more than a toy. Imagine a filmmaking book that discussed cameras and special effects software, but ignored cinematography and storytelling! In order to create compelling augmented reality experiences that stand the test of time and cause the participant in the AR experience to focus on the content of the experience - rather than the technology - one must consider how to maximally exploit the affordances of the medium.

Understanding Augmented Reality addresses core conceptual issues regarding the medium of augmented reality as well as the technology required to support compelling augmented reality. By addressing AR as a medium at the conceptual level in addition to the technological level, the reader will learn to conceive of AR applications that are not limited by todays technology. At the same time, ample examples are provided that show what is possible with current technology.
Explore the different techniques, technologies and approaches used in developing AR applications Learn from the author's deep experience in virtual reality and augmented reality applications to succeed right off the bat, and avoid many of the traps that catch new developers and users of augmented reality experiences Some AR examples can be experienced from within the book using downloadable software

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Vertebrate Endocrinology represents more than just a treatment of the endocrine system-it integrates hormones with other chemical bioregulatory agents not classically included with the endocrine system. It provides a complete overview of the endocrine system of vertebrates by first emphasizing the mammalian system as the basis of most terminology and understanding of endocrine mechanisms and then applies that to non-mammals. The serious reader will gain both an understanding of the intricate relationships among all of the body systems and their regulation by hormones and other bioregulators, but also a sense of their development through evolutionary time as well as the roles of hormones at different stages of an animal's life cycle. Includes new full color format includes over 450 full color, completely redrawn image Features a companion web site hosting all images from the book as PPT slides and .jpeg files Presents completedly updated and revitalized content with new chapters, such as Endocrine Disrupters and Behavioral Endocrinology Offers new clinical correlation vignettes throughout

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Advances in Applied Mechanics draws together recent significant advances in various topics in applied mechanics. Published since 1948, Advances in Applied Mechanics aims to provide authoritative review articles on topics in the mechanical sciences, primarily of interest to scientists and engineers working in the various branches of mechanics, but also of interest to the many who use the results of investigations in mechanics in various application areas, such as aerospace, chemical, civil, environmental, mechanical and nuclear engineering. Covers all fields of the mechanical sciences Highlights classical and modern areas of mechanics that are ready for review Provides comprehensive coverage of the field in question

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SQL server is the most widely used database platform in the world, and a large percentage of these databases are not properly secured, exposing sensitive customer and business data to attack.

In Securing SQL Server, 2e, readers learn about the potential attack vectors that can be used to break into SQL server databases as well as how to protect databases from these attacks. In this book written by Denny Cherry, a Microsoft SQL MVP and one of the biggest names in SQL server today, readers learn how to properly secure a SQL server database from internal and external threats using best practices as well as specific tricks the authors employ in their roles as database administrators for some of the largest SQL server deployments in the world.

"Denny Cherry is what would happen if Bill Gates and AC/DC got together to create a sibling. He's a bare-knuckles, no holds-barred technologist, and you can bet that if he tells you that something does or doesn't work, he's speaking from experience. Active in the community, his passion is sharing. You'll enjoy this book."--Buck Woody, Senior Technology Specialist, Microsoft
Presents hands-on techniques for protecting your SQL Server database from intrusion and attack Provides the most in-depth coverage of all aspects of SQL Server database security, including a wealth of new material on Microsoft SQL Server 2012 (Denali) Explains how to set up your database securely, how to determine when someone tries to break in, what the intruder has accessed or damaged, and how to respond and mitigate damage if an intrusion occurs

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Crafting the Information Experience for Web and Software Apps

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Writing for Interaction focuses on the art of creating the information experience as it appears within software and web applications, specifically in the form of user interface text. It also provides strategies for ensuring a consistent, positive information experience across a variety of delivery mechanisms, such as online help and social media.

