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Current Topics in Cellular Regulation: Volume 23 is a collection of papers that discusses pyruvate carboxylase, the regulation of carbohydrate metabolism, and the plasma membrane ATPase of fungi or plants. Other papers deal with adrenergic control of phosphofructokinase, protein phosphatase, as well as the regulation of polypeptide precursors of mature mitochondrial proteins. One paper explains the three dimensional structure of pyruvate carboxylase and its reaction mechanism. Electron microscopic analyses show that four monomers of pyruvate carboxylases isolated from vertebrate sources form a tight tetrahedron-like structure. Another paper describes the regulation of fructose 2,6-bisphosphate concentration in the liver and of the enzymes that are responsible for its metabolism, and the mechanism involved in fructose, particularly in the regulation of 6-phosphofructo-1-kinase and fructose-1,6-bisphosphatase activity. The paper also explains the role of this effector in the regulation of hepatic carbohydrate metabolism. One paper deals with the different levels of biological organization (whole cells, isolated plasma membranes, and purified enzyme) that characterizes the plasma membrane ATPase of fungi and plants as a novel type of proton pump. The collection can prove useful for biologists, microbiologists, students, and professors of biology and biophysics.

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Current Topics in Bioenergetics, Volume 14 provides information pertinent to the structure and function relationship of energy-transducing membranes. This book presents a number of biochemical and biophysical approaches that are valuable in some systems.  Organized into five chapters, this volume begins with an overview of cytochrome oxidase, a noncrystallizable membrane protein. This text then determines the interaction of small organic molecules with biological membranes on a molecular level. Other chapters consider the various physical techniques that are used to investigate the structural and dynamic properties of proteins, lipids, and membranes, including neutron diffraction, X-ray diffraction, electron microscopy, optical rotatory dispersion, nuclear magnetic resonance, fluorescence spectroscopy, and Raman spectroscopy. This book discusses as well the biological importance of metal ions. The final chapter deals with optical activity spectroscopy as a recognized tool for the examination of the conformation of biological macromolecules.  This book is a valuable resource for biochemists, biophysicists, and biologists.

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Current Topics in Cellular Regulation, Volume 20 evaluates the basic mechanisms involved in the regulation of diverse cellular activities.  This book discusses the role of glutamine in the flow of nitrogen, regulation of glycogen synthase activity by covalent phosphorylation, and physiological role of PFK phosphorylation. The in vivo modulation of HMG-CoA reductase activity, hypotheses on the role of eIF-2 phosphorylation, and ADP-ribosyltransferase from turkey erythrocytes are also elaborated. This text likewise covers the non-enzymic effects of vanadate and phosphorylation of liver and muscle PFK.  This volume is a good source for biologists and researchers interested in advances in the general area of cellular regulation.

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Calcium And Cell Function, Volume II covers the status of the multifunctional role of calcium in cell function. The book discusses the chemistry and metabolism of calcium, the various calcium-binding proteins in addition to calmodulin; and the functions of calcium, some mediated by calmodulin and some by other proteins. Physiologists, oncologists, and biochemists will find the book invaluable.

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Current Topics in Comparative Pathobiology

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Current Topics in Comparative Pathobiology, Volume 1 covers topics on the pathobiology of animals, invertebrate and vertebrate. The book discusses diseases of the insect integument; neoplasia in fish; and the status of paralytic shellfish poisoning. The text also describes small, free-living amebas with regard to its cultivation, quantitation, identification, classification, pathogenesis, and resistance. Pathobiologists, cellular biologists, parasitologists, and microbiologists will find the book invaluable.

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Current Topics in Cellular Regulation, Volume 11 focuses on the biochemical mechanisms and key role of the liver in the homeostasis of blood glucose.  This book begins with a discussion of glucokinase that is known to play a key role in glucose uptake by liver, followed by a broad overview of the mechanisms that control both glucose uptake by and release from the liver and enzymes involved in glycogen synthesis and breakdown. The classical enzyme models for allosteric regulatory mechanisms known as the biodegradative threonine deaminase are also elaborated.  Other topics include the control of blood cholesterol levels, use of cultured mammalian cells, and studies of mutant cell lines. A model for protein turnover is likewise presented, including other mechanisms for the selective degradation of protein, selective uptake by lysosomes, and possible role of stabilizing factors. This publication concludes with an evaluation of complex regulatory mechanisms proposed for the regulation of photosynthetic carbon assimilation.  This volume is recommended for biologists and researchers interested in advances in the general area of cellular regulation.

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Current Topics in Cellular Regulation, Volume 10 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation.  Organized into six chapters, this volume begins with an overview of the enzymes that exhibit half-of-the-sites activity. This text then examines the two different aspects of cyclic AMP-mediated systems. Other chapters consider the possible role of citrate synthase in the regulation of the citric acid cycle. This book discusses as well the regulation of the pentose phosphate pathway. The final chapter reviews the evidence for the occurrence of futile cycles at three control points in the metabolism of glucose, namely, at the level of glucose phosphorylation, at the interconversion of fructose mono- and biophosphates, and between pyruvate and phosphenol pyruvate.  This book is a valuable resource for biochemists, biologists, and research workers.

