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The second edition of Wine Science: Principles, Practice, Perception updates the reader with current processes and methods of wine science, including an analysis of the advantages and disadvantages of various new grape cultivar clones, wine yeast strains, and malolactic bacteria. It also addresses current research in wine consumption as related to health. The many added beautiful color photographs, graphs, and charts help to make the sophisticated techniques described easily understandable. This book is an essential part of a any library.

Key Features
* Univerally appealing to non-technologists and technologists alike
* Includes section on Wine and Health which covers the effects of wine consumption on cardiovascular diseases, headaches, and age-related macular degeneration
* Covers sophisticated techniques in a clear, easily understood manner
* Presents a balance between the objective science of wine chemistry and the subjective study of wine appreciation
* Provides updated information involving advantages/disadvantages of various grape cultivar clones, wine yeast strains, and malolactic bacteria
* Chapter on recent historical findings regarding the origin of wine and wine making processes

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This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.

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From Normal Development to Congenital Disease

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Organogenesis of the kidney has been intensely studied for over a century. In recent years advances in molecular techniques have not only made great inroads into exploring the genetic regulation of this complex process but also began to unravel the molecular basis of many forms of congenital kidney disease. This book is a comprehensive study on these findings and the only book available with such in depth coverage of the kidney. Hundreds of color figures depicting key events in all aspects of kidney development Full coverage of the genetic and cellular basis of kidney development Analysis of the genetic basis of the major congenital kidney diseases

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Peter D. Vize, Adrian S. Woolf, Jonathan B.L. Bard

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International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Paternal Contributions to the Mammalian Zygote Coat Proteins Regulating Membrane Traffic Regulation of Monoamine Receptors in the Brain Rhodopsin Trafficking and Its Role in Retinal Dystrophy Calcium Signaling during Abiotic Stress in Plants

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Protein Modules and Protein-Protein Interactions

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Protein modules engage in a multitude of interactions with one another and with other cellular components, notably with DNA. These interactions are a central aspect of protein function of great relevance in the post-genomic era. This volume describes a panel of approaches for analyzing protein modules and their interactions, ranging from bioinformatics to physical chemistry, to biochemistry, with an emphasis on the structure-function relationship in protein-protein complexes involved in cellular processes including signal transduction. Comprehensive overview of different facets of macromolecule interactions Computational and bioinformatics aspects of analyzing protein modules and their interactions Emphasis on structure-function relationship in protein-protein complexes involved in cellular processes

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Substance Use Disorders: Assessment and Treatment is a summary of everything a therapist should know about substance abuse in one easy-to-read comprehensive book. The book begins with a discussion of the pharmacology of specific drug classes (opioids, hallucinogens, etc.) and the epidemiology of abuse. It then presents psychological theories of substance abuse, the initiation and progression of substance abuse disorders, issues of prevention and early intervention, and screening and assessment for substance abuse (including specific tests for assessment) and discusses in detail the various treatment methodologies available. Two final chapters explore issues relevant to special populations and legal and ethical considerations, regarding issues such as confidentiality and coerced treatment. A synthesis of the current research and clinical literature Includes strengths and weaknesses of commonly used psychometric assessment measures Presentation and review of a complete Psychosocial/Substance Use Assessment form Discussion of treatment settings and criteria for placement decisions Discussion of treatment alternatives and effectiveness of major pharmacological and psychotherapeutic approaches Discussion of factors leading to Relapse, and components of Relapse Prevention programs

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The Psychology of Serial Killer Investigations

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Serial killers like Seattle's Ted Bundy, Maryland's Beltway Sniper, Atlanta's Wayne Williams, or England's Peter Sutcliffe usually outsmart the task forces on their trail for long periods of time. Keppel and Birnes take readers inside the operations of serial killer task forces to learn why. What is the underlying psychology of a serial killer and why this defeats task force investigations?

This is the first book of its kind that combines state-of-the-art psychological assessment experience with the expertise of a homicide investigator who has tracked some of this country's most notorious serial killers. The author also brings to the book hands-on best practices gleaned from the experience of other task forces.

