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Methods in Enzymology volumes provide an indispensable tool for the researcher. Each volume is carefully written and edited by experts to contain state-of-the-art reviews and step-by-step protocols.

In this volume, we have brought together a number of core protocols concentrating on RNA, complementing the traditional content that is found in past, present and future Methods in Enzymology volumes.
Indispensable tool for the researcher Carefully written and edited by experts to contain step-by-step protocols In this volume we have brought together a number of core protocols concentrating on RNA

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Public Debt Dynamics of Europe and the U.S.

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Public Debt Dynamics of Europe and the U.S., provides the evidence and implications of current policies by sovereigns and central banks, in dealing with the debt abyss. It brings in perspective the diversity of opinion reigning in modern economics and finance and outlines the themes which, among themselves, are defining the society in which we live.

Our epoch has accepted the theory that leveraging is good for a person, a company or even a nation. This has led to the debt syndrome and its disastrous aftereffects. Throughout the book evidence emerges that piling up public debt can lead to an unmitigated disaster. This is demonstrated through case studies on Greece, Spain, Italy, France and the United States in short, those western countries that nowadays have lost control of their senses and of their economy.

This book uses real life examples, using case studies as evidence of good and bad approaches to social, economic and financial life. Live events also help as undisputable demonstrators of successes and failures in the search for solutions in getting out of the hole western governments find themselves. As Denis Healey, a former British chancellor of the Exchequer, once said: The first law of holes is that if you are in one stop digging.
Provides insight and implications on the current policies of sovereigns and central banks Uses real life practical examples and case studies on Greece, Spain, Italy, France and the United States Examines developing countries, particularly BRICS, and their exposure to debt Focuses on public health and the effects it has on the economy

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Seismic Data Analysis Techniques in Hydrocarbon Exploration

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Seismic Data Analysis Techniques in Hydrocarbon Exploration explains the fundamental concepts and skills used to acquire seismic data in the oil industry and the step-by-step techniques necessary to extract the sections that trap hydrocarbons as well as seismic data interpretation skills.

It enhances the ability to interpret seismic data and use that data for basin evaluation, structural modeling of a fault, reservoir characterization, rock physics analysis, field development, and production studies.

Understanding and interpreting seismic data is critical to oil and gas exploration companies. Arming young geoscientists with a reference that covers the key principles of seismic data analysis will enhance their job knowledge, skills and performance. A fundamental grasp of seismic data enhances employability and aids scientists in functioning effectively when working with seismic data in industry.
Edited by a team of petroleum geoscientists with more than 30 years of experience in hydrocarbon exploration and data analysis at O&G; companies. More than 200 figures, photographs, and illustrations aid in the understanding of the fundamental concepts and techniques used to acquire seismic data Takes an easy-to-follow, step-by-step approach to presenting the techniques and skills used to extract the geologic sections from acquired seismic data. Enhances the geoscientists effectiveness when using seismic data for field development and other exploration and production studies

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Monolithic Nanoscale Photonics-Electronics Integration in Silicon and Other Group IV Elements

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Silicon technology is evolving rapidly, particularly in board-to-board or chip-to chip applications. Increasingly, the electronic parts of silicon technology will carry out the data processing, while the photonic parts take care of the data communication. For the first time, this book describes the merging of photonics and electronics in silicon and other group IV elements. It presents the challenges, the limitations, and the upcoming possibilities of these developments. The book describes the evolution of CMOS integrated electronics, status and development, and the fundamentals of silicon photonics, including the reasons for its rapid expansion, its possibilities and limitations. It discusses the applications of these technologies for such applications as memory, digital logic operations, light sources, including drive electronics, optical modulators, detectors, and post detector circuitry. It will appeal to engineers in the fields of both electronics and photonics who need to learn more about the basics of the other field and the prospects for the integration of the two.
Combines the topics of photonics and electronics in silicon and other group IV elements Describes the evolution of CMOS integrated electronics, status and development, and the fundamentals of silicon photonics

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From an Antagonistic to a Synergistic Predator Prey Perspective

