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Neural Models of Plasticity: Experimental and Theoretical Approaches is an outgrowth of a conference that was held at Woods Hole, Massachusetts, in the spring of 1987. The purpose of that conference was to review recent developments in both areas and to foster communication between those researchers pursuing theoretical approaches and those pursuing more empirical approaches. Contributions have been solicited from individuals who represent both ends of the spectrum of approaches as well as those using a combination of the two. These indicate that our knowledge of the plastic capabilities of the nervous system is accelerating rapidly due to rapid advances in the understanding of basic subcellular and molecular mechanisms of plasticity, and because of the computational capabilities and plastic properties that emerge from neural networks and assemblies.   The book contains 19 chapters and opens with a study on the role of the neuromodulator in associative learning of the marine mollusk Hermissend. Subsequent chapters examine topics such as learning and memory in Aplysia; the Hebb rule for synaptic plasticity; olfactory processing and associative memory in the mollusk Limax maximus; simulation of a classically conditioned response; and the neural substrates of memory, focusing on the role of the hippocampus.

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Introduction to Parallel Programming focuses on the techniques, processes, methodologies, and approaches involved in parallel programming.   The book first offers information on Fortran, hardware and operating system models, and processes, shared memory, and simple parallel programs. Discussions focus on processes and processors, joining processes, shared memory, time-sharing with multiple processors, hardware, loops, passing arguments in function/subroutine calls, program structure, and arithmetic expressions. The text then elaborates on basic parallel programming techniques, barriers and race conditions, and nested loops.   The manuscript takes a look at overcoming data dependencies, scheduling summary, linear recurrence relations, and performance tuning. Topics include parallel programming and the structure of programs, effect of the number of processes on overhead, loop splitting, indirect scheduling, block scheduling and forward dependency, and induction variable.   The publication is a valuable reference for researchers interested in parallel programming.

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Structure, Biogenesis, and Assembly of Energy Transducing Enzyme Systems

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Current Topics in Bioenergetics, Volume 15: Structure, Biogenesis, and Assembly of Energy Transducing Enzyme Systems presents the reaction mechanisms involved in membrane-associated energy transducing processes at the molecular level. This book discusses the developments in the energy transducing systems.  Organized into 11 chapters, this volume begins with an overview of the composition and structural aspects of the four respiratory chain complexes. This text then discusses the genetic aspects of various energy transducing systems. Other chapters consider the electron transfer chains of chloroplast, mitochondria, and some photosynthetic bacteria, which contain a multiprotein complex with similar functional and structural properties. This book discusses as well the structure and function of multiple and variable amounts of subunits in cytochrome-c oxidase from various organisms. The final chapter deals with the interdisciplinary path of bioenergetics, with the center of gravity moving from chemistry through genetics to physics.  This book is a valuable resource for biologists.

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Current Topics in Cellular Regulation, Volume 3 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation.  Organized into five chapters, this volume begins with an overview of the classification of the various pathways of intermediary metabolisms from a physiological standpoint. This text then examines the immunological surface disparities between normal and tumor cells. Other chapters consider a general nomenclature for enzyme systems that exist in interconvertible phosphorylated and dephosphorylate forms. This book discusses as well the correlation between yeast pyruvate kinase activity and ADP concentration at various KCI levels. The final chapter deals with the systematic investigation concerning the fluctuations of pyruvate kinase in liver and muscle.  This book is a valuable resource for biologists, biochemists, pathologists, and research workers.

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Current Topics in Cellular Regulation, Volume 2 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation.  Organized into eight chapters, this volume begins with an overview of the occurrence of the enzyme in plants and microorganisms. This text then examines the biosynthesis of aromatic amino acids and vitamins, which is proving an interesting model system for the study of regulation. Other chapters consider the control of cholesterol biosynthesis in normal tissues, with emphasis on the pathologic implications of derangements of cholesterol feedback control. This book discusses as well the aspects of the biogenesis of yeast mitochondria. The final chapter deals with regulation in the pyrimidine biosynthetic pathway at the level of enzyme activity.  This book is a valuable resource for biochemists, biologists, and research workers.

