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Handbook of the Aging Brain brings together diverse scientific disciplines to cover the most recent research findings in an easy-to-read summary. Scientists and clinicians will find a wide spectrum of subjects including gerontology, neurology, psychology, molecular biology, and cellular biology. The book includes general chapters on the neuroanatomy and neurobiology of the aging brain, and moves on to discussion of specifics including signal transduction, cell death, and specific cellular and neurological changes associated with dementia, Alzheimer's and Parkinson's Disease. Other chapters discuss the affect of aging on learning and memory, language, and cognition.

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Computer access is the only way to retrieve up-to-date sequences and this book shows researchers puzzled by the maze of URLs, sites, and searches how to use internet technology to find and analyze genetic data. The book describes the different types of databases, how to use a specific database to find a sequence that you need, and how to analyze the data to compare it with your own work. The content also covers sequence phenotype, mutation, and genetic linkage databases; simple repetitive DNA sequences; gene feature identification; and prediction of structure and function of proteins from sequence information. This book will be invaluable to those starting a career in life sciences research as well as to established researchers wishing to make full use of available resources. Describes a wide range of databases: DNA, RNA, protein, pathways, and gene expression Enables readers to access the information they need from databases on the web Includes a directory of URLs for easy reference Invaluable for those starting a career in life sciences research and also for established researchers wishing to make full use of available resources

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Now in two-colour throughout, the fourth edition of Eukaryotic Transcription Factors has been completely rewritten and restructured to take into account the tremendous advances in our understanding of transcription factors and the mechanisms by which they act. Considerable emphasis has been given to the interaction between transcription factors and chromatin structure. Also included is an entirely new section on the mediator complex and expansion of the space devoted to co-activators and co-repressors.This book is essential reading for all those who wish to understand the impact of molecular biology on medicine, whatever their speciality. Major families of eukaryotic transcription factors described Mechanisms of gene activation and repression analysed Structure-function relationships indicated Interaction between transcription factors and chromatin structure described Roles in inducible and cell type-specific gene expression Roles in development, differentiation and human diseases including cancer Methods of study in vitro and in vivo

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The emotional attachment of a child to caregivers, and the attachment of the caregivers to the child, is of vital importance to the child's socioemotional development. Proper attachment can affect one's ability to feel and express love, moral development, motivation to achieve, and sense of identity. Modern industrial societies have seen a recent surge in attachment problems, yet there has been little information on clinical interventions for attachment disorders. The Handbook of Attachment Interventions meets this need by providing information on diverse patient populations across different therapeutic philosophies, while providing specific techniques for treating attachment disordered children and their families. The book begins with a discussion of how attachment disorders relate to subsequent antisocial behavior patterns and other disorders, as well as general issues parents may encounter with an attachment disordered child. Subsequent chapters discuss special patient populations (the adopted child, military families, etc.) and techniques for intervention.<br>Practitioners in clinical, private practice, managed care, and hospital settings, social workers, developmental psychologists, and interested parents find the Handbook of Attachment Interventions a valuable reference.

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The Encyclopedia of Foods: A Guide to Healthy Nutrition is a definitive resource for what to eat for maximum health as detailed by medical and nutritional experts. This book makes the connection between health, disease, and the food we eat.

The Encyclopedia describes more than 140 foods, providing information on their history, nutrient content, and medical uses.

The Encyclopedia also describes the "fit kitchen", including the latest in food safety, equipment and utensils for preparing fit foods, and ways to modify favorite recipes to ensure health and taste.
Details healthy eating guidelines based on the RDA food pyramid Provides scientific basis and knowledge for specific recommendations Beautifully illustrated Extensive list of reliable nutrition resources Describes the fit kitchen from the latest in food safety to equipment and utensils for preparing fit foods to ways to modify favorite recipes to ensure health and taste

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Experts from Dole Food Experts from Dole Food Company, Experts from The Mayo Experts from The Mayo Clinic, Experts from UCLA Center for Experts from UCLA Center for H

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Essentials of Mucosal Immunology presents basic concepts as well as new and exciting advances in mucosal immunology and inflammation, the development of mucosal vaccines, and the role of the immune system in mucosal disease. Specific chapters highlight novel approaches to the treatment of autoimmune disease, including the use of oral tolerance; approaches to and vectors for new vaccines; and current concepts in mucosal inflammation and its role in inflammatory bowel disease and ulcer disease. Contains the most current research on mucosal immunology and is comprehensive in scope Includes ideal coverage of both the basic and clinical aspects of the mucosal immune system Provides an understanding of the mucosal immune system with regard to new treatments and preventative methods, including vaccine development Includes contributions from an international team of experts

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The first of its kind, Doing What Works in Brief Therapy is a guidebook to strategic solution focused therapy, a model which combines the principles and techniques of the Mental Research Institute's brief strategic therapy and the Brief Family Therapy Center's solution focused therapy. The book explains how the strategic emphasis on clarification of the problem and interruption of what does not work can complement and enhance the solution-focused emphasis on amplification of what does work. The text reviews the theory and presents specific treatment techniques. Case examples illustrate how the model has been used in brief, intermittent, and single-session therapy in a managed care setting.

