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From the Laboratory to Clinical Practice

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Human papillomavirus (HPV) is one of the most common causes of sexually transmitted diseases worldwide, both in men and women. Human papillomavirus infections provides the scientific background needed to understand the natural history and pathogenesis of HPV infection and offers discussion of its clinical features, diagnosis, treatment and prevention. The book begins with chapters covering the epidemiology, virology, history and transmission of the infection, as well as its pathogenesis and clinical features. Following a discussion of the relationship between HPV and cancer, chapters in the second half of the book look at diagnosis, testing and treatment. The book concludes with detailed coverage of the prevention of HPV through worldwide vaccination programmes.Covers all the important issues relating to both male and female HPV infectionProvides overview of the current knowledge about epidemiology, basic virology, pathogenesis and diagnosis methodsExplores the relationship between HPV and cancer

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Practical Approaches to formulation in the Laboratory, Manufacturing, and the Clinic

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Therapeutic protein drug products provides a comprehensive overview of therapeutic protein drug products, with an emphasis on formulation beginning in the laboratory, followed by manufacturing and administration in the clinic. A list of many commercial therapeutic drug products are described and include the product name, dosages, active concentration, buffer, excipients, Ph, container type and route of administration. The laboratory formulation sections focus on the most common buffers, excipients, and Ph ranges that are commonly tested in addition to systematic approaches. A brief section on biophysical and analytical analysis is also provided. Properties of therapeutic protein formulations are described and include opalescence, phase separation, color, and subvisible particles. An emphasis is placed on material and process testing to ensure success during manufacturing. The drug product manufacturing process, which includes the process of compounding to filling, is also covered. Methods of delivery in the clinic are addressed, as well as delivery strategies. Finally, a perspective on the regulatory requirements for therapeutic protein formulations is discussed.Provides a list and description of commercially available therapeutic drug products and their formulationsA comprehensive and practical overview of protein formulation in the laboratory, manufacturing, and the clinicDiscusses recent topics including high protein concentration, phase separation, opalescence, and subvisible particles

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From in Silico Screening to Experimental Validation

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In recent years, a number of academic and commercial software packages and databases have been developed for the analysis and screening of biological data; however, the usability of these data is compromised by so-called novel genes to which no biological function is assigned. Annotating new genes outlines an approach to the analysis of evolutionary-conserved, heart-enriched genes with unknown functions, offering a step-by-step description of the procedure from screening to validation. The book begins by offering an introduction to the databases and software available, before moving on to cover programming guidelines, including a specific case study on the use of C-It for in silico screening. The second half of the book offers a step-by-step guide to experimental validation concepts and procedures, as well as an overview of additional potential applications of this approach in the field of stem cells and tissue regeneration, before a concluding chapter summarises the concepts and theories presented.Focuses not only on screening but also on biological validationsProvides details of databases and software (web interface) products for biologists with minimal computation skillsOffers a step-by-step outline of the procedure involved

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A new edition of a well established and respected textbook from an author who is a recognised authority in this field. Joining techniques are one of the key technologies in materials engineering and this book provides comprehensive coverage of the subject. It is intended for undergraduate and graduate students of metallurgy, as well as those attending specialist welding courses.It is also a valuable source of reference for practising engineers and metallurgists concerned with joining processes. The text covers the metallurgical changes that take place during the welding process, the properties of welded joints, defects associated with welding and the behaviour of welded joints in service. There is a chapter devoted to joints between metals and ceramics, and on the use of structural adhesives. The various techniques used in microwelding and the joining of solid-state devices to printed circuit boards are briefly described.In addition to revising and updating the text throughout the author has made some specific alterations and additions to the book:Brittle and ductile behaviour of solids, ductile francture, and the velocity of crack propogation are now included in the section on Fracture; Friction stir welding in now included; There is an additional chapter on adhesive bonding which includes bonding; forces, polymer chemistry, types of adhesive, production technology, quality control and applications; The section on heat flow has been expanded and includes worked examples; A section on weld defects and the evaluation of non-destructive tests has been added; A section on the welding metallurgy of aluminium-lithium alloys has been added; A new section describes major structural failure in such catastrophes as the 'Alexander L Kielland' accident and the Kobe earthquake, and considers the role of welding in such failures.

