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Mesenchymal Stem Cells in Cancer Therapy

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With the thorough understanding of stem cell biology and the advent of targeted therapeutics for cancer, stem cell-based therapeutic strategies are being increasingly explored for the treatment of various cancer types. Mesenchymal Stem Cells in Cancer Therapy sheds light on current stem cell based targeted therapies for cancer, by focusing on the application of mesenchymal stem cells (MSC) in various cancers with emphasis on a number of aspects that are critical to the success of future stem cell based therapies for cancer. Sections of this publication are devoted to developing stem cell based therapies for cancer with the main focus on tumoritrophic properties of stem cells, engineering targeted therapeutics, utilization of imaging techniques and the recent combination studies utilizing currently employed therapeutics with stem cells. Mesenchymal Stem Cells in Cancer Therapy informs readers about critical and cutting edge stem cell therapies for cancer and also enables them to appreciate the vast plain of unresolved questions in stem cell research for cancer therapeutics.
Includes biological foundation on key sources of mesenchymal stem cells and the various ways they can be utilized to treat cancer Provides examples of current MSC based cancer therapies and prospects for the future with insights from the leading lab on cancer cell therapies Technically advanced topic written for widespread understanding for clinical and research audiences

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First U.K. National Conference on Heat Transfer

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The Institution of Chemical Engineers Symposium Series, Volume 2.86

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First U.K. National Conference on Heat Transfer, Volume 2, documents the proceedings of the conference organized by the U.K. National Committee for Heat Transfera joint committee of the Institutions of Chemical and Mechanical Engineers and includes a member nominated by the Heat Transfer Societyheld at the University of Leeds, on 3-5 July 1984. It is intended that the Leeds conference will be the first of a series of UK National Conferences which will be held at four-yearly intervals (1984, 1988, 1992 etc). Thus, for people working in the heat transfer field there will be an opportunity to present and discuss their work at a major conference every two years.  This volume contains 52 papers that were presented during Sessions 11-20. The papers in Session 11 deal with enhanced heat transfer. Session 12 presents studies on two-phase flow and boiling. Session 13 contains papers on natural convection. Session 14 focuses measurement techniques in heat transfer while Session 15 deals with heat transfer in high temperature systems. The presentations in Session 16 cover heat transfer in combustion systems while those in Session 17 focus on convective heat transfer. Session 18 takes up heat transfer in cross-flow. Session 19 discusses papers on applied heat transfer. Session 20 deals with studies on industrial heat exchangers.

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An Introduction to the Concepts, Systems, and Applications of Nuclear Processes

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Nuclear Energy is one of the most popular texts ever published on basic nuclear physics, systems, and applications of nuclear energy. This newest edition continues the tradition of offering a holistic treatment of everything the undergraduate engineering student needs to know in a clear and accessible way. The book presents a comprehensive overview of radioactivity, radiation protection, nuclear reactors, waste disposal, and nuclear medicine.

The seventh edition is restructured into three parts: Basic Concepts, Nuclear Power (including new chapters on nuclear power plants and introduction to reactor theory), and Radiation and Its Uses. Part Two in particular has been updated with current developments, including a new section on Reactor Safety and Security (with a discussion of the Fukushima Diiachi accident); updated information on naval and space propulsion; and revised and updated information on radioactive waste storage, transportation, and disposal. Part Three features new content on biological effects of radiation, radiation standards, and radiation detection.
Coverage of energy economics integrated into appropriate chapters More worked examples and end of chapter exercises Updated final chapter on nuclear explosions for current geopolitical developments

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William Richard Lethaby: His Life and Work 1857-1931 focuses on the masterpieces, achievements, and legacy of Lethaby in architecture.   The book first underscores the early life of Lethaby and his humble beginnings in the field of architecture. The text then ponders on the craftsmanship and architectural genius of Lethaby as shown in the design of the Stanmore Hall, Avon Tyrrell, The Hurst, Melsetter House, Rysa Lodge, Eagle Insurance Buildings, and High Coxlease.   The publication highlights the creative mind of Lethaby through the artistic presentation of SS Colm and Margaret, All Saints' Church, Liverpool Cathedral Competition, and the Central School of Arts and Crafts. The text also takes a look at the works of Lethaby for the London County Council, his early architectural education and training, and his legacy as a theorist and writer.   The book is a fine reference for historians, architects, and researchers interested in the works, contributions, and influence of Lethaby on architecture.

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High-precision cleaning is required across many sectors, including aerospace, defense, medical device manufacturing, pharmaceutical processing, semiconductor/electronics, and more. In this comprehensive reference work, solvent cleaning equipment is thoroughly covered with a focus on the engineering details of its operation and selection. Key data is provided alongside practical guidance, giving scientists and engineers in multiple sectors the information they need not only to choose the correct machine in the first place, but also how to operate it effectively and efficiently.