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Current Topics in Cellular Regulation, Volume 17 deals with the basic mechanisms involved in the regulation of diverse cellular activities.  This book discusses the regulation of proteinase inhibitor accumulation in excised tomato leaves, inhibitors associated with cysteine proteinases, and stimulation of DNA synthesis in quiescent cultured cells. The regulation of the biosynthesis of RNA polymerase subunits, molecular consequences of formyl peptide binding, and instability versus homeostasis in cell energy metabolism are also elaborated. This text likewise covers the physiological significance of desensitization and cooperation between nuclear and mitochondrial genetic systems.  This volume is beneficial to biologists and researchers concerned with advances in the general area of cellular regulation.

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Current Topics in Cellular Regulation, Volume 21 examines the advances in the general area of cellular regulation.  This book discusses the roles of eukaryotic initiation factor 2 ancillary factors in the regulation of eukaryotic protein synthesis initiation and phosphorylation state of eIF-2. The monoclonal antibodies to cap-binding proteins, criteria for establishment of the biological significance of ribosomal protein phosphorylation, and comparison with casein kinases from mammary gland are also elaborated. This text likewise covers the regulation of phosphoprotein phosphatases, poly(ADP-ribosyl)ation reactions in vitro, and induced commitment to terminal erythroid differentiation. Other topics include the turnover characteristics of lactate dehydrogenase and role of urea synthesis in the removal of metabolic bicarbonate and regulation of blood pH.  This volume is useful to biologists and researchers interested in basic mechanisms involved in the regulation of diverse cellular activities.

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The Cell Nucleus, Volume IX: Nuclear Particles, Part B discusses "splicing", "processing", and the controls of transcriptional and transport events which must be essential to cells that are either growing or are phenotypically differentiated. The book describes the characteristics and structure of nuclear 30 S RNP particles; as well as the composition and general topology of RNA and protein in monomer 40 S ribonucleoprotein particles. The text also demonstrates the two-dimensional gel electrophoresis of nuclear particles and immunocytochemistry of nuclear hnRNP complexes; the enzymatic activities associated with hnRNP; and the digestion products of nuclear ribonucleoprotein. The nucleocytoplasmic transport of mRNA; the nucleocytoplasmic transport of ribosomal subparticles; and the rnp particles involved in release of in vitro synthesized poly(a)-containing RNA in isolated nuclei are also considered. The book further tackles nuclear bodies as functional indicators in the target cells of sex steroid hormone; and the functional implications of nuclear glycoproteins and glycosaminoglycans. Cell biologists, geneticists, pharmacologists, molecular biologists, biochemists, and students taking related courses will find the book invaluable.

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An Information-Processing Approach to Amnesia

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Alcoholic Korsakoff's Syndrome: An Information-Processing Approach To Amnesia presents an overview of one of the theories of amnesia, namely, the extent to which it represents an information-processing deficit. The book discusses the clinical symptoms, neuropathology, and etiology of the alcoholic Korsakoff's syndrome; the influence of the original memory model on the research in amnesia; and the functional differences among long-term memory, short-term memory, and sensory memory. The text also describes encoding deficits; the depth of encoding and visuoperceptive deficits; as well as alternative theories of amnesia. Sensory capacities and the memory and cognitive disorders of chronic alcoholics are also considered. The book further reviews the differences among various amnesic and dementing populations. Neurologist, neuropsychologists, and students taking related courses will find the book invaluable.

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Current Topics in Bioenergetics, Volume 10 provides information pertinent to the developments in the study of dynamic mechanisms in functioning muscle by following fluctuations in kinetic states. This book explores the method that permits analysis of cyclic rotational motions in cross-bridge formation and has considerable potential in other bioenergetics systems.  Organized into six chapters, this volume begins with an overview of the structure and function of muscles. This text then examines the bioenergetic aspects of nitrogen fixation. Other chapters consider one aspect of the regulation of the in vivo activity of organelles, namely, the regulation of mitochondrial activities at the level of substrate. This book discusses as well the status of the controversial findings on the protonoxygen ratios in mitochondria and the mechanism of H+ pumping in oxidative reactions. The final chapter deals with the usefulness of bacterial mutants in the study of cell metabolism.  This book is a valuable resource for biologists and biochemists.

