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The Biology of the Coleoptera covers the branches of modern biology of Coleoptera. The book discusses the biological study of beetles; some skeletal peculiarities and the internal structures of the adults. The text also describes some structural features of larvae and pupae; food, digestion and the alimentary canal; and blood, osmoregulation, reserves, excretion and endocrine organs. The locomotion, respiration and energetics; the senses; and the cuticular properties, appearance, color and luminosity are also considered. The book further tackles the adult and larval behavior; the development and life-cycles; and the cytology and genetics. The text also looks into water beetles; special habitats; predation and defence; and symbiotic and parasitic relations. The ecological triangle: beetles, fungi and trees; and herbivorous beetles are also looked into. The book also discusses the role of beetles as ecological indicators; and the evolutionary history of beetles. Entomologists, ecologists, and biologists will find the book useful.

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Calcium and Cell Function, Volume 7 covers the signal transduction across the cell membrane. The book discusses phosphoinositides and calcium signaling; calmodulin-stimulated adenylate cyclases; and calcium/calmodulin-dependent protein kinases. The text also describes the regulation of gene expression by calcium; the dynamics of intracellular calcium concentration during mitosis; and the methods for the measurement of intracellular ionized calcium in mammalian cells. Pharmacologists, physiologists, and people involved in the study of calcium and cell function will find the book invaluable.

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Queueing and Computer System Applications

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Decomposability: Queueing and Computer System Applications presents a set of powerful methods for systems analysis. This 10-chapter text covers the theory of nearly completely decomposable systems upon which specific analytic methods are based.  The first chapters deal with some of the basic elements of a theory of nearly completely decomposable stochastic matrices, including the Simon-Ando theorems and the perturbation theory. The succeeding chapters are devoted to the analysis of stochastic queuing networks that appear as a type of key model. These chapters also discuss congestion problems in information processing systems, which could be studied by the queuing network models. A method of analysis by decomposition and aggregation for these models is proposed. Other chapters highlight the problem of computer system performance evaluation, specifically the analysis of hardware and software of the dynamic behavior of computer systems and user programs. These topics are followed by a description of an aggregative model of a typical multiprogramming time-sharing computer system. The last chapter examines the existing affinity between the concept of aggregate in nearly completely decomposable structures and the notions of module and level of abstraction so frequently invoked in computer system design and software engineering.    This book will prove useful to both hardware and software designers and engineers, as well as scientists who are investigating complex systems.

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Published Under the Auspices of the Protein Society

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Techniques in Protein Chemistry V highlights current methods in peptide and protein mass spectrometry, sequence and amino acid analysis, fragmentations, separations, protein folding and modeling, peptide and protein NMR, and peptide synthesis. This volume emerged from the manuscripts presented at the Seventh Symposium of the Protein Society, held in San Diego on July 24-28, 1993.   This volume is organized into eight parts encompassing 61 chapters. The first part surveys the peptide and protein characterization, detection, and analysis by mass spectrometry. The subsequent parts describe the structural characterization and analysis of posttranslational processing events, as well as the characterization of protein and amino acid sequences using several analytical techniques. Other parts explore other analytical methods for peptide and protein separations; some aspects involved in protein design and functional domain analysis; and the evaluation of protein conformation, folding, and modeling. The last parts contain research papers on NMR analysis of peptide and protein solution structures. These parts also look into topics related to peptide synthesis and peptide libraries.  This book is intended primarily for protein and analytical chemists.

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VLSI Electronics Microstructure Science, Volume 14: VLSI Design presents a comprehensive exposition and assessment of the developments and trends in VLSI (Very Large Scale Integration) electronics.   This volume covers topics that range from microscopic aspects of materials behavior and device performance to the comprehension of VLSI in systems applications. Each article is prepared by a recognized authority. The subjects discussed in this book include VLSI processor design methodology; the RISC (Reduced Instruction Set Computer); the VLSI testing program; silicon compilers for VLSI; and specialized silicon compiler and programmable chip for language recognition.  Scientists, engineers, researchers, device designers, and systems architects will find the book very useful.