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Threats and Opportunities in the Years Ahead

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This report provides a detailed overview of the market position and outlook in these two closely related metals, looking at supply and demand trends in each individually and addressing key issues for the future, including the impact of developments in the environmental arena and the recycling marketplace.A clear and detailed analysis of the industry and its major marketsA survey of trends in mining, refining, processing, end-use and consumptionUnique industry and market forecasts

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This book focuses on the plastic property of materials, and the way in which structures made of such material behave under load. It is intended for civil, mechanical, electro-mechanical, marine, and aeronautical engineers for under-graduate or post-graduate courses or research, and professionals in industry. Professor Calladine, from long experience in teaching, research and industry, here delivers a readable and authoritative account of theory and applications. He presents the classical "perfect plasticity material" as a model of irreversible mechanical behaviour, using this perfect plasticity property to analyse a range of continuum structural problems and metal-forming processes relevant to engineering practice.

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Qualitative Research and the Modern Library

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Qualitative Research and the Modern Library examines the present-day role and provides suggestions for areas that might be suited to this type of research for the purposes of evaluation. The author discusses how the results from such research might be applied, and the overall impact of using this type of research to inform development of a more user-centred organisation. The book provides a thoughtful look at the implications of using qualitative research to inform decision-making processes within libraries and is written by an author and library researcher with international experience in various types of libraries, implementing/improving programs and services, and supporting user needs.Fills a gap in the current literature that hasnt been found in journal articles written on this topicContains practical applications of qualitative research principles, with practical examples of select projectsWritten by an author and library researcher with international experience in various types of libraries, including work with large-scale qualitative studies, research design and evaluation of library services

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Microfluidic Devices for Biomedical Applications

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Microfluidics or lab-on-a-chip (LOC) is an important technology suitable for numerous applications from drug delivery to tissue engineering. Microfluidic devices for biomedical applications discusses the fundamentals of microfluidics and explores in detail a wide range of medical applications.

The first part of the book reviews the fundamentals of microfluidic technologies for biomedical applications with chapters focussing on the materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies. Chapters in part two examine applications in drug discovery and controlled-delivery including micro needles. Part three considers applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering. The final part of the book covers the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis.

Microfluidic devices for biomedical applications is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries.Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores in detail a wide range of medical applicationsConsiders materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologiesConsiders applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds and stem cell engineering

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This book presents a comprehensive treatment of both functional and decorative textiles used in the automotive industry including seat covers, headliners, airbags, seat belts and tyres. Written in a clear, concise style it explains material properties and the way in which they influence manufacturing processes as well as providing practical production details.

The subject treatment cuts across the disciplines of textile chemistry, fabric and plastics technology and production engineering. Environmental effects and recycling are also covered. It is aimed at the design and process engineer in industry as well as researchers in universities and colleges. Quality engineers will also benefit from the book's sections on identifying problems and material limitations.

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Eco-efficient concrete is a comprehensive guide to the characteristics and environmental performance of key concrete types.Part one discusses the eco-efficiency and life cycle assessment of Portland cement concrete, before part two goes on to consider concrete with supplementary cementitious materials (SCMs). Concrete with non-reactive wastes is the focus of part three, including municipal solid waste incinerator (MSWI) concrete, and concrete with polymeric, construction and demolition wastes (CDW). An eco-efficient approach to concrete carbonation is also reviewed, followed by an investigation in part four of future alternative binders and the use of nano and biotech in concrete production.With its distinguished editors and international team of expert contributors, Eco-efficient concrete is a technical guide for all professionals, researchers and academics currently or potentially involved in the design, manufacture and use of eco-efficient concrete.The first part of the book examines the eco-efficiency and life cycle assessment of Portland cement concreteChapters in the second part of the book consider concrete with supplementary cementitious materials, including properties and performanceReviews the eco-efficient approach to concrete carbonation

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Fernando Pacheco-Torgal, S Jalali, Joao Labrincha, V M John

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Biscuit, Cookie and Cracker Manufacturing Manuals

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Manual 4: Baking and Cooling of Biscuits

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This manual explains the principles and machinery involved in baking and post-baking processes, and the key issues in maintaining both quality and throughput.

