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This volume in the International Review of Neurobiology is a comprehensive overview of the state-of-the-art research into autism pathophysiology. Its chapters cover a wide range of etiologies, from genetics and development to environmental factors. In addition, it discusses key cell and behavioral phenotypes, including cortical and cerebellar phenotypes, as well as language and motor outputs. Finally, this volume's chapters on gene expression in the brain describe how genes may be connected to phenotypes in autism. Broad coverage of genetic and cellular phenotypes in autism Focused on basic research  Chapters primarily written by new investigators with a fresh perspective on the biological underpinnings of autism

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Reliability of Large and Complex Systems

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Reliability of Large and Complex Systems, previously titled Reliability of Large Systems, is an innovative guide to the current state and reliability of large and complex systems.

In addition to revised and updated content on the complexity and safety of large and complex mechanisms, this new edition looks at the reliability of nanosystems, a key research topic in nanotechnology science. The author discusses the importance of safety investigation of critical infrastructures that have aged or have been exposed to varying operational conditions. This reference provides an asymptotic approach to reliability; its methodology, whilst largely mathematical, is designed to help the reader understand and construct general models of large and systems in a wide range of engineering fields.
A complete and innovative guide to the reliability of large and complex systems Provides the reader with a strong foundational knowledge of safety investigation into critical infrastructures; the main research area in the world of safety science Explains how to construct large, reliable and safe systems in variable operation conditions

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Offshore Safety Management, Second Edition provides an experienced engineer's perspective on the new Safety and Environmental System (SEMS) regulations for offshore oil and gas drilling, how they compare to prior regulations, and how to implement the new standards seamlessly and efficiently. The second edition is greatly expanded, with increased coverage of technical areas such as engineering standards and drilling, and procedural areas such as safety cases and formal safety assessments. The new material both complements the SEMS coverage and increases the book's relevance to a global audience.

Following the explosion, fire, and sinking of the Deepwater Horizon floating drilling rig in April 2010, the Bureau of Ocean Energy Management, Regulations, and Enforcement (BOEMRE) issued many new regulations. One of them was the Safety and Environmental System rule, which is based on the American Petroleum Institute's SEMP recommended practice, finalized in April 2013.

Author Ian Sutton explains the SEMS rule, and describes what must be done to achieve compliance. Each of the twelve elements of the SEMS rule (such as Management of Change and Safe Work Practices) is described in the book, and guidance is provided on how to meet BOEMRE requirements.
Detailed explanation of how to implement the new SEMS standard for offshore operations Ties the new regulations in with existing safety management approaches, helping managers leverage existing processes and paperwork With CEOs now signing off on compliance paperwork, this book provides expert insights so you can get SEMS compliance right the first time

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Imaging of the Human Brain in Health and Disease

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Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases.

Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease.

This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease.
A focused introduction to imaging healthy and diseased brains Focuses on the primary neurotransmitter release Includes sigma, acetylcholine, opioid, and dopamine receptors Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease

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Data Mining and Knowledge Discovery for Geoscientists

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Currently there are major challenges in data mining applications in the geosciences. This is due primarily to the fact that there is a wealth of available mining data amid an absence of the knowledge and expertise necessary to analyze and accurately interpret the same data. Most geoscientists have no practical knowledge or experience using data mining techniques. For the few that do, they typically lack expertise in using data mining software and in selecting the most appropriate algorithms for a given application. This leads to a paradoxical scenario of "rich data but poor knowledge".

The true solution is to apply data mining techniques in geosciences databases and to modify these techniques for practical applications. Authored by a global thought leader in data mining, Data Mining and Knowledge Discovery for Geoscientists addresses these challenges by summarizing the latest developments in geosciences data mining and arming scientists with the ability to apply key concepts to effectively analyze and interpret vast amounts of critical information.
Focuses on 22 of data minings most practical algorithms and popular application samples Features 36 case studies and end-of-chapter exercises unique to the geosciences to underscore key data mining applications Presents a practical and integrated system of data mining and knowledge discovery for geoscientists Rigorous yet broadly accessible to geoscientists, engineers, researchers and programmers in data mining Introduces widely used algorithms, their basic principles and conditions of applications, diverse case studies, and suggests algorithms that may be suitable for specific applications

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To reduce the risk of digital forensic evidence being called into question in judicial proceedings, it is important to have a rigorous methodology and set of procedures for conducting digital forensic investigations and examinations. Digital forensic investigation in the cloud computing environment, however, is in infancy due to the comparatively recent prevalence of cloud computing.