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VLSI Electronics: Microstructure Science, Volume 7 presents a comprehensive exposition and assessment of the developments and trends in VLSI (Very Large Scale Integration) electronics.   This treatise covers subjects that range from microscopic aspects of materials behavior and device performance to the comprehension of VLSI in systems applications. Each chapter is prepared by a recognized authority. The topics contained in this volume include a basic introduction to the application of superconductivity in high-speed digital systems; the expected impact of VLSI technology on the implementation of AI (artificial intelligence); the limits to improvement of silicon integrated circuits; and the various spontaneous noise sources in VLSI circuits and their effect on circuit operation.  Scientists, engineers, researchers, device designers, and systems architects will find the book very useful.

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Calcium and Cell Function, Volume III covers the many aspects of research on calcium, dealing with its biochemistry, biology, and pharmacology in animals as well as in plants. The book discusses a novel cellular signaling system based on the integration of phospholipid and calcium metabolism; the transport of calcium by sarcoplasmic reticulum; and the energetics and chemistry for interactions between calmodulin and calmodulin-binding proteins. The text also describes the specificity of trifluoperazine and related phenothiazines for calcium-binding proteins; the structure, function, and regulation of phosphorylase kinase; and the regulation of glycogen synthase by multiple protein kinases. The role of calmodulin in synaptic function and neurosecretion; the stimulation of the synthesis of neurotransmitters by calmodulin-dependent phosphorylation; as well as the role of calcium in axoplasmic transport in nerve are also considered. The book further tackles calcium control of the intestinal microvillus cytoskeleton; the possible role of calmodulin in the regulation of insulin release and protein phosphorylation by calcium and cyclic AMP; and the role of calcium in mediating cellular functions important for growth and development in higher plants. The text also looks into the localization of calmodulin in tissue culture cells; and the characterization and regulation of calcium-dependent neutral protease. Zoologists, cell biologists, biochemists, and pharmacologists will find the book invaluable.

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How to Move from Heterogeneous Structures to Federated Concepts

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Solutions for Networked Databases: How to Move from Heterogeneous Structures to Federated Concepts reviews developments in standards and ad hoc solutions aimed at providing cross-database connectivity for networked databases. The emphasis is on how to move from heterogeneous structures to federated concepts. The advent of the multidatabase is discussed, along with schemata, dictionaries, and protocols. Applications with federated databases are also considered.  Comprised of 18 chapters, this book begins with an introduction to database and knowledge bank concepts; reliability and availability characteristics; and the synergy necessary to create and sustain federated databases. Centralized and distributed databases are then compared, and the different ways of managing distributed databases are outlined. Subsequent chapters focus on the importance of treating the networked database as a corporate resource; the use of schemata to solve cross-database problems; the Information Resource Dictionary System; and application programming interface and remote data access. A solution to heterogeneous distributed databases, the Data Access Integrated Services (DAIS), is described.   This monograph is written for specialists in computers and communications.

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Dimitris N. Chorafas, Heinrich Steinmann

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Designing Usable Texts covers the analysis of textual communication processes in the real world of publishing systems and work sites. The book presents topics on designing and understanding of written texts; authoring, editing, and the production process; and training authors of informative documents. The text also describes the policies and processes of editing; lessons in text design from an instructional design perspective; and graphics and design alternatives such as studying strategies and their implications for textbook design. The identification of information requirements such as understanding readers and their uses of texts, modeling users and their use of technical manuals, is also considered. Psychologists and people involved in communication design, document design, information mapping, and educational technology will find the book invaluable.

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Calcium and Cell Function, Volume I: Calmodulin covers calmodulin-regulated functions. The book discusses the preparation, properties, structure, function, evolution, and structure-function relationships of calmodulin; and calmodulin-dependent adenylate cyclase. The text also describes the transport of calmodulin and plasma membrane calcium; the role of calmodulin and troponin in the regulation of phosphorylase kinase from mammalian skeletal muscle; and calcium-dependent protein phosphorylation in mammalian brain and other tissues. The role of calmodulin in dopaminergic transmission; the immunocytochemical localization of calmodulin in rat tissues; and the immunocytochemical studies of the localization of calmodulin and caM-BP80 in the brain are also considered. The book further tackles the mechanisms and pharmacological implications of altering calmodulin activity. Molecular cardiologists, biochemists, and pharmacologists will find the book invaluable.