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From an Antagonistic to a Synergistic Predator Prey Perspective: Bifurcations in Marine Ecosystems is a groundbreaking reference that challenges the widespread perception that predators generally have a negative impact on the abundance of their prey, and it proposes a novel paradigm  Predator-prey Synergism  in which both predator and prey enhance abundance by their co-existence. Using this model, the text explains a number of issues that appear paradoxical in the case of a negative predator-prey relationship, including observed ecosystem bifurcations (regime shifts), ecosystem resilience, red tides in apparently nutrient depleted water, and the dominance of grazed phytoplankton over non-grazed species under high grazing pressure. This novel paradigm can also be used to predict the potential impact of global warming on marine ecosystems, identify how marine ecosystem may respond to gradual environmental changes, and develop possible measures to mitigate the negative impact of increasing temperature in marine ecosystems. This book approaches the long-standing question of what generates recruitment variability in marine fishes and invertebrates in an engaging and unique way that students and researchers in marine ecosystems will understand. Introduces a new paradigm, Predator-prey Synergism, as a building block on which to construct new ecological theories. It suggests that Predator-prey Synergism is important in some terrestrial ecosystems and is in agreement with the punctuated equilibria theory of evolution (i.e., stepwise evolution). Suggests a general solution to the recruitment puzzle in marine organisms Proposes a holistic hypothesis for marine spring blooming ecosystems by considering variability enhancing and variability dampening processes Asserts that fisheries will induce variability in marine ecosystems and alter the energy flow patterns in predictable ways

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Cyber Security and IT Infrastructure Protection

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This book serves as a security practitioners guide to todays most crucial issues in cyber security and IT infrastructure. It offers in-depth coverage of theory, technology, and practice as they relate to established technologies as well as recent advancements. It explores practical solutions to a wide range of cyber-physical and IT infrastructure protection issues.

Composed of 11 chapters contributed by leading experts in their fields, this highly useful book covers disaster recovery, biometrics, homeland security, cyber warfare, cyber security, national infrastructure security, access controls, vulnerability assessments and audits, cryptography, and operational and organizational security, as well as an extensive glossary of security terms and acronyms.

Written with instructors and students in mind, this book includes methods of analysis and problem-solving techniques through hands-on exercises and worked examples as well as questions and answers and the ability to implement practical solutions through real-life case studies. For example, the new format includes the following pedagogical elements: Checklists throughout each chapter to gauge understanding Chapter Review Questions/Exercises and Case Studies Ancillaries: Solutions Manual; slide package; figure files

This format will be attractive to universities and career schools as well as federal and state agencies, corporate security training programs, ASIS certification, etc.
Chapters by leaders in the field on theory and practice of cyber security and IT infrastructure protection, allowing the reader to develop a new level of technical expertise Comprehensive and up-to-date coverage of cyber security issues allows the reader to remain current and fully informed from multiple viewpoints Presents methods of analysis and problem-solving techniques, enhancing the reader's grasp of the material and ability to implement practical solutions

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Fundamentals and Application of Spark Assisted Chemical Engraving

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Micro-machining is an advanced manufacturing technique of growing importance, and adoption of micro-machining using electrochemical discharges (Micro-ECDM) has increased steadily in recent years. Among new developments is the interest of industry in Micro-ECDM. However, the potential of the technology is not being fully utilized and there is no comprehensive reference book available today covering it. Micromachining Using Electrochemical Discharge Phenomenon, Second Edition fills this gap. It is unique in its detailed coverage of all aspects of the Micro-ECDM process, as well as Spark Assisted Chemical Engraving (SACE). As such, it covers technologies such as chemical etching, micro-drilling, and other material removal mechanisms, high aspect ratio machining, design and construction of the machining apparatus, and a wide range of applications. The new edition compares Micro-ECDM and SACE with other micromachining technologies such as laser machining and traditional EDM. ECDM is used for machining of electrically non-conductive materials. Micro-ECDM/SACE is mainly applied to glass and the book focuses on glass, but the authors also present new results on other materials such as ceramics. In addition, techniques to modify material properties for the machining process are explained. The authors discuss machining strategies including the latest developments in micro-texturing of glass micro-channels and reports on developments in controlling and analysis aspects of machining. This book is a unique reference for engineers and industrial researchers involved in development, design and use of micromachining, chemical micro-drilling or chemical engraving techniques and equipment.
Only all-encompassing reference coving Micro-ECDM and SACE available on the market Covers a wide range of applications, including applications in the MEMS industry and the Medical Devices and Medical Diagnostics industries New edition includes expanded sections on comparing Micro-ECDM/SACE with other micromachining technologies

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Engineered Uplift of Venice Through Seawater Injection