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Current Topics in Cellular Regulation, Volume 15 deliberates the basic mechanisms involved in the regulation of diverse cellular activities.  This book discusses the kinetics and thermodynamics of cGMP binding to G-kinase, activation of cyclic nucleotide phosphodiesterase, and polymeric forms of phosphofructokinase. The genetic control of pentose phosphate pathway enzymes in drosophila, discrepancies in the interpretation of the ODC assay, and comparison of chemotaxis in leukocytes and other cells are also elaborated. This publication likewise covers the biochemical aspects of neurosecretion and neurophysin-neurohormone complexes.  This volume is valuable to biologists and researchers concerned with advances in the general area of cellular regulation.

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The Molecular Biology of Cancer discusses the state of progress in the molecular biology of cancer. The book describes the effects of anticancer agents on nucleolar ultrastructure; the role of chromosomes in the causation and progression of cancer and leukemia; the replication, modification, and repair of DNA. The text also describes the metabolism and utilization of messenger RNA and other high molecular weight RNA and low molecular weight nuclear RNA; the characteristics, structures, and functions of nuclear proteins; and the process of protein synthesis. Nucleotides are reviewed with regard to its biosynthesis, inhibition of synthesis, and development of resistance to inhibitors. The book further tackles the biochemical mechanisms of chemical carcinogenesis; the oncogenic viruses; and the molecular correlation concept. The text also demonstrates phenotypic variability as a manifestation of translational control; and plasmacytomas. Molecular biologists, virologists, pathologists, cell biologists, oncologists, pharmacologists, and students taking related courses will find the book useful.

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Current Topics in Cellular Regulation, Volume 12 focuses on the binding of polypeptide hormones to the specific receptor sites on the cellular membrane.  This book consists of six chapters. Chapter 1 describes how several polypeptide regulators, hormones, and growth factors act through very similar mechanisms. The second messenger roles of cAMP and cGMP in the regulation of various protein kinases are dealt with in Chapter 2. Chapter 3 discusses the experimental conditions employed in studying the characteristics of regulatory enzymes in vitro and in vivo, while Chapter 4 elaborates the intracellular compartmentation of enzymes, cofactors, and metabolic intermediates of glycolysis in various tissues from different organisms. The biochemical mechanisms that underlie the induction of enzymes in catabolic pathways are considered in Chapter 5. The last chapter is devoted to the role of T4 phage-induced covalent modification reactions in the transcriptional control of DNA-dependent RNA-polymerase in E. coli.  This volume is suitable for biologists and researchers concerned with the basic mechanisms involved in the regulation of diverse cellular activities.

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Current Topics in Cellular Regulation, Volume 8 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation.  Organized into seven chapters, this volume begins with an overview of the roles of multiple protein factors in the conversion of chitin synthetase zymogen to its catalytically active form. This text then examines the mechanisms that underlie differential metabolic control of the diverse functions of glucose-6-phosphatase. Other chapters consider the results of studies in Klebsiella aerogenes. This book discusses as well the physicalchemical properties of the enzymes from animals and bacteria. The final chapter deals with the mechanisms of regulating lipogenesis in animal tissues, the deamidation of glutamyl and asparaginyl residues in peptides and proteins.  This book is a valuable resource for biochemists, biologists, and research workers.

