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Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes.

Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.
Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response

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Tasuku Honjo, Michael Reth, Andreas Radbruch, Frederick Alt

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Leveraging Analytics and User Segmentation to Drive Revenue

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Freemium Economics presents a practical, instructive approach to successfully implementing the freemium model into your software products by building analytics into product design from the earliest stages of development.

Your freemium product generates vast volumes of data, but using that data to maximize conversion, boost retention, and deliver revenue can be challenging if you don't fully understand the impact that small changes can have on revenue. In this book, author Eric Seufert provides clear guidelines for using data and analytics through all stages of development to optimize your implementation of the freemium model. Freemium Economics de-mystifies the freemium model through an exploration of its core, data-oriented tenets, so that you can apply it methodically rather than hoping that conversion and revenue will naturally follow product launch.
Learn how to apply data science and big data principles in freemium product design and development to maximize conversion, boost retention, and deliver revenue Gain a broad introduction to the conceptual economic pillars of freemium and a complete understanding of the unique approaches needed to acquire users and convert them from free to paying customers Get practical tips and analytical guidance to successfully implement the freemium model Understand the metrics and infrastructure required to measure the success of a freemium product and improve it post-launch Includes a detailed explanation of the lifetime customer value (LCV) calculation and step-by-step instructions for implementing key performance indicators in a simple, universally-accessible tool like Excel

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Database: Principles Programming Performance provides an introduction to the fundamental principles of database systems. This book focuses on database programming and the relationships between principles, programming, and performance.  Organized into 10 chapters, this book begins with an overview of database design principles and presents a comprehensive introduction to the concepts used by a DBA. This text then provides grounding in many abstract concepts of the relational model. Other chapters introduce SQL, describing its capabilities and covering the statements and functions of the programming language. This book provides as well an introduction to Embedded SQL and Dynamic SQL that is sufficiently detailed to enable students to immediately start writing database programs. The final chapter deals with some of the motivations for database systems spanning multiple CPUs, including client-server and distributed transactions.  This book is a valuable resource for database administrators, application programmers, specialist users, and end users.

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Technical Aspects of Data Communication, Third Edition provides information pertinent to the technical aspects of data communication. This book discusses a simple asynchronous interface implemented with a specialized integrated circuit called a UART.  Organized into 28 chapters, this edition begins with an overview of the interface standards ranging from the classic EIA-232-D to the EIA-530. This text then describes modems and modem control, with material on high-speed modems and error-correcting modems. Other chapters discuss hardware and software methods. This book discusses as well digital transmission systems and the Integrated Service Digital Network (ISDN). The final chapter deals with local area networks (LANs) and shows how data communication is the key to information and resources sharing in modern networks of personal computers and work stations.  This book is intended to be suitable for readers who are about to design a data communication system, are about to purchase a program data communication hardware, or are just interested in learning more about data communication.

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Freight Transport Modelling is a unique new reference book that provides insight into the state-of-the-art of freight modelling. Focusing on models used to support public transport policy analysis, Freight Transport Modelling systematically introduces the latest freight transport modelling approaches and describes the main methods and techniques used to arrive at operational models.

As freight transport has grown exponentially in recent decades, policymakers now need to include freight flows in quantitative evaluations of transport systems. Whereas early freight modelling practice was inspired by passenger transport models, by now it has developed its separate stream of methods and techniques inspired by disciplines such as economic geography and supply chain management.

