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Aquaporins summarizes the present knowledge in this expanding field of research, starting with the structural analysis of water channel proteins. Subsequent chapters begin with mammalian aquaporins, examining physiology and pathophysiology, analysis of knock-out model animals, and the regulation of aquaporin function. Also covered is the distribution and regulation of aquaporins in plants and the function of water and glycerol channels in microbial systems. Comprehensive treatment of a topical research field Authored by world leaders in the field Covers structural biology and physiology Covers different experimental and biological systems Chapters on plant and microbial systems Extensive treatment of mammalian physiology and pathophysiology Structural analysis excellently illustrated

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Dale J. Benos, Sidney A. Simon, Stefan Hohmann, Peter Agre, Soren Nielsen

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This book discusses research and theory on how motivation changes as children progress through school, gender differences in motivation, and motivational differences as an aspect of ethnicity. Motivation is discussed within the context of school achievement as well as athletic and musical performance.

Key Features* Coverage of the major theories and constructs in the motivation field* Focus on developmental issues across the elementary and secondary school period* Discussion of instructional and theoretical issues regarding motivation* Consideration of gender and ethnic differences in motivation

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Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.

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This volume is the first in a planned series of thematic volumes for Advances in Virus Research. It covers the etiology, pathogenetic mechanisms, and clincial consequences of human neurotropic viruses. Buchmeier is a virologist, Campbell an immunologist, and both are extremely well known in their fields.
Numerous illustrations including colour Knowledgeable discussion of the potential role of viral infections in teratogenic and developmental disorders Frank discussion of the role of stress in disease Behavioural consequences of chronic CNS infection

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Resource for Mental Health and Legal Professionals

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Forensic psychology has mushroomed into a diverse and increasingly complex field that is equal parts law and psychology. Psychologists act as expert witnesses in legal cases - sometimes without knowing much about the laws involved, and legal professionals rely on the assessment of psychologists sometimes without knowing much about how such assessments are made.

The purpose of this handbook is to provide professionals with current, practical, and empirically based information to guide their work in forensic settings, or to better their understanding of the issues and debates in forensic psychology.

Divided into four sections, the Handbook of Forensic Psychology covers basic issues, assessment, mental disorders and forensic psychology, and special topics. The basic issue chapters present a primer on law for the psychologist, a primer on psychology for attorneys, an overview of ethical issues relevant to forensic psychology, and a chapter on forensic report writing. The assessment section discusses factors and measures relevant for assessing a variety of behaviors, propensities, and capabilities, including dangerousness, violence, suicide, competency, substance abuse, PTSD and neuropsychological evaluations, as well as discussing interviewing children and child custody evaluations. Additional chapters discuss eyewitness testimony, recovered memory, polygraphs, sexual harassment, juror selection, and issues of ethnicity in forensic psychology.

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Principles and Applications of Enviromagnetics

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Magnetism is important in environmental studies for several reasons, the two most fundamental being that most substances exhibit some form of magnetic behavior, and that iron is one of the most common elements in the Earth's crust. Once sequestered in a suitable material, magnetic particles constitute a natural archive of conditions existing in former times. Magnetism provides a tracer of paleo-climatic and paleo-environmental conditions and processes.Environmental Magnetism details the occurrence and uses of magnetic materials in the natural environment. The first half of the volume describes the basic principles. The second half discusses the applications of magnetic measurements in various environmental settings on land, in lakes, in the ocean, and even various biological organisms.

* Material is broadly applicable to environmental studies* Case histories illustrate key points* Extensive bibliography makes further research quick and easy

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Batten Disease: Diagnosis, Treatment, and Research

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This title will present all current knowledge of Batten disease from research to clinical evaluation. NCL is not well recognized in underdeveloped countries because the diagnostic technology is lacking. With the information in this volume, however, a specific diagnosis of NCL could be made. Also, specific familial mutations obtained through genetic tests may guide prenatal diagnoses for at-risk families.

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Jeffrey C. Hall, Jay C. Dunlap, Theodore Friedmann, Francesco Giannelli, Krystyna E. Wisniewski, Nanbert Zhong

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Questioned documents are any documents that may be used as evidence in a trial, ranging from handwritten notes to counterfeit currency to contracts. This concise new handbook is designed specifically to aid lawyers involved in cases that involve questioned documents (QD) evidence. It explains the basics of document examination and helps litigators improve the way they present document evidence and question witnesses. It also provides references to professional literature and other legal sources, making it easy to find further information when needed.
Questioned Documents: A Lawyer's Handbook provides analyses applied to many types of investigations and types of documents. It outlines the techniques for determining authenticity, age, ink and paper sources, handwriting identification, equipment used, forgeries, alterations, erasures, and more. In addition to helping the attorneys who mush present the QD evidence and ask the questions, this handbook is also an important resource for the expert witnesses who will be asked those questions at trial.