Low emission open-top vapor degreasers, enclosed machines of the vacuum and pressurized type, cosolvent machines, and adsorption of "tailpipe emissions" are covered in detail and fully illustrated in color. This unique book covers material known by designers and manufacturers of solvent cleaning machines, but not collected and organized for the benefit of users.

The comprehensive coverage provided by John Durkee makes this book relevant and timely not only for readers who wish to know more about how solvent cleaning equipment works but also those who are under pressure from environmental regulators or corporate management to find effective alternatives and those engaged in non-solvent cleaning operations who are unsatisfied with their cleaning results.
Clear, straightforward explanations of how various types of cleaning solvents should be managed to clean parts Full-color, hand-drawn illustrations and photographs of the important internal sections of solvent cleaning machines Design calculations of operating parameters in solvent cleaning machines

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Meat provides an introductory review of the meat-eating habit in man and covers the production, preservation, composition, eating quality, human nutrition, and assessment of the future role of meat.  Meat continues to be a major food commodity. Despite the high cost of production of meat animals and their lower efficiency of protein synthesis compared with that of plants and micro-organisms, meat is likely to be important in the human diet for as long as can be foreseen in the future. This book intends to emphasize the fact that the sequence of events, from the conception of meat animals to their incorporation in the human diet, is continuous. The properties of the commodity when eaten are influenced, in the nature and degree of their expression, by all the earlier components in this chain of circumstances.  This text is a useful reference for students conducting research within the fields of agriculture science, biochemistry, and nutrition.

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Letters to Architects presents letters addressed to architects practicing throughout the world, many of them contemporaries with Frank Lloyd Wright during the first half of the twentieth century. Taken as a whole, this selection of letters aims at revealing an underlying unity of purpose: the growth of his work and the unquestionable magnitude of influence it engendered in the world of architecture.   The letters are organized into five sections. Section One presents the first publication ever to be made of the letters between Frank Lloyd Wright and Louis H. Sullivan. Section Two traces Wright's concern, through letters addressed to both European and American architects, that his work be understood as the cornerstone of an American Culture. In Section Three, correspondence has been selected to include three specific persons: Henry-Russell Hitchcock, Lewis Mumford, and Howard Myers. These men offered Wright a special forum from which he could speak to the profession as a whole, most particularly through the medium of publication. Section Four narrates, by means of letters to various architects concerned with the assembling and exhibition of the largest one man architectural exhibition ever to be produced, the details, trials, problems, and results of such a large undertaking. Section Five recounts the honors bestowed on Frank Lloyd Wright first in England, in 1941, and then in his own country, in 1949. It shows his concern for the profession of architecture in the moving address he gave at the occasion of his receiving the Gold Medal from the American Institute of Architects.

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An Introduction to Psychological and Physiological Acoustics

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Hearing: An Introduction to Psychological and Physiological Acoustics is concerned with the physiology and psychophysics of audition. It aims to introduce the new student to the sciences of hearing and to rekindle the interests of the experienced reader.   The book begins with an overview of the auditory system. This is followed by separate chapters on theories of hearing; the routes over which sound is conducted to the inner ear; the cochlear mechanism; the auditory nerve and pathways; and psychoacoustic methods. Subsequent chapters cover the theory of signal detection; how sensitivity for one sound is affected by the presence of another sound; loudness; pitch; aspects of binaural hearing; and speech perception.  This book provides both an introduction and a broad overview of the field of hearing science for the advanced undergraduate student or the postgraduate student in such disciplines as audiology and psychology. It should be an extremely useful guide to these students, as well as to those researchers who wish to refresh their knowledge of the field beyond their areas of specialization.

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An Introduction to the Vegetative Functions

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Physiology of the Eye: An Introduction to the Vegetative Functions, Second Edition discusses the fundamental concept of the operating process of the visual system. The book is comprised 10 chapters that cover the functions and properties of the parts of the ocular system.  The text first provides a review of ocular anatomy, and then proceeds to covering parts, including aqueous humor, vitreous body, and lens. The next two chapters deal with various concerns in cornea, such as swelling pressure and metabolism. Chapter 8 discusses the sclera, while Chapter 9 tackles the retina. The last chapter talks about the tears and the lids.  The book will be most useful to both optometrists and ophthalmologists. Readers who are curious about the operating process of the eye will find this text interesting.