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Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes in drugs metabolism; the distribution of barbiturates to the central nervous system; and the urinary excretion of barbiturates. The formation of morphine from heroin and codeine, and the dealkylation to form normorphine and to reduce naloxone to another compound is also considered in the first essay. The second essay discusses the time-course of enzyme inhibition at single-inhibitor concentrations and the effect of various inhibitor concentrations on the rate constants governing inhibition. The third essay is about the recondite toxicity of trace elements, taking into consideration the effects of these trace elements on body weight, survival, and longevity, clues to mechanisms of toxicity, and the production of chronic diseases simulating human disorders. Toxicologists, oncologists, biochemists, and pharmacologists will find the book invaluable.

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Special Topics on the Physical and Biological Aspects of Arid Regions

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Desert Biology: Special Topics on the Physical and Biological Aspects of Arid Regions, Volume II records the conditions and life in the arid regions of the world.  This book discusses the hydrogeology of arid regions, desert soil surfaces and classes, and physical and vegetational aspects of the Sahara Desert. The Piman Indians of the Sonoran Desert, approach to the water relations of desert plants, desert arthropods, and aquatic environments of deserts are also considered.  Other topics include the artificial changes in the hydrogeology of deserts, soils of individual world deserts, rainfall and water supply of desert plants, and ecological plant types in arid regions. The hydrature in true xerophytes, chloride accumulation in halophytes, and biological response to desert water conditions are likewise covered in this publication.  This volume is recommended for researchers and specialists interested in the hot, dry regions of the planet.

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Bacterial Immunoglobulin-Binding Proteins: Applications in Immunotechnology, Volume 2 covers the state of knowledge of bacterial immunoglobulin-binding proteins. The book focuses on practical approaches to isolation, characterization, and use of bacterial immunoglobulin-binding proteins. The majority of these studies involve the type I Fc-binding protein (staphylococcal protein A) and the type III Fc-binding protein (streptococcal protein G). Physiological chemists, pediatricians, and microbiologists will find the book invaluable.

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The Cell Nucleus, Volume III: Nuclear Particles, Part A covers topics on "splicing" and "processing" and on the controls of transcriptional and transport events that must be essential to cells that are either growing and/or are phenotypically differentiated. The book discusses the immunolocalization and structural organization of nascent RNP; the in situ localization of RNA structures; and the morphogenesis, cytochemistry, and putative role of perichromatin granules. The text describes transcription in the isolated nuclei; the isolation and structure of the ribonucleoprotein fibrils containing heterogeneous nuclear RNA; and low-molecular-weight nuclear ribonucleoprotein particles. The sequence, function, and role of U snRNAs of nuclear snRNPs; the maturation of low-molecular-weight RNA species; and the properties of the heterogeneous nuclear RNA-protein complexes and nuclear matrix are also encompassed. The book further tackles human antibodies to RNA-containing particles. Cellular biologists, microbiologists, pharmacologists, geneticists, and students taking related courses will find the book useful.

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Current Topics in Cellular Regulation, Volume 7 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation.  Organized into six chapters, this volume begins with an overview of the activity of RuDP carboxylase in plant photosynthesis that appears to be controlled by the relative concentrations of F6P and FDP. This text then examines the glycolate pathway of metabolism in plants and algae. Other chapters consider the sequence of events as well as the mechanisms of regulation that are involved in the formation of the fibrin clot. This book discusses as well the biology of spermatogenesis. The final chapter deals with the mechanism of enzyme synthesis and its regulation at the gene level.  This book is a valuable resource for biochemists, biologists, and research workers.

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Current Topics in Bioenergetics, Volume 13 presents the biophysical and biochemical approaches that are valuable in some systems and that may be readily be applied to others. This book discusses the function and structure relationship of energy-transducing membranes that has played an essential role in the progress and development in the field of bioenergetics.  Organized into six chapters, this volume begins with an overview of the bioenergetics processes that require a molecular description of the structure and reaction mechanisms of the individual energy-transducing catalysts. This text then provides an understanding to the methodology for initiation of an electron paramagnetic resonance (EPR) investigation in this field of research. This book discusses as well the developments in spin label EPR techniques. The final chapter deals with immunological techniques that are used for studying the biochemistry and molecular biology of membrane proteins.  This book is a valuable resource for physiologists, biologists, and biochemists.