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Current Topics in Clinical and Community Psychology

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Current Topics in Clinical and Community Psychology, Volume 3 covers new approaches to the treatment of emotional disorders. The book discusses the use of imagery, fantasy, and daydream techniques in psychotherapy; the psychosocial-behavioral model for therapeutic intervention; and theory and research on family therapy. The text describes the use of information feedback as a method of clinical intervention and consultation; the need for psychologists who work with minority groups (i.e. black community); as well as the epidemiology and prognosis of psychiatric disorders in the naval service. Community psychologists, clinical psychologists, psychiatrists, and students taking related courses will find the book useful.

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Current Topics in Cellular Regulation, Volume 16 considers the advances in the general area of cellular regulation.  This book discusses the subcellular distribution of hexokinase in brain homogenates and experimental evidence for bound hexokinase as a compartmental control point. The enzymology and biologic significance of cytochrome c methylation, polyaromatic-biosynthetic multienzyme system, and proteolytic modulation of gene expression in sporulation are also elaborated. This text likewise covers the occurrence of cyclic nucleotide-synthesizing and -degrading enzymes in the mammalian brain and calcium ion as a positive effector of oocyte maturation.  This volume is beneficial to biologists and researchers conducting work on the basic mechanisms involved in the regulation of diverse cellular activities.

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Engineering Principles in Physiology, Volume II covers the mechanisms of cardiovascular systems, respiration, and cellular processes.  This volume is organized into three parts encompassing 17 chapters. The first part describes the structure, function, mechanical properties, circulation, and control of the cardiovascular system. This part also examines the mechanism of cardiac pump, the atrial electrical activity, and the venous system. The second part explores the interrelationships between the morphology, physiology, and control mechanisms of respiration. This part also considers the mathematical theory of renal function. The third part looks into the cellular dynamics and intracellular processes.  This book will prove useful to physiologists, biomedical engineers, and workers in the related fields.

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Current Topics in Experimental Endocrinology

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Current Topics in Experimental Endocrinology, Volume 3 covers the relationship between the endocrine system and some types of tumors. The book discusses the perspectives, pitfalls, and potentials of tissue culture in endocrine research; the tumor types associated with ectopic adrenocorticotropin hormone secretion, particularly nonendocrine tumors; and the hormonal control of breast cancer growth in women and rats. The text also describes the status of steroid receptors in breast tumors; the physiopathological aspects of prolactin secretion in patients with pituitary tumors; and the biochemical endocrinology of prostatic tumors. The ectopic production of human chorionic gonadotropin and its alpha- and beta-subunits is also considered. Endocrinologists, oncologists, chemists, gynecologists, and students taking related courses will find the book invaluable.

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Current Topics in Experimental Endocrinology

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Current Topics in Experimental Endocrinology, Volume 2 covers major developments in the ever-expanding field of endocrinology. The book discusses the progress in cyclic nucleotide research; the hypothalamic control of the anterior pituitary hormone secretion-characterized hypothalamic hypophysiotropic peptides; and the pituitary-ovarian interrelationships in the rat. The text also describes the melatonin and the endocrine role of the pineal organ; the integration of the secretory control mechanisms for insulin, glucagon, and growth hormone; and the biological activity of somatomedin. The chemistry and physiology of parathyroid hormone, calcitonin, and vitamin d; and the physicochemical properties and activities of luteinizing hormone and human chorionic gonadotropin are also encompassed. Endocrinologists, physiologists, and students taking related courses will find the book invaluable.

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Current Topics in Cellular Regulation, Volume 13 emphasizes the basic mechanisms involved in the regulation of diverse cellular activities.  This book discusses the enzymology of aminoacyl-tRNA protein transferases, analysis of mutant phenotypes, and protein kinase reaction with pyruvate kinase as substrate. The rapid hormonal regulation of pyruvate kinase in vivo, interconvertible enzyme cascades in metabolic regulation, monocyclic cascade systems, and metabolism of fructose in the liver are also elaborated. This publication likewise covers the influence of fructose on lipid metabolism, lactose operator-repressor interaction, and regulation of nitrogenase synthesis. Other topics include the involvement of isozymes in metabolic regulation and molecular approach to the complement system.  This volume is a good reference for biologists and researchers conducting work on the advances in the general area of cellular regulation.

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Current Topics in Cellular Regulation, Volume 1 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including the transfer of genetic information, intermediary metabolism, and cellular differentiation. This book discusses the advances in the general area of cellular regulation.  Organized into 10 chapters, this volume begins with an overview of the molecular models that attempt to provide the correlation of the kinetic properties of the protein with its structural architecture. This text then examines several aspects of metabolism and of metabolic enzymes that appear to represent adaptations to the need to limit solute concentrations and conserve solvent capacity. Other chapters consider the factors that determine the overall rates of metabolic pathways. This book discusses as well the biosynthetic pathways leading to the branched-chain amino acids. The final chapter deals with the structure and mechanism of action of pyruvate carboxylase.  This book is a valuable resource for biologists and biochemists.

