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NMR in Molecular Biology provides an introduction to the basic concepts and principles of nuclear magnetic resonance (NMR) that are essential to a critical evaluation of experimental data. It also aims to acquaint readers in some detail with those prototype experiments in which a definite, biologically relevant answer has been obtained.  The book opens with a chapter on the historical development of NMR technology. Separate chapters follow on the fundamental principles of NMR; paramagnetic perturbations of NMR spectra; time scales, chemical exchange, and problems of exchange; and characteristics of NMR spectra through investigations of compounds such as amino acids and peptides; and nucleic acid bases, nucleosides, and nucleotides. Subsequent chapters deal with protein NRM spectra, protein-ligand interactions, and the structure and dynamics of membranes.  This book is intended for the student or practicing scientist wishing to gain a critical understanding of the applications of NMR to a wide range of problems in molecular biology.

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Oleg Jardetzky, G. C. K. Roberts, Bernard Horecker, Nathan O. Kaplan, Julius Marmur

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Development in the Preschool Years: Birth to Age Five reports a prospective longitudinal analysis of influences on development in the years from birth to age five. While speculation on the ways in which young children grow tends to be in terms of generalities, this volume emphasizes the role of empirical data in such discourse, and attempts to relate observations to an antecedent set o f quantitative findings. At a more particular level, the investigation considers six aspects of development: motor, intellectual, language, somatic, social, and physical development.   The book is organized into three parts. The first part contains chapters that review of the corpus of longitudinal studies, specific approaches, and recent research; and describe the methods used to generate and analyze the data. The second part provides multivariate regression analyses of the data in six domains while the third part presents a discussion of the findings. The fundamental intent of this investigation is to make a contribution to policy formation for the early years of life.

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Wave Propagation and Scattering in Random Media

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Multiple Scattering, Turbulence, Rough Surfaces, and Remote Sensing

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Wave Propagation and Scattering in Random Media, Volume 2, presents the fundamental formulations of wave propagation and scattering in random media in a unified and systematic manner.  The topics covered in this book may be grouped into three categories: waves in random scatterers, waves in random continua, and rough surface scattering. Random scatterers are random distributions of many particles. Examples are rain, fog, smog, hail, ocean particles, red blood cells, polymers, and other particles in a state of Brownian motion. Random continua are the media whose characteristics vary randomly and continuously in time and space. Examples are clear air turbulence, jet engine exhaust, tropospheric and ionospheric turbulence, ocean turbulence, and biological media such as tissue and muscle. Rough surface examples are the ocean surface, planetary surfaces, interfaces between different biological media, and the surface roughness of an optical fiber.  This book is intended for engineers and scientists interested in optical, acoustic, and microwave propagation and scattering in atmospheres, oceans, and biological media, and particularly for those involved in communication through such media and remote sensing of the characteristics of these media.

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The Oxygen Evolving System of Photosynthesis

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The Oxygen Evolving System of Photosynthesis documents the proceedings of an international symposium entitled ""Photosynthetic Water Oxidation and Photosystem II Photochemistry,"" held at The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama, Japan, 15-17 March 1983. Several other papers from authorities in this field are also included. This book provides in a systematic fashion the most current thoughts and insights into the field of photosynthetic oxygen evolution.  The volume contains 46 chapters organized into five parts. Part I deals with the subunit structure of photosystem II reaction center pigment proteins and the charge separation (generation of positive and negative charges, P680+ and Pheo-). Part II examines the components and their function on the donor side. Part III discusses the biochemistry of the water oxidation enzyme system, polypeptide composition, and functional reconstitution. Part IV take up the functions of chloride and bicarbonate in electron transport and the mechanism of photoactivation in latent or Tris-inactivated chloroplasts. Part V discusses the fate of reducing equivalents going through the two-electron gate mechanism, together with the biochemistry of the quinone components on the acceptor side.