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Impact Behaviour of Fibre-Reinforced Composite Materials and Structures

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This study covers impact response, damage tolerance and failure of fibre-reinforced composite materials and structures. Materials development, analysis and prediction of structural behaviour and cost-effective design all have a bearing on the impact response of composites and this book brings together for the first time the most comprehensive and up-to-date research work from leading international experts.State of the art analysis of impact response, damage tolerance and failure of FRC materialsDistinguished contributors provide expert analysis of the most recent materials and structuresValuable tool for R&D; engineers, materials scientists and designers

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Biscuit, Cookie and Cracker Manufacturing Manuals

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Manual 5: Secondary Processing in Biscuit Manufacturing

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This manual takes readers through such secondary processes as coating, sandwiching and icing, concentrating on common production problems and how they can be solved.

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This second edition of an established and well received book has been carefully revised, in many instances by the original authors, and enlarged by the addition of two completely new chapters. These deal with the use of computers in the paint industry and with the increasingly important subject of health and safety. The chapter on pigments has also been re-written by an author new to this edition.

It was the editors intention in the first edition to provide science graduates entering the paint industry with a bridge between academia and the applied science and technology of paints. The great strength and appeal of this book remains that it deals with the technology of paints and surface coatings while also providing a basic understanding of the chemistry and physics of coatings.Extensive revision of first editionNew chapter on computers and modellingNew chapter on health and safety

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Whole Brain Learning in Higher Education

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Facilitating of learning in higher education can be transformed through the use of Whole Brain learning. Whole Brain Learning in Higher Education argues that facilitating learning in Higher Education should undergo transformation in order to develop the full academic potential of all stakeholders following the principles of action research. Empirical data was collected from participants in a number of projects across diverse disciplines. Participants included students, academic staff, instructional designers, and professionals attending short courses at tertiary level.

A number of case studies are discussed as evidence for the value of the proposed model for higher education. This title consists of seven chapters, covering: the theoretical framework, baseline study, professional development, studies in Whole Brain application, learning material that makes a difference, multidisciplinary collaboration, and the way forward.Defines Whole Brain learningExplains the rationale behind Whole Brain learningDemonstrates how the model can be applied in facilitating Whole Brain learning in order to develop the full academic potential of students

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Ann-Louise de Boer, Pieter du Toit, Detken Scheepers, Theo Bothma

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Open Source Software in Life Science Research

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Practical Solutions to Common Challenges in the Pharmaceutical Industry and Beyond

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The free/open source approach has grown from a minor activity to become a significant producer of robust, task-orientated software for a wide variety of situations and applications. To life science informatics groups, these systems present an appealing proposition - high quality software at a very attractive price. Open source software in life science research considers how industry and applied research groups have embraced these resources, discussing practical implementations that address real-world business problems.

The book is divided into four parts. Part one looks at laboratory data management and chemical informatics, covering software such as Bioclipse, OpenTox, ImageJ and KNIME. In part two, the focus turns to genomics and bioinformatics tools, with chapters examining GenomicsTools and EBI Atlas software, as well as the practicalities of setting up an omics platform and managing large volumes of data. Chapters in part three examine information and knowledge management, covering a range of topics including software for web-based collaboration, open source search and visualisation technologies for scientific business applications, and specific software such as DesignTracker and Utopia Documents. Part four looks at semantic technologies such as Semantic MediaWiki, TripleMap and Chem2Bio2RDF, before part five examines clinical analytics, and validation and regulatory compliance of free/open source software. Finally, the book concludes by looking at future perspectives and the economics and free/open source software in industry.Discusses a broad range of applications from a variety of sectorsProvides a unique perspective on work normally performed behind closed doorsHighlights the criteria used to compare and assess different approaches to solving problems

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The biomaterials sector is rapidly expanding and significant advances have been made in the technology of biomedical coatings and materials, which provide a means to improve the wear of joints, change the biological interaction between implant and host and combine the properties of various materials to improve device performance. Coatings for biomedical applications provides an extensive review of coating types and surface modifications for biomedical applications.

