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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. Methods to assess mitochondrial function is of great interest to neuroscientists studying chronic forms of neurodegeneration, including Parkinson's, Alzheimer's, ALS, Huntington's and other triplet repeat diseases, but also to those working on acute conditions such as stroke and traumatic brain injury. This volume covers research methods on how to assess the life cycle of mitochondria including trafficking, fusion, fission, and degradation. Multiple perspectives on the complex and difficult problem of measurement of mitochondrial reactive oxygen species production with fluorescent indicators and techniques ranging in scope from measurements on isolated mitochondria to non-invasive imaging of metabolic function. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Provides invaluable details on state-of-the-art methods to assess a broad array of mitochondrial functions

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Waking and the Reticular Activating System in Health and Disease

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Waking and the Reticular Activating System in Health and Disease provides a comprehensive overview on the activating properties of the RAS. In health, the RAS provides the basis against which we assess the external world, and in disease it distorts that world and shatters our self-image. This book describes the physiology of each process, how it is disturbed in each disorder, and what the most appropriate treatment should be.

Dr. Garcia-Rill, along with contributions from leading specialists, discusses the understanding of the RAS as a system not only modulating waking, but also in charge of survival mechanisms such as fight vs flight responses and reflexes. The full spectrum of these functions helps explain the complexity of symptoms evident in such disorders as disparate as schizophrenia and Parkinsons disease. The book reviews the mechanisms that control waking and arousal, and especially how those mechanisms malfunction in certain neurological and psychiatric disorders.
First comprehensive overview on the RAS and its role in schizophrenia, major depression, autism, Parkinsons, Alzheimers, and other neurologic and mental diseases Offers a new way of thinking about brain function and the role of the RAS in our waking lives Written by a leading translational neuroscience researcher with contributions by specialists in the field

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Awareness of design smells  indicators of common design problems  helps developers or software engineers understand mistakes made while designing, what design principles were overlooked or misapplied, and what principles need to be applied properly to address those smells through refactoring. Developers and software engineers may "know" principles and patterns, but are not aware of the "smells" that exist in their design because of wrong or mis-application of principles or patterns. These smells tend to contribute heavily to technical debt  further time owed to fix projects thought to be complete  and need to be addressed via proper refactoring.Refactoring for Software Design Smells presents 25 structural design smells, their role in identifying design issues, and potential refactoring solutions. Organized across common areas of software design, each smell is presented with diagrams and examples illustrating the poor design practices and the problems that result, creating a catalog of nuggets of readily usable information that developers or engineers can apply in their projects. The authors distill their research and experience as consultants and trainers, providing insights that have been used to improve refactoring and reduce the time and costs of managing software projects. Along the way they recount anecdotes from actual projects on which the relevant smell helped address a design issue. Contains a comprehensive catalog of 25 structural design smells (organized around four fundamental designprinciples) that contribute to technical debt in software projects Presents a unique naming scheme for smells that helps understand the cause of a smell as well as pointstoward its potential refactoring Includes illustrative examples that showcase the poor design practices underlying a smell and the problemsthat result Covers pragmatic techniques for refactoring design smells to manage technical debt and to create and maintainhigh-quality software in practice Presents insightful anecdotes and case studies drawn from the trenches of real-world projects

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Girish Suryanarayana, Ganesh Samarthyam, Tushar Sharma

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Fundamentals of Forensic Science, Third Edition, provides current case studies that reflect the ways professional forensic scientists work, not how forensic academicians teach. The book includes the binding principles of forensic science, including the relationships between people, places, and things as demonstrated by transferred evidence, the context of those people, places, and things, and the meaningfulness of the physical evidence discovered, along with its value in the justice system.