Brief psychotherapy doesn't have to result in chronic frustration for the therapist or superficial, second-rate care for the client. This book presents an approach that is upbeat, practical, and eminently workable in managed care. The reader learns to focus on critical issues with exquisite precision and to construct creative, individualized interventions that amplify what works and interrupt what does not.
Integrates strategic therapy and solution focused therapy Includes guidelines for intervention and when to do what Provides applications for couples: indications for separate or joint sessions Considers both therapy and medication as successful and unsuccessful solutions Features excerpts and clinically rich examples

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This book clearly identifies nearly 170 families of fishes through the use of high-quality illustrations and includes an accurate account of selected members of that particular fish family, as well as a distribution map and accompanying commentary on classification, distribution, and diversity.

Key Features* High-quality illustrations of representatives from each family* Distribution map provided for each family* Commentary for each family

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CNS Regeneration focuses on some of the leading current neurological disease models and methods for promoting central nervous system regeneration. Editors and authors are experts in the field, with experience in basic as well as applied neuroscience. In a comprehensive, logical manner, the book unites important basic science advances in neuroscience with novel medical strategies. The first comprehensive, authoritative volume on the topic of CNS regeneration Reviews current therapeutic approaches Editors and authors are experts in the field Appeals to those interested in basic science as well as those concerned with its medical application

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Computing the Brain provides readers with an integrated view of current informatics research related to the field of neuroscience. This book clearly defines the new work being done in neuroinformatics and offers information on resources available on the Web to researchers using this new technology. It contains chapters that should appeal to a multidisciplinary audience with introductory chapters for the nonexpert reader. Neuroscientists will find this book an excellent introduction to informatics technologies and the use of these technologies in their research. Computer scientists will be interested in exploring how these technologies might benefit the neuroscience community. An integrated view of neuroinformatics for a multidisciplinary audience Explores and explains new work being done in neuroinformatics Cross-disciplinary with chapters for computer scientists and neuroscientists An excellent tool for graduate students coming to neuroinformatics research from diverse disciplines and for neuroscientists seeking a comprehensive introduction to the subject Discusses, in-depth, the structuring of masses of data by a variety of computational models Clearly defines computational neuroscience - the use of computational techniques and metaphors to investigate relations between neural structure and function Offers a guide to resources and algorithms that can be found on the Web Written by internationally renowned experts in the field

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Developmental Juvenile Osteology gives an account of the development of all the bones of the human skeleton, from their earliest embryological form to final adult form. This volume collates information never before assembled in one volume. Profusely illustrated with high quality drawings, it also provides a complete description of the adult skeleton and its anomalies. Covers anatomy of the adult skeleton Discusses skeletal embryology Explains development of the child's skeleton Collates information never before assembled in one book Contains excellent (never seen before) illustrations Covers important and unique topics Contains an extensive bibliography and comprehensive index

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Craig Cunningham, Louise Scheuer, Sue Black, Louise Scheuer, Sue Black, Angela Christie

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The Complement FactsBook contains entries on all components of the Complement System, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families. The FactsBook also includes the cDNA sequences, marked with intron/exon boundaries, which will facilitate genetic studies. Includes the cDNA sequences, marked with intron/exon boundaries, facilitating genetic studies Presents detailed structural information including cDNA and gene structure for all proteins Introduces complement function, simply described for each function Data is as up-to-date as possible, including unpublished work from many contributors Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, familiesEach chapter has been written by an expert in the field Data is as up-to-date as possible, including unpublished work from many contributors Entries provide information on: Alternative nomenclature, Physiochemical properties, Structure and function, Tissue distribution and regulation expression, Protein sequence/modules, Chromosomal location, Genomic structure, Database accession numbers, Deficiency and polymorphic variants, Key references

