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VLSI Electronics Microstructure Science, Volume 20: VLSI and Computer Architecture reviews the approaches in design principles and techniques and the architecture for computer systems implemented in VLSI.  This volume is divided into two parts. The first section is concerned with system design. Chapters under this section focus on the discussion of such topics as the evolution of VLSI; system performance and processor design considerations; and VLSI system design and processing tools. Part II of the book focuses on the architectural possibilities that have become cost effective with the development of VLSI circuits. Topics on architectural requirements and various architectures such as the Reduced Instruction Set, Extended Von Neumann, Language-Oriented, and Microprogrammable architectures are elaborated in detail. Also included are chapters that discuss the evaluation of architecture, multiprocessing configurations, and the future of VLSI.  Computer designers, those evaluating computer systems, researchers, and students of computer architecture will find the book very useful.

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Ravi Shankar, Eduardo B. Fernandez, Norman G. Einspruch

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Neuropeptide Analogs, Conjugates, and Fragments

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Methods in Neurosciences, Volume 13: Neuropeptide Analogs, Conjugates, and Fragments covers the synthesis and characterization of peptide analogs, conjugates, and fragments, their use as ligands for receptors, and their role in the development and use of antisera. The book discusses techniques such as novel synthetic approaches; biotinylation; purification and characterization; radioligand techniques and assay development; use of agonists and antagonists; distinguishing receptor subtypes; conjugation to carrier proteins; antiidiotypic antibody development; and radiolabeling. Neuroscientists, biochemists, neurochemists, and pharmacologists will find the book useful.

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The Handbook of Immunopharmacology: Lipid Mediators covers a comprehensive overview of lipid mediators, from synthesis through to inhibition. The book discusses the metabolism of arachidonic acid; the measurement of fatty acids and their metabolites; and the biological properties of cyclooxygenase products. The text also describes other essential fatty acids, their metabolites and cell-cell interactions; the inhibitors of fatty acid-derived mediators; as well as the biosynthesis and catabolism of platelet-activating factor. The cellular sources of platelet-activating factor and related lipids; the biological properties of platelet-activating factor; and the effects of platelet-activating factor receptor antagonists are also considered. Immunopharmacologists, immunologists, and pharmacologists will find the book invaluable.

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Current Topics in Cellular Regulation, Vol. 18

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Current Topics in Cellular Regulation, Volume 18: Biological Cycles covers topics on the events of molecular biology, cellular communication, and the merging of cell structure to biochemical function.  The book discusses the ornithin-urea cycle; the cycles of glutathione metabolism and transport; and the role of multienzymatic proteins in mammalian pyrimidine biosynthesis. The text also describes the significance of interconvertible enzyme cycles in cellular regulation; regulation of mammalian pyruvate dehydrogenase complex by a phosphorylation-dephosphorylation cycle; replenishment of citric acid cycle intermediates by the purine nucleotide cycle in rat skeletal muscle. The control of a secondary pathway of ethanol metabolism by differences in redox state; the role of aldolase and fructose bisphosphatase in the control of gluconeogenesis and glycolysis; and the fructose 6-phosphate/fructose 1,6-bisphosphate cycle are also considered. The book further tackles the cycles in polysaccharide biosynthesis and other important biological cycles. Biologists, microbiologists, cellular biologists, and biochemists will find the book invaluable.

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Metal  Semiconductor Contacts and Devices

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VLSI Electronics Microstructure Science, Volume 13: Metal-Semiconductor Contacts and Devices presents the physics, technology, and applications of metal-semiconductor barriers in digital integrated circuits. The emphasis is placed on the interplay among the theory, processing, and characterization techniques in the development of practical metal-semiconductor contacts and devices.  This volume contains chapters that are devoted to the discussion of the physics of metal-semiconductor interfaces and its basic phenomena; fabrication procedures; and interface characterization techniques, particularly, ohmic contacts. Contacts that involve polycrystalline silicon; applications of the metal-semiconductor barriers in MOS, bipolar, and MESFET digital integrated circuits; and methods for measuring the barrier height are covered as well.  Process engineers, device physicists, circuit designers, and students of this discipline will find the book very useful.