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Current Topics in Cellular Regulation, Volume 9 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation.  Organized into six chapters, this volume begins with an overview of the properties of the various hemoglobins present in trout blood. This text then introduces an interesting system for the study of differentiation and morphogenesis, the unicellular prokaryote Caulobacter crescentus. Other chapters consider the possible function of intracellular proteases in the regulation of enzyme activity in microorganisms and in their adaptation to changes in environmental conditions. This book discusses as well the physiological role and regulation of malic enzymes. The final chapter provides a comprehensive kinetic analysis of the phenomenon of enzyme induction in both eukaryotic and prokaryotic cells.  This book is a valuable resource for biochemists, biologists, and research workers.

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Current Topics in Bioenergetics, Volume 6 provides information pertinent to the phenomenon of energy transduction. This book covers a wide variety of topics, including photosynthesis, muscle contraction, transport across membranes, and oxidative phosphorylation.  Organized into six chapters, this volume begins with an overview of the solute transport functions of membrane vesicles from kidney and intestine. This text then examines the specialized calcium transport system of mitochondria from both mechanistic and biological viewpoints. Other chapters consider the energy-transducing mechanisms in bacteria and chromoplast from the standpoint of mechanism. This book discusses as well ionophores and channel formers as powerful tools in the study of membrane function. The final chapter deals with the metabolic link between fundamental cell physiological events, such as hormonal perturbation of metabolism and cell development, on the one hand, and an altered ability of mitochondria to transport Ca2+, on the other.  This book is a valuable resource for bioenergeticists, biochemists, biologists, and microbiologists.

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Current Topics in Cellular Regulation: Volume 32 is a collection of papers that discusses the role of GTP-binding proteins in signal transduction, the activation of cholera toxin by ADP-ribosylation factors, and the signal transduction by the colony-stimulating factor-1 receptor. Other papers explain the secretory granule, the mechanism of stimulus-secretion coupling, calcium pumps in the plasma and intracellular membranes, as well as the protein phosphorylation in translational control. One paper proposes a linkage between the multimeric structures and cytoskeletal elements to bridge the signal transducing systems and the cytoskeletal network. Another paper describes the signaling mechanisms utilized by CSF-1R, the similarities, and differences when compared to other receptor tyrosine kinases (RTKs). The paper explains in detail the mechanism of ligand-induced kinase activation, and also the possible biological role of certain intracellular substrates. Another paper examines the role played by protein phosphorylation in the control of translation, or when possible, any additional regulatory mechanisms operating in other eukaryotic species. Biochemists, micro-biologists, bio-physicists, cellular researchers, and researchers involved in the study of cellular biology will find the collection very useful.

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Earl R. Stadtman, P. Boon Chock, Alexander Levitzki

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Current Topics in Cellular Regulation, Vol. 26

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Current Topics in Cellular Regulation, Volume 26: Modulation by Molecular Interactions covers various aspects of biochemical regulation that were presented in the International Symposium on the Molecular Basis of Cellular Regulation held at the National Institutes of Health on May 3-5, 1984. The book discusses the coordination and control of cellular metabolism and function, focusing on modulation by molecular interactions. Biochemists, molecular biologists, geneticists, microbiologists, and physiologists will find the book invaluable.

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Current Topics in Cellular Regulation: Volume 25 is a collection of papers that deals with GTP, the central regulator of cellular anabolism, and the quantitative approach to metabolic control. , Other papers describe the inactivation and aldolases by limited proteolysis by lysosomal cathepsin M, the regulatory functions of proline, pyrroline-5-carboxylic acid, as well as the characteristics of a hormonal regulation of amino acid transport. One paper suggests that GTP, possibly acting through high guanine nucleotide energy charge, acts to stimulate a wide variety of anabolic processes involved in cell growth or proliferation. Another paper proposes that lysosomes are responsible for the degradation of proteins and other macromolecules, and in regulating cytosolic enzymes. This action is due to the presence of selected proteinases (located on the outer lysosomal surface) that are active at neutral pH, and also which catalyze only limited proteolysis of cytosolic proteins. One paper describes the characteristics and hormonal regulation of a specific transport system for neutral amino acids, namely, the System A-mediated transport. The collection can prove beneficial for biochemists, micro-biologists, bio-physicists, cellular researchers, and academicians involved in the study of cellular biology.

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Current Topics in Cellular Regulation, Volume 5 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation.  Organized into eight chapters, this volume begins with an overview of the role of phosphofructokinase in the regulation of glycolysis. This text then outlines the structural aspects of phosphofructokinase, its main kinetic properties, and the various mechanisms that have been proposed for its regulation. Other chapters consider the four-stage approach to analysis of control mechanisms. This book discusses as well the regulation of cellular function through the mechanism of protein phosphorylation. The final chapter deals with the pathway for histidine biosynthesis in Salmonella typhimurium, which consists of a series of reactions, each catalyzed by a specific enzyme.  This book is a valuable resource for biologists and biochemists.