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The city of Venice, Italy, has been subjected to periodic flooding, or acqua alta, for centuries. Venice Shall Rise Again presents a unique proposition to halt this flooding. Based on years of work and experiment, experts Gambolati and Teatini describe an innovative yet technologically simple, economically inexpensive, and environmentally friendly project to raise Venice by 25-30 cm over ten years by injecting seawater into 650-1000 m deep geological formations. This project would be conducted under conditions of absolute safety, stability and integrity conserving the unique artistic and architectural patrimony of this deeply beloved city. Beginning with a brief history of the Venetian Republic, Venice Shall Rise Again addresses the actions undertaken by Venice to protect the city and the lagoon from the sea and land attack for more than a millennium, including the MoSE project, a system of mobile barriers presently under construction. Detailed in its engineering details and ideas, but with enough background information and context to help the interested reader understand the concepts, this book will be of interest to all readers concerned about the fate of Venice.
Provides a history of the technical measures taken by the Venetian Republic to preserve the lagoon and the city or Venice Details technical specifications of a new method to secure Venice against periodic flooding

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Techniques for More Effective and Strategic Drug Discovery

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A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research.
Highlights changes surrounding the strategy of drug discovery to provide you with a comprehensive reference featuring advances in the methods involved in lead optimization and more effective drug discovery Includes a new chapter on data-driven drug discovery in terms of the optimal design of pharmacological experiments to identify mechanism of action of new molecules Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data

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Chemostratigraphy: Concepts, Techniques, and Applications is the first collection of contributed articles that introduces young geoscientists to the discipline while providing seasoned practitioners with a standard reference that showcases the topics most recent research and application developments. This multi-contributed reference on one of the youngest and most dynamic branches of the geosciences includes articles from some of the worlds leading researchers. This book is a one-stop source of chemostratigraphy theory and application, helping geoscientists navigate through the wealth of new research that has emerged in recent years.
Edited by one of the worlds foremost chemostratigraphy experts Features contributed articles from a broad base of topics including stratigraphic correlation, hydrocarbon exploration, reservoir characterization, and paleo-climatic interpretation Includes a range of application-based case studies addressing spatio-temporal scales for practical, field-specific concepts

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Revised to include current components considered for todays unconventional and multi-fracture grids, Mechanics of Hydraulic Fracturing, Second Edition explains one of the most important features for fracture design the ability to predict the geometry and characteristics of the hydraulically induced fracture. With two-thirds of the worlds oil and natural gas reserves committed to unconventional resources, hydraulic fracturing is the best proven well stimulation method to extract these resources from their more remote and complex reservoirs. However, few hydraulic fracture models can properly simulate more complex fractures. Engineers and well designers must understand the underlying mechanics of how fractures are modeled in order to correctly predict and forecast a more advanced fracture network.

Updated to accommodate todays fracturing jobs, Mechanics of Hydraulic Fracturing, Second Edition enables the engineer to:
Understand complex fracture networks to maximize completion strategies Recognize and compute stress shadow, which can drastically affect fracture network patterns Optimize completions by properly modeling and more accurately predicting for todays hydraulic fracturing completions Discusses the underlying mechanics of creating a fracture from the wellbore Enhanced to include newer modeling components such as stress shadow and interaction of hydraulic fracture with a natural fracture, which aids in more complex fracture networks Updated experimental studies that apply to todays unconventional fracturing cases

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Unpredictable, unwanted, and costly, oil and gas well fishing is not a typical practice for drilling, workover and completion projects, but roughly one in every five wells experience this intervention. To stay on top, The Guide to Oilwell Fishing Operations, Second Edition will keep fishing tool product managers, drilling managers and all other well intervention specialists keyed in to all the latest tools, techniques and rules of thumb critical to conventional and complex wellbore projects, such as extended reach horizontal wells, thru-tubing, and coiled tubing operations.

