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This treatment guide is based on selected disorders taken from the American Psychiatric Association DSM-IV Diagnostic Classifications. The disorders selected are treatable or responsive to brief therapy methods.<br>The therapist or student in training can use this book to identify the elements needed for formulating a treatment plan on disorders typically encountered in clinical practice. The approaches taken are based on cognitive behavioral principles and makes use of empirical findings. However, the case study format allows the reader to see how the assessment and treatment is implemented in a "real-life" patient, and not as a clinical abstraction distilled from research studies. Moreover, the treatment plan is outlined in a manner that makes reimbursement likely from managed care organizations and insurance companies. Effective Brief Therapies is useful as a reference for therapists and as a training guide for graduate students. Case Descriptions Treatment Conceptualization Assessment Techniques Treatment Implementation Techniques Concurrent Diagnoses and Treatment Complications and Treatment Implications Dealing with Managed Care and Accountability Outcome and Follow-up Dealing with Recidivism

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The Primer on the Autonomic Nervous System presents, in a readable and accessible format, key information about how the autonomic nervous system controls the body, particularly in response to stress. It represents the largest collection of world-wide autonomic nervous system authorities ever assembled in one book. It is especially suitable for students, scientists and physicians seeking key information about all aspects of autonomic physiology and pathology in one convenient source. Providing up-to-date knowledge about basic and clinical autonomic neuroscience in a format designed to make learning easy and fun, this book is a must-have for any neuroscientists bookshelf! Greatly amplified and updated from previous edition including the latest developments in the field of autonomic cardiovascular regulation and neuroscience Provides key information about all aspects of autonomic physiology and pathology Discusses stress and how its effects on the body are mediated Compiles contributions by over 140 experts on the autonomic nervous system

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Volume 324 of Methods in Enzymology supplements Volume 166. It includes genetic information (cloning, gene expression) and information on human genetic diseases not available when Volume 166 was published.General Description of the Series:The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences. Preparation of substrates and assay of enzymes Cloning, expression, and purification of enzymes Detection and consequences of genetic defects Regulation and expression of enzymes

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John N. Abelson, Melvin I. Simon, John R. Sokatch, Robert Adron Harris

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International Handbook of Earthquake & Engineering Seismology, Part A

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Modern scientific investigations of earthquakes began in the 1880s, and the International Association of Seismology was organized in 1901 to promote collaboration of scientists and engineers in studying earthquakes. The International Handbook of Earthquake and Engineering Seismology, under the auspices of the International Association of Seismology and Physics of the Earth's Interior (IASPEI), was prepared by leading experts under a distinguished international advisory board and team of editors.The content is organized into 56 chapters and includes over 430 figures, 24 of which are in color.

This large-format, comprehensive reference summarizes well-established facts, reviews relevant theories, surveys useful methods and techniques, and documents and archives basic seismic data. It will be the authoritative reference for scientists and engineers and a quick and handy reference for seismologists.Also available is The International Handbook of Earthquake and Engineering Seismology, Part B.

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William H.K. Lee, Paul Jennings, Carl Kisslinger, Hiroo Kanamori

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Paleomagnetism is the study of the fossil magnetism in rocks. It has been paramount in determining that the continents have drifted over the surface of the Earth throughout geological time. The fossil magnetism preserved in the ocean floor has demonstrated how continental drift takes place through the process of sea-floor spreading. The methods and techniques used in paleomagnetic studies of continental rocks and of the ocean floor are described and then applied to determining horizontal movements of the Earth's crust over geological time. An up-to-date review of global paleomagnetic data enables 1000 million years of Earth history to be summarized in terms of the drift of the major crustal blocks over the surface of the Earth.

The first edition of McElhinny's book was heralded as a "classic and definitive text." It thoroughly discussed the theory of geomagnetism, the geologic reversals of the Earth's magnetic field, and the shifting of magnetic poles. In the 25 years since the highly successful first edition of Palaeomagnetism and Plate Tectonics (Cambridge, 1973) the many advances in the concepts, methodology, and insights into paleomagnetism warrant this new treatment. This completely updated and revised edition of Paleomagnetism: Continents and Oceans will be a welcome resource for a broad audience of earth scientists as well as laypeople curious about magnetism, paleogeography, geology, and plate tectonics.