Cloud Storage Forensics presents the first evidence-based cloud forensic framework. Using three popular cloud storage services and one private cloud storage service as case studies, the authors show you how their framework can be used to undertake research into the data remnants on both cloud storage servers and client devices when a user undertakes a variety of methods to store, upload, and access data in the cloud. By determining the data remnants on client devices, you gain a better understanding of the types of terrestrial artifacts that are likely to remain at the Identification stage of an investigation. Once it is determined that a cloud storage service account has potential evidence of relevance to an investigation, you can communicate this to legal liaison points within service providers to enable them to respond and secure evidence in a timely manner.
Learn to use the methodology and tools from the first evidenced-based cloud forensic framework Case studies provide detailed tools for analysis of cloud storage devices using popular cloud storage services Includes coverage of the legal implications of cloud storage forensic investigations Discussion of the future evolution of cloud storage and its impact on digital forensics

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4G: LTE/LTE-Advanced for Mobile Broadband

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This book focuses on LTE with full updates including LTE-Advanced (Release-11) to provide a complete picture of the LTE system. Detailed explanations are given for the latest LTE standards for radio interface architecture, the physical layer, access procedures, broadcast, relaying, spectrum and RF characteristics, and system performance.

Key technologies presented include multi-carrier transmission, advanced single-carrier transmission, advanced receivers, OFDM, MIMO and adaptive antenna solutions, radio resource management and protocols, and different radio network architectures. Their role and use in the context of mobile broadband access in general is explained, giving both a high-level overview and more detailed step-by-step explanations.

This book is a must-have resource for engineers and other professionals in the telecommunications industry, working with cellular or wireless broadband technologies, giving an understanding of how to utilize the new technology in order to stay ahead of the competition.

New to this edition:

In-depth description of CoMP and enhanced multi-antenna transmission including new reference-signal structures and feedback mechanisms
Detailed description of the support for heterogeneous deployments provided by the latest 3GPP release
Detailed description of new enhanced downlink control-channel structure (EPDDCH)
New RF configurations including operation in non-contiguous spectrum, multi-bands base stations and new frequency bands
Overview of 5G as a set of well-integrated radio-access technologies, including support for higher frequency bands and flexible spectrum management, massive antenna configurations, and ultra-dense deployments Covers a complete update to the latest 3GPP Release-11 Two new chapters on HetNet, covering small cells/heterogeneous deployments, and CoMP, including Inter-site coordination Overview of current status of LTE release 12 including further enhancements of local-area, CoMP and multi-antenna transmission, Machine-type-communication, Device-to-device communication

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Erik Dahlman, Stefan Parkvall, Johan Skold

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A Workbench for Inventing and Sharing Digital Forensic Technology

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Python Forensics provides many never-before-published proven forensic modules, libraries, and solutions that can be used right out of the box. In addition, detailed instruction and documentation provided with the code samples will allow even novice Python programmers to add their own unique twists or use the models presented to build new solutions.

Rapid development of new cybercrime investigation tools is an essential ingredient in virtually every case and environment. Whether you are performing post-mortem investigation, executing live triage, extracting evidence from mobile devices or cloud services, or you are collecting and processing evidence from a network, Python forensic implementations can fill in the gaps.

Drawing upon years of practical experience and using numerous examples and illustrative code samples, author Chet Hosmer discusses how to:
Develop new forensic solutions independent of large vendor software release schedules Participate in an open-source workbench that facilitates direct involvement in the design and implementation of new methods that augment or replace existing tools Advance your career by creating new solutions along with the construction of cutting-edge automation solutions to solve old problems Provides hands-on tools, code samples, and detailed instruction and documentation that can be put to use immediately Discusses how to create a Python forensics workbench Covers effective forensic searching and indexing using Python Shows how to use Python to examine mobile device operating systems: iOS, Android, and Windows 8 Presents complete coverage of how to use Python scripts for network investigation

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Emerging Applications of Molecular Imaging to Oncology

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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume, number 124, covers emerging applications of molecular imaging to oncology, including molecular-genetic imaging, imaging the tumor microenvironment, tracking cells and vaccines in vivo, and more. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students

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Applications for Genetic Improvement and Agronomy

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From climate change to farming systems to genetic modification of organisms, Crop Physiology, Second Edition provides a practical tool for understanding the relationships and challenges of successful cropping. With a focus on genetic improvement and agronomy, this book addresses the challenges of environmentally sound production of bulk and quality food, fodder, fiber, and energy which are of ongoing international concern. The second edition of Crop Physiology continues to provide a unique analysis of these topics while reflecting important changes and advances in the relevant science and implementation systems.