Written by two of the leading experts in forensic science today, the book approaches the field from a truly unique and exciting perspective, giving readers a new understanding and appreciation for crime scenes as recent pieces of history, each with evidence that tells a story.
Straightforward organization that includes key terms, numerous feature boxes emphasizing online resources,historical events, and figures in forensic science Compelling, actual cases are included at the start of each chapter to illustrate the principles being covered Effective training, including end-of-chapter questions paired with a clear writing style making this an invaluableresource for professors and students of forensic science Over 250 vivid, color illustrations that diagram key concepts and depict evidence encountered in the field

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Handbook of Microalgae: Biotechnology Advances offers complete coverage of marine microalgae, including biology, production techniques, biotechnological applications, economic perspectives of applications, and environmental effects of marine microalgae blooms. With contributions from world experts, Handbook of Microalgae: Biotechnology Advances focuses on microalgae from an organism perspective to offer a complete picture from evolution to biofuel.
Focuses on a comprehensive approach from an organism point of view Contains full coverage of all aspects of microalgae from biology through biotechnological and biomedical applications Includes biological properties of commercial algal species Provides microalgae screening and identification methods, culturing methods and new aspects of processing

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Fungi and Mycotoxins Risk Assessment and Management

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Environmental Mycology in Public Health: Fungi and Mycotoxins Risk Assessment and Management provides the most updated information on fungi, an essential element in the survival of our global ecology that can also pose a significant threat to the health of occupants when they are present in buildings.

As the exposure to fungi in homes is a significant risk factor for a number of respiratory symptoms, including allergies and hypersensitivity pneumonitis, this book presents information on fungi and their disease agents, important aspects of exposure assessment, and their impacts on health.

This book answers the hard questions, including, "How does one detect and measure the presence of indoor fungi?" and "What is an acceptable level of indoor fungi?" It then examines how we relate this information to human health problems.
Provides unique new insights on fungi and their metabolites detection in the environmental and occupational settings Presents new information that is enriched by significant cases studies Multi-contributed work, edited by a proficient team in medical and environmental mycology with different individual expertise Guides the readers in the implementation of preventive and protective measures regarding exposure to fungi

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Carla Viegas, Ana Catarina Pinheiro, Raquel Sabino, Susana Viegas, João Brandão, Cristina Veríssimo

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A Comprehensive Guide to Their Identification

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This new edition of Marine Mammals of the World describes and illustrates newly discovered and rarely photographed species, making it the most comprehensive and up-to-date identification guide available.

This edition continues to meet the research-focused needs of marine biologists and conservation biologists by providing a tremendous influx of new photos, taking advantage of advances in digital and auto-focusing photography, and the emergence of marine mammal studies and "whalewatching" around the world. The book encompasses cetacean, pinniped, and sirenian species, as well as extinct species, and describes basic biology and taxonomic groupings of marine mammals.
Contains superb photographs of every species of marine mammal for accurate identification Authors possess nearly 80 years of collective experience with almost all of the species and distinctive geographic forms described in the guide Provides the most detailed and anatomically accurate illustrations currently available, including more than 750 new illustrations Special emphasis is placed on the identification of species in "problem groups," such as the beaked whales, long-beaked oceanic dolphins, and southern fur seals Includes a detailed list of sources for more information Contains updated taxonomy including four new species

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Marc A. Webber, Thomas Allen Jefferson, Robert L. Pitman

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Hydrogen Sulfide in Redox Biology Part A

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These new volumes of Methods in Enzymology (554 and 555) on Hydrogen Sulfide Signaling continue the legacy established by previous volumes on another gasotransmitter, nitric oxide (Methods in Enzymology volumes 359, 396, 440, and 441), with quality chapters authored by leaders in the field of hydrogen sulfide research. These volumes of Methods in Enzymology were designed as a compendium for hydrogen sulfide detection methods, the pharmacological activity of hydrogen sulfide donors, the redox biochemistry of hydrogen sulfide and its metabolism in mammalian tissues, the mechanisms inherent in hydrogen sulfide cell signaling and transcriptional pathways, and cell signaling in specific systems, such as cardiovascular and nervous system as well as its function in inflammatory responses. Two chapters are also devoted to hydrogen sulfide in plants and a newcomer, molecular hydrogen, its function as a novel antioxidant. Continues the legacy of this premier serial with quality chapters on hydrogen sulfide research authored by leaders in the field  Covers conventional and new hydrogen sulfide detection methods Covers the pharmacological activity of hydrogen sulfide donors Contains chapters on important topics on hydrogen sulfide modulation of cell signaling and transcriptional pathways, and the the role of hydrogen sulfide in the cardiovascular and nervous systems and in inflammation

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Materials and Concepts for Advanced Drug Formulation

