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The Use of CRISPR/cas9, ZFNs, TALENs in Generating Site-Specific Genome Alterations

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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers recent research and methods development for changing the DNA sequence within the genomes of cells and organisms. Focusing on enzymes that generate double-strand breaks in DNA, the chapters describe use of molecular tools to introduce or delete genetic information at specific sites in the genomes of animal, plant and bacterial cells. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Contains sections on such topics as genome editing, genome engineering, CRISPR, Cas9, TALEN and zinc finger nuclease

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Advancing Tools for Dealing with Emerging Risks

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Aquatic Ecotoxicology: Advancing Tools for Dealing with Emerging Risks presents a thorough look at recent advances in aquatic ecotoxicology and their application in assessing the risk of well-known and emerging environmental contaminants.

This essential reference, brought together by leading experts in the field, guides users through existing and novel approaches to environmental risk assessment, then presenting recent advances in the field of ecotoxicology, including omics-based technologies, biomarkers, and reference species.

The book then demonstrates how these advances can be used to design and perform assays to discover the toxicological endpoints of emerging risks within the aquatic environment, such as nanomaterials, personal care products, PFOS and chemical mixtures. The text is an invaluable reference for any scientist who studies the effects of contaminants on organisms that live within aquatic environments.
Provides the latest perspectives on emerging toxic risks to aquatic environments, such as nanomaterials, pharmaceuticals, chemical mixtures, and perfluorooctane sulfonate (PFOS) Offers practical guidance on recent advances to help in choosing the most appropriate toxicological assay Presents case studies and information on a variety of reference species to help put the ecotoxicological theory into practical risk assess

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Essential Chemistry for Formulators of Semisolid and Liquid Dosages

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A needed resource for pharmaceutical scientists and cosmetic chemists, Essential Chemistry for Formulators of Semisolid and Liquid Dosages provides insight into the basic chemistry of mixing different phases and test methods for the stability study of nonsolid formulations. The book covers foundational surface/colloid chemistry, which forms the necessary background for making emulsions, suspensions, solutions, and nano drug delivery systems, and the chemistry of mixing, which is critical for further formulation of drug delivery systems into semisolid (gels, creams, lotions, and ointments) or liquid final dosages. Expanding on these foundational principles, this useful guide explores stability testing methods, such as particle size, rheological/viscosity, microscopy, and chemical, and closes with a valuable discussion of regulatory issues. Essential Chemistry for Formulators of Semisolid and Liquid Dosages offers scientists and students the foundation and practical guidance to make and analyze semisolid and liquid formulations. Unique coverage of the underlying chemistry that makes possible stable dosages Quality content written by experienced experts from the drug development industry Valuable information for academic and industrial scientists developing topical and liquid dosage formulations for pharmaceutical as well as skin care and cosmetic products

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What is the role of social media on fundamental change in Arab countries in the Middle East and North Africa? Online Arab Spring responds to this question, considering five countries: Egypt, Libya, Jordan, Yemen, and Tunisia, along with additional examples. The book asks why the penetration rate for social media differs in different countries: are psychological and social factors at play? Each chapter considers national identity, the legitimacy crisis, social capital, information and media literacy, and socialization. Religious attitudes are introduced as a key factor in social media, with Arabic countries in the Middle East and North Africa being characterized by Islamic trends. The insight gained will be helpful for analysing online social media effects internationally, and predicting future movements in a social context. provides innovative interdisciplinary research, incorporating media studies, cultural aspects, identity and psychology presents a detailed study of factors such as national heritage, cultural homogeneity, belief system and consumer ethnocentrism focuses on religious attitudes in the context of online media

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Despite recent advances, therapeutic efforts have not been successful establishing a definitive strategy of treatment for brain gliomas, because of the presence of the blood-brain barrier. Innovative Brain Tumor Therapy presents a synopsis of the studies on nanoparticles as ideal devices for brain tumor treatment. Their nanometric size, electrostatic charge, and lipophilic characteristics allow them to penetrate into the brain tissue freely. Promising in-vitro results have been reported, but remain to be validated in humans. This title focuses on the blood-brain barrier pathophysiology in brain tumors, and the possibilities of overcoming this with nanoparticle-based systems. Relevant patents of nanoparticles used as drug delivery carriers are also reported, as well as future scenarios in nanoparticles and stem cells.