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Simon S. Cohen, Gennady Sh. Gildenblat, Norman G. Einspruch

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Beam Processing Technologies is a collection of papers that deals with the miniaturization of devices that will be faster, consume less power, and cost less per operation or fabrication. One paper discusses metal oxide semiconductor (MOS) integrated circuit technology including the operation of devices whose lateral and vertical dimensions are scaled down. If the devices' silicon doping profiles are increased by the same scale factor, they can operate on lower voltages and currents, with the same performance. Another paper describes laser beam processing and wafer-scale integration as techniques to increase the number of devices on a silicon chip. Electron beam technologies can be used in many fabrication processes such as in microlithography, selective oxidation, doping, metrology. Ion beam applications depend on the presence of the ion introduced into the device (e.g. implantation doping), on pseudoelastic collisions (e.g. physical sputtering or crystal damage), and on inelastic scattering (e.g. polymer resist exposure). Silicon molecular beam epitaxy (SiMBE) can also grow high-quality layers at low temperature, particularly concerning germanium, especially as reagrds the growth system design and utilization of n- and p-type doping. Chemical beam epitaxy (CBE) is another epitaxial growth technique that can surpass MBE and metal organic chemical vapor deposition (MO-CVD). The collection is suitable chemical engineers, industrial physicists, and researchers whose work involve micro-fabrication and development of integrated circuits.

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Norman G. Einspruch, S. S. Cohen, Raj N. Singh

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The Biology of the Coleoptera covers the branches of modern biology of Coleoptera. The book discusses the biological study of beetles; some skeletal peculiarities and the internal structures of the adults. The text also describes some structural features of larvae and pupae; food, digestion and the alimentary canal; and blood, osmoregulation, reserves, excretion and endocrine organs. The locomotion, respiration and energetics; the senses; and the cuticular properties, appearance, color and luminosity are also considered. The book further tackles the adult and larval behavior; the development and life-cycles; and the cytology and genetics. The text also looks into water beetles; special habitats; predation and defence; and symbiotic and parasitic relations. The ecological triangle: beetles, fungi and trees; and herbivorous beetles are also looked into. The book also discusses the role of beetles as ecological indicators; and the evolutionary history of beetles. Entomologists, ecologists, and biologists will find the book useful.

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Calcium and Cell Function, Volume 7 covers the signal transduction across the cell membrane. The book discusses phosphoinositides and calcium signaling; calmodulin-stimulated adenylate cyclases; and calcium/calmodulin-dependent protein kinases. The text also describes the regulation of gene expression by calcium; the dynamics of intracellular calcium concentration during mitosis; and the methods for the measurement of intracellular ionized calcium in mammalian cells. Pharmacologists, physiologists, and people involved in the study of calcium and cell function will find the book invaluable.

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Queueing and Computer System Applications

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Decomposability: Queueing and Computer System Applications presents a set of powerful methods for systems analysis. This 10-chapter text covers the theory of nearly completely decomposable systems upon which specific analytic methods are based.  The first chapters deal with some of the basic elements of a theory of nearly completely decomposable stochastic matrices, including the Simon-Ando theorems and the perturbation theory. The succeeding chapters are devoted to the analysis of stochastic queuing networks that appear as a type of key model. These chapters also discuss congestion problems in information processing systems, which could be studied by the queuing network models. A method of analysis by decomposition and aggregation for these models is proposed. Other chapters highlight the problem of computer system performance evaluation, specifically the analysis of hardware and software of the dynamic behavior of computer systems and user programs. These topics are followed by a description of an aggregative model of a typical multiprogramming time-sharing computer system. The last chapter examines the existing affinity between the concept of aggregate in nearly completely decomposable structures and the notions of module and level of abstraction so frequently invoked in computer system design and software engineering.    This book will prove useful to both hardware and software designers and engineers, as well as scientists who are investigating complex systems.