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Inorganic Controlled Release Technology: Materials and Concepts for Advanced Drug Formulation provides a practical guide to the use and applications of inorganic controlled release technology (iCRT) for drug delivery and other healthcare applications, focusing on newly developed inorganic materials such as bioresorbable glasses and bioceramics. The use of these materials is introduced for a wide range of applications that cover inorganic drug delivery systems for new drug development and the reformulation of existing drugs. The book describes basic concepts, principles, and industrial practices by discussing materials chemistry, physics, nano/microstructure, formulation, materials processing, and case studies, as well as the evaluation and characterization of iCRT systems commonly investigated during industrial R&D.;
Provides the first book on inorganic controlled release technology (iCRT), covering key aspects from chemistry, physics, synthetic methods, formulation design, characterization and evaluation Includes several industry-related case studies to provide practical guidance on how to use iCRT as an alternative to organic polymers systems for both future drug developments and other active ingredient applications Demonstrates how iCRT offers an unmet business need for improved, controlled release of actives versus traditional CRT systems, which are known to have difficulty with the controlled delivery of both poorly and highly water soluble drug compounds

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Heterogeneous Computing with OpenCL 2.0 teaches OpenCL and parallel programming for complex systems that may include a variety of device architectures: multi-core CPUs, GPUs, and fully-integrated Accelerated Processing Units (APUs). This fully-revised edition includes the latest enhancements in OpenCL 2.0 including:

Shared virtual memory to increase programming flexibility and reduce data transfers that consume resources Dynamic parallelism which reduces processor load and avoids bottlenecks Improved imaging support and integration with OpenGL

Designed to work on multiple platforms, OpenCL will help you more effectively program for a heterogeneous future. Written by leaders in the parallel computing and OpenCL communities, this book explores memory spaces, optimization techniques, extensions, debugging and profiling. Multiple case studies and examples illustrate high-performance algorithms, distributing work across heterogeneous systems, embedded domain-specific languages, and will give you hands-on OpenCL experience to address a range of fundamental parallel algorithms.
Updated content to cover the latest developments in OpenCL 2.0, including improvements in memory handling, parallelism, and imaging support Explanations of principles and strategies to learn parallel programming with OpenCL, from understanding the abstraction models to thoroughly testing and debugging complete applications Example code covering image analytics, web plugins, particle simulations, video editing, performance optimization, and more

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David R. Kaeli, Perhaad Mistry, Dana Schaa, Dong Ping Zhang

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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers computational prediction RNA structure and dynamics, including such topics as computational modeling of RNA secondary and tertiary structures, riboswitch dynamics, and ion-RNA, ligand-RNA and DNA-RNA interactions. Continues the legacy of this premier serial with quality chapters authored by leaders in the field  Covers computational methods and applications in RNA structure and dynamics Contains chapters with emerging topics such as RNA structure prediction, riboswitch dynamics and thermodynamics, and effects of ions and ligands.

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Creating and Restoring Wetlands: From Theory to Practice describes the challenges and opportunities relating to the restoration of freshwater and estuarine wetlands in natural, agricultural, and urban environments in the coming century.

The underpinnings of restoration, driven by ecological (disturbance, dispersal, succession) theory, are described and applied to various activities (restoring hydrology, soils, and biota) that are used to improve the short- and long-term success of wetland restoration projects.

Unforeseen problems that hinder restoration efforts and solutions to these problems are discussed in this comprehensive book that contains five sections and 13 chapters that include an introduction describing the defining characteristics of wetland hydrology, soils, biota, the role of theory in guiding wetland succession, ecosystem development following restoration, and differentiating wetland reclamation, restoration, and creation, restoration of various estuarine and freshwater wetlands, case studies of estuarine and freshwater restoration and large-scale restoration, and finally, the future of wetland restoration.
Explicitly links ecological theory to restoration efforts in a variety of freshwater and estuarine, natural, agricultural, urban landscapes, and wetland ecosystems Contains case studies of small- and large-scale restoration activities ensuring relevance to individuals and organizations Illustrates successes as well as failures of freshwater and estuarine wetland restorations in order to learn from them Presents specific information on hydrology, biota, wetland succession, ecosystem development following restoration, and more

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Electroencephalograms, Recurrent Quantum Neural Networks, and User-Centric Graphical Interfaces

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Brain-computer interface (BCI) technology provides a means of communication that allows individuals with severely impaired movement to communicate with assistive devices using the electroencephalogram (EEG) or other brain signals. The practicality of a BCI has been possible due to advances in multi-disciplinary areas of research related to cognitive neuroscience, brain-imaging techniques and human-computer interfaces. However, two major challenges remain in making BCI for assistive robotics practical for day-to-day use: the inherent lower bandwidth of BCI, and how to best handle the unknown embedded noise within the raw EEG.