Readers, both professionals and students, will benefit from the comprehensive and critical case reviews, the analysis of what went wrong, what went right, and the after-action recommendations of evaluators in the US, UK, and Canada.

The book covers:
* The nature of the psychology of a serial killer
* How crime assessment profiling reveals that psychology
* Why psychological profiles fail
* How serial killer task forces defeat themselves
* How the media can, and usually does, undermine the task force operation
* The big secret of all serial killer investigations: police already have the killer's name
* The best practices for catching a serial killer

* Comprehensive case reviews of some of the US's and UK's most baffling serial killer cases
* A list of best practices for serial killer task force investigators
* Recommendations for how to manage comprehensive files and computer records
* Practical advice on how to manage the media: what to say and not to say
* Insight into what a serial killer might be thinking and doing to stay away from police
* Recommendations for setting up and administering long-term investigations
* Practical tips on how to maintain a task force's psychological edge and avoid defeatism

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An Introduction to Cellular and Molecular Neuroscience

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An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells that is needed by advanced undergraduates and graduate students, as well as researchers in need of a thorough reference.

* Highly referenced for readers to pursue topics of interest in greater detail* Unique coverage of the application of mathematical modeling and simulation approaches not found in other textbooks* Richly illustrated, four color presentation throughout* Includes CD-ROM of all of the illustrations

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John H. Byrne, Ruth Heidelberger, M. Neal Waxham, James L. Roberts

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The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.This volume presents an extensive collection of new methodologies to aid progress in solving unanswered questions concerning the bioavailability and metabolism of flavonoids and polyphenols, their biochemical and molecular biological effects on cell regulation, and their effects on health. Major topics in this volume include sources, characterization, analytical methods, bioavailability, antioxidant action, and biological activity.

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The chapters contained in this two-volume set provide a broad perspective on the novel strategies and conceptual paradigms that drive the current resurgence of interest in somitogenesis - the process by which somites form and elaborate differentiated tissues and structures. Because somites are a ubiquitous feature of vertebrate embryos, they can be studied in a variety of experimental animal models including those amenable to genetic (zebrafish, mammalian), molecular/genetic (mammalian, avian) as well as those already well established for classical experimental embryological and cell biological studies (amphibians, avian). The wide variety of experimental approaches to somitogenesis that are presented in these volumes will leave the reader with a broad perspective on how current research in somitogenesis is helping to solve fundamental questions in vertebrate development and morphogenesis. Novel transcriptional mechanisms that control repetitive pattern formation Wide-scale genetic screens for mutations affecting somitogenesis Molecular/genetic control of pattern and tissue formation during somitogenesis Transplantation of mouse embryo somites Classical embryological approaches and concepts Evolutionary perspectives on somitogenesis

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Roger A. Pedersen, Gerald P. Schatten, Charles P. Ordahl

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This second edition of a very successful text reflects the tremendous pace of human genetics research and the demands that it places on society to understand and absorb its basic implications. The human genome has now been officially mapped and the cloning of animals is becoming a commonplace scientific discussion on the evening news. Join authors Julia Richards and Scott Hawley as they examine the biological foundations of humanity, looking at the science behind the sensation and the current and potential impact of the study of the genome on our society. The Human Genome, Second Edition is ideal for students and non-professionals, but will also serve as a fitting guide for the novice geneticist by providing a scientific, humanistic, and ethical frame of reference for a more detailed study of genetics.

New in this edition: 60% new material, including data from the Human Genome Project and the latest genetics and ethics discussions Several new case studies and personal stories that bring the concepts of genetics and heredity to life Simplified treatment of material for non-biology majors New full-color art throughout the text New co-author, Julia Richards, joins R. Scott Hawley in this revision

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Vertebrae Phototransduction and the Visual Cycle, Part B

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Major topics covered include photoreceptor proteins, phototransduction calcium-binding proteins and calcium measurement in photoreceptor cells, enzymes of the visual cycle, posttranslational and chemical modifications, analysis of animal models of retinal diseases. Inherited retinal disease; from the defective gene to its function and repair. This volume and its companion Volume 315 include newly developed methods to study vertebrate phototransduction and the visual cycle.<br>The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