The first part of the book explores a range of coating types and their biomedical applications. Chapters look at hydrophilic, mineral and pyrolytic carbon coatings in and ex vivo orthopaedic applications and finally at surface modification and preparation techniques. Part two presents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices.

With its clear structure and comprehensive review of research, Coatings for biomedical applications is a valuable resource to researchers, scientists and engineers in the biomedical industry. It will also benefit anyone studying or working within the biomedical sector, particularly those specialising in biomedical coatings.Provides an extensive review of coating types and surface modifications for biomedical applicationsChapters look at hydrophilic coatings for biomedical applications in and ex vivo, mineral coatings for orthopaedic applications, pyrolytic carbon coating and other commonly-used biomedical coatingsPresents case studies of orthopaedic and ophthalmic coatings, and biomedical applications including vascular stents, cardiopulomonary by-pass equipment and ventricular assist devices

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Recent Advances in Environmentally Compatible Polymers

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Based on the proceedings of the eleventh international Cellucon conference held in Tsukuba, Japan, this book offers a comprehensive overview of important research undertaken into all aspects of environmentally compatible polymers.

It deals with natural and synthetic polymer materials such as gels, fibres, pulp and paper, films, foams, blends and composites and shows how environmental compatibility such as biodegradability and recyclability can be developed by utilising natural polymers such as polysaccharides and polyphenols.Based on the proceedings of the eleventh international Cellucon conference held in Tsukuba, JapanOffers a comprehensive overview of important research undertaken into all aspects of environmentally compatible polymersDeals with natural and synthetic polymer materials such as gels, fibres, pulp and paper, films, foams, blends and composites

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J F Kennedy, Glyn O. Phillips, Peter A. Williams

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Ways of Experiencing Information Literacy

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Making the Case for a Relational Approach

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This book has two aims: firstly to present an investigation into information literacy by looking at how people engage with information to accomplish tasks or solve problems in personal, academic and professional contexts (also known as the relational approach). This view of information literacy illustrates a learner-centred perspective that will be of interest to educators who wish to go beyond the teaching of information skills. The second aim of this book is to illustrate how the relational approach can be used as an investigative framework. As a detailed account of a relational study, this book will appeal to researchers interested in using the relational framework to examine pedagogical experiences from the learners perspective.Offers an investigation of the relational approach to examine information literacy from the perspective of the learner and the educator within diverse pedagogical conditions, both academic and professionalPresents concrete examples of measuring the impact of the information literacy experience through the application of newly developed information literacy practices to unknown situations (described as Transfer), or through the changes in the learners view of the world (described as Transformation)Written by an internationally known scholar and practitioner of information literacy

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Controller Design for Industrial Robots and Machine Tools

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Advanced manufacturing systems are vital to the manufacturing industry. It is well known that if a target work piece has a curved surface, then automation of the polishing process is difficult. Controller design for industrial robots and machine tools presents results where industrial robots have been successfully applied to such surfaces, presenting up to date information on these advanced manufacturing systems, including key technologies. Chapters cover topics such as velocity-based discrete-time control system for industrial robots; preliminary simulation of intelligent force control; CAM system for an articulated industrial robot; a robot sander for artistic furniture; a machining system for wooden paint rollers; a polishing robot for PET bottle blow moulds; and a desktop orthogonal-type robot for finishing process of LED lens cavity; and concludes with a summary. The book is aimed at professionals with experience in industrial manufacturing, and engineering students at undergraduate and postgraduate level.Presents results where industrial robots have been used successfully to polish difficult surfacesPresents the latest technology in the fieldIncludes key technology such as customized several position and force controllers