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Yorinao Inoue, Norio Murata, Antony R. Crofts

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Papers Dedicated to Professor Mikio Sato on the Occasion of His Sixtieth Birthday

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Algebraic Analysis: Papers Dedicated to Professor Mikio Sato on the Occasion of his 60th Birthday, Volume I is a collection of research papers on algebraic analysis and related topics in honor to Professor Mikio Satos 60th birthday.   This volume is composed of 35 chapters and begins with papers concerning Satos early career in algebraic analysis. The succeeding chapters deal with research works on the existence of local holomorphic solutions, the holonomic q-difference systems, partial differential equations, and the properties of solvable models. Other chapters explore the fundamentals of hypergeometric functions, the Toda lattice in the complex domain, the Lie algebras, b-functions, p-adic integrals, analytic parameters of hyperfunctions, and some applicatioins of microlocal energy methods to analytic hypoeellipticity. This volume also presents studies on the complex powers of p-adic fields, operational calculus, extensions of microfunction sheaves up to the boundary, and the irregularity of holonomic modules. The last chapters feature research works on error analysis of quadrature formulas obtained by variable transformation and the analytic functional on the complex light cone, as well as their Fourier-Borel transformations.  This book will prove useful to mathematicians and advance mathematics students.

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Psychoanalytic and Behavioral Studies of Surgical Patients

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Psychological Stress: Psychoanalytic and Behavioral Studies of Surgical Patients attempts to present as complete a picture as possible of the psychological aspects of surgery.   The primary purpose is to highlight the theoretical implications by conveying what has been learned concerning the dynamics of human adjustment to stressful life events. It also draws attention to some of the main practical implications with respect to three important types of problems : (a) the formulation of policies of medical management which take account of the psychological needs of sick people; (b) the improvement of diagnostic procedures relevant for predicting high or low stress tolerance; and (c) the development of effective methods of psychological preparation which could be widely applied as part of a mental health program designed to reduce the disruptive emotional impact of many different types of potential disasters.  The book is organized into two parts. Part I formulates a large number of propositions concerning the dynamics of stress behavior. These propositions generally deal with the causes and consequences of various types of emotional reactions and adjustment mechanisms that are frequently activated when people are exposed to severe environmental threats, dangers, or deprivations. Part II focuses on two reaction variables which appear to be of fundamental importance in adjustment to stress: (a) fear of body damage, as manifested by verbalized attitudes of apprehensiveness, overt signs of emotional tension, and overt attempts to execute protective actions; and (b) externalized anger, as manifested by verbalized attitudes of resentment toward persons in the immediate environment outbursts of rage, and overt acts of opposition or resistanceto the demands of danger-control personnel.

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Elementary Linear Algebra reviews the elementary foundations of linear algebra in a student-oriented, highly readable way. The many examples and large number and variety of exercises in each section help the student learn and understand the material. The instructor is also given flexibility by allowing the presentation of a traditional introductory linear algebra course with varying emphasis on applications or numerical considerations. In addition, the instructor can tailor coverage of several topics.  Comprised of six chapters, this book first discusses Gaussian elimination and the algebra of matrices. Applications are interspersed throughout, and the problem of solving AX = B, where A is square and invertible, is tackled. The reader is then introduced to vector spaces and subspaces, linear independences, and dimension, along with rank, determinants, and the concept of inner product spaces. The final chapter deals with various topics that highlight the interaction between linear algebra and all the other branches of mathematics, including function theory, analysis, and the singular value decomposition and generalized inverses.  This monograph will be a useful resource for practitioners, instructors, and students taking elementary linear algebra.

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The Endocrine Function of the Human Testis

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The Endocrine Function of the Human Testis, Volume 1, contains papers that comprise the series of lectures given in a short course on the "Endocrine Function of the Human Testis" which was organized by the Post-Graduate School of Endocrinology in the University of Florence. The course was held in two parts, the first on April 25-27 and the second on October 24-26, 1972. The topics which were covered were: methods for the assay of androgens; binding of androgens in plasma; metabolism of testosterone; the chemistry, biology, and radioimmunoassay of hypophiseal gonadotrophins; the mechanism of control of the secretion of pituitary gonadotrophins; and the biosynthesis of androgens in the human testis.