Strengthened with updated material and a new chapter on wellbore cleaning, The Guide to Oilwell Fishing Operations, Second Edition ensures that the life of the well will be saved no matter the unforeseen circumstances. Crucial aspects include:
Enhancements with updated equipment, technology, and a new chapter on wellbore cleaning methods Additional input from worldwide service companies, providing a more comprehensive balance Remains the only all-inclusive guide exclusively devoted to fishing tools, techniques, and rules of thumb Remodeled with latest jars on the market, catch tools, and retrieving stuck packers with cutting technology Improved with information on methods such as sidetracking and plug-and-abandon operations Modernized with approaches and tactics on more advanced well projects such as high-angle deviated and horizontal wells and expandable casing technology to repair casing failure and leaks

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An Introduction to Aquatic Toxicology is an introductory reference for all aspects of toxicology pertaining to aquatic environments. As water sources diminish, the need to understand the effects that contaminants may have on aquatic organisms and ecosystems increases in importance. This book will provide you with a solid understanding of aquatic toxicology, its past, its cutting-edge present and its likely future.

An Introduction to Aquatic Toxicology will introduce you to the global issue of aquatic contamination, detailing the major sources of contamination, from where they originate, and their effects on aquatic organisms and their environment. State-of-the-art toxicological topics covered include nanotoxicology, toxicogenomics, bioinformatics, transcriptomics, metabolomics, as well as water management and the toxicological effects of major environmental issues such as algal blooms, climate change and ocean acidification.

This book is intended for anyone who wants to know more about the impact of toxicants on aquatic organisms and ecosystems, or to keep up to date with recent and future developments in the field.
Provides with the latest perspectives on the impacts of toxicants on aquatic environments, such as nanotoxicology, toxicogenomics, ocean acidification and eutrophication Offers a complete overview, beginning with the origins of aquatic toxicology and concluding with potential future challenges Includes guidance on testing methods and a glossary of aquatic toxicology terms

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Diet and Nutrition in Dementia and Cognitive Decline

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Diet and Nutrition in Dementia and Cognitive Decline offers researchers and clinicians a single authoritative source which outlines the complex interrelationships between cognitive decline, dementia and the way diet can be modified to improve outcomes. In a cross-disciplinary field like dementia research and practice, clinicians and researchers need a comprehensive resource which will quickly help them identify a range of nutritional components and how they affect cognitive decline and the development of dementia.

While the focus is on clinical applications, the book also features landmark and innovative preclinical studies that have served as the foundation of rigorous trials. Chapters explore the evidence of how nutritional components, either in the diet or supplements, can either impede the development to, or progression from, the onset of dementia. Authors investigate how conditions and processes overlap between defined conditions and present studies which show that dietary components may be equally effective in a number of conditions characterized by declining cognition or dementia. This book represents essential reading for researchers and practicing clinicians in nutrition, dietetics, geriatrics, nursing, neurology, and psychology, as well as researchers, such as neuroscientists, molecular and cellular biochemists, interested in dementia.

http://www.acnr.co.uk/2015/07/diet-and-nutrition-in-dementia-and-cognitive-decline/
Explores the complex interrelationships between cognitive decline, dementia and the way diet can be modified to improve outcomes Focuses on both clinical nutrition applications and the innovative preclinical studies that serve as the foundation for rigorous trials Covers specific conditions and mechanisms in dementias, as well as general aspects, risk factors, lifestyle and guidelines for practitioners Organizes chapter content in terms of the molecular, mechanistic, epidemiologic, and practical, so that correlations can be observed across conditions

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Developmental and Evolutionary Skeletal Biology

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Bones and Cartilage provides the most in-depth review and synthesis assembled on the topic, across all vertebrates. It examines the function, development and evolution of bone and cartilage as tissues, organs and skeletal systems. It describes how bone and cartilage develop in embryos and are maintained in adults, how bone is repaired when we break a leg, or regenerates when a newt grows a new limb, or a lizard a new tail.

The second edition of Bones and Cartilage includes the most recent knowledge of molecular, cellular, developmental and evolutionary processes, which are integrated to outline a unified discipline of developmental and evolutionary skeletal biology. Additionally, coverage includes how the molecular and cellular aspects of bones and cartilage differ in different skeletal systems and across species, along with the latest studies and hypotheses of relationships between skeletal cells and the most recent information on coupling between osteocytes and osteoclasts All chapters have been revised and updated to include the latest research.
Offers complete coverage of every aspect of bone and cartilage, with updated references and extensive illustrations Integrates development and evolution of the skeleton, as well a synthesis of differentiation, growth and patterning Treats all levels from molecular to clinical, embryos to evolution, and covers all vertebrates as well as invertebrate cartilages Includes new chapters on evolutionary skeletal biology that highlight normal variation and variability, and variation outside the norm (neomorphs, atavisms) Updates hypotheses on the origination of cartilage using new phylogenetic, cellular and genetic data Covers stem cells in embryos and adults, including mesenchymal stem cells and their use in genetic engineering of cartilage, and the concept of the stem cell niche