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Spectroscopy in Biology and Chemistry discusses the use of thermal neutron diffraction and inelastic scattering, and the related techniques of x-ray diffraction, Raman and Rayleigh scattering, in investigating biological macromolecules and chemical systems. The book describes neutron, x-ray and laser spectroscopy; quasielastic scattering in neutron and laser spectroscopy; and interatomic forces, molecular structure and molecular vibrations. The text also discusses the x-ray crystallography of biological molecules; neutron diffraction studies of hydrogen bonding in organic and biochemical systems; and comparative x-ray and neutron diffraction from nerve myelin membranes. Neutron spectroscopy of chain polymers; chemical and biological applications of neutron inelastic scattering; and neutron scattering and optical studies of molecular vibrations are also considered. The book further tackles small angle neutron scattering from polymers; the use of tunable laser resonance Raman spectroscopy in biology; and the use photon correlation spectroscopy in biology. Students and faculty members in physics, chemistry, and biology, and research workers in related fields will find the text invaluable.

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Current Topics in Cellular Regulation, Volume 4 presents the fundamental mechanisms involved in the regulation of diverse cellular activities, including cellular differentiation, intermediary metabolism, and the transfer of genetic information. This book provides information pertinent to the various aspects of cellular regulation.  Organized into six chapters, this volume begins with an overview of the activity of ornithine transcarbamylase that catalyzes the condensation of carbamyl phosphate with ornithine. This text then presents and discusses the in vitro data that are available on the molecular interactions that govern the expression of lactose (lac) operon. Other chapters consider the bovine liver, which has been characterized in terms of molecular and kinetic characteristics. This book discusses as well the de novo synthesis of saturated fatty acids, which is catalyzed by two enzyme systems. The final chapter deals with the factors leading to glycogenolysis as it occurs in mammalian skeletal muscle.  This book is a valuable resource for biologists and biochemists.

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Current Topics in Cellular Regulation: Volume 31 is a collection of papers that deals with the role of calcium as intracellular messenger, calcium release or entry across the plasma membrane, calcium in neurotransmitter release, and the regulation of free calmodulin levels in neurons by neuromodulin. Other papers discuss the calcium/calmodulin-dependent protein kinase II, the regulation of muscular calcium channels, and the Na+-Ca2+ exchangers. One paper describes the mechanisms of intracellular calcium release or entry in which agonists acting through the phosphoinositide system, or possibly by metabolites or secondary messenger system,can regulate the mechanisms of cellular Ca2+. Another paper describes different approaches in evaluating the possible mechanisms of calcium in neurotransmitter release. The paper notes that imaging techniques can be used in the timing and order of events in the release process. Possible identification by the investigator of specific "releasing" regions at the membranes, such as active zones, can also define more precisely the exact localization of the process. One paper discusses the interaction between released calmodulin and cytoskeleton proteins that can affect polymerization and cross-linking of cytoskeleton polymers, that leads to filopodia formation or extension. The collection will prove beneficial to molecular biologists, general biologists, microbiologists, biochemists, and researchers involved in cellular biology.

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Bernard L. Horecker, Earl R. Stadtman, P. Boon Chock

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VLSI Electronics: Microstructure Science, Volume 6: Materials and Process Characterization addresses the problem of how to apply a broad range of sophisticated materials characterization tools to materials and processes used for development and production of very large scale integration (VLSI) electronics.  This book discusses the various characterization techniques, such as Auger spectroscopy, secondary ion mass spectroscopy, X-ray topography, transmission electron microscopy, and spreading resistance. The systematic approach to the technologies of VLSI electronic materials and device manufacture are also considered.  This volume is beneficial to materials scientists, chemists, and engineers who are commissioned with the responsibility of developing and implementing the production of materials and devices to support the VLSI era.