Brain-Computer Interfacing for Assistive Robotics is a result of research focusing on these important aspects of BCI for real-time assistive robotic application. It details the fundamental issues related to non-stationary EEG signal processing (filtering) and the need of an alternative approach for the same. Additionally, the book also discusses techniques for overcoming lower bandwidth of BCIs by designing novel use-centric graphical user interfaces. A detailed investigation into both these approaches is discussed.
An innovative reference on the brain-computer interface (BCI) and its utility in computational neuroscience and assistive robotics Written for mature and early stage researchers, postgraduate and doctoral students, and computational neuroscientists, this book is a novel guide to the fundamentals of quantum mechanics for BCI Full-colour text that focuses on brain-computer interfacing for real-time assistive robotic application and details the fundamental issues related with signal processing and the need for alternative approaches A detailed introduction as well as an in-depth analysis of challenges and issues in developing practical brain-computer interfaces.

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Understand and Implement Effective PCI Data Security Standard Compliance

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Identity theft and other confidential information theft have now topped the charts as the leading cybercrime. In particular, credit card data is preferred by cybercriminals. Is your payment processing secure and compliant? The new Fourth Edition of PCI Compliance has been revised to follow the new PCI DSS standard version 3.0, which is the official version beginning in January 2014. Also new to the Fourth Edition: additional case studies and clear guidelines and instructions for maintaining PCI compliance globally, including coverage of technologies such as NFC, P2PE, CNP/Mobile, and EMV. This is the first book to address the recent updates to PCI DSS. The real-world scenarios and hands-on guidance are also new approaches to this topic. All-new case studies and fraud studies have been added to the Fourth Edition.

Each chapter has how-to guidance to walk you through implementing concepts, and real-world scenarios to help you relate to the information and better grasp how it impacts your data. This book provides the information that you need in order to understand the current PCI Data Security standards and how to effectively implement security on network infrastructure in order to be compliant with the credit card industry guidelines, and help you protect sensitive and personally-identifiable information.
Completely updated to follow the most current PCI DSS standard, version 3.0 Packed with help to develop and implement an effective strategy to keep infrastructure compliant and secure Includes coverage of new and emerging technologies such as NFC, P2PE, CNP/Mobile, and EMV Both authors have broad information security backgrounds, including extensive PCI DSS experience

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Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease.

It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells.

With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and students seeking current translational knowledge in epigenesis and epigenomics.

Coverage includes the latest findings on epigenome-wide research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories.
Presents critical reviews that provide the means for reviewing and analyzing the epigenome as a whole, also discussing its translational potential Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and data analysis Includes coverage of relatively new topics, including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging

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Mario Fraga, Agustin Fernandez Fernandez

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Interactive Processes in Group Perception

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This volume presents a collection of chapters exploring the interface of cognitive and affective processes in stereotyping. Stereotypes and prejudice have long been topics of interest in social psychology, but early literature and research in this area focused on affect alone, while later studies focused primarily on cognitive factors associated with information processing strategies. This volume integrates the roles of both affect and cognition with regard to the formation, representation, and modification of stereotypes and the implications of these processes for the escalation or amelioration of intergroup tensions. Reviewed Development, maintenance, and change of stereotypes and prejudice Interaction of affective and cognitive processes as antecendents of stereotyping and prejudice Affect and cognitive consequences of group categorization, preception, and interaction The interaction of cognitive and affective processes in social perception Award Winning Chapter "The Esses et al", was the 1992 winner of the Otto Klineberg award given by the Society for the Psychological Study of Social Issues, which cited the chapter as having offered, "a substantial advance in our understanding of basic psychological processes, underlying racism, stereotyping, and prejudice."