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Robustness of Statistical Tests provides a general, systematic finite sample theory of the robustness of tests and covers the application of this theory to some important testing problems commonly considered under normality. This eight-chapter text focuses on the robustness that is concerned with the exact robustness in which the distributional or optimal property that a test carries under a normal distribution holds exactly under a nonnormal distribution.  Chapter 1 reviews the elliptically symmetric distributions and their properties, while Chapter 2 describes the representation theorem for the probability ration of a maximal invariant. Chapter 3 explores the basic concepts of three aspects of the robustness of tests, namely, null, nonnull, and optimality, as well as a theory providing methods to establish them. Chapter 4 discusses the applications of the general theory with the study of the robustness of the familiar Students r-test and tests for serial correlation. This chapter also deals with robustness without invariance. Chapter 5 looks into the most useful and widely applied problems in multivariate testing, including the GMANOVA (General Multivariate Analysis of Variance). Chapters 6 and 7 tackle the robust tests for covariance structures, such as sphericity and independence and provide a detailed description of univariate and multivariate outlier problems. Chapter 8 presents some new robustness results, which deal with inference in two population problems.  This book will prove useful to advance graduate mathematical statistics students.

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Takeaki Kariya, Bimal K. Sinha, Gerald L. Lieberman, Ingram Olkin

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A New Analysis of Anxiety and Depression

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Patterns of Emotions: A New Analysis of Anxiety and Depression provides a theoretical and empirical analysis of anxiety and depression phenomena experienced in some degree by everyone and in crippling intensity by many. This book is a sequel to The Face of Emotion (Izard, 1971), which presented a general conceptual framework for the study of the personality, a theory of the emotions, and evidence for the universality of the fundamental emotions of interest, joy, surprise, distress, anger, disgust, contempt, shame, and fear.  The book defines the problems of anxiety and depression, in the framework of differential emotion theory, as combinations or patterns of interacting fundamental emotions and bodily feelings. The differential emotion theory of anxiety and depression is compared with psychoanalytic theory, cognitive theory, and biogenetic theory. A number of studies are presented which support the differential emotion analysis of anxiety and depression. The book also presents studies of various life situations in which a particular fundamental emotion is dominant. What has been found repeatedly is that, in each such situation, the dominant emotion occurs in a pattern of dynamically related fundamental emotions. The patterns for a variety of commonly experienced and universal emotion situations are presented and discussed.

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Poverty and Policy in American History is about people who needed help in the nineteenth and early twentieth centuries. It is about the ways in which the perception of poverty and other forms of dependence affected the development of public programs and the conduct of voluntary reform. It also about the ways in which people have written about welfare.  The book contains three chapters and opens with a description of the life and death of a poor family in early twentieth-century Philadelphia based on case records. It attempts to show many of the themes in the lives of the poor through the close analysis of one extended example. The second chapter moves back in time and consists of four case studies drawn from the project's empirical research. The first case study takes up the history of a neglected institution, the poorhouse. The second case reports on a survey of the causes of pauperism undertaken by the New York Board of State Charities in the mid-1870s. The third case analyzes a sample of the seven special schedules of the 1880 U.S. census, which enumerated the ""defective, dependent, and delinquent"" population. The final case uses a register of tramps from various places in New York State during the mid-1870s to assess the relation between popular images of tramps and what appeared to be their actual characteristics. The third chapter uses the results of the project's research and other recent work on related topics to examine American historical writing about dependence as a field and offers a sympathetic critique.

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Michael B. Katz, Charles Tilly, Edward Shorter

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Lymphocyte Differentiation, Recognition, and Regulation provides an overview of the state of knowledge on cellular immunology. The focus is on animal work than on studies in man, although in certain areas human lymphocyte biology has been discussed in some detail. The book attempts to integrate information from diverse areas of cellular immunology, immunogenetics, and immunochemistry to form some cohesive concepts that can be perhaps utilized as a working foundation for students and investigators in various areas of immunology.   The book begins with a general description of some of techniques and principles underlying the systems frequently employed in cellular immunology. This is followed by detailed analyses of lymphocyte differentiation, receptor function, and regulatory processes. The main points that emerge from such analyses are that the immune system is an infinitely complex and finely tuned network of cells, receptors, and molecules which interact with one another in a genetically controlled manner that is manifested ultimately in the process known as differentiation.