Besides summarizing the latest achievements in fundamental research, this book describes the state of practice and advises practitioners on how to cope with typical challenges such as limitations in data availability.
Uniquely focused book exploring the key issues and logistics of freight transport modelling Highlights the latest approaches and describes the main methods and techniques used to arrive at operational models Summarizes fundamental research into freight transport modeling, as well as current practices and advice for practitioners facing day-to-day challenges

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Network and System Security provides focused coverage of network and system security technologies. It explores practical solutions to a wide range of network and systems security issues. Chapters are authored by leading experts in the field and address the immediate and long-term challenges in the authors respective areas of expertise. Coverage includes building a secure organization, cryptography, system intrusion, UNIX and Linux security, Internet security, intranet security, LAN security; wireless network security, cellular network security, RFID security, and more.
Chapters contributed by leaders in the field covering foundational and practical aspects of system and network security, providing a new level of technical expertise not found elsewhere Comprehensive and updated coverage of the subject area allows the reader to put current technologies to work Presents methods of analysis and problem solving techniques, enhancing the readers grasp of the material and ability to implement practical solutions

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Lectures on Renal and Urinary Diseases describes the general anatomy of the kidney. This book is organized into four sections encompassing 25 chapters that discuss the pathology of albuminuria, dropsy, uremia, and polyuria.   Some of the topics covered in the book are the clinical examination of the urine; etiology, morbid anatomy, and clinical history of diabetes; treatment of diabetes insipidus; analysis of diabetic coma; development of stone in the kidney; congestions of the kidney; pathological relations of tube casts; and cardio-vascular changes in dropsy patient. Other sections are concerned with the complications of chronic Brights disease, infective, and lithemic nephritis. This discussion then shifts to the amaurosis, or defect of the eye after developing dropsy, as well as the treatment of Brights disease. The remaining sections deal with the physiology of glycosuria, hydronephrosis, pyonephrosis, and pyelitis. These chapters also focus on the diseases that cause the presence of blood in the urine.   The book can provide useful information to doctors, nephrologists, students, and researchers.

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Managing Information Security offers focused coverage of how to protect mission critical systems, and how to deploy security management systems, IT security, ID management, intrusion detection and prevention systems, computer forensics, network forensics, firewalls, penetration testing, vulnerability assessment, and more. It offers in-depth coverage of the current technology and practice as it relates to information security management solutions. Individual chapters are authored by leading experts in the field and address the immediate and long-term challenges in the authors respective areas of expertise.
Chapters contributed by leaders in the field covering foundational and practical aspects of information security management, allowing the reader to develop a new level of technical expertise found nowhere else Comprehensive coverage by leading experts allows the reader to put current technologies to work Presents methods of analysis and problem solving techniques, enhancing the readers grasp of the material and ability to implement practical solutions

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Eye Tracking for User Experience Design explores the many applications of eye tracking to better understand how users view and interact with technology. Ten leading experts in eye tracking discuss how they have taken advantage of this new technology to understand, design, and evaluate user experience. Real-world stories are included from these experts who have used eye tracking during the design and development of products ranging from information websites to immersive games. They also explore recent advances in the technology which tracks how users interact with mobile devices, large-screen displays and video game consoles. Methods for combining eye tracking with other research techniques for a more holistic understanding of the user experience are discussed. This is an invaluable resource to those who want to learn how eye tracking can be used to better understand and design for their users.
Includes highly relevant examples and information for those who perform user research and design interactive experiences Written by numerous experts in user experience and eye tracking Highly relevant to anyone interested in eye tracking & UX design Features contemporary eye tracking research emphasizing the latest uses of eye tracking technology in the user experience industry

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Jennifer Romano Bergstrom, Andrew Schall

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On Growing Up, Sex Relationships, and Marriage

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Lectures to Youth Clubs on Growing Up, Sex Relationships & Marriage presents a critical review of two lectures about the responsibilities of young adults. The book discusses the definition and psychological implications of growing up; the emotional components of sex relationship; and the value and factors involved in marriage.  Some of the topics covered in the text are the description of changes in puberty; the difference of puberty in a boy and a girl; and the development of reproductive organs. The development of a fetus; the description of bodily changes in a female under pregnancy; and the progress of relationship from friendship to marriage are also considered. The book further tackles the types of sexually transmitted disease; the descriptions of times when the female will not conceive; and the clinical description of gonorrhea. The text also looks into the development of twins, Siamese twins, and homosexual. A chapter is devoted to a list of questions pertaining to human interactions.   The book can provide useful information to councillors, psychiatrists, students, and researchers.