Contemporary agriculture confronts the challenge of increasing demand in terms of quantitative and qualitative production targets. These targets have to be achieved against the background of soil and water scarcity, worldwide and regional shifts in the patterns of land use driven by both climate change and the need to develop crop-based sources of energy, and the environmental and social aspects of agricultural sustainability.
Provides a view of crop physiology as an active source of methods, theories, ideas, and tools for application in genetic improvement and agronomy Written by leading scientists from around the world Combines environment-specific cropping systems and general principles of crop science to appeal to advanced students, and scientists in agriculture-related disciplines, from molecular sciences to natural resources management

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The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases.
Part 1 provides an in-depth look at structural differences and distribution of various pre- and post-synaptic proteins found at glutamatergic synapses. Part 2 is dedicated to dendritic spines and their associated perisynaptic glia, which together constitute the tripartite synapse. The spines are portrayed as major sites for calcium sequestration and local protein synthesis. Part 3 highlights the important regional and cellular differences between glutamatergic transmission and that of neurotransmitters such as dopamine and acetylcholine that are commonly found in axon terminals without synaptic membrane specializations. Part 4 provides an overview of the synapse from the time of formation to degeneration under the powerful influence of aging or hormonal decline that leads to severe deficits in cognitive function.
Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings.
A comprehensive reference focused on the structure and function of the synapse Covers the links between the synapse and neural plasticity and the cellular basis of neurologic disease Detailed coverage of dendritic spines and associated perisynaptic gliathe tripartite synapse Includes in-depth coverage of synapse degeneration due to aging or hormonal decline related to severe cognitive impairment

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Special Lectures Presented at the Symposium on the Control of Mycotoxins Held at Goteborg, Sweden, 2122 August 1972

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Control of Mycotoxins provides information pertinent to the fundamental aspects of the control of mycotoxins. This book provides a review of the toxicology of aflatoxins in the food industry.  Organized into 13 chapters, this book begins with an overview of the significant association between tumor-bearing and alpha-foetoprotein when a sensitive immunoautoradiographic method was used. This text then examines the methodology of assay of aflatoxins in food and feed products, as well as their application to the control of mycotoxins. Other chapters review some areas of research at the Northern Regional Research Laboratory involving the effects of insecticide treatment of sterile and unsterile wheat on the formation of aflatoxin and ochratoxin. This book discusses as well the methods for the extraction and determination of aflatoxins from cereals. The final chapter deals with the toxicological study of Fusarium toxicoses.  This book is a valuable resource for chemists, microbiologists, biologists, toxicologists, nutritionists, scientists, and veterinarians.

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This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, The Alkaloids, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Up-to-date reviews on a large and very important group of natural products from both a chemical and biological perspective Comprehensive, dynamic reviews written by leading authors in the respective fields Broad coverage on the biological aspects

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Design of High Speed Interconnects and Signaling

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High Speed Digital Design discusses the major factors to consider in designing a high speed digital system and how design concepts affect the functionality of the system as a whole. It will help you understand why signals act so differently on a high speed digital system, identify the various problems that may occur in the design, and research solutions to minimize their impact and address their root causes. The authors offer a strong foundation that will help you get high speed digital system designs right the first time.

Taking a systems design approach, High Speed Digital Design offers a progression from fundamental to advanced concepts, starting with transmission line theory, covering core concepts as well as recent developments. It then covers the challenges of signal and power integrity, offers guidelines for channel modeling, and optimizing link circuits. Tying together concepts presented throughout the book, the authors present Intel processors and chipsets as real-world design examples.
Provides knowledge and guidance in the design of high speed digital circuits Explores the latest developments in system design Covers everything that encompasses a successful printed circuit board (PCB) product Offers insight from Intel insiders about real-world high speed digital design

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Hanqiao Zhang, Steven Krooswyk, Jeffrey Ou

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Commercial Airplane Design Principles is a succinct, focused text covering all the information required at the preliminary stage of aircraft design: initial sizing and weight estimation, fuselage design, engine selection, aerodynamic analysis, stability and control, drag estimation, performance analysis, and economic analysis.