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David H. Katz, F. J. Dixon, Henry G. Kunkel

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Numerical Solution of Partial Differential EquationsIII, SYNSPADE 1975

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Proceedings of the Third Symposium on the Numerical Solution of Partial Differential Equations, SYNSPADE 1975, Held at the University of Maryland, College Park, Maryland, May 19-24, 1975

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Numerical Solution of Partial Differential EquationsIII: Synspade 1975 provides information pertinent to those difficult problems in partial differential equations exhibiting some type of singular behavior. This book covers a variety of topics, including the mathematical models and their relation to experiment as well as the behavior of solutions of the partial differential equations involved. Organized into 16 chapters, this book begins with an overview of elastodynamic results for stress intensity factors of a bifurcating crack. This text then discusses the effects of nonlinearities, such as bifurcation, which occur in problems of nonlinear mechanics. Other chapters consider the equations of changing type and those with rapidly oscillating coefficients. This book discusses as well the effective computational methods for numerical solutions. The final chapter deals with the principal results on G-convergence, such as the convergence of the Green's operators for Dirichlet's and other boundary problems. This book is a valuable resource for engineers and mathematicians.

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Probability and Mathematical Statistics: Measure and Integral provides information pertinent to the general mathematical notions and notations. This book discusses how the machinery of ?-extension works and how ?-content is derived from ?-measure.  Organized into 16 chapters, this book begins with an overview of the classical HahnBanach theorem and introduces the Banach limits in the form of a major exercise. This text then presents the Daniell extension theory for positive ?-measures. Other chapters consider the transform of ?-contents and ?-measures by measurable mappings and kernels. This text is also devoted to a thorough study of the vector lattice of signed contents. This book discusses as well an abstract regularity theory and applied to the standard cases of compact, locally compact, and Polish spaces. The final chapter deals with the rudiments of the KreinMilman theorem, along with some of their applications.  This book is a valuable resource for graduate students.

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Konrad Jacobs, Z. W. Birnbaum, E. Lukacs

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Infrared and Raman Spectroscopy of Lunar and Terrestrial Minerals

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Infrared and Raman Spectroscopy of Lunar and Terrestrial Minerals makes available in a single reference work original descriptions and summaries of the research on infrared and Raman spectroscopy of lunar and terrestrial minerals so that this information will be readily available not only to those researchers in the continuing programs on lunar samples from the completed Apollo series and on the remote sensing of solar system objects, but, in particular, to that much larger group of researchers in government, industry, and universities involved in the many programs on terrestrial minerals and earth sciences by remote sensing.  The chapters in this volume are arranged according to spectroscopic technique and/or frequency range rather than application. Thus there are chapters on visible and near-infrared, followed by those on mid-infrared, far-infrared, and Raman spectroscopy. Applications are roughly divided between lunar and terrestrial, although the broad range of interchangeability of applications is obvious in many instances. There are also chapters on remote sensing of space targets and earth sciences; on lunar mineralogy and terrestrial mineralogy and geology; and on structures of lunar minerals and structures of terrestrial minerals.

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Molecular Biology of RNA: New Perspectives provides an overview of the developments in RNA research as well as the approaches, strategies, and methodologies used. Most of the contributing authors in the present volume participated in the Fifth Stony Brook Symposium entitled "New Perspectives on the Molecular Biology of RNA" in May 1986. The text is organized into six parts. Part I contains papers dealing with RNA as an enzyme. Part II presents studies on RNA splicing. Part III examines RNA viruses while Part IV focuses on the role of RNA in DNA replication. Part V is devoted to the structure, function, and isolation of RNA. Finally, Part VI takes up the role of RNA in regulation and repression. This volume will help provide new direction and insight for those already working on the subject and will serve as a useful guide to those about to start research in the molecular biology of RNA.