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Fundamentals of Chemistry, Fourth Edition covers the fundamentals of chemistry. The book describes the formation of ionic and covalent bonds; the Lewis theory of bonding; resonance; and the shape of molecules. The book then discusses the theory and some applications of the four kinds of spectroscopy: ultraviolet, infrared, nuclear (proton) magnetic resonance, and mass. Topics that combine environmental significance with descriptive chemistry, including atmospheric pollution from automobile exhaust; the metallurgy of iron and aluminum; corrosion; reactions involving ozone in the upper atmosphere; and the methods of controlling the pollution of air and water, are also considered. Chemists and students taking courses related to chemistry and environmental chemistry will find the book invaluable.

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Frank Brescia, John Arents, Herbert Meislich

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Cellular Endocrinology in Health and Disease

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Cellular Endocrinology in Health and Disease describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. Among these are those whose function was not obvious until recently, including the endocrine functions of bone and the adipose tissue.

Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and P. Michael Conn, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts.
Covers systemic endocrine action at the cellular level in both health and disease Delivers information on the integration of cell identity and endocrinology Incorporates recent developments in endocrinology to provide an up-to-date reference to researchers

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A Synopsis of Children's Diseases, Fourth Edition serves as a guide to the common as well as rare diseases in children. This book discusses the importance of hereditarily determined diseases.  Organized into two parts encompassing 196 chapters, this edition begins with an overview of the norms of development of children. This text then discusses the various types of congenital malformations if mother contracts rubella during pregnancy, including deafness, congenital heart disease, eye defects, and other lesions. Other chapters consider the incidence of infant mortality during the first twelve months of life. This book discusses as well the pathology and cause of intracranial hemorrhage, which is the common cause of death or permanent disability in infants. The final chapter deals with the various causes of sudden death in young infants.  This book is a valuable resource for pediatricians and general practitioners. Undergraduate students will also find this book extremely useful.

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Mendip: Cheddar, Its Gorge and Caves describes the landscape and historical background of the Swildons Hole at Priddy. This book is divided into nine chapters that discuss the Coxs Cave and the story of discovery at Cheddar. It looks into the condition of the Goughs cave and the archaeological findings made at the Long Hole which used to be the Romano-British cave dwelling.   Some of the topics covered in the book are the description of the smaller caves and cave shelters of the Gorge; features of the Great Gorge of Cheddar; portrayal of the Swallets of the Cheddar system; the medieval and post-medieval history of Cheddar; and description of the Coopers Hole, Soldiers Hole, and Sugarloaf Rock. Other chapters examine the rock formations and rivers inside the White Spot cave, as well as the types of fossils found in the Bone Hole. The physical characteristics of the tools made of stone found in the caves are presented. The last chapter is devoted to a detailed description of the trails going inside the caves at Cheddar.  The book can provide useful information to archaeologists, mountain climbers, explorers, students, and researchers.

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Alpha AXP Architecture Reference Manual, Second Edition describes the required behavior of all Alpha implementations, as seen by the machine-language programmer. This book discusses Alpha single-board computers, which have been introduced to cover the high-end embedded controller market.  Organized into five parts, this edition begins with an overview of the instruction-set architecture. This text then describes the supporting PALcode routines for three operating systems. Other parts consider a particular console implementation that is specific to platforms that support the OpenVMS AXP or DEC OSF/1 operating systems. This book discusses as well the specific operating system PALcode architecture. The final part provides a discussion of console issues for Windows NT with its PALcode description.  This book is a valuable resource for machine-language programmers.