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Gerardo Caruso, Lucia Merlo, Maria Caffo

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Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

This volume, concentrates on the brain transcriptome.
Brings together cutting-edge research on the brain transcriptome

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Handbook of Materials Failure Analysis with Case Studies from the Aerospace and Automotive Industries

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Handbook of Materials Failure Analysis: With Case Studies from the Aerospace and Automotive Industries provides a thorough understanding of the reasons materials fail in certain situations, covering important scenarios, including material defects, mechanical failure as a result of improper design, corrosion, surface fracture, and other environmental causes.

The book begins with a general overview of materials failure analysis and its importance, and then logically proceeds from a discussion of the failure analysis process, types of failure analysis, and specific tools and techniques, to chapters on analysis of materials failure from various causes. Later chapters feature a selection of newer examples of failure analysis cases in such strategic industrial sectors as aerospace, oil & gas, and chemicals.
Covers the most common types of materials failure, analysis, and possible solutions Provides the most up-to-date and balanced coverage of failure analysis, combining foundational knowledge, current research on the latest developments, and innovations in the field Ideal accompaniment for those interested in materials forensic investigation, failure of materials, static failure analysis, dynamic failure analysis, fatigue life prediction, rotorcraft, failure prediction, fatigue crack propagation, bevel pinion failure, gasketless flange, thermal barrier coatings Presents compelling new case studies from key industries to demonstrate concepts Highlights the role of site conditions, operating conditions at the time of failure, history of equipment and its operation, corrosion product sampling, metallurgical and electrochemical factors, and morphology of failure

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Abdel Salam Hamdy Makhlouf, Mahmood Aliofkhazraei

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Riboswitch Discovery, Structure and Function

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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in riboswitch discovery and validation, synthesis and sample prep methods for large RNAs, riboswitch structure and function methods, folding pathways and dynamics, and ligand interactions and thermodynamics. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in riboswitch discovery, structure and function Contains sections on such topics as riboswitch discovery and validation, synthesis and sample prep methods for large RNAs, riboswitch structure and function methods, folding pathways and dynamics, ligand interactions and thermodynamics

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Metacognition is a set of active mental processes that allows users to monitor, regulate, and direct their personal cognitive strategies. Improving Student Information Search traces the impact of a tutorial on education graduate students problem-solving in online research databases. The tutorial centres on idea tactics developed by Bates that represent metacognitive strategies designed to improve information search outcomes. The first half of the book explores the role of metacognition in problem-solving, especially for education graduate students. It also discusses the use of metacognitive scaffolds for improving students problem-solving. The second half of the book presents the mixed method study, including the development of the tutorial, its impact on seven graduate students search behaviour and outcomes, and suggestions for adapting the tutorial for other users. Provides metacognitive strategies to improve students information search outcomes Incorporates tips to enhance database search skills in digital libraries Includes seminal studies on information behaviour

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Essentials of 3D Biofabrication and Translation

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Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine.

The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction.

Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine.
Provides a new and versatile method to fabricating living tissue Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction Describes current approaches and future challenges for translational science Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms

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Power and Performance: Software Analysis and Optimization is a guide to solving performance problems in modern Linux systems. Power-efficient chips are no help if the software those chips run on is inefficient. Starting with the necessary architectural background as a foundation, the book demonstrates the proper usage of performance analysis tools in order to pinpoint the cause of performance problems, and includes best practices for handling common performance issues those tools identify.
Provides expert perspective from a key member of Intels optimization team on how processors and memory systems influence performance Presents ideas to improve architectures running mobile, desktop, or enterprise platforms Demonstrates best practices for designing experiments and benchmarking throughout the software lifecycle Explains the importance of profiling and measurement to determine the source of performance issues

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Microencapsulation and Microspheres for Food Applications

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Microencapsulation and Microspheres for Food Applications is a solid reflection on the latest developments, challenges, and opportunities in this highly expanding field. This reference examines the various types of microspheres and microcapsules essential to those who need to develop stable and impermeable products at high acidic conditions. Its also important for the novel design of slow releasing active compound capsules.