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Sertoli Cell Biology, Second Edition summarizes the progress since the last edition and emphasizes the new information available on Sertoli/germ cell interactions. This information is especially timely since the progress in the past few years has been exceptional and it relates to control of sperm production in vivo and in vitro. Fully revised Written by experts in the field Summarizes 10 years of research Contains clear explanations and summaries Provides a summary of references over the last 10 years

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Advances in Planar Lipid Bilayers and Liposomes

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Advances in Planar Lipid Bilayers and Liposomes volumes cover a broad range of topics, including main arrangements of the reconstituted system, namely planar lipid bilayers as well as spherical liposomes. The invited authors present the latest results of their own research groups in this exciting multidisciplinary field.
Incorporates contributions from newcomers and established and experienced researchers Explores the planar lipid bilayer systems and spherical liposomes from theoretical and experimental perspectives Serves as an indispensable source of information for new scientists

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Modeling Enterprise Architecture with TOGAF

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Modeling Enterprise Architecture with TOGAF explains everything you need to know to effectively model enterprise architecture with The Open Group Architecture Framework (TOGAF), the leading EA standard. This solution-focused reference presents key techniques and illustrative examples to help you model enterprise architecture.

This book describes the TOGAF standard and its structure, from the architecture transformation method to governance, and presents enterprise architecture modeling practices with plenty of examples of TOGAF deliverables in the context of a case study.

Although widespread and growing quickly, enterprise architecture is delicate to manage across all its dimensions. Focusing on the architecture transformation method, TOGAF provides a wide framework, which covers the repository, governance, and a set of recognized best practices. The examples featured in this book were realized using the open source Modelio tool, which includes extensions for TOGAF.
Includes intuitive summaries of the complex TOGAF standard to let you effectively model enterprise architecture Uses practical examples to illustrate ways to adapt TOGAF to the needs of your enterprise Provides model examples with Modelio, a free modeling tool, letting you exercise TOGAF modeling immediately using a dedicated tool Combines existing modeling standards with TOGAF

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Design of Experiments for Engineers and Scientists

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The tools and techniques used in Design of Experiments (DoE) have been proven successful in meeting the challenge of continuous improvement in many manufacturing organisations over the last two decades. However research has shown that application of this powerful technique in many companies is limited due to a lack of statistical knowledge required for its effective implementation.

Although many books have been written on this subject, they are mainly by statisticians, for statisticians and not appropriate for engineers. Design of Experiments for Engineers and Scientists overcomes the problem of statistics by taking a unique approach using graphical tools. The same outcomes and conclusions are reached as through using statistical methods and readers will find the concepts in this book both familiar and easy to understand.

This new edition includes a chapter on the role of DoE within Six Sigma methodology and also shows through the use of simple case studies its importance in the service industry. It is essential reading for engineers and scientists from all disciplines tackling all kinds of manufacturing, product and process quality problems and will be an ideal resource for students of this topic. Written in non-statistical language, the book is an essential and accessible text for scientists and engineers who want to learn how to use DoE Explains why teaching DoE techniques in the improvement phase of Six Sigma is an important part of problem solving methodology New edition includes a full chapter on DoE for services as well as case studies illustrating its wider application in the service industry

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In Contemporary Financial Intermediation, Third Edition, Greenbaum, Thakor and Boot offer a distinctive approach to financial markets and institutions, presenting an integrated portrait that puts information at the core.

Instead of simply naming and describing markets, regulations, and institutions as competing books do, the authors explore the endless subtlety and plasticity of financial institutions and credit markets.

This edition has six new chapters and increased, enhanced pedagogical supplements. The book is ideal for anyone working in the financial sector, presenting professionals with a comprehensive understanding of the reasons why markets, institutions, and regulators act as they do. Readers will find an unmatched, thorough discussion of the world's financial markets and how they function.
Provides a distinctive and thought-provoking approach to the world's financial markets Explores the endless subtleties and plasticity of financial institutions and credit markets Newly revised, with six new chapters and increased pedagogical supplements Presents anyone working in the financial markets and sector with a comprehensive understanding of the inner workings of world markets

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Stuart I. Greenbaum, Anjan V. Thakor, Arnoud W. A. Boot