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Understanding the Rare Disease Market and its Dynamics

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This authoritative and comprehensive book makes the reader familiar with the processes of bringing orphan drugs to the global market. There are between 5,000 and 7,000 rare diseases and the number of patients suffering from them is estimated to be more than 50 million in the US and Europe. Before the orphan drug legislation enacted in the US in 1983, there was a limited interest from industry to develop treatment for very small patient groups. One of the difficulties is, of course, that similar levels of investment are needed from a pharmaceutical company to bring a drug to the market for both small and large patient groups.The journey from application of an orphan drug designation to a reimbursed market- approved drug is long and many obstacles occur during the journey.After reading the book, readers will: Understand who the players/stakeholders are in the rare orphan disease field and their specific needs and concerns: patients and patient organizations, researchers and treating physicians within the field, industry, regulatory and reimbursement bodies* Understand the strong partnership between the different players and the various initiatives to improve and increase access to treatment for patients; minimizing the gap between numbers of known diseases, orphan designations, approved drugs and paid drugs.The book also provides short practical case stories from patients and researchers, as well as representatives from industry and authorities on the challenges they came across in developing orphan drugs or getting access to orphan drugs.A comprehensive overview of strategy, key activities and considerations of how to bring an orphan drug from concept to the market and make it available to patientsA source of updated information, news and trends for those who are already active in this fast-evolving fieldCovers the global definitions and the criteria for getting an orphan drug designation in, for example, the US and Europe

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Specialist yarn, woven and fabric structures are key elements in the manufacturing process of many different types of textiles with a variety of applications. This book explores a number of different specialist structures, discussing the developments in technology and manufacturing processes that have taken place in recent years.

With its distinguished editor and international team of contributors, Specialist yarn, woven and fabric structures is essential reading for all textile researchers, technicians, engineers and technologies, and will also be suitable for academic purposes.Looks at developments that have occurred in the manufacturing of specialist yarn, weave and fabric structuresDiscusses different types of specialist yarn structures, such as hybrid, fancy and compound yarnsOffers insight into multicomponent fabric structures such as 3D nonwovens, flocked, knotted and jacquard woven fabrics

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Optimisation of Composite Structures Design

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Composite materials have been used more and more during the last decade to lighten structures. But until now, there has been no clear way of establishing how to design properly optimised laminated composite plates with no reduction in strength. Most modern references lack adequate information for the designer wanting to tailor or synthesise a design. This exciting package offers a solution. It relates the theory of composite materials to real life and provides 'rules' for designing composites structures properly and in an optimum way.In the book, Professor Miravete demonstrates the optimisation of beams, plates and sandwich constructions in the designs of advanced composite materials. He also illustrates optimal material systems, fibre orientations and lay-up through functions of geometry, load type and boundary conditions. The associates software, on two disks, will enableusers to adapt the information to their own requirements and is very user-friendly with helpful manuals. This will be an essential package for designers and engineers in a wide range of areas, from aeronautics to automotive andmarine as well as general industry.Chapter 1 provides a general background on composite materials.Chapters 2, 3, 4, and 5 are concerned with constant thickness composite structures, and provide a survey of various design methodologies of shells, plates and sandwich constructions.Chapters 6, 7, 8 and 9 examine variable thickness composite structures, and consider beams, plates and sandwiches.A completemanual for anyone concerned with designing composite structuresIncludes book and used-friendly softwareCan be easily applied to any area - aeronautics, automotive, marine or general industry

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Enhancing Learning and Teaching Through Student Feedback in Engineering

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Student feedback has appeared in the forefront of higher education quality, particularly the issues of effectiveness and the use of student feedback to affect improvement in higher education teaching and learning, and other areas of the students tertiary experience. Despite this, there has been a relative lack of academic literature available, especially in a book format. This book focuses on the experiences of academics, higher education leaders and managers with expertise in these areas.Enhancing Learning and Teaching through Student Feedback in Engineering is the first in a series on student feedback focusing on a specific discipline, in this case engineering. It expands on topics covered in the previous book, by the same authors. Valuable contributions have been made from a variety of experts in the area of higher education quality and student feedback in the field of engineering.Will interrogate student feedback in engineering, on the basis of establishing a better understanding of its forms, purposes and effectiveness in learningThe first book of its kind on student feedback in engineering education and will be a scholarly resource for all stakeholders to enhance learning and teaching practices thorough student feedbackWritten by experienced academics, experts and practitioners in the area