Each chapter provides an in-depth account of controlled release technologies, evidence based abstracts, descriptions of chemical and physical principals, and key relevant facts relating to food applications. Written in an accessible manner, the book is a must have resource for scientists, researchers, and engineers.
Discusses the most current encapsulation technology applied in the food industry, including radiography, computed tomography, magnetic resonance imaging, and dynamic NMR microscopy Presents the use of microsphere immunoassay for mycotoxins detection Covers a broad range of applications of microcapsules and microspheres, including food shelf-life, pesticides for crop protection, and nanoencapsulated bacteriophage for food safety

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Interleukins in Cancer Biology responds to the growing need for credible and up-to-date information about the impact of interleukins on occurrence, development and progression of cancer. It provides reliable information about all known interleukins (38), describes recent discoveries in the field, and moreover, suggests further directions of research on the most promising aspects of this topic. The structure and presentation of the work is very understandable and clear with attention to detail maintained throughout. There are multiple illustrations throughout to help in comprehending and remembering the most important facts. .
Summarizes and discusses existing facts on the impact of all known interleukins in occurrence, development, and progression of cancer Categorizes and clarifies all interleukins based on their role in cancer Contains comprehensive and exhaustive information on each molecule

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Negotiating in the Leadership Zone expertly addresses the question: How do leaders become better negotiators? Much has been written about leadership, and negotiating skills have long been the subject of academics and business consultants. This book successfully brings negotiation and leadership together for the first time, building separate insights about them into practical, applied lessons and tools that can be used immediately.

Leaders will find unique cases, examples, and insights for high-stakes and routine negotiations alike. Mixng a readable, non-jargon approach with real-world stories and wide applicability, the author's use of 50+ years of experience as a business owner, negotiation consultant, and teacher to convey the fundamental logic and strategies underlying negotiations. The results are more than convincing.
Draws upon 50+ years of the authors' relevant experience to teach leaders the logic and strategy behind successful negotiations Connects research and principles to actual events via short vignettes and extended case studies Features website tools, tips, stories, and video lessons on effective negotiating Encourages the leader in every reader

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Handbook of Nanoceramic and Nanocomposite Coatings and Materials

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In this new handbook, top researchers from around the world discuss recent academic and industrial advances in designing ceramic coatings and materials. They describe the role of nanotechnology in designing high performance nanoceramic coatings and materials in terms of the unique advantages that can be gained from the nano scale, including the latest techniques for the synthesis and processing of ceramic and composite coatings for different applications.
Focuses on the most advanced technologies for industry-oriented nano-ceramic and nano-composite coatings, including recent challenges for scaling up nano-based coatings in industry Covers the latest evaluation methods for measuring coatings performance Discusses novel approaches for improving the performance of ceramic and composite coatings and materials via nanotechnology Provides the most recent and advanced techniques for surface characterization

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Abdel Salam Hamdy Makhlouf, Dieter Scharnweber

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Superhydrophobic Surfaces analyzes the fundamental concepts of superhydrophobicity and gives insight into the design of superhydrophobic surfaces. The book serves as a reference for the manufacturing of materials with superior water-repellency, self-cleaning, anti-icing and corrosion resistance. It thoroughly discusses many types of hydrophobic surfaces such as natural superhydrophobic surfaces, superhydrophobic polymers, metallic superhydrophobic surfaces, biological interfaces, and advanced/hybrid superhydrophobic surfaces.
Provides an adequate blend of complex engineering concepts with in-depth explanations of biological principles guiding the advancement of these technologies Describes complex ideas in simple scientific language, avoiding overcomplicated equations and discipline-specific jargon Includes practical information for manufacturing superhydrophobic surfaces Written by experts with complementary skills and diverse scientific backgrounds in engineering, microbiology and surface sciences

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Headache and Migraine Biology and Management

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There are two crucial issues in the treatment and management of headache patients: More than 50% of individuals experiencing headache have only been treated symptomatically, with no appropriate diagnosis established; and history and neurologic examination are essential to establishing a diagnosis, and thus selecting appropriate therapy.