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Norman G. Einspruch, Graydon B. Larrabee

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From Metabolite, to Metabolism, to Metabolon

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Current Topics in Cellular Regulation, Volume 33: From Metabolite, to Metabolism, to Metabolon is a collection of articles on the study of the machinery of the living cell. The book is also a tribute to Paul Srere, an eminent biochemist, on the occasion of his sixty-fifth birthday.  The book contains contributions written by students, postdoctoral fellows, and biochemists within Paul Srere's broad sphere of influence. The text provides articles that discuss topics on cellular infrastructure and metabolic organization; how carbohydrates cross the lipid membrane of bacterial cells; and macromolecular processes. The structural aspects of citrate biochemistry; the electron transport systems; nucleotide biosynthesis; enzyme organization and the direction of metabolic flow; and bioengineering applications are tackled as well.  Biochemists, cytologists, and cell biologists will find the book very insightful.

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Current Topics in Clinical and Community Psychology

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Current Topics in Clinical and Community Psychology, Volume 2 covers the need of scientific work in the field of clinical and community psychology to the problems of modern society. The book discusses a new area of specialization - clinical neuropsychology; and the behavior deficits that result from brain damage in humans that may result from agents such as mind-altering drugs, alcohol, tranquilizers, and inadequate diet. The text also describes the sequential system for personality scale development; the prediction of violence with psychological tests; the relationship between depression and oral contraception. The quest for valid preventive interventions is also considered. Clinical psychologists, community psychologists, psychiatrists and students taking related courses will find the book useful.

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Current Topics in Experimental Endocrinology, Vol. 5

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Current Topics in Experimental Endocrinology, Volume 5: Fetal Endocrinology and Metabolism covers various aspects of fetal endocrinology. The book discusses studies of the hypothalamic-pituitary unit which emphasize the unique aspects of the fetal endocrine system; in vitro fertilization; and factors controlling placental endocrine function in domestic animals. The text also describes the role and kinetics of thyroid in fetal development; the placental transfer of carbohydrates; and fetal hormones and carbohydrate utilization. The regulation of partition of protein during pregnancy; the mineral needs of the fetus; and the fetal metabolism of cortisol are also considered. The book further tackles normal and abnormal sexual differentiation and the metabolic errors of adrenal steroidogenesis. Physiologists, endocrinologists, obstetricians, gynecologists, and students taking related courses will find the book invaluable.

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Essays on the Intentionality of Machines

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Thinking Computers and Virtual Persons: Essays on the Intentionality of Machines explains how computations are meaningful and how computers can be cognitive agents like humans. This book focuses on the concept that cognition is computation.  Organized into four parts encompassing 13 chapters, this book begins with an overview of the analogy between intentionality and phlogiston, the 17th-century principle of burning. This text then examines the objection to computationalism that it cannot prevent arbitrary attributions of content to the various data structures and representations involved in a computational process. Other chapters consider that the notion of original intentionality is incoherent. This book argues as well that the only way to build an intelligent machine is to build a neural network. The final chapter claims that an entire theoretical framework in cognitive psychology is incompatible with the view that human brains are computers of some sort.  This book is a valuable resource for cognitive scientists.

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The Endocrinology of Pregnancy and Parturition

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Current Topics in Experimental Endocrinology, Vol. 4

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Current Topics in Experimental Endocrinology, Volume 4: The Endocrinology of Pregnancy and Parturition deals with the various aspects of pregnancy and parturition. The book discusses pregnancy and parturition in marsupials; the vital role of the corpus luteum; and the endocrinology of the preimplantation period, looking into the variety of hormones and other agents and their involvement in the implantation process. The text also describes the critical role of prolactin in pregnancy; the role of human chorionic gonadotropin in early pregnancy; and specific pregnancy proteins. The clinical use of human placental lactogen in pregnancy; estrogen and progestrone production in human pregnancy; and the role of oxytocin in parturition; threatened abortion are also considered. Endocrinologists, obstetricians, gynecologists, reproductive physiologists, and students taking related courses will find the book invaluable.