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Chenicheri Sid Nair, Arun Patil, Patricie Mertova

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Disinfection By-Products in Drinking Water

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This volume brings together contributors from water regulators, and water suppliers in Europe and North America to discuss the main issues associated with reaching a cost-effective balance between microbial and chemical risks. Overviews of research are presented alongside illuminating case studies of the practical approaches taken by water companies and regulators on both sides of the Atlantic.

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Optical coatings, including mirrors, anti-reflection coatings, beam splitters, and filters, are an integral part of most modern optical systems. Optical thin films and coatings provides an overview of thin film materials, the properties, design and manufacture of optical coatings and their use across a variety of application areas.

Part one explores the design and manufacture of optical coatings. Part two highlights unconventional features of optical thin films including scattering properties of random structures in thin films, optical properties of thin film materials at short wavelengths, thermal properties and colour effects. Part three focusses on novel materials for optical thin films and coatings and includes chapters on organic optical coatings, surface multiplasmonics and optical thin films containing quantum dots. Finally, applications of optical coatings, including laser components, solar cells, displays and lighting, and architectural and automotive glass, are reviewed in part four.

Optical thin films and coatings is a technical resource for researchers and engineers working with optical thin films and coatings, professionals in the security, automotive, space and other industries requiring an understanding of these topics, and academics interested in the field.An overview of the materials, properties, design and manufacture of thin filmsSpecial attention is given to the unconventional features and novel materials of optical thin filmsReviews applications of optical coatings including laser components, solar cells, glasing, displays and lighting

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8th International Conference on Compressors and their Systems

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This book contains the papers from the 2013 International Conference on Compressors and Their Systems, held from 9-10 September at City University London. The long-running conference series is the ultimate global forum for reviewing the latest developments and novel approaches in compressor research. High-quality technical papers are sourced from around the globe, covering technology development, operation, maintenance and reliability, safety and environmental impact, energy efficiency and carbon footprint, system integration and behaviour, upgrades and refurbishment, design and manufacture, education and professional development. All the papers are previously unpublished and constitute leading edge research.Presents leading edge developments in compressor technologyGives the latest prediction and modelling techniquesDetails the new technology and machinery

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A detailed original perspective from a leading expert on welding metallurgy of the self-shielded arc welding process and its applications. The author explains the basic process metallurgy of the process and its relationship with other arc welding processes. He promotes self-shielded arc welding (SSAW) as a distinct process in its own right, dispels some widely held misconceptions, and sets out to bring its existence and advantages to the attention of designers and fabricators.

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Fatigue Design Procedure for Welded Hollow Section Joints

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Recommendations of IIW Subcommission XV-E

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This International Institute of Welding (IIW) report was presented at the 52nd Annual Assembly in Lisbon in June 1999. It contains recommendations representing a consensus on international best practice, focusing on a 'hot spot stress' approach.A wide range of joint types is covered, the new fatigue design curve for both RHS and CHS is dealt with and detailed values for stress concentration factors are provided.The purpose of this current IIW document is to serve both as an International Standards Organisation (ISO) draft specification and as a model standard for national and regional specifications worldwide.The Recommendations (Part one) and Commentary (Part two) were edited by Dr X-L Zhao of Monash University, Australia and Professor J A Packer of the University of Toronto, Canada.

