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Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.

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James G. Fox, Stephen Barthold, Muriel Davisson, Christian E. Newcomer, Fred W. Quimby, Abigail Smith

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Eye-movement recording has become the method of choice in a wide variety of disciplines investigating how the mind and brain work. This volume brings together recent, high-quality eye-movement research from many different disciplines and, in doing so, presents a comprehensive overview of the state-of-the-art in eye-movement research.

Sections include the history of eye-movement research, physiological and clinical studies of eye movements, transsaccadic integration, computational modelling of eye movements, reading, spoken language processing, attention and scene perception, and eye-movements in natural environments. Includes recent research from a variety of disciplines Divided into sections based on topic areas, with an overview chapter beginning each section Through the study of eye movements we can learn about the human mind, and eye movement recording has become the method of choice in many disciplines

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International Review of Research in Mental Retardation

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Mental Retardation, Personality, and Motivational Systems

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Volume 31 of the International Review of Research in Mental Retardation is a thematic exploration of personality and motivation in persons with mental retardation. Looking at a broad spectrum of intellectual disabilities, Mental Retardation, Personality, and Motivational Systems explores motivation as a moderator for performance and individualized effort. Coverage includes discussions of intrinsic and extrinsic motivation in both mentally retarded and non-retarded children, self-determination, interpersonal decision making in adolescents and adults with mental retardation, interpersonal relationships, and the connection between etiological-specific differences and motivation to form "behavioral phenotypes." A final chapter presents a transactional perspective on human ability, relying on constructs of intelligence, cognitive processes, and motivation, with implications for developmental interventions in the lives of persons with mental retardation. Explores personality and motivation in persons with mental retardation Discusses intrinsic and extrinsic motivation in both mentally retarded and non-retarded children A useful reference for researchers and scholars in developmental and cognitive psychology, as well as neuropsychology

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Laraine Masters Glidden, Harvey N. Switzky

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Regulators and Effectors of Small GTPases: Rho Family

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The Ras superfamily (>150 human members) encompasses Ras GTPases involved in cell proliferation, Rho GTPases involved in regulating the cytoskeleton, Rab GTPases involved in membrane targeting/fusion and a group of GTPases including Sar1, Arf, Arl and dynamin involved in vesicle budding/fission. These GTPases act as molecular switches and their activities are controlled by a large number of regulatory molecules that affect either GTP loading (guanine nucleotide exchange factors or GEFs) or GTP hydrolysis (GTPase activating proteins or GAPs). In their active state, they interact with a continually increasing, functionally complex array of downstream effectors.

Since the last Methods in Enzymology volume on this topic in 2000, Rho GTPases have continued to receive a huge amount of attention. The human genome sequence has revealed the full extent of the Rho GEF and Rho GAP families (over 80 members for each) and the challenge of identifying the molecular interactions and cellular pathways influenced by each of these regulators is a daunting prospect. This new volume, Regulators and Effectors of Small GTPases: Rho Family, describes some of the methods currently being used to examine Rho family GTPase regulation at the biochemical and cellular level.
Describes the methods currently being used to examine Rho family GTPase regulation at the biochemical and cellular levels Includes new imaging techniques that revolutionize the ability to visualize GTPase activities Over 150 international contributors

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Multispecies Assemblages, Ecosystem Development and Environmental Change

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Dynamic Food Webs challenges us to rethink what factors may determine ecological and evolutionary pathways of food web development. It touches upon the intriguing idea that trophic interactions drive patterns and dynamics at different levels of biological organization: dynamics in species composition, dynamics in population life-history parameters and abundances, and dynamics in individual growth, size and behavior. These dynamics are shown to be strongly interrelated governing food web structure and stability and the role of populations and communities play in ecosystem functioning.

Dynamic Food Webs not only offers over 100 illustrations, but also contains 8 riveting sections devoted to an understanding of how to manage the effects of environmental change, the protection of biological diversity and the sustainable use of natural resources.