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Published Under the Auspices of the Protein Society

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Techniques in Protein Chemistry V highlights current methods in peptide and protein mass spectrometry, sequence and amino acid analysis, fragmentations, separations, protein folding and modeling, peptide and protein NMR, and peptide synthesis. This volume emerged from the manuscripts presented at the Seventh Symposium of the Protein Society, held in San Diego on July 24-28, 1993.   This volume is organized into eight parts encompassing 61 chapters. The first part surveys the peptide and protein characterization, detection, and analysis by mass spectrometry. The subsequent parts describe the structural characterization and analysis of posttranslational processing events, as well as the characterization of protein and amino acid sequences using several analytical techniques. Other parts explore other analytical methods for peptide and protein separations; some aspects involved in protein design and functional domain analysis; and the evaluation of protein conformation, folding, and modeling. The last parts contain research papers on NMR analysis of peptide and protein solution structures. These parts also look into topics related to peptide synthesis and peptide libraries.  This book is intended primarily for protein and analytical chemists.

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VLSI Electronics Microstructure Science, Volume 14: VLSI Design presents a comprehensive exposition and assessment of the developments and trends in VLSI (Very Large Scale Integration) electronics.   This volume covers topics that range from microscopic aspects of materials behavior and device performance to the comprehension of VLSI in systems applications. Each article is prepared by a recognized authority. The subjects discussed in this book include VLSI processor design methodology; the RISC (Reduced Instruction Set Computer); the VLSI testing program; silicon compilers for VLSI; and specialized silicon compiler and programmable chip for language recognition.  Scientists, engineers, researchers, device designers, and systems architects will find the book very useful.

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VLSI Electronics: Microstructure Science, Volume 7 presents a comprehensive exposition and assessment of the developments and trends in VLSI (Very Large Scale Integration) electronics.   This treatise covers subjects that range from microscopic aspects of materials behavior and device performance to the comprehension of VLSI in systems applications. Each chapter is prepared by a recognized authority. The topics contained in this volume include a basic introduction to the application of superconductivity in high-speed digital systems; the expected impact of VLSI technology on the implementation of AI (artificial intelligence); the limits to improvement of silicon integrated circuits; and the various spontaneous noise sources in VLSI circuits and their effect on circuit operation.  Scientists, engineers, researchers, device designers, and systems architects will find the book very useful.

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Calcium and Cell Function, Volume III covers the many aspects of research on calcium, dealing with its biochemistry, biology, and pharmacology in animals as well as in plants. The book discusses a novel cellular signaling system based on the integration of phospholipid and calcium metabolism; the transport of calcium by sarcoplasmic reticulum; and the energetics and chemistry for interactions between calmodulin and calmodulin-binding proteins. The text also describes the specificity of trifluoperazine and related phenothiazines for calcium-binding proteins; the structure, function, and regulation of phosphorylase kinase; and the regulation of glycogen synthase by multiple protein kinases. The role of calmodulin in synaptic function and neurosecretion; the stimulation of the synthesis of neurotransmitters by calmodulin-dependent phosphorylation; as well as the role of calcium in axoplasmic transport in nerve are also considered. The book further tackles calcium control of the intestinal microvillus cytoskeleton; the possible role of calmodulin in the regulation of insulin release and protein phosphorylation by calcium and cyclic AMP; and the role of calcium in mediating cellular functions important for growth and development in higher plants. The text also looks into the localization of calmodulin in tissue culture cells; and the characterization and regulation of calcium-dependent neutral protease. Zoologists, cell biologists, biochemists, and pharmacologists will find the book invaluable.

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How to Move from Heterogeneous Structures to Federated Concepts

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Solutions for Networked Databases: How to Move from Heterogeneous Structures to Federated Concepts reviews developments in standards and ad hoc solutions aimed at providing cross-database connectivity for networked databases. The emphasis is on how to move from heterogeneous structures to federated concepts. The advent of the multidatabase is discussed, along with schemata, dictionaries, and protocols. Applications with federated databases are also considered.  Comprised of 18 chapters, this book begins with an introduction to database and knowledge bank concepts; reliability and availability characteristics; and the synergy necessary to create and sustain federated databases. Centralized and distributed databases are then compared, and the different ways of managing distributed databases are outlined. Subsequent chapters focus on the importance of treating the networked database as a corporate resource; the use of schemata to solve cross-database problems; the Information Resource Dictionary System; and application programming interface and remote data access. A solution to heterogeneous distributed databases, the Data Access Integrated Services (DAIS), is described.   This monograph is written for specialists in computers and communications.