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Securing the Safety of Navigation in East Asia

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Safe navigation of the seas is of global importance. Sea lanes provide vital connections for the growth of the global economy and the wellbeing of people everywhere. The sea lanes are of particular importance for the East Asian region, as most trade is undertaken on the ocean. Booming economies in the region such as China and Vietnam put more pressure on sea lanes, triggering concern for the safety of navigation. Securing the Safety of Navigation in East Asia identifies salient issues for academic debate, and further explores those that have practical implications for the safety of navigation in East Asia. Contemporary maritime security concentrates on safe navigation and inhibiting transnational crimes, including sea piracy and maritime terrorism. Maritime environmental security and search and rescue at sea are also important. Securing the Safety of Navigation in East Asia is structured into four sections: the first part introduces the topic, and looks at the safety of navigation and the search for a cooperative mechanism. The second part considers the international legal framework and its implications for East Asia. The third part presents national perspectives on the safety of navigation, and fi nally part four considers navigational issues in the South China Sea.Places a special focus on East AsiaAccommodates national perspectives in East Asia on navigation given by scholars from China, Japan, South Korea, Malaysia, the Philippines, and SingaporePresents a special section on the South China Sea, located in Southeast Asia and connecting the Indian and Pacific oceans; a critical sea route for maritime transport

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Understanding and Improving the Durability of Textiles

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The ability of a fabric to resist wear is an essential aspect of its performance. Understanding and improving the durability of textiles provides a comprehensive guide to the factors affecting the durability of a range of different textiles.Part one addresses the different factors that affect textile durability, including the influence of fabric construction and fibre type, as well as properties affecting strength and dimensional stability. Colour fastness and the effects of light are discussed, along with methods for testing and improving wrinkle-resistance and textile durability. Part two goes on to explore the durability of particular types of textile including antimicrobial textiles, protective clothing, historic textiles, silk and geotextiles.With its distinguished editor and international team of expert contributors, Understanding and improving the durability of textiles is an indispensable book for textile scientists, technologists, engineers and those designing, testing and manufacturing textiles. It also provides a comprehensive guide to textile durability for researchers and academics of all levels in this sector.Provides a comprehensive guide to the factors affecting the durability of a range of different textilesDiscusses colour fastness and the effects of light, and methods for testing and improving wrinkle-resistance and textile durabilityExplores the durability of particular types of textile

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Advances in Science and Technology of Mn+1AXn Phases

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Advances in Science and Technology of Mn+1AXn Phases presents a comprehensive review of synthesis, microstructures, properties, ab-initio calculations and applications of Mn+1AXn phases and targets the continuing research of advanced materials and ceramics. An overview of the current status, future directions, challenges and opportunities of Mn+1AXn phases that exhibit some of the best attributes of metals and ceramics is included. Students of materials science and engineering at postgraduate level will value this book as a reference source at an international level for both teaching and research in materials science and engineering. In addition to students the principal audiences of this book are ceramic researchers, materials scientists and engineers, materials physicists and chemists. The book is also an invaluable reference for the professional materials and ceramics societies.The most up-to-date and comprehensive research data on MAX phases is presentedWritten by highly knowledgeable and well-respected researchers in the fieldDiscusses new and unusual properties

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Handbook of Mems for Wireless and Mobile Applications

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The increasing demand for mobile and wireless sensing necessitates the use of highly integrated technology featuring small size, low weight, high performance and low cost: micro-electro-mechanical systems (MEMS) can meet this need. The Handbook of MEMS for wireless and mobile applications provides a comprehensive overview of radio frequency (RF) MEMS technologies and explores the use of these technologies over a wide range of application areas.Part one provides an introduction to the use of RF MEMS as an enabling technology for wireless applications. Chapters review RF MEMS technology and applications as a whole before moving on to describe specific technologies for wireless applications including passive components, phase shifters and antennas. Packaging and reliability of RF MEMS is also discussed. Chapters in part two focus on wireless techniques and applications of wireless MEMS including biomedical applications, such as implantable MEMS, intraocular pressure sensors and wireless drug delivery. Further chapters highlight the use of RF MEMS for automotive radar, the monitoring of telecommunications reliability using wireless MEMS and the use of optical MEMS displays in portable electronics.With its distinguished editor and international team of expert authors, the Handbook of MEMS for wireless and mobile applications is a technical resource for MEMS manufacturers, the electronics industry, and scientists, engineers and academics working on MEMS and wireless systems.Reviews the use of radio frequency (RF) MEMS as an enabling technology for wireless applicationsDiscusses wireless techniques and applications of wireless MEMS, including biomedical applicationsDescribes monitoring structures and the environment with wireless MEMS