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New Approaches to Immunological Problems

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Vaccines: New Approaches to Immunological Problems presents the advances in the range of strategies and approaches for producing vaccines. The book is comprised of 20 chapters that cover the properties of different vaccines.  The coverage of the text includes vaccines for cholera, malaria, helminth, and influenza. The book also discusses topics about the key elements of modern technologies that can be applied to different vaccines, such as active immunization strategies using anti-idiotypic antibodies; passive immunoprophylaxis with human monoclonal antibodies; and immunological adjuvants and their mode of action.  The text will be of great use to scientists involved in the research and development of vaccines, such as molecular biologists, biochemists, and virologists.

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Advanced Organics for Electronic Substrates and Packages

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Advanced Organics for Electronic Substrates and Packages provides information on packaging, which is one of the most technologically intensive activities in the electronics industry.  The electronics packaging community has realized that while semiconductor devices continue to be improved upon for performance, cost, and reliability, it is the interconnection or packaging of these devices that will limit the performance of the systems. Technology must develop packaging for transistor chips, with high levels of performance and integration providing cooling, power, and interconnection, and yet preserve the performance of the semiconductors with minimum package delay to the system.  Trends in each of the major packaging technologies include chip level connection, providing the required connections between the chip and the semiconductor package. The power distribution to the chip and heat removal from the chip; first level packages providing all the necessary wiring; interconnections and power distribution; first-to-second level interconnections; and second level packages providing all the necessary wiring, connections, power distribution, and power supply connection are included as well.  This book is a useful and informative reference to students or individuals studying or conducting research within the field of electronic engineering.

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Foundation Design discusses fundamental concepts in the design of foundations. As with the author's previous work, the AJ Handbook of Building Structure, the emphasis is on practical matters and, while every architect may not aspire to more complicated designs, with the aid of this book he will be able to talk with more authority to his engineer.  The book begins with an introduction to the properties rocks and soils, including sands and gravels, clays, and silts and peat. This is followed by discussions of the site investigation process, soil mechanics, and the principles of foundation design. Separate chapters cover foundation types (spread foundations and piles); foundation hazards and construction problems; and underpinning. Examples of foundation design are presented, such as simple bases, a column on the edge of a building, and examples of piling. The final two chapters discuss specifications for mass bases, reinforced pads, and trench foundations and pile caps; information to be given when inviting piling tenders; and the supervision of site works.

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Inside the Bauhaus presents the story of an idea about how people might live. It is also the story of a school, the Bauhaus, whose life span coincided with the Weimar Republic's and whose history mirrors German history between the two world wars. Through mass-production, the Bauhaus, like the German Werkbund, hoped to change the quality of the designed object and the designed environment for everyone. Quality of life was an important design consideration in the housing schemes developed by Walter Gropius and Hannes Meyer, respectively the first and second directors of the school, and Ludwig Hilberseimer, whose teaching responsibilities at the Bauhaus included the planning curriculum.   Howard Dearstyne, the author of the present work, was one of a handful of Americans to study at the Bauhaus and the only one to earn a diploma in architecture. His account of life and education at the Bauhaus is drawn chiefly from contemporary sources, from his letters, from journals and letters kept by members of the Bauhaus faculty, from newspaper articles, and from the recollections of others. Dearstyne also includes historical background of the structure of the curriculum of the Bauhaus as well as discussions of the various workshops and how they functioned prior to his admission to the school.

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Women in Computing presents how the computing industry delivered the opportunities for women. This book identifies the distinct attitudes in companies towards equal opportunities.  Organized into eight chapters, this book begins with an overview of the problems, the opportunities, the successes and failures, and provides some insight into what can be done by women to make use of the massive potential they have in the future industry. This text then examines the problem to introduce computing to girls in school, which has not been taught properly in schools due to lack of right equipment or lack of training of the teachers. Other chapters consider the positive attitude of most major computer manufacturers and software houses to the employment of women. This book discusses as well the problems faced by women in the work place, including sexual harassment and lack of cooperation from male colleagues. The final chapter deals with the need for change in the computing industry.  This book is a valuable resource for employees and employers.

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Vascular Surgery: Current Questions discusses the queries concerning modes of therapy, surgical practices, and management of vascular problems.  This book contains 19 chapters and begins with an overview of the clinical vascular laboratory. The succeeding chapters deal with the risk factors in peripheral vascular disease and the pragmatic viewpoint of carotid body tumors and carotid endarterectomy. Considerable chapters are devoted to several surgical options and practices for specific vascular disease management. Other chapters discuss the challenges in prevention of vascular surgical sepsis, treatment for diabetic foot, and amputation. The final chapters describe the clinical features and therapeutic management of chronic venous insufficiency and deep vein thrombosis.  This book will prove useful to consultants and trainee vascular and general surgeons and other specialists who share in the overall management of patients with vascular problems.