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Dimitris N. Chorafas, Heinrich Steinmann

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Designing Usable Texts covers the analysis of textual communication processes in the real world of publishing systems and work sites. The book presents topics on designing and understanding of written texts; authoring, editing, and the production process; and training authors of informative documents. The text also describes the policies and processes of editing; lessons in text design from an instructional design perspective; and graphics and design alternatives such as studying strategies and their implications for textbook design. The identification of information requirements such as understanding readers and their uses of texts, modeling users and their use of technical manuals, is also considered. Psychologists and people involved in communication design, document design, information mapping, and educational technology will find the book invaluable.

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Calcium and Cell Function, Volume I: Calmodulin covers calmodulin-regulated functions. The book discusses the preparation, properties, structure, function, evolution, and structure-function relationships of calmodulin; and calmodulin-dependent adenylate cyclase. The text also describes the transport of calmodulin and plasma membrane calcium; the role of calmodulin and troponin in the regulation of phosphorylase kinase from mammalian skeletal muscle; and calcium-dependent protein phosphorylation in mammalian brain and other tissues. The role of calmodulin in dopaminergic transmission; the immunocytochemical localization of calmodulin in rat tissues; and the immunocytochemical studies of the localization of calmodulin and caM-BP80 in the brain are also considered. The book further tackles the mechanisms and pharmacological implications of altering calmodulin activity. Molecular cardiologists, biochemists, and pharmacologists will find the book invaluable.

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Spectroscopy in Biology and Chemistry discusses the use of thermal neutron diffraction and inelastic scattering, and the related techniques of x-ray diffraction, Raman and Rayleigh scattering, in investigating biological macromolecules and chemical systems. The book describes neutron, x-ray and laser spectroscopy; quasielastic scattering in neutron and laser spectroscopy; and interatomic forces, molecular structure and molecular vibrations. The text also discusses the x-ray crystallography of biological molecules; neutron diffraction studies of hydrogen bonding in organic and biochemical systems; and comparative x-ray and neutron diffraction from nerve myelin membranes. Neutron spectroscopy of chain polymers; chemical and biological applications of neutron inelastic scattering; and neutron scattering and optical studies of molecular vibrations are also considered. The book further tackles small angle neutron scattering from polymers; the use of tunable laser resonance Raman spectroscopy in biology; and the use photon correlation spectroscopy in biology. Students and faculty members in physics, chemistry, and biology, and research workers in related fields will find the text invaluable.

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Current Topics in Cellular Regulation, Volume 4 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation.  Organized into six chapters, this volume begins with an overview of the activity of ornithine transcarbamylase that catalyzes the condensation of carbamyl phosphate with ornithine. This text then presents and discusses the in vitro data that are available on the molecular interactions that govern the expression of lactose (lac) operon. Other chapters consider the bovine liver, which has been characterized in terms of molecular and kinetic characteristics. This book discusses as well the de novo synthesis of saturated fatty acids, which is catalyzed by two enzyme systems. The final chapter deals with the factors leading to glycogenolysis as it occurs in mammalian skeletal muscle.  This book is a valuable resource for biologists and biochemists.

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Current Topics in Cellular Regulation: Volume 31 is a collection of papers that deals with the role of calcium as intracellular messenger, calcium release or entry across the plasma membrane, calcium in neurotransmitter release, and the regulation of free calmodulin levels in neurons by neuromodulin. Other papers discuss the calcium/calmodulin-dependent protein kinase II, the regulation of muscular calcium channels, and the Na+-Ca2+ exchangers. One paper describes the mechanisms of intracellular calcium release or entry in which agonists acting through the phosphoinositide system, or possibly by metabolites or secondary messenger system,can regulate the mechanisms of cellular Ca2+. Another paper describes different approaches in evaluating the possible mechanisms of calcium in neurotransmitter release. The paper notes that imaging techniques can be used in the timing and order of events in the release process. Possible identification by the investigator of specific "releasing" regions at the membranes, such as active zones, can also define more precisely the exact localization of the process. One paper discusses the interaction between released calmodulin and cytoskeleton proteins that can affect polymerization and cross-linking of cytoskeleton polymers, that leads to filopodia formation or extension. The collection will prove beneficial to molecular biologists, general biologists, microbiologists, biochemists, and researchers involved in cellular biology.

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Bernard L. Horecker, Earl R. Stadtman, P. Boon Chock