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Solving Disputes for Regional Cooperation and Development in the South China Sea

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This book discusses the South China Sea dispute from a Chinese perspective with regards to history, law, international politics, the economy, diplomacy and military affairs. Not only does it detail Chinas official position on the sovereignty and maritime disputes in the South China Sea, but also provides analyses of the related factors influencing the origin and development of these disputes. It further assesses the complexity, internationalisation and long-term struggle over the South China Sea and Chinas efforts in dispute resolution.

Solving Disputes for Regional Cooperation and Development aims to help readers better understand a Chinese perspective on the complexity of the South China Sea disputes, including competition over the sovereignty of the islets, islands regime and its impact on maritime delimitation, overlapping maritime claims, and how the adjacent states can cooperate for resource development in the South China Sea.

This title is highly pertinent in the context of the growing attention paid to potential international conflicts in the South China Sea, and covers a wide range of topics including history, law, international politics, economy, diplomacy and military affairs.Highly pertinent in the context of the growing attention paid to potential international conflicts in the South China SeaCovers a wide range of topics including history, law, international politics, economy, diplomacy and military affairsOne of the very few books written by a Chinese scholar in English in this area

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The field of fibre rope technology has witnessed incredible change and technological advance over the last few decades. At the forefront of this change has been the development of synthetic fibres and modern types of rope construction. This handbook updates the history and structural mechanics of fibre rope technology and describes the types and properties of modern rope-making materials and constructions.Following an introduction to fibre ropes, the Handbook of fibre rope technology takes a comprehensive look at rope-making materials, rope structures, properties and mechanics and covers rope production, focusing on laid strand, braided, low-twist and parallel yarn ropes. Terminations are also introduced and the many uses of rope are illustrated. The key issues surrounding the inspection and retirement of rope are identified and rope testing is thoroughly examined. The final two chapters review rope markets, distribution and liability and provide case studies from the many environments in which fibre rope is used.The Handbook of fibre rope technology is an essential reference for everyone assisting in the design, selection, use, inspection and testing of fibre rope.A comprehensive look at rope-making materials and structures, properties and mechanicsCovers rope production including laid strand, braided, low-twist and parallel yarn ropes and rope terminationsRope testing is examined in depth, as well as the key issues surrounding rope retirement

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Problem Solving and Training Strategies for Success in the Pharmaceutical and Life Science Industries

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Quality assurance is necessary to maintain quality and services in the pharmaceutical and life science industries. Quality assurance demonstrates that the logic and practice of problem solving can integrate both program efficacy and regulatory compliance. This title is divided into three parts; the first part discusses the process by which a problem in regulated industry is identified, for example a manufacturing deviation that leads to an adulterated drug product, and reviews the decision-making steps involved in remedying the problem. The second part delves into the staff training requirements of procedures that are thereby revised. The third part expands on this discussion by considering piloting the proposed training module, preparing assessments of trainee proficiency, evaluating the training module, including integrating rigorous evaluative designs with formative program improvement, and documenting the entire effort.Presents a comprehensive view of the field of quality assuranceAn approach grounded in direct experienceUses diagrams and figures to clarify analytical points

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This major handbook provides comprehensive coverage of the manufacture, processing and applications of high tech textiles for a huge range of applications including: heat and flame protection; waterproof and breathable fabrics; textiles in filtration; geotextiles; medical textiles; textiles in transport engineering and textiles for extreme environments.Handbook of technical textiles is an essential guide for textile yarn and fibre manufacturers; producers of woven, knitted and non-woven fabrics; textile finishers; designers and specifiers of textiles for new or novel applications as well as lecturers and graduate students on university textile courses.Comprehensive handbook for all aspects of technical textilesDetailed coverage of processes, fabric structure and applicationsContributions from recognised experts world-wide