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Heredity and Environment in the Functional Psychoses

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Heredity and Environment in the Functional Psychoses involves an epidemiological clinical study of twins carried out at the University Psychiatric Institute in Oslo. The author reviews the history and nosological aspects of psychiatry. In his study of twin genetics, the author seeks to answer the questions "What is inherited?" and "How is it inherited?" In his review of 342 pairs of twins in the Central Register of Psychosis, his study had the following aims: to obtain  true concordance figures for all types of functional psychoses; to study problems pertaining to nosology; and to study a larger sample of discordant pairs in order to clarify crucial environmental factors. His findings show that concordance figures for schizophrenia are 25-38 per cent in monozygotic twins and 4-10 per cent ion dizygotic twins. He points out that the difference in such concordance rates between the two types of twins is statistically significant.  The data supports the (weak) assumption of a genetic factor in the etiology of schizophrenia. Behavioral scientists, psychiatrists, child psychologists, and researchers involved in genetics will find this book helpful and informative.

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The Art of Technical Documentation presents concepts, techniques, and practices in order to produce effective technical documentation.  The book provides the definition of technical documentation; qualities of a good technical documentation; career paths and documentation management styles; precepts of technical documentation; practices for gathering information, understanding what you have gathered, and methods for testing documentation; and considerations of information representation, to provide insights on how different representations affect reader perception of your documents.  Technical writers and scientists will find the book a good reference material.

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What Is Tuberculosis?: Its Control and Prevention provides an introduction to the understanding of tuberculosis, a contagious lung disease caused by tubercle bacillus. This book discusses the characteristics, causes, treatment, control, and prevention of this disease.  Organized into two parts encompassing 85 chapters, this book begins with an overview of the nature of the problem of tuberculosis. This text then explores the characteristics of tubercle bacillus, which is very resistant and can live for a long time outside the body especially in damp dark places. Other chapters consider the modes of infection and explain how bacillus tuberculosis enters the body by inhalation and by ingestion. This book discusses as well the most dangerous source of infection, namely, a patient with open tuberculosis of the lungs. The final chapter deals with tuberculosis as a useful index of the social and economic conditions of a community.  This book is a valuable resource for physicians and scientists.

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Medical Aspects of Sport and Physical Fitness

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The Commonwealth and International Library: Physical Education, Health and Recreation Division

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Medical Aspects of Sport and Physical Fitness describe the medical and paramedical aspects of sport, physical education, and fitness. The author reviews the concept of physical fitness as a person being able to perform work. The author also discusses the cardiovascular, respiratory, muscular and nervous systems of the body that partake during physical work and activity. The psychological aspects such as motivation, personality, sport, insight, ritual, team games and problem also affect the player's performance. Many misconceptions pertain to warm up exercises; less is known about warm down but both have a purpose in keeping the body fit before and after some physical activity. The author describes the nature of sports injuries, their diagnosis and the types of injury. He emphasizes the importance of prevention of sports injuries, the prevention of diseases such as infections, allergies or occupational diseases, as well as their treatment. The book also discusses sports for the physically disabled and mentally-challenged persons. This book can be helpful for physical education instructors, coaches, trainers, and team managers, as well as students and team players engaged in sports.

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Pharmaceutical Monographs, Volume 4: Polysaccharides Peptides and Proteins provides information pertinent to a wide variety of naturally-occurring macromolecules that are either peptide, protein, or polysaccharide in nature, which are important as medicinal and pharmaceutical agents. This monograph presents the basic physical and chemical properties of polysaccharides.  Organized into four chapters, this volume begins with an overview of the pharmaceutical importance of the class of compounds known as polysaccharides. This text then provides data on the structure of the polysaccharides that is obtained by isolating and identifying the product formed on hydrolysis of the molecule itself. Other chapters consider plant gums and mucilages as important medicinal and pharmaceutical products. This monograph discusses as well the autohydrolysis of gum arabic. The final chapter deals with the clinical applications of various peptide-type antibiotics.  This monograph is a valuable resource for undergraduate students of pharmacy and allied subjects.

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R. T. Coutts, G. A. Smail, J. B. Stenlake