Dynamic Food Webs is a volume in the Theoretical Ecology series.
Relates dynamics on different levels of biological organization: individuals, populations, and communities Deals with empirical and theoretical approaches Discusses the role of community food webs in ecosystem functioning Proposes methods to assess the effects of environmental change on the structure of biological communities and ecosystem functioning Offers an analyses of the relationship between complexity and stability in food webs

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Peter C de Ruiter, Volkmar Wolters, John C Moore

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Glutamate and GABA are the main information carrying neurotransmitters in the brain. Their action is modulated by a further series of small molecules called neuromodulators. The major neuromodulators in the brain are acetylcholine (both muscarinic and nicotinic), dopamine, norepinephrine, epinephrine and serotonin.  These have an enormous range of functions in a wide variety of brain mechanisms. This book attempts to give a general overview of this field with a section devoted to each of these. Each section starts with anatomy, both structural and functional. The various types of receptors for these agents are described and then the effects of stimulating these receptors. These receptors trigger a variety of electrical reactions that generally involve potassium, sodium or calcium channels.  Also reviewed are other receptors that trigger a wide variety of post-synaptic signaling cascades that influence a large number of neuronal functions including receptor sensitivity, synaptic plasticity and gene manipulation. Finally the relevance of these systems to disease states is detailed. There are many reviews of individual neuromodulators but this is the only book where one author attempts to cover the whole field.

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Ronald J. Bradley, R. Adron Harris, Peter Jenner, John Smythies

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Towards an Interdisciplinary Perspective on the Life Course

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Despite the well-established consensus on the need for an interdisciplinary research paradigm to understand the unfolding of human lives within their social context, existing empirical research rarely embraces this belief. This volume aims at examining the feasibility and hurdles of interdisciplinarity specific to given research fields by bringing together leading North-American and European researchers in sociology, psychology, social psychology and social demography, all highly concerned with fostering an interdisciplinary perspective for the study of the human life course. The contributions are organized along four major axes, three of them substantive (agency and structure, transitions, and biographical re-constructions) and one methodological (methodological innovations), leaving ample leeway for the contributions to address the specific gains and difficulties of empirical interdisciplinary research within their particular domain. The editors introduce the volume by discussing general features, theoretical linkages, and transversal substantive themes of interdisciplinarity in life course research. Likewise, the volume is ended by the editors conclusions based on the contributions; they single out major challenges and difficulties for the interdisciplinary study of the life course, together with some promising research meant to address such difficulties and improve current knowledge about the life course. <p>The volume speaks to both experienced scholars and graduate students of the life course. Advanced scholars will benefit from the latest in life course research domains and from a comprehensive overview of life course methodologies. Graduate students of the life course will find in the book an original introduction to many empirical aspects of life course research and to the application of innovative methods to various research settings, as well as rich bibliographical references from the research literature in English, German and French.

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René Levy, Paolo Ghisletta, Jean-Marie Le Goff, Dario Spini, Eric Widmer

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Current major interests in this area include the study of higher level phylogenetic relationships and character evolution in the angiosperms, floral evolution, the genetic basis of key floral differences in basal angiosperms, the genetic and genomic consequences of polyploid speciation, conservation genetics of rare plant species, and phylogeography. Developmental Genetics of the Flower provides a series of papers focused on the developmental genetics of flowering as well as the genetic control of the timing of flowering. Investigation of speciational mechanisms, evolutionary relationships, and character evolution in flowering plants and land plants utilizing a variety of experimental approaches are discussed. The chapters are excellent reviews of the current fast-moving area of research. Provides a brief review of genes known to regulate flower development Articles emphasize the classic ABC model of flower development

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Doug Soltis, Pamela Soltis, Jim Leebens-Mack

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Edited by J.A. Callow and supported by an international Editorial Board, Advances in Botanical Research publishes in-depth and up-to-date reviews on a wide range of topics in plant sciences. Currently in its 43rd volume, the series features a wide range of reviews by recognized experts on all aspects of plant genetics, biochemistry, cell biology, molecular biology, physiology and ecology. This eclectic volume features four reviews on cutting-edge topics of interest to post-graduates and researchers alike. Includes such topics as defensive ecology of brown algae Multidisciplinary reviews written from a broad range of scientific perspectives Discusses opportunities for the control of brassicaceous weeds of cropping systems using mycoherbicides For over 40 years, series has enjoyed a reputation for excellence Contributors internationally recognized authorities in their respective fields

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Protein methylation has recently emerged as one of the most exciting areas of study on posttranslational modification.  A large family of protein methyltransferases