The text places emphasis on making informed choices from an array of competing options, and developing the confidence to do so.
Shows the use of standard, empirical, and classical methods in support of the design process Explains the preparation of a professional quality design report Provides a sample outline of a design report Can be used in conjunction with Sforza, Manned Spacecraft Design Principles to form a complete course in Aircraft/Spacecraft Design

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Advances in Planar Lipid Bilayers and Liposomes

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Although the origin and the basic meaning of the terms "planar lipid bilayers" and "liposome" have not changed during the years, the present advances in the scientific, technological, biomedical and consumer product fields are remarkable. Ever since its launch the "Advances in Planar Lipid Bilayers and Liposomes (APLBL) has provided a global platform for a community of researchers having very broad scientific interests in theoretical, experimental and simulation studies on lipid and cell membrane micro and nanostructures. Ranging from artificial lipid membranes to cell membranes, controlled release of functional molecules, drug delivery to cancer cells, pharmaceutical formulations to food products, the applications are simply enormous. An assortment of chapters in APLBL represents both an original research as well as comprehensives reviews written by world leading experts and young researchers. Gives a survey on recent theoretical as well as experimental results on lipid micro and nanonanostructures In addition, the potential use of the basic knowledge in applications like clinically relevant diagnostic and therapeutic procedures, biotechnology, pharmaceutical engineering and food products is presented

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Object-Oriented Analysis and Design for Information Systems

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Object-Oriented Analysis and Design for Information Systems clearly explains real object-oriented programming in practice. Expert author Raul Sidnei Wazlawick explains concepts such as object responsibility, visibility and the real need for delegation in detail. The object-oriented code generated by using these concepts in a systematic way is concise, organized and reusable.

The patterns and solutions presented in this book are based in research and industrial applications. You will come away with clarity regarding processes and use cases and a clear understand of how to expand a use case. Wazlawick clearly explains clearly how to build meaningful sequence diagrams. Object-Oriented Analysis and Design for Information Systems illustrates how and why building a class model is not just placing classes into a diagram. You will learn the necessary organizational patterns so that your software architecture will be maintainable.
Learn how to build better class models, which are more maintainable and understandable.Write use cases in a more efficient and standardized way, using more effective and less complex diagrams.Build true object-oriented code with division of responsibility and delegation.

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Modern Concepts of Focal Epileptic Networks

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This volume of International Review of Neurobiology concentrates on modern concepts of focal epileptic networks. The volume addresses specific topics such as seizures (including transition and termination), limbic networks, alteration of metabolism, and neocortical focus and malformation of cortical development, among others.

Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews, and thematic volumes that focus on recent progress in a specific area of neurobiology research.
Our knowledge about the mechanisms involved in pathophysiology of epilepsy has rapidly expanded during last decade This special volume brings overview about modern concepts of epileptic focus organization and about the altered neural network dynamics which results in propensity of the brain tissue to generate spontaneous and repeated seizures

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Premysl Jiruska, Marco De Curtis, John G. R. Jefferys

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The Effects of Drug Abuse on the Human Nervous System

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Drug use and abuse continues to thrive in contemporary society worldwide and the instance and damage caused by addiction increases along with availability. The Effects of Drug Abuse on the Human Nervous System presents objective, state-of-the-art information on the impact of drug abuse on the human nervous system, with each chapter offering a specific focus on nicotine, alcohol, marijuana, cocaine, methamphetamine, MDMA, sedative-hypnotics, and designer drugs. Other chapters provide a context for drug use, with overviews of use and consequences, epidemiology and risk factors, genetics of use and treatment success, and strategies to screen populations and provide appropriate interventions. The book offers meaningful, relevant and timely information for scientists, health-care professionals and treatment providers.
A comprehensive reference on the effects of drug addiction on the human nervous system Focuses on core drug addiction issues from nicotine, cocaine, methamphetamine, alcohol, and other commonly abused drugs Includes foundational science chapters on the biology of addiction Details challenges in diagnosis and treatment options

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Plastics in Medical Devices is a comprehensive overview of the main types of plastics used in medical device applications. It focuses on the applications and properties that are most important in medical device design, such as chemical resistance, sterilization capability and biocompatibility. The roles of additives, stabilizers, and fillers as well as the synthesis and production of polymers are covered and backed up with a wealth of data tables.

Since the first edition the rate of advancement of materials technology has been constantly increasing. In the new edition Dr. Sastri not only provides a thorough update of the first edition chapters with new information regarding new plastic materials, applications and new requirements, but also adds two chapters one on market and regulatory aspects and supplier controls, and one on process validation. Both chapters meet an urgent need in the industry and make the book an all-encompassing reference not found anywhere else.
Comprehensive coverage of uses of polymers for medical devices Unique coverage of medical device regulatory aspects, supplier control and process validation Invaluable guide for engineers, scientists and managers involved in the development and marketing of medical devices and materials for use in medical devices