Throughout this book, you'll learn simple techniques for writing consistent text with the right tone, how to select content delivery mechanisms, and how straightforward, clear layouts help your customer interact with your application. Divided into five sections, the book completely covers the information experience design process from beginning to end. You'll cover everything from understanding your users and their needs, to creating personas, designing the IX strategy, creating your information, and evaluating the resulting information experience. This is your one-stop reference for information experience!
Illuminates writing principles and practices for use in interactive design Includes examples, checklists, and sample processes, highlighting practical approaches to designing the information experience Provides the complete picture: understanding customer needs, creating personas, and writing the text appearing within the user interface

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Understand and Implement Effective PCI Data Security Standard Compliance

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The credit card industry established the PCI Data Security Standards to provide a minimum standard for how vendors should protect data to ensure it is not stolen by fraudsters. PCI Compliance, 3e, provides the information readers need to understand the current PCI Data Security standards, which have recently been updated to version 2.0, and how to effectively implement security within your company to be compliant with the credit card industry guidelines and protect sensitive and personally identifiable information. Security breaches continue to occur on a regular basis, affecting millions of customers and costing companies millions of dollars in fines and reparations. That doesnt include the effects such security breaches have on the reputation of the companies that suffer attacks. PCI Compliance, 3e, helps readers avoid costly breaches and inefficient compliance initiatives to keep their infrastructure secure.
Provides a clear explanation of PCI Provides practical case studies, fraud studies, and analysis of PCI The first book to address version 2.0 updates to the PCI DSS, security strategy to keep your infrastructure PCI compliant

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Current State of Alzheimer's Disease Research and Therapeutics

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This new volume of Advances in Pharmacology explores the Current State of Alzheimer's Disease Research and Therapeutics. Chapters cover such topics as the The role heat shock proteins play in the Alzheimer's Theater, Gamma-Secretase as a Target for Alzheimer's Disease, and Identification of protein kinase C for the treatment of dementias. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.
Explores the current state of Alzheimer's disease research and therapeutics Chapters cover a variety of topics such as the role heat shock proteins play in the Alzheimer's theater, gamma-secretase as a target for Alzheimer's disease, and identification of protein kinase C for the treatment of dementias With the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike

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Introduction to Probability and Statistics for Engineers and Scientists

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Introduction to Probability and Statistics for Engineers and Scientists, Fifth Edition is a proven text reference that provides a superior introduction to applied probability and statistics for engineering or science majors. The book lays emphasis in the manner in which probability yields insight into statistical problems, ultimately resulting in an intuitive understanding of the statistical procedures most often used by practicing engineers and scientists.

Real data from actual studies across life science, engineering, computing and business are incorporated in a wide variety of exercises and examples throughout the text. These examples and exercises are combined with updated problem sets and applications to connect probability theory to everyday statistical problems and situations. The book also contains end of chapter review material that highlights key ideas as well as the risks associated with practical application of the material. Furthermore, there are new additions to proofs in the estimation section as well as new coverage of Pareto and lognormal distributions, prediction intervals, use of dummy variables in multiple regression models, and testing equality of multiple population distributions.

This text is intended for upper level undergraduate and graduate students taking a course in probability and statistics for science or engineering, and for scientists, engineers, and other professionals seeking a reference of foundational content and application to these fields.
Clear exposition by a renowned expert author Real data examples that use significant real data from actual studies across life science, engineering, computing and business End of Chapter review material that emphasizes key ideas as well as the risks associated with practical application of the material 25% New Updated problem sets and applications, that demonstrate updated applications to engineering as well as biological, physical and computer science New additions to proofs in the estimation section New coverage of Pareto and lognormal distributions, prediction intervals, use of dummy variables in multiple regression models, and testing equality of multiple population distributions.

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Boundary Layer Flow over Elastic Surfaces

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Compliant Surfaces and Combined Methods for Marine Vessel Drag Reduction

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While other methods of drag reduction are well-known in marine R&D; and ship design environments worldwide, compliant coating drag reduction remains less well-known and poorly understood. This important book presents cutting-edge techniques and findings from research sources not generally accessible by Western researchers and engineers, aiding the application and further development of this potentially important technology.