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Recent Progress of Life Science Technology in Japan

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Recent Progress of Life Science Technology in Japan discusses developments in cancer research technologies in Japan. In June 1983 an intra-cabinet panel of the Japanese Government drafted a 10-year strategy for cancer control, recognizing the importance of this field of research. A scientific research group was organized to comprise two sectionsthe first concerning the development and evaluation of DNA technologies, and the second on protein-related technologies.  In the promotion of fundamental cancer research, the development and refinement of basic technologies for each component of the ""triangle of bio-sciences""DNA, protein, and antibodyare essential, particularly in the elucidation of tumor-inducing and tumor-suppressing genes, tumor-specific antigens, and so forth. Part I of the book details the achievements of the first group in developing automated instrumentations for DNA sequencing. The second scientific research group worked on three major subareas: (1) gene transfer and expression technologies; (2) technologies for extraction, purification, and structural analysis of cancer-related proteins; and (3) technologies for analysis and synthesis of saccharide chains. Reports from these areas are respectively grouped in Part II, Part III, and Part IV of this monograph.

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Molecular Biology of Plant Tumors provides an opportunity to learn in detail about the latest insights into the mechanism of transformation of plant cells by Agrobacterium tumefaciens. The study of the molecular mechanism responsible for the crown gall phenomenon (induced by Agrobacterium tumefaciens) illustrates the point that the fundamental study of the cause(s) and mechanism(s) of abnormal growth might be one of the most efficient ways to understand cellular differentiation and the molecular basis of gene expression.   The book is organized into three parts that contain research on abnormal plant growth, crown gall tumors, and potential vectors for genetic engineering in agriculture. The genetic structure responsible for the neoplasmic transformation of plant cells in crown galls is a bacterial plasmid (called Ti for tumor-inducing). Research described in this volume demonstrates that these Ti plasmids were designed by evolution as natural gene vectors with which some bacteria can introduce active genes into plants. These transferred genes are maintained by integration in the plant genome and their expression is directly or indirectly responsible for the tumorous growth pattern.

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Microeconomic Simulation Models for Public Policy Analysis, Volume 1: Distributional Impacts is a collection of papers presented at a conference of the same title held in Washington, D.C. in March 1978. This collection discusses extended micro data models for first-round distributional analysis, models that incorporate behavioral responses to the policies being stimulated, models of macroeconomics, and models that have sectorial or regional impacts. One paper explains that increasing support for the negative income tax scheme can result in bigger increase in the budgetary cost of the program itself. Another paper evaluates the Kasten, Greenberg, Betson program as useful for policymakers to determine the distributional consequences of any proposed changes in policy in welfare reforms. With the oil embargo and energy crisis in the U.S., one author presents a model to measure the impacts these events have on energy consumers, especially on the lower-income group. Such model employs a comprehensive human resources data system that measures the distributional impacts of energy policies. This book is beneficial for policy makers and regulators involved in economic and public services. This book can also help sociologists and academicians in the field of political science and developmental studies.

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Essentials of Error-Control Coding Techniques

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Essentials of Error-Control Coding Techniques presents error-control coding techniques with an emphasis on the most recent applications. It is written for engineers who use or build error-control coding equipment. Many examples of practical applications are provided, enabling the reader to obtain valuable expertise for the development of a wide range of error-control coding systems. Necessary background knowledge of coding theory (the theory of error-correcting codes) is also included so that the reader is able to assimilate the concepts and the techniques.  The book is divided into two parts. The first provides the reader with the fundamental knowledge of the coding theory that is necessary to understand the material in the latter part. Topics covered include the principles of error detection and correction, block codes, and convolutional codes. The second part is devoted to the practical applications of error-control coding in various fields. It explains how to design cost-effective error-control coding systems. Many examples of actual error-control coding systems are described and evaluated.  This book is particularly suited for the engineer striving to master the practical applications of error-control coding. It is also suitable for use as a graduate text for an advanced course in coding theory.