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It is now widely recognised that biological psychiatry is rapidly coming into its own. For over the last three decades dramatic advances in this young discipline have been made, all of which attest to the staying power of the experimental method. Those who made this revolution in knowledge happen are a breed of investigators availing themselves of the tools of molecular biology, pharmacology, genetics, and perhaps, above all, the technology of neuroimaging. The introduction of the interdisciplinary method of approach to the study of psychopathology had made it very clear that neuroimaging, as a set of techniques, is unique in that it is gradually providing us with evidence supporting Kraepelin's original view that mental illness is closely associated with abnormal changes in the brain.
Broadly speaking, there are presently two structural techniques in neuroimaging - computed tomography and magnetic resonance imaging (MRI) - and three functional techniques - single photon emission tomography (SPECT), positron emission tomography and magnetic resonance imaging (fMRI). Through PET technology, for example, we have learned that, in early brain development, the primitive areas, mostly the brain stem and thalamus, are the first to show high activity in an infant. This is followed by the development of cortical areas by year one. Between the ages of four to 10, the cortex is almost twice as active in the child as in the adult. This information alerts us to what might happen in the way of trauma in abused children, especially those under the age of three. Child abuse increases the risk of physical changes, not only in the stress systems, but also in brain development (Glaser and Weissman). In addition to the difficult problem of post-traumatic stress disorder (PTSD), we have to take into account the possibility of other types of mental illness as the consequences of child abuse. These include depression, eating disorders, and drug and alcohol problems.
The combination of PET and fMRI represents a more remarkable example of the power of neuroimaging since the two have made it feasible to map accurately in vitro identifiable cortical fields, or networks. In a landmark NIH investigation of human cortical reorganization (plasticity), persuasive evidence was brought forward showing that the process of learning as a motor task involves a specific network of neurons. These neurons occur in the cortical field that is responsible for that particular task. Such findings are important partly because they provide evidence supporting the current notion that labor in the cortex is divided among ensembles of specialized neurons that cooperate in the performance of complex tasks. Cooperation, then, in this, sense implies crosstalk among ensembles and that signals are both processed and retransmitted to neighbouring ensembles. To understand the workings of these ensembles, much better spatial and temporal resolution in functional brain mapping is required. This can be achieved with an NMR instrument whose magnet is 4.1 Tesla or more.

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Applications of Physiological Ecology to Forest Management

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Forest management is a complex process that now incorporates information obtained from many sources. It is increasingly obvious that the physiological status of the trees in a forest has a dramatic impact on the likely success of any particular management strategy. Indeed, models described in this book that deal with forest productivity and sustainability require physiological information. This information can only be obtained from an understanding of the basic biological mechanisms and processes that contribute to individual tree growth.

This valuable book illustrates that physiological ecology is a fundamental element of proficient forest management.
Provides essential information relevant to the continuing debate over sustainable forest management Outlines how modern tools for physiological ecology can be used in planning and managing forest ecosystems Reviews the most commonly used forest models and assesses their value and future

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J. J. Landsberg, S. T. Gower, Jacques Roy

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With data from the United States and Europe, Jon Miller and Linda Kimmel examine the public's understanding of and attitude toward biotechnology and biomedicine while they present methods of introducing cutting edge science to thenonscientist. Biomedical Communications illustrates how vital it is for researchers, journalists, and policy makers to clearly communicate their findings in a way that avoids general misconception or confusion. The authors explore how to acquire information about biomedical policy, discuss strategies for informing consumers, and present tactics for improving biomedical communication with the public. Using Research to Improve Biomedical Communications The Public Understanding of Biomedical Science Strategies for Communications to Consumers Public Attitudes Toward Biotechnology Issues

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Specialty Articles from the Encyclopedia of Mental Health

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Assessment and Therapy is a derivative volume of articles pulled from the award-winning Encyclopedia of Mental Health, presenting a comprehensive overview of assessing and treating the many disorders afflicting mental health patients, including alcohol problems, Alzheimer's disease, depression, epilepsy, gambling, obsessive-compulsive disorder, phobias, and suicide.

According to 1990 estimates, mental disorders represent five of the ten leading causes of disability. Among "developed" nations, including the United States, major depression is the leading cause of disability. Also near the top of these rankings are bipolar depression, alcohol dependence, schizophrenia, and obsessive-compulsive disorder. In addition, mental disorders are tragic contributors to mortality, with suicide perennially representing one of the leading preventable causes of death worldwide.

Assessment and Therapy describes the impact of mental health on the individual and society and illustrates the factors that aid positive mental health. Twenty-six peer-reviewed articles written by more than 40 expert authors include essential material on assessing and treating schizophrenia, manic-depressive illness, major depression, anxiety disorders, and other mental illnesses. Professionals and libraries will find this timely work indispensable.