Beginning with an introduction to drag reduction that places the authors work on elastic surfaces and combined techniques in context, the book moves on to provide a comprehensive study of drag reduction through elastic coating with both flow and material properties considered. Coverage includes:

Experimental findings around coherent vortical structures (CVS) in turbulent boundary layers and methods of controlling them
Static and dynamic mechanical characteristics of elastic composite coatings, as well as new techniques and devices developed for their measurement
Combined methods of flow control and drag reduction, including the effect of injection of polymer solutions, elastic coatings and generated longitudinal vortical structures on hydrodynamic resistance
Intended as a reference for senior engineers and researchers concerned with the drag reduction and the dynamics of turbulent boundary layer flows, Boundary Layer Flow over Elastic Surfaces provides a unique source of information on compliant surface drag reduction and the experimental techniques around it that have shown measurable and repeatable improvements over recent years.

This compilation of research findings and new techniques developed for measurement will aid R&D; engineers, naval architects and senior designers in their quest to achieve drag reductions that will deliver significant efficiency savings.
Unique source of information on compliant surface drag reductionan important area of technology with practical application to shipsfrom otherwise inaccessible research studies Updates the knowledge-base on boundary layer flow and surface friction reduction, critical topics in the global quest for increased ship efficiency and fuel economy Reveals new techniques and devices developed for measurement and provides a comprehensive study of drag reduction through elastic coating with both flow and material properties covered

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Viktor V. Babenko, Ho-Hwan Chun, Inwon Lee

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Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology.

The series contains comprehensive reviews of the most current research in applied microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays.

Impact factor for 2010: 3.913. Contributions from leading authorities Informs and updates on all the latest developments in the field

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Allen I. Laskin, Geoffrey M. Gadd, Sima Sariaslani

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Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.

Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.
Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system

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Welding Deformation and Residual Stress Prevention

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Generally, welding produces welding deformation and residual stress in the products, which influences the quality and performance of the products. Although many engineers and researchers have made great effort how to control these incidents, they have still remained unresolved. Welding Deformation and Residual Stress Prevention provides a unique computational approach to the prediction of the effects of deformation and residual stress on materials. The goal is to provide engineers and designers with the ability to create their own computational system for predicting and possibly avoiding the problem altogether. The basic theories including "theory of elastic-plastic analysis" and "inherent strain theory" , and analysis procedures are described using a simple three-bar model Online simulation software to perform basic analysis on welding mechanics Examples of strategic methods and procedures are illustrated to have solved various welding-related problems encountered in the process of construction Appendices present data bases for welding residual stresses, temperature dependent material properties, etc.

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Ninshu Ma, Hidekazu Murakawa, Yukio Ueda

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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on sleep hormones.
Contributions from leading authorities Informs and updates on all the latest developments in the field

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This volume, the first of a two-part series, covers topics including historical, ecological and evolutionary considerations, genomics and molecular biology, and interaction of phages with their hosts. Contributions from leading authorities Informs and updates on all the latest developments in the field

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DNA typing has revolutionized criminal investigations and has become a powerful tool in the identification of individuals in criminal and paternity cases. Forensic DNA Biology: A Laboratory Manual is comprised of up-to-date and practical experiments and step-by-step instructions on how to perform DNA analysis, including pipetting, microscopy and hair analysis, presumptive testing of body fluids and human DNA typing. Modern DNA typing techniques are provided, reflecting real life, where not all institutions and crime labs can afford the same equipment and software. Real case studies will be used throughout.
Provides practical step-by-step instruction on how to perform forensic DNA analysis Includes analysis of hair, presumptive testing of body fluids, human DNA typing and statistics Covers techniques such as pipetting, microscopy and DNA extraction Pre- and post-lab exercises and questions assist the reader in learning the material Report writing templates assure the reader learns real world crime lab procedure