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Lead Compounds from Medicinal Plants for the Treatment of Cancer

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Lead Compounds from Medicinal Plants for the Treatment of Cancer is the first volume in the series, Pharmaceutical Leads from Medicinal Plants. The plant species described in this reference have been carefully selected based on pharmacological evidence and represent todays most promising sources of natural products for the discovery of anti-cancer drugs. Containing references to primary source material, over a hundred botanical illustrations, a table of chemical structures and much more, this book is an essential starting point for cancer researchers and those involved in anti-cancer drug discovery helping you identify the best novel lead molecules for further anti-cancer drug development.
Provides a compilation of hundreds of medicinal plants from Europe, Asia, North and South America and Africa that contain prominent lead candidates for anti-cancer drug discovery Contains primary source references and hundreds of the most relevant citations from the current literature for additional research Offers cancer researchers and pharmaceutical scientists valuable tools such as chemical structures and promising pharmacological data to help them select the novel lead compounds that will best aid drug discovery.

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Current Concepts in Drug Metabolism and Toxicology

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This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.
Explores the current concepts in drug metabolism and toxicology Chapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity An essential resource for pharmacologists, immunologists and biochemists alike

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Metaheuristic Applications in Structures and Infrastructures

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Due to an ever-decreasing supply in raw materials and stringent constraints on conventional energy sources, demand for lightweight, efficient and low-cost structures has become crucially important in modern engineering design. This requires engineers to search for optimal and robust design options to address design problems that are commonly large in scale and highly nonlinear, making finding solutions challenging. In the past two decades, metaheuristic algorithms have shown promising power, efficiency and versatility in solving these difficult optimization problems.

This book examines the latest developments of metaheuristics and their applications in structural engineering, construction engineering and earthquake engineering, offering practical case studies as examples to demonstrate real-world applications. Topics cover a range of areas within engineering, including big bang-big crunch approach, genetic algorithms, genetic programming, harmony search, swarm intelligence and some other metaheuristic methods. Case studies include structural identification, vibration analysis and control, topology optimization, transport infrastructure design, design of reinforced concrete, performance-based design of structures and smart pavement management. With its wide range of everyday problems and solutions, Metaheursitic Applications in Structures and Infrastructures can serve as a supplementary text for design courses and computation in engineering as well as a reference for researchers and engineers in metaheuristics, optimization in civil engineering and computational intelligence.
Review of the latest development of metaheuristics in engineering. Detailed algorithm descriptions with focus on practical implementation. Uses practical case studies as examples and applications.

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Xin-She Yang, Siamak Talatahari, Amir Hossein Alavi

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Applications of Viruses for Cancer Therapy

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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Applications of viruses for cancer therapy". With outstanding and original reviews, this volume covers topics such as Cancer Terminator Viruses and Approaches for Enhancing Therapeutic Outcomes, esign of improved oncolytic adenoviruses, and Adenovirus-based immunotherapies for cancer.
Provides invaluable information on the exciting and fast-moving field of cancer research This thematic volume looks at "Applications of viruses for cancer therapy" Outstanding and original reviews

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Comprehensive Addictive Behaviors and Disorders, Volume 3

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Interventions for Addiction examines a wide range of responses to addictive behaviors, including psychosocial treatments, pharmacological treatments, provision of health care to addicted individuals, prevention, and public policy issues. Its focus is on the practical application of information covered in the two previous volumes of the series, Comprehensive Addictive Behaviors and Disorders.

Readers will find information on treatments beyond commonly used methods, including Internet-based and faith-based therapies, and criminal justice interventions. The volume features extensive coverage of pharmacotherapies for each of the major drugs of abuseincluding disulfiram, buprenorphine, naltrexone, and othersas well as for behavioral addictions. In considering public policy, the book examines legislative efforts, price controls, and limits on advertising, as well as World Health Organization (WHO) efforts.