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Bioconjugate Techniques is the essential guide to the modification and crosslinking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. Armed with this information and the abundant protocols provided, readers will form unique complexes that can be used for detecting, quantifying, and targeting important analytes. This book helps readers make: high activity antibody-enzymes conjugates, immunotoxins, immunogen complexes, liposome conjugates; as well as biotinylated molecules, avidin or streptavidin conjugates, colloidal gold labeled proteins, PEG or dextran complexes, labeled oligonucleotide probes, and fluorescently tagged or radiolabeled molecules. This book is the first to thoroughly capture the entire field of bioconjugate chemistry in a single volume Serves as a practical guide to modification and cross-linking technology for research, diagnostics, and therapeutics Provides useful, detailed, easy-to-follow, step-by-step protocols Contains easy-to-read, and easy-to-understand key concepts for making bioconjugates of all types Efficiently covers the chemistry of bioconjugation, the major reagents available for modification and cross-linking, and the application of these reagents to the synthesis of highly active conjugates Cites over more than references keyed to concepts covered in the book Uses more than 600 figures to illustrate bioconjugate reagents, their reactions, and applications Suggests sources for all key reagents

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Psychological and Social Development in Middle Age

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There is a growing body of scientific knowledge regarding development during the middle years which has so far been relegated to discipline-specific texts and journals (e.g., clinical psychology and endocrinology).

Life in the Middle consolidates main findings across disciplines, with a life-span perspective regarding mid-life. Coverage includes individual development in middle age from the psychological and biological perspectives as well as the sociocultural context in which middle-aged individuals live and work, including physical health in mid-life, psychological well-being, cognitive development, the impact of work on the individual, and the general development of the "self." This age period is increasingly becoming the focus of scholarly attention as the largest cohort in U.S. history are now moving into the middle years (e.g., the "babyboomers"). From 1990 to 2015 the number of middle-aged people will increase 72 percent from 47 to 80 million.
Contributors are outstanding scholars in the field of adult development Addresses critical theoretical issues in midlife Includes important contributions to our understanding of physical health at midlife Presents a thorough review of women's health at midlife Takes a holistic approach to biopsychosocial functioning at midlife

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Air Breathing Fishes: Evolution, Diversity, and Adaptation is unique in its coverage of the evolution of air-breathing, incongruously because it focuses exclusively on fish. This important and fascinating book, containing nine chapters that present the life history, ecology, and physiology of many air-breathing fishes, provides an exceptional overview of air-breathing biology.Each chapter provides a historical background, details the present status of knowledge in the field, and defines the questions needing attention in future research. Thoroughly referenced, containing more than 1,000 citations, and well documented with figures and tables, Air-Breathing Fishes is comprehensive in its coverage and will certainly have wide appeal. Researchers in vertebrate biology, paleontology, ichthyology, vertebrate evolution, natural history, comparative physiology, anatomy and many other fields will find something new and intriguing in Air-Breathing Fishes. Offers a complete overview of an important and immensely interesting area of research Provides a perspective of air-breathing fish that spans 300 million years of vertebrate evolution Contains numerous illustrations as well as comprehensive charts Provides a synoptic treatment of all the known air-breathing species with important data on their morphological and physiological adaptations

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This volume, the first of its kind ever, is designed to provide both laypersons and professionals with a detailed description of the occurrence of each common form of cancer in the ethnically, socially, and environmentally complex milieu of a modern urban complex. The place is Los Angeles County, and the patterns of 72 different malignancies are described according to race, age, sex, social class calendar time (since 1972) and most notably, individual neighborhood, using detailed maps of high risk.The book permits residents to screen the malignancies and identify those of special concern locally, and to identify other communities with similar concerns. The pattern of each malignancy is briefly discussed with reference to background knowledge of causation and the degree to which the observed pattern was expected on that basis. Persons residing outside Los Angeles County will identify patterns likely to prevail in their own communities.Physicians and scientific investigators in California and elsewhere can use the material provided to counsel patients and evaluate the consistency of any specific pattern of occurrence with each specific causal hypothesis. A detailed appendix describes the source of data, provides the basis for the choices made in the production of the volume, and gives a perspective on the search for clusters of malignancy.

* Compares different types of cancers with respect to the degree of non-random occurrence* Contains numerous maps detailing the demographic and geographic pattern of cancer occurrence in Los Angeles County* Provides an empirical perspective to the search for disease "clusters"