Headache and Migraine Biology and Management is a practical text that addresses these issues, featuring contributions from expert clinical authors. The book covers in detail topics including chronic and episodic migraine, post-traumatic headache, sinus headache, cluster headache, tension headache, and others. Chapters are also dedicated to treatment subjects, including psychiatric and psychological approaches, medication overuse, inpatient treatment, and pediatric issues.

This book is an ideal resource for researchers and clinicians, uniting practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs. This resource is useful to those who want to understand headache biology, treat and manage symptoms, and for those performing research in the headache field.
A practical discussion of headache biology, current ideas on etiology, future research, and genetic significance and breakthroughs Features chapters from leading physicians and researchers in headache medicine Full-color text that includes both an overview of multiple disciplines and discusses the measures that can be used to treat headaches

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Seymour Diamond, Roger K. Cady, Merle L. Diamond, Mark W. Green, Vincent T. Martin

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Techniques and Applications of C and PIC MCUS

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This book provides a hands-on introductory course on concepts of C programming using a PIC microcontroller and CCS C compiler. Through a project-based approach, this book provides an easy to understand method of learning the correct and efficient practices to program a PIC microcontroller in C language. Principles of C programming are introduced gradually, building on skill sets and knowledge. Early chapters emphasize the understanding of C language through experience and exercises, while the latter half of the book covers the PIC microcontroller, its peripherals, and how to use those peripherals from within C in great detail.

This book demonstrates the programming methodology and tools used by most professionals in embedded design, and will enable you to apply your knowledge and programming skills for any real-life application. Providing a step-by-step guide to the subject matter, this book will encourage you to alter, expand, and customize code for use in your own projects.
A complete introduction to C programming using PIC microcontrollers, with a focus on real-world applications, programming methodology and tools Each chapter includes C code project examples, tables, graphs, charts, references, photographs, schematic diagrams, flow charts and compiler compatibility notes to channel your knowledge into real-world examples Online materials include presentation slides, extended tests, exercises, quizzes and answers, real-world case studies, videos and weblinks

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Case Studies in Nanotoxicology and Particle Toxicology

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Case Studies in Nanotoxicology and Particle Toxicology presents a highly-illustrated analysis of the most prominent cases on the adverse effects of nanoparticles and their impact on humans and the environment.

This comprehensive reference demonstrates the possible risks imposed by managing and handling nanoparticles, showing the effects of involuntary inhalation or ingestion during their use and after their incineration.

Through the use of numerous examples, readers will discover the possible risks and effects of working with nanoparticles, along with best practices to prevent these effects. The text is an essential reference for anyone working in the risk assessment of nanoparticles, including nanosafety professionals, occupational toxicologists, regulatory toxicologists, and clinicians.
Presents real-life cases showing the potential risks to human health following exposure to nanoparticles An ideal reference for anyone working in the risk assessment of nanoparticles, including nanosafety professionals, occupational toxicologists, regulatory toxicologists, and clinicians Provides examples to help assess risks of handling engineered nanomaterials Advises on the best forms of protection and the safest nanotechnological products

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Ultrafiltration for Bioprocessing is key reading for all those involved in the biotechnology and biopharmaceutical areas. Written by a leading worker in the area, it includes many practical applications and case studies in the key process of ultrafiltration (UF), which is used in almost every bioprocess. Focuses on ultrafiltration for biopharmaceuticalsother books look at general ultrafiltration or general biopharmaceuticals A mix of theory and practical applicationsother books tend to be more theory-oriented Addresses the main issues encountered in development and scale-up through recommendations and case studies