Key Features
* Explains the basics of document examination and shows how they apply to a variety of cases
* Helps litigators improve the way they present document evidence and interrogate witnesses
* Saves hours in pre-trial interviews by providing lawyers with the a thorough knowledge of the topic
* Presents case examples from the US, UK, The Netherlands, Germany, Nepal, Israel, Jordan, Russia, Romania and more
* Includes actual questions that can be asked of expert witnesses
* Provides an extensive list of references and research suggestions
* Helps document examiners learn about the application of their expertise in the courtroom, and what to expect when questioned by attorneys

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A volume in the Handbook of Experimental Animals series, The Laboratory Primate details the past and present use of primates in biomedical research, and the husbandry, nutritional requirements, behaviour, and breeding of each of the commonly used species. Practical information on regulatory requirements, not available in other texts, is covered. Sections on experimental models cover the major areas of biomedical research, including AIDS, cancer, neurobiology and gene therapy. Assisted reproductive technology, tissue typing, and minimum group sizes for infectious disease/vaccine studies are also included. Two-color, user-friendly format, with copious illustrations and color plates Includes detailed, well-illustrated sections on gross & microscopic anatomy, common diseases, and special procedures, including surgical techniques

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Therapist's Guide to Substance Abuse Intervention

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Author of AP's bestselling "Therapist's Guide to Clinical Intervention" now turns her attention to substance abuse intervention. The book will follow a similar format to her previous book, presenting information in easy to read outline form, with relevant forms, patient questionnaires, checklists, business documents, etc.

Part I discusses the social impact of substance abuse and provides a general overview of the physiological and psychological characteristics of abuse, DSM IV definition of abuse, and classifications of the varying types of drugs. Part II is the main section of the book and covers assessment, different stages of abuse/recovery, and treatment choices. Coverage includes the discussion of myriad self help choices (e.g. AA), group therapy, brief therapy, and more. Discussion will also include making a determination of treatment as inpatient or outpatient, and issues relevant to special populations (teenagers, geriatrics, comorbidity patients, etc.). Part III presents skill building resources. Part IV covers prevention, quality assurance, and also includes a glossary.

* Outlines treatment goals and objectives
* Outlines for assessing special circumstances
* Offers skill building resources to supplement treatment

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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. New Paradigms for the Treatment of Cancer: The Role of Anti-aiogenesis Agents The Hepatocyte Growth Factor/Met Pathway in Development, Tumorigenesis, and B-Cell Differentiation Clinical Targets for Anti-metastasis Therapy Animal Models of Melanoma: Recent Advances and Future Prospects The Indispensable Role of Microenvironment in the Natural History of Low-Grade B-Cell Neoplasms Epstein-Barr Virus Latency: LMP2, a Regulator or Means for Epstein-Barr Birus Biochemistry and Pathological Importance of Mucin-Associated Antigens in Gastrointenstinal Neoplasia Studies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Relation to the Immune System

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Drug-Facilitated Sexual Assault educates readers on the ways in which drugs are used as weapons in committing sexual assaults and how to successfully investigate these crimes.

It looks at the history of these crimes over the years, and includes an in-depth discussion of the drugs and drug classes in use today. It describes the effects of these drugs on the victims, the process for reporting these crimes, details on the type of person who uses drugs to sexually assault an individual, and obstacles to investigating the suspect. The authors show the proper techniques in collecting and analyzing evidence; ways to overcome some of the unique difficulties encountered in these types of investigations; and how to work with other professionals to prosecute these cases successfully. The concluding appendixes are valuable samples of the necessary forms needed to complete these investigations.

This book is ideal for anyone involved in investigating these crimes, including forensic scientists, law enforcement officers, lawyers, toxicologists, and medical professionals.
* Ideal for everyone involved in the investigation of these crimes, including forensic scientists, police officers, lawyers, toxicologists and medical professionals

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Nutrition in the Prevention and Treatment of Disease

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As we enter the 21st century, a new era of nutrition in the prevention and treatment of disease emerges. Clinical nutrition involves the integration of diet, genetics, environment, and behavior promoting health and well being throughout life. Expertly edited, Nutrition in the Prevention and Treatment of Disease provides overall perspective and current scientifically supported evidence through in-depth reviews, key citations, discussions, limitations, and interpretations of research findings.

This comprehensive reference integrates basic principles and concepts across disciplines and areas of research and practice, while detailing how to apply this knowledge in new creative ways. Nutrition in the Prevention and Treatment of Disease is an essential part of the tool chest for clinical nutritionists, physicians, nurse practitioners, and dieticians in this new era of practice. This book prepares the clinical nutrition investigator or practitioner for a life-long commitment to learning.

CONTAINS INFORMATION ON:
* Diet assessment methodologies
* Strategies for diet modification
* Clinical status of herbals, botanicals, and modified food products
* Preventing common diseases such as cardiovascular disease, diabetes, osteoporosis, and breast cancer through nutrition
* The Importance of genetic factors
* Understanding of cultural and socio-economic influences on eating and exercise behaviors and integrating that knowledge with biological or functional markers of disease

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Carol J. Boushey, Ann M. Coulston, Cheryl L. Rock, Elaine Monsen

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Nuclear Magnetic Resonance of Biological Macromolecules, Part A

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This volume and its companion, Volume 339, supplement Volumes 176, 177, 239, and 261. Chapters are written with a "hands-on" perspective. That is, practical applications with critical evaluations of methodologies and experimental considerations needed to design, execute, and interpret NMR experiments pertinent to biological molecules.