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Sterilisation of Biomaterials and Medical Devices

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The effective sterilisation of any material or device to be implanted in or used in close contact with the human body is essential for the elimination of harmful agents such as bacteria. Sterilisation of biomaterials and medical devices reviews established and commonly used technologies alongside new and emerging processes.Following an introduction to the key concepts and challenges involved in sterilisation, the sterilisation of biomaterials and medical devices using steam and dry heat, ionising radiation and ethylene oxide is reviewed. A range of non-traditional sterilisation techniques, such as hydrogen peroxide gas plasma, ozone and steam formaldehyde, is then discussed together with research in sterilisation and decontamination of surfaces by plasma discharges. Sterilisation techniques for polymers, drug-device products and tissue allografts are then reviewed, together with antimicrobial coatings for self-sterilisation and the challenge presented by prions and endotoxins in the sterilisation of reusable medical devices. The book concludes with a discussion of future trends in the sterilisation of biomaterials and medical devices.With its distinguished editors and expert team of international contributors, Sterilisation of biomaterials and medical devices is an essential reference for all materials scientists, engineers and researchers within the medical devices industry. It also provides a thorough overview for academics and clinicians working in this area.Reviews established and commonly used technologies alongside new and emerging processesIntroduces and reviews the key concepts and challenges involved in sterilisationDiscusses future trends in the sterilisation of biomaterials and medical devices

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Advanced Materials in Automotive Engineering

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The automotive industry is under constant pressure to design vehicles capable of meeting increasingly demanding challenges such as improved fuel economy, enhanced safety and effective emission control. Drawing on the knowledge of leading experts, Advanced materials in automotive engineering explores the development, potential and impact of using such materials.Beginning with a comprehensive introduction to advanced materials for vehicle lightweighting and automotive applications, Advanced materials in automotive engineering goes on to consider nanostructured steel for automotive body structures, aluminium sheet and high pressure die-cast aluminium alloys for automotive applications, magnesium alloys for lightweight powertrains and automotive bodies, and polymer and composite moulding technologies. The final chapters then consider a range of design and manufacturing issues that need to be addressed when working with advanced materials, including the design of advanced automotive body structures and closures, technologies for reducing noise, vibration and harshness, joining systems, and the recycling of automotive materials.With its distinguished editor and international team of contributors, Advanced materials in automotive engineering is an invaluable guide for all those involved in the engineering, design or analysis of motor vehicle bodies and components, as well as all students of automotive design and engineering.Explores the development, potential and impact of using advanced materials for improved fuel economy, enhanced safety and effective mission control in the automotive industryProvides a comprehensive introduction to advanced materials for vehicle lightweighting and automotive applicationsCovers a range of design ideas and manufacturing issues that arise when working with advanced materials, including technologies for reducing noise, vibration and harshness, and the recycling of automotive materials

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Finite Element Modelling of Composite Materials and Structures

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Finite element modelling of composite materials and structures provides an introduction to a technique which is increasingly being used as an analytical tool for composite materials.The text is presented in four parts:Part one sets the scene and reviews the fundamentals of composite materials together with the basic nature of FRP and its constituents. Two-dimensional stress-strain is covered, as is laminated plated theory and its limitations. Part two reviews the basic principles of FE analysis, starting with underlying theoretical issues and going on to show how elements are derived, a model is generated and results are processed. Part three builds on the basics of FE analysis and considers the particular issues that arise in applying finite elements to composites, especially to the layered nature of the material. Part four deals with the application of FE to FRP composites, presenting analytical models alongside FE representations. Specific issues addressed include interlaminar stresses, fracture delamination, joints and fatigue.This book is invaluable for students of materials science and engineering, and for engineers and others wishing to expand their knowledge of structural analysis.Covers important work on finite element analysis of composite material performanceBased on material developed for an MSc course at Imperial College, London, UKCovers particular problems such as holes, free edges with FE results compared with experimental data and classical analysis

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F L Matthews, G A O Davies, D Hitchings, C Soutis