Interventions for Addiction is one of three volumes comprising the 2,500-page series, Comprehensive Addictive Behaviors and Disorders. This series provides the most complete collection of current knowledge on addictive behaviors and disorders to date. In short, it is the definitive reference work on addictions.
Includes descriptions of both psychosocial and pharmacological treatments. Addresses health services research on attempts to increase the use of evidence-based treatments in routine clinical practice. Covers attempts to slow the progress of addictions through prevention programs and changes in public policy.

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Comprehensive Addictive Behaviors and Disorders, Volume 2

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Biological Research on Addiction examines the neurobiological mechanisms of drug use and drug addiction, describing how the brain responds to addictive substances as well as how it is affected by drugs of abuse. The book's four main sections examine behavioral and molecular biology; neuroscience; genetics; and neuroimaging and neuropharmacology as they relate to the addictive process.

This volume is especially effective in presenting current knowledge on the key neurobiological and genetic elements in an individuals susceptibility to drug dependence, as well as the processes by which some individuals proceed from casual drug use to drug dependence.

Biological Research on Addiction is one of three volumes comprising the 2,500-page series, Comprehensive Addictive Behaviors and Disorders. This series provides the most complete collection of current knowledge on addictive behaviors and disorders to date. In short, it is the definitive reference work on addictions.
Each article provides glossary, full references, suggested readings, and a list of web resources Edited and authored by the leaders in the field around the globe the broadest, most expert coverage available Discusses the genetic basis of addiction Covers basic science research from a variety of animal studies

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Comprehensive Addictive Behaviors and Disorders, Volume 1

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Principles of Addiction provides a solid understanding of the definitional and diagnostic differences between use, abuse, and disorder. It describes in great detail the characteristics of these syndromes and various etiological models.

The book's three main sections examine the nature of addiction, including epidemiology, symptoms, and course; alcohol and drug use among adolescents and college students; and detailed descriptions of a wide variety of addictive behaviors and disorders, encompassing not only drugs and alcohol, but caffeine, food, gambling, exercise, sex, work, social networking, and many other areas.

This volume is especially important in providing a basic introduction to the field as well as an in-depth review of our current understanding of the nature and process of addictive behaviors.

Principles of Addiction is one of three volumes comprising the 2,500-page series, Comprehensive Addictive Behaviors and Disorders. This series provides the most complete collection of current knowledge on addictive behaviors and disorders to date. In short, it is the definitive reference work on addictions.
Each article provides glossary, full references, suggested readings, and a list of web resources Edited and authored by the leaders in the field around the globe the broadest, most expert coverage available Encompasses types of addiction, as well as personality and environmental influences on addiction

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Demand for fuel cell technology is growing rapidly. Fuel cells are being commercialized to provide power to buildings like hospitals and schools, to replace batteries in portable electronic devices, and as replacements for internal combustion engines in vehicles. PEM (Proton Exchange Membrane) fuel cells are lighter, smaller, and more efficient than other types of fuel cell. As a result, over 80% of fuel cells being produced today are PEM cells.

This new edition of Dr. Barbirs groundbreaking book still lays the groundwork for engineers, technicians and students better than any other resource, covering fundamentals of design, electrochemistry, heat and mass transport, as well as providing the context of system design and applications. Yet it now also provides invaluable information on the latest advances in modeling, diagnostics, materials, and components, along with an updated chapter on the evolving applications areas wherein PEM cells are being deployed.
Comprehensive guide covers all aspects of PEM fuel cells, from theory and fundamentals to practical applications Provides solutions to heat and water management problems engineers must face when designing and implementing PEM fuel cells in systems Hundreds of original illustrations, real-life engineering examples, and end-of-chapter problems help clarify, contextualize, and aid understanding

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Windows Server 2012 Security from End to Edge and Beyond

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Architecting, Designing, Planning, and Deploying Windows Server 2012 Security Solutions

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Windows Server 2012 Security from End to Edge and Beyond shows you how to architect, design, plan, and deploy Microsoft security technologies for Windows 8/Server 2012 in the enterprise. The book covers security technologies that apply to both client and server and enables you to identify and deploy Windows 8 security features in your systems based on different business and deployment scenarios. The book is a single source for learning how to secure Windows 8 in many systems, including core, endpoint, and anywhere access.