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Security Supervision and Management, Fourth Edition, fills the basic training needs for security professionals who want to move into supervisory or managerial positions. Covering everything needed from how to work with todays generation security force employees to the latest advances in the security industry, Security Supervision and Management, Fourth Edition, shows security officers how to become a more efficient and well-rounded security professional. Security Supervision and Management, Fourth Edition, is also the only text needed to prepare for the Certified in Security Supervision and Management (CSSM) designation offered by International Foundation for Protection Officers (IFPO).

The IFPO also publishes The Professional Protection Officer: Practical Security Strategies and Emerging Trends, now in its 8th edition.
Core text for completing the Security Supervision and Management Program/Certified in Security Supervision and Management (CSSM) designation offered by IFPO Contributions from more than 50 experienced security professionals in a single volume Completely updated to reflect the latest procedural and technological changes in the security industry Conforms to ANSI/ASIS standards

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IFPO, Sandi J. Davies, Brion P. Gilbride, Chris A. Hertig

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Understanding Tissue Physiology and Development to Engineer Functional Substitutes

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Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies.

Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices.

Contributions from scientists, clinicians, and engineers who are the leading figures in their respective fields present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field.
Provides an overview of tendon biology, disease, and tissue engineering approaches Presents modern, alternative approaches to developing functional tissue solutions discussed Includes valuable information for those interested in tissue engineering, tissue regeneration, tissue physiology, and regenerative medicine Explores physiology, pathology, and surgical reconstruction, building a natural progression that enhances tendon regeneration practices Covers recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field

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Manuela E. Gomes, Rui L. Reis, Márcia T. Rodrigues

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Risk Analysis and Control for Industrial Processes - Gas, Oil and Chemicals

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A System Perspective for Assessing and Avoiding Low-Probability, High-Consequence Events

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Risk Analysis and Control for Industrial Processes - Gas, Oil and Chemicals provides an analysis of current approaches for preventing disasters, and gives readers an overview on which methods to adopt.

The book covers safety regulations, history and trends, industrial disasters, safety problems, safety tools, and capital and operational costs versus the benefits of safety, all supporting project decision processes.

Tools covered include present day array of risk assessment, tools including HAZOP, LOPA and ORA, but also new approaches such as System-Theoretic Process Analysis (STPA), Blended HAZID, applications of Bayesian data analytics, Bayesian networks, and others. The text is supported by valuable examples to help the reader achieve a greater understanding on how to perform safety analysis, identify potential issues, and predict the likelihood they may appear.
Presents new methods on how to identify hazards of low probability/high consequence events Contains information on how to develop and install safeguards against such events, with guidance on how to quantify risk and its uncertainty, and how to make economic and societal decisions about risk Demonstrates key concepts through the use of examples and relevant case studies

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A Comprehensive Database of Critical and Threshold Flux Values for Membrane Practitioners

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The Boundary Flux Handbook summarizes over 90 chemical compounds (single compounds, in mixed solution) and different feed streams from industry (complex streams exiting the agricultural, biological, pharmaceutical, food, dye, textile, etc. industries) and the respective critical and threshold fluxes (hereafter referred to the boundary flux), together with data on rejection and permeabilities. It gives the reader valuable data to quickly estimate membrane performances in respect to productivity, selectivity and longevity, and permits to estimate capital and operating costs of membrane processes during the plant design operations.

The book is valuable for scientific researchers and chemical engineers working with membrane technology as a reference for lab work, membrane process design and control. For each specific feedstock, only the best performing membrane(s) are listed. At least one commercial membrane module and a maximum of 4 different choices were reported, in order to assure the possibility to easily integrate the proposed membranes into the systems by contacting the relevant commercial partner, and to define the best choice of the pretreatment steps, permitting quick membrane process optimization or revamping operations. This text summarizes over 100 chemical compounds, different feed streams from industry, and the respective critical and threshold fluxes It gives the reader valuable data to quickly estimate membrane performances in respect to productivity, selectivity and longevity For each studied feedstock, only the best performing membrane(s) are listed, including one commercial and a maximum of four different choices, to assure the possibility to easily integrate the proposed membranes into the systems by contacting the relevant commercial partner

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Marco Stoller, Javier Miguel Ochando-Pulido