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Thomas L. James, Volker Dotsch, Uli Schmitz

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Volume 322 of Methods in Enzymology is dedicated to apoptosis. Major topics covered include measuring apoptosis and apoptosis-induced endonucleases, measuring apoptosis in lower organisms, proteases involved in apoptosis and their inhibitors, cell free systems for monitoring steps in apoptosis pathways, mitochondria and apoptosis, bCl-2 family proteins, and studying receptors and signal transduction events implicated in cell survival and cell death.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

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John N. Abelson, Melvin I. Simon, John C. Reed

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International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Involvement of Gap Junctional Communication in Myogenesis Genetic Analysis of Plant Morphogenesis in Vitro The Cell and Developmental Biology of Tendons and Ligaments Some Aspects of Plant Karyology and Karyosystematics Eph Receptors and Ephrins: Regulators of Guidance and Assembly Renewal of Photoreceptor Outer Segments and Their Phagocytosis by the Retinal Pigment Epithelium

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Optical instruments are routinely employed to obtain a wealth of information about the atmosphere, including its composition, temperature, and winds. A bewildering variety of optical instruments have been proposed over the years, making it difficult to decide which instrument should be chosen to make a specific measurement. Spectral Imaging of the Atmosphere traces the historical development of both spectral and imaging methods and places them in a unified framework relevant to observations of the troposphere, stratosphere, mesosphere and thermosphere. The underlying concepts of various measurement methodologies are presented and paired with appropriate applications. A selection of specific spectral imaging instruments, appropriate to illustrate each conceptual type, is described in detail.Shepherd's work provides both scientists and engineers with an in-depth understanding of the fundamental concepts they need to know in order to plan a program of atmospheric measurements. Expected future methods and developments are also presented. Problems designed to test and enhance the reader's understanding of the material are included in each chapter.

Provides a unique and unifed approach to the methodology of optical atmospheric observations from the troposphere through the thermosphere, which allows the practitioner to choose the best instrument for a given measurement.Describes state-of-the-art atmospheric observing instruments with an eye to future developments.Includes problems designed to test and enhance students' unerstanding of the material presented in each chapter.Contains concise descriptions of selected current and planned spectral imagers, including the Fabry-Perot spectrometer, the Michelson interferometer and the diffraction grating spectrometer.Written from a scientific perspective in an engineering framework, this work is accessible to atmospheric scientists and instrumentation engineers alike.

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Learning and Teaching on the World Wide Web

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This book is about using the Internet as a teaching tool. It starts with the psychology of the learner and looks at how best to fit technology to the student, rather than the other way around. The authors include leading authorities in many areas of psychology, and the book takes a broad look at learners as people. Thus, it includes a wide range of materials from how the eye "reads" moving graphs on a Web page to how people who have never met face-to-face can interact on the Internet and create "communities" of learners. The book considers many Internet technologies, but focuses on the World Wide Web and new "hybrid" technologies that integrate the Web with other communications technologies. This book is essential to researchers is psychology and education who are interested in learning. It is also used in college and graduate courses in departments of psychology and educational psychology. Teachers and trainers at any level who are using technology in their teaching (or thinking about it) find this book very useful.

Key Features
* Distinguished authors with considerable expertise in their fields
* Broad "intra-disciplinary" perspective on learning and teaching on the Web
* Focus on the Web and emerging Web-based technologies
* Special attention to conducting educational research on-line
* Emphasis on the Social and Psychological Context
* Analyses of effective Web-based learning resources
* Firmly grounded in contemporary psychological research and theory

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Sphingolipid Metabolism and Cell Signaling, Part B

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This volume contains information on analyzing sphingolipids, sphingolipid transport and trafficking, and sphingolipid-protein interactions and cellular targets. Its companion Volume 311 presents methods used in studying enzymes of sphingolipid biosynthesis and turnover, including inhibitors of some of these enzymes, genetic approaches, and organic and enzymatic syntheses of sphingolipids and analogs. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

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John N. Abelson, Melvin I. Simon, Alfred H. Merrill Jr., Yusuf A. Hannun

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RNA-Ligand Interactions, Part B: Molecular Biology Methods

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RNA-Ligand Interactions, Part B focuses on molecular biology methods. Major topics covered include: solution probe methods, tethered-probe methodologies, in vitro affinity selection methodologies, genetic methodologies for detecting RNA-protein interactions, protein engineering methodologies useful for RNA-protein interaction studies, and cell biology methods.RNA-Ligand Interactions, Part A, its companion, VOLUME 317 focuses on structural biology methods.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

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Melvin I. Simon, Daniel W. Celander, John N. Abelson