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John N. Abelson, Melvin I. Simon, Krzysztof Palczewski

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Observing and Modelling the Global Ocean

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The book represents all the knowledge we currently have on ocean circulation. It presents an up-to-date summary of the state of the science relating to the role of the oceans in the physical climate system.The book is structured to guide the reader through the wide range of World Ocean Circulation Experiment (WOCE) science in a consistent way.  Cross-references between contributors have been added, and the book has a comprehensive index and unified reference list.The book is simple to read, at the undergraduate level. It was written by the best scientists in the world who have collaborated to carry out years of experiments to better understand ocean circulation.

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Gerold Siedler, John Gould, John A. Church

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This updated second edition provides the state of the art perspective of the theory, practice and application of modern non-invasive imaging methods employed in exploring the structural and functional architecture of the normal and diseased human brain. Like the successful first edition, it is written by members of the Functional Imaging Laboratory - the Wellcome Trust funded London lab that has contributed much to the development of brain imaging methods and their application in the last decade. This book should excite and intrigue anyone interested in the new facts about the brain gained from neuroimaging and also those who wish to participate in this area of brain science.

* Represents an almost entirely new book from 1st edition, covering the rapid advances in methods and in understanding of how human brains are organized* Reviews major advances in cognition, perception, emotion and action* Introduces novel experimental designs and analytical techniques made possible with fMRI, including event-related designs and non-linear analysis

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William D. Penny, Karl J. Friston, Christopher D. Frith, Raymond J. Dolan, Cathy J. Price, Semir Zeki, John T. Ashburner, Richard S.J. Frackowiak

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Antisense Technology, Part B: Applications

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Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods which inhibit gene expression permit studies probing the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedically-oriented research.<br>The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today-truly an essential publication for researchers in all fields of life sciences.

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John N. Abelson, Melvin I. Simon, M. Ian Phillips

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Prion Proteins is "issue-oriented" and edited by a well-known authority in the field. Topics covered include structure, diversity, and energetics as well as the diseases associated with prion proteins.

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Regulators and Effectors of Small GTPases, Part D: Rho Family

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This volume and its companions (Volumes 255, 256, 257, and the forthcoming 329) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in these aspects of cell biology at the molecular level.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

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John N. Abelson, Melvin I. Simon, W. E. Balch, Channing J. Der, Alan Hall

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Psychological Experiments on the Internet

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Until recently, most psychological research was conducted using subject samples in close proximity to the investigators--namely university undergraduates. In recent years, however, it has become possible to test people from all over the world by placing experiments on the internet. The number of people using the internet for this purpose is likely to become the main venue for subject pools in coming years. As such, learning about experiments on the internet will be of vital interest to all research psychologists.

Psychological Experiments on the Internet is divided into three sections. Section I discusses the history of web experimentation, as well as the advantages, disadvantages, and validity of web-based psychological research. Section II discusses examples of web-based experiments on individual differences and cross-cultural studies. Section III provides readers with the necessary information and techniques for utilizing the internet in their own research designs.
Innovative topic that will capture the imagination of many readers Includes examples of actual web based experiments

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Regulators and Effectors of Small GTPases, Part E: GTPases Involved in Vesicular Traffic

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Small GTPases play a key role in many aspects of contemporary cell biology: control of cell growth and differentiation; regulation of cell adhesion and cell movement; the organization of the actin cytoskeleton; and the regulation of intracellular vesicular transport.<br>This volume and its companions (Volumes 255, 256, 257, and the forthcoming 325) cover all biochemical and biological assays currently in use for analyzing the role of small GTPases in these aspects of cell biology at the molecular level.

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John N. Abelson, Melvin I. Simon, W. E. Balch, Channing J. Der, Alan Hall

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Evolutionary Approaches to Protein Design

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This is the first high-quality, comprehensive overview of the field of evolutionary protein design. Topics include new protein design strategies, the structures of laboratory-evolved proteins, the evolution of non-natural enzyme functions, and the theory of laboratory evolution.