Because the book is intended for a wide audience of geologists, geophysicists, and oceanographers, it balances the mathematical and descriptive aspects of each topic.
Details the theory and methodology of rock magnetism, with particular emphasis on intrepreting crustal movements from continental and oceanic measurements Outlines Earth history for the past 1000 million years, from the Rodinia super-continent through its breakup and the formation of Gondwana to the formation and breakup of Pangea and the amalgamation of Eurasia Provides a comprehensive treatment of oceanic paleomagnetism Provides a set of color pateogeographic maps covering the past 250 million years Written by two internationally recognized experts in the field

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Michael W. McElhinny, Phillip L. McFadden, Renata Dmowska, James R. Holton, H. Thomas Rossby

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Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways.
Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians.

Key Features
* Presents state-of-the art developments of nonviral vectors as tools for modern molecular medicine
* Covers all types of nonviral vectors, from molecular structure to therapeutic application
Provides a comprehensive review of synthetic vectors
* Includes contributions from major investigators and leading experts in the field

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Mien-Chie Hung, Leaf Huang, Ernst Wagner

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Carbon Dioxide, Populations, and Communities

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In past decades and in association with a continuing global industrial development, the global atmospheric concentration of carbon dioxide has been rising. Among the many predictions made concerning this disturbing trend is global warming sufficient to melt polar ice-caps thereby dramatically altering existing shorelines. This book will help fill an obvious gap in the carbon dioxide debate by substituting date for speculation.

*
* Includes contributions from leading authorities around the world
* Serves as a companion to Carbon Dioxide and Terrestrial Ecosystems
* The first book of its kind to explore evolutionary responses of both populations and communities to elevated carbon dioxide

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Sea Level Rise, History and Consequences includes a special emphasis on the evidence for historical sea level change; case studies are used to demonstrate the resulting consequences. A CD-ROM is included which contain tide gauge data and trends of relative sea level from the Permanent Service for Mean Sea Level. The material on the CD-ROM is either in the form of text files, or web sites that can be opened by widely available web-browsers.

Sea level is expected to rise as much as 60-100 centimeters over the next century due to greenhouse-induced global warming -- or at least that is what the some scientists predict. However, the concept of sea level is extremely complex, which makes the prediction of sea level rise anything but certain. The reviewers are in consensus in enthusiastically endorsing this comprehensive book and CD-ROM treatment.

This book will be a comprehensive review of the subject using the data themselves (on CD-ROM) to illustrate the principles involved, rather than detailed mathematical treatments. The book should be readily accessible to upper division and first-year graduate students in the environmental sciences, geography, geology, and other interdisciplinary fields. Four pages (up to 16 pages) of color in the printed text.

The book will have wide appeal. It will be read by geologists, geophysicists, climatologists, oceanographers, meteorologists, environmental scientists, geomorphologists, coastal engineers, and policy makers in all of these fields.

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Bruce Douglas, Mark T Kearney, Stephen P. Leatherman

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Carbon Dioxide and Terrestrial Ecosystems

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The importance of carbon dioxide extends from cellular to global levels of organization and potential ecological deterioration may be the result of increased CO2 in our atmosphere. Recently, the research emphasis shifted from studies of photosynthesis pathways and plant growth to ground-breaking studies of carbon dioxide balances in ecosystems, regions, and even the entire globe.

Carbon Dioxide and Terrestrial Ecosystems addresses these new areas of research. Economically important woody ecosystems are emphasized because they have substantial influence on global carbon dioxide balances. Herbaceous ecosystems (e.g., grasslands, prairies, wetlands) and crop ecosystems are also covered. The interactions among organisms, communities, and ecosystems are modeled, and the book closes with an important synthesis of this growing nexus of research.

Carbon Dioxide and Terrestrial Ecosystems is a compilation of detailed scientific studies that reveal how ecosystems generally, and particular plants specifically, respond to changed levels of carbon dioxide.
Contributions from an international team of experts Empirical examination of the actual effects of carbon dioxide Variety of terrestrial habitats investigated Specific plants and whole ecosystems offered as studies

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The second edition of Mesoscale Meteorological Modeling is a fully revised resource for researchers and practitioners in the growing field of meteorological modeling at the mesoscale. Pielke has enhanced the new edition by quantifying model capability (uncertainty) by a detailed evaluation of the assumptions of parameterization and error propagation. Mesoscale models are applied in a wide variety of studies, including weather prediction, regional and local climate assessments, and air pollution investigations.

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Sphingolipid Metabolism and Cell Signaling, Part A

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Sphingolipids are found in all eukaryotic and in some prokaryotic organisms and provide structure for cell membranes, lipoproteins, and other biological materials as well as participate in the regulation of cell growth, differentiation, and diverse cell functions, including cell-cell communication, cell-substratum interactions, and intracellular signal transduction. This volume presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. Its companion Volume 312 will contain information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets.<br>The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

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John N. Abelson, Melvin I. Simon, Alfred H. Merrill Jr., Yusuf A. Hannun

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Assessment and Treatment of Diverse Populations

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Clinicians and mental health practitioners are regularly called upon to treat patients of diverse cultural and ethnic backgrounds. Not only do these patients differ from Anglos in culture and language, but also in customs, beliefs, values, and practices. Understanding these differences is vital to performing an accurate diagnosis/assessment of psychopathology as well as in determining an effective treatment regimen.<br>This book provides vital information to clinicians worldwide in bettering their treatment of diverse populations. Each chapter identifies relevant cultural variables specific to each racial/ethnic group, along with ethnocultural measures and their relevant psychometric properties. Part 1 presents introductory material on the definition of mental illness and pathological behavior in differing cultures, epidemiological data on the prevalence of different disorders between differing population groups, culture specific beliefs (e.g. hexes), and the influence of culture on treatment. Part 2 discusses assessment issues including how specific measures (Rorschach, MMPI, etc.) are best interpreted with different population groups, and the existence and use of ethnocultural specific measures. Part 3 discusses assessment and treatment of specific population groups (e.g., Indians, Asians, Latinos, etc.).

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Handbook of Water and Wastewater Microbiology

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"Access to safe water is a fundamental human need and therefore a basic human right" --Kofi Annan, United Nations Secretary General

Edited by two world-renowned scientists in the field, The Handbook of Water and Wastewater Microbiology provides a definitive and comprehensive coverage of water and wastewater microbiology. With contributions from experts from around the world, this book gives a global perspective on the important issues faced in the provision of safe drinking water, the problems of dealing with aquatic pollution and the processes involved in wastewater management.

Starting with an introductory chapter of basic microbiological principles, The Handbook of Water and Wastewater Microbiology develops these principles further, ensuring that this is the essential text for process engineers with little microbiological experience and specialist microbiologists alike.
Comprehensive selection of reviews dealing with drinking water and aquatic pollution Provides an understading of basic microbiology and how it is applied to engineering process solutions Suitable for all levels of knowledge in microbiology -from those with no background to specialists who require the depth of information

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The Natural History of an Arctic Oil Field

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In spite of the harsh conditions that characterize the Arctic, it is a surprisingly fragile ecosystem. The exploration for oil in the Arctic over the past 30 years has had profound effects on the plants and animals that inhabit this frozen clime. The Natural History of an Arctic Oil Field synthesizes decades of research on these myriad impacts. Specialists with years of field experience have contributed to this volume to create the first widely available synopsis of the ecology and wildlife biology of animals and plants living in close association with an actively producing oil field. First widely available synthesis of arctic oil field ecology and wildlife biology Concise yet readable treatment of a diverse polar ecosystem Useful for land managers, policy makers as well as ecologists, and population biologists Chapters authored by recognized authorities and contributions are peer-reviewed for accuracy and scientific rigor Illustrations attractively designed to enhance comprehension

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It is well recognized that there is an intimate and reciprocal interaction between epilepsy and sleep. The book, Epilepsy and Sleep is a ground-breaking, comprehensive source for exploring this correlation and is especially timely because of the considerable growth in the understanding of the physiology underlying both sleep and epilepsy. An insightful reference, it presents many of the complex physiologic mechanisms underlying epilepsy--sleep interaction and highlights sleeping disorder symptoms that may be related to epilepsy.

The annual cost of treating epilepsy in the United States is an estimated $12.5 billion, according to a report issued January 2000 by The Epilepsy Foundation. The Foundation also reports that more than 180,000 Americans develop epilepsy each year. However, thousands more cases may be misdiagnosed as sleeping disorders, causing these figures to jump significantly. This correlation and diagnosis can help determine the correct type of medication to administer to regulate the symptoms, in turn saving hundreds of hours of lost time at work and millions of dollars.
Provides the first comprehensive source of information available on the correlation between epilepsy and sleep Outlines sleeping disorder symptoms which may in fact be caused by epilepsy Well illustrated, easy-to-read text An essential text for epileptologists, psychiatrists, physicians, and sleep disorder therapists Written by internationally recognized experts in the field

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Energetics of Biological Macromolecules, Part C

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Volume 323 of Methods in Enzymology is dedicated to the energetics of biological macromolecules. Understanding the molecular mechanisms underlying a biological process requires detailed knowledge of the structural relationships within the system and an equally detailed understanding of the energetic driving forces that control the structural interactions. This volume presents modern thermodynamic techniques currently being utilized to study the energetic driving forces in biological systems. It will be a useful reference source and textbook for scientists and students whose goal is to understand the energetic relationships between macromoleculer structures and biological functions.
This volume supplements Volumes 259 and Volume 295 of Methods in Enzymology.

Key Features
* Probing Stability of Helical Transmembrane Proteins
* Energetics of Vinca Alkaloid Interactions with Tubulin
* Deriving Complex Ligand Binding Formulas
* Mathematical Modeling of Cooperative Interactions in Hemoglobin
* Analysis of Interactions of Regulatory Protein TyrR with DNA
* Parsing Free Energy of Drug-DNA Interactions
* Use of Fluorescence as Thermodynamics Tool

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John N. Abelson, Melvin I. Simon, Michael L. Johnson, Gary K. Ackers

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Applications of Chimeric Genes and Hybrid Proteins, Part B: Cell Biology and Physiology

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The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

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Melvin I. Simon, Jeremy Thorner, Scott D. Emr, John N. Abelson

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Advances in Insect Physiology is committed to publishing eclectic volumes containing comprehensive and in-depth reviews on all aspects of insect physiology. First published in 1963, it is an essential reference source for invertebrate physiologists and neurobiologists, entomologists, zoologists, and insect biochemists.
In 1999, the Institute for Scientific Information released figures showing that Advances in Insect Physiology has an Impact Factor of 4.5, placing it second in the highly competitive category of Entomology.

Key Features
* This volume includes five reviews on the following topics:
* The Drosophila melanogaster Malpighian tubule
* Plasticity in the insect nervous system
* Neutral amino acid absorption in the midgut of lepidopteran larvae
* The unpaired median neurons of insects
* FMRFamide related peptides: a multifunctional family of structurally related neuropeptides in insects

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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. The Yin Yang of TCF/b-Catenin Signalling Biochemical and Clinical Implications of the Erb/HER Signaling Network of Growth Factor Receptors p53 and Human Cancer: The First Ten Thousand Mutations Macrophage Stimulating Protein CD44 Glycoproteins in Colorectal Cancer; Expression; Function; and Prognostic Value A Simple Modes for Carcinogenesis of Colorectal Cancer with Microsatellite Instability

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Enzyme Kinetics and Mechanisms, Part E, Energetics of Enzyme Catalysis

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This volume supplements Volumes 63, 64, 87, and 249 of Methods in Enzymology. These volumes provide a basic source for the quantitative interpretation of enzyme rate data and the analysis of enzyme catalysis. Among the major topics covered are Engergetic Coupling in Enzymatic Reactions, Intermediates and Complexes in Catalysis, Detection and Properties of Low Barrier Hydrogen Bonds, Transition State Determination, and Inhibitors.<br>The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

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John N. Abelson, Melvin I. Simon, Vern L. Schramm, Daniel L. Purich