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Aires A. B. Barros D'Sa, Peter R. F. Bell, Simon G. Darke

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The Le Corbusier Guide presents the architecture of Le Corbusier. The focus is on Paris given that it is his adopted city and the place where he came of age. Within its environs is a representative sample of his built work. It contains most of his purist houses, and an early foray away from the crisp surfaces of Purism.  This itinerary follows the outlines of Le Corbusier's life's work. Beginning at his birthplace in La Chaux-de-Fonds, Switzerland, the route continues to Paris, to the perimeter of France, and finally to the international scene architects, architecture, Paris. Also presented are Le Corbusier's work in Switzerland, Belgium, Germany, Italy, United States, Argentina, Brazil, Tunisia, Iraq, Japan, USSR, and India. The itinerary includes not only the buildings but also the process of getting from one to the next. On the ""open road"" it is a pleasure to remember Le Corbusier's own joy of self-propulsion in the automobile, efficiency, and speed in the train; and the thrill of flight as he experienced it with the poet of flight, Antoine de Saint Exupery. All these mimetic pleasures are ancillary to the experience of the buildings in situ in their complex relationship to local landscape, national spirit, and international vision.

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IT Perspectives Conference is a documentation of the top-level conference sponsored by the publishers of Computer Weekly, which aims to examine the issues that concern computer professionals and to provide at least some of the answers while indicating the directions which IT may be expected to take moving on to the 1990s.  Leading figures from the IT industry and from major computer users show how they are tackling the transition from the limited task based approach of traditional computing to the more wide-ranging strategic issues implicit in the concept of information as a resource to be managed, used competitively, and even sold. In looking towards a future characterized by transaction-oriented systems, online databases, and distributed processing, the significance of tools such as fourth generation languages and computer-assisted software engineering is described and the vital role of communications at all levels from local area networks to the development of international standards is examined.  This book will be useful to anyone wishing to discern the main trends in IT development and computer systems implementation as they set out to develop the systems of the 1990s.

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Architectural Graphics focuses on the techniques, methodologies, and graphic tools used in conveying architectural ideas.   The book takes a look at equipment and materials, architectural drafting, and architectural drawing conventions. Discussions focus on drawing pencils, technical drawing pens, set squares/templates, circle templates/compasses, line weight/line types, drafting technique, drawing circular elements, floor plan, doors and windows in plan, stairs, wall indications, plan grids, and site boundaries. The manuscript examines rendition of value and context and graphic symbols and lettering. Topics include tonal values, media and techniques, value/texture rendition, material rendition, shades and shadows, people, furniture, graphic representation symbols, and hand lettering. The text explores freehand drawing and architectural presentations, including freehand sketching, graphic diagraming, and sketching equipment.   The publication is a valuable reference for architects interested in doing further studies in architectural graphics.

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Emergency Repairs for Historic Buildings

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Emergency Repairs for Historic Buildings is a compilation of 12 case studies that emphasize the necessity of emergency repairs for historic buildings in poor condition. These buildings are defined in this book as listed buildings in England, together with those which, although unlisted, add an historical dimension to their environment.  Emergency repairs could consist of permanent or temporary work. Permanent work should always be carried out according to the best historic buildings practice. Temporary work is second best made necessary by lack of money but having the advantage of speed. In an emergency, this is sometimes the most important factor as decay spreads very quickly, especially in empty buildings. Chapter 2 of this book provides guidelines for temporary repair, which indicate that even this work should be the best quality of its kind.  This book mainly relates to the great majority of buildings, rather than to major country houses, historic engineering works, or ancient monuments. This text is a useful and informative reference for individuals or students who conduct research on studies relating to architectural or historical arts.

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Artificial Intelligence in Design '91 is a collection of 47 papers from the First International Conference on Artificial Intelligence in Design held at Edinburgh in June 1991.   The papers in this book are grouped into 13 headings, starting with a background of AI design systems and to which extent AI that results from being used as planning tool be applied to quality-oriented design processes in architecture. A constraint-driven approach to object-oriented design is also shown on real-world objects. The use of CADSYN in the structural design of buildings is examined, along with design-dependent knowledge and design-independent knowledge. Discussions on empowering designers with integrated design environments are given whereby design objects may be retrieved from catalogues without requiring users to form queries. Mention is given to automated adjustment of parameter values frequently used in computer routine applications.   The book also introduces the Computer Aided Design (CAD) as applied to architecture. Design representation using data models, non-monotonic reasoning in design, and the cognitive aspects of design using empirical studies are discussed. Topics of the industrial applications of AI in design, such as the needed steps to develop a successful AI-based tool, and a review of the Castlemain Project and telecommunication distribution networks follow.   This book is suitable for programmers, computer science students, and architects and engineers who use computers in their line of work.