Authors Tom Shinder and Yuri Diogenes, both Microsoft employees, bring you insider knowledge of the Windows 8 platform, discussing how to deploy Windows security technologies effectively in both the traditional datacenter and in new cloud-based solutions. With this book, you will understand the conceptual underpinnings of Windows 8 security and how to deploy these features in a test lab and in pilot and production environments.

The book's revolutionary "Test Lab Guide" approach lets you test every subject in a predefined test lab environment. This, combined with conceptual and deployment guidance, enables you to understand the technologies and move from lab to production faster than ever before. Critical material is also presented in key concepts and scenario-based approaches to evaluation, planning, deployment, and management. Videos illustrating the functionality in the Test Lab can be downloaded from the authors blog http://blogs.technet.com.b.security_talk/. Each chapter wraps up with a bullet list summary of key concepts discussed in the chapter.
Provides practical examples of how to design and deploy a world-class security infrastructure to protect both Windows 8 and non-Microsoft assets on your system Written by two Microsoft employees who provide an inside look at the security features of Windows 8 Test Lab Guides enable you to test everything before deploying live to your system

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Yuri Diogenes, Debra Littlejohn Shinder, Thomas W Shinder

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Morphogenesis is the set of processes that generate shape and form in the embryo--an important area within developmental biology. An exciting and up-to-the-minute account of the very latest research into the factors that create biological form, Mechanisms of Morphogenesis, second edition is a text reference on the mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi.

By combining hard data with computer modeling, Mechanisms of Morphogenesis, second edition equips readers with a much broader understanding of the scope of modern research than is otherwise available. The book focuses on the ways in which the genetic program is translated to generate cell shape, to direct cell migration, and to produce the shape, form and rates of growth of the various tissues. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and pointers to future
Includes over 200 four-color figures Offers an integrated view of theoretical developmental biology and computer modelling with laboratory-based discoveries Covers experimental techniques as a guide to the reader Organized around principles and mechanisms, using them to integrate discoveries from a range of organisms and systems

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Now in its fourth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fourth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the worlds experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future.

This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies such as brain-machine interfaces for controlling bionics and neuroprostheses is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike.
Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves Offers expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems Full-color presentation throughout

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Robert Lanza, Robert Langer, Joseph P. Vacanti

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Advances in Analog and RF IC Design for Wireless Communication Systems

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Advances in Analog and RF IC Design for Wireless Communication Systems gives technical introductions to the latest and most significant topics in the area of circuit design of analog/RF ICs for wireless communication systems, emphasizing wireless infrastructure rather than handsets. The book ranges from very high performance circuits for complex wireless infrastructure systems to selected highly integrated systems for handsets and mobile devices. Coverage includes power amplifiers, low-noise amplifiers, modulators, analog-to-digital converters (ADCs) and digital-to-analog converters (DACs), and even single-chip radios.

This book offers a quick grasp of emerging research topics in RF integrated circuit design and their potential applications, with brief introductions to key topics followed by references to specialist papers for further reading. All of the chapters, compiled by editors well known in their field, have been authored by renowned experts in the subject. Each includes a complete introduction, followed by the relevant most significant and recent results on the topic at hand.

This book gives researchers in industry and universities a quick grasp of the most important developments in analog and RF integrated circuit design.
Emerging research topics in RF IC design and its potential application Case studies and practical implementation examples Covers fundamental building blocks of a cellular base station system and satellite infrastructure Insights from the experts on the design and the technology trade-offs, the challenges and open questions they often face References to specialist papers for further reading

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Gabriele Manganaro, Domine M W Leenaerts

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Knowledge-based Configuration incorporates knowledge representation formalisms to capture complex product models and reasoning methods to provide intelligent interactive behavior with the user. This book represents the first time that corporate and academic worlds collaborate integrating research and commercial benefits of knowledge-based configuration. Foundational interdisciplinary material is provided for composing models from increasingly complex products and services. Case studies, the latest research, and graphical knowledge representations that increase understanding of knowledge-based configuration provide a toolkit to continue to push the boundaries of what configurators can do and how they enable companies and customers to thrive.
Includes detailed discussion of state-of-the art configuration knowledge engineering approaches such as automated testing and debugging, redundancy detection, and conflict management Provides an overview of the application of knowledge-based configuration technologies in the form of real-world case studies from SAP, Siemens, Kapsch, and more Explores the commercial benefits of knowledge-based configuration technologies to business sectors from services to industrial equipment Uses concepts that are based on an example personal computer configuration knowledge base that is represented in an UML-based graphical language

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Alexander Felfernig, Lothar Hotz, Claire Bagley, Juha Tiihonen

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Reliable Maintenance Planning, Estimating, and Scheduling

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Written specifically for the oil and gas industry, Reliable Maintenance Planning, Estimating, and Scheduling provides maintenance managers and engineers with the tools and techniques to create a manageable maintenance program that will save money and prevent costly facility shutdowns. The ABCs of work identification, planning, prioritization, scheduling, and execution are explained. The objective is to provide the capacity to identify, select and apply maintenance interventions that assure an effective maintenance management, while maximizing equipment performance, value creation and opportune and effective decision making. The book provides a pre- and post- self-assessment that will allow for measure competency improvement. Maintenance Managers and Engineers receive an expert guide for developing detailed actions including repairs, alterations, and preventative maintenance.
The nuts and bolts of the planning, estimating, and scheduling process for oil and gas facilities Step-by-step maintenance guide will provide long-term, results-based operational services Case studies based on the oil and gas industry

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Subsea Pipeline Integrity and Risk Management

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Subsea repairs and inspection are costly for petroleum and pipeline engineers and proper training is needed to focus on ensuring system strength and integrity. Subsea Pipeline Integrity and Risk Management is the perfect companion for new engineers who need to be aware of the state-of-the-art techniques. This handbook offers a "hands-on" problem-solving approach to integrity management, leak detection, and reliability applications such as risk analysis.

Wide-ranging and easy-to-use, the book is packed with data tables, illustrations, and calculations, with a focus on pipeline corrosion, flexible pipes, and subsea repair. Reliability-based models also provide a decision making tool for day-to-day use. Subsea Pipeline Integrity and Risk Management gives the engineer the power and knowledge to protect offshore pipeline investments safely and effectively.
Includes material selection for linepipe, especially selection of standard carbon steel linepipe Covers assessment of various types of corrosion processes and definition of anti-corrosion design against internal as well as external corrosion Gives process and flow assurance for pipeline systems including pipeline integrity management

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Global Change in Multispecies Systems: Part II

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Advances in Ecological Research is one of the most successful series in the highly competitive field of ecology. Each volume publishes topical and important reviews, interpreting ecology as widely as in the past, to include all material that contributes to our understanding of the field. Topics in this invaluable series include the physiology, populations, and communities of plants and animals, as well as landscape and ecosystem ecology.
Advances in Ecological Research is one of the most successful series in the highly competitive field of ecology Each volume publishes topical and important reviews, interpreting ecology as widely as in the past, to include all material that contributes to our understanding of the field Topics in this invaluable series include the physiology, populations, and communities of plants and animals, as well as landscape and ecosystem ecology

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This issue of International Review of Neurobiology is split over 2 volumes, bringing together cutting-edge research on Bioinformatics of Behavior. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

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Bringing Together Experiments and Computing

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Both strategies for investigation (computational and experimental) in structural and mechanistic Enzymology have developed to some extent independently. However, over the last few years a trend has emerged for strengthening their integration. This combination not only brings together computations and experiments focused on the same enzymatic problems, but also provides complementary insights into the investigated properties and has a powerful synergy effect. This thematic volume of Advances in Protein Chemistry and Structural Biology focuses on the recent success in structural and mechanistic enzymology and has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches. The selected contributions demonstrate how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design.
Focuses on the recent success in structural and mechanistic enzymology Has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches Demonstrates how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design

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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
Contributions from leading authorities Informs and updates on all the latest developments in the field

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Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. Covers reviews of methodology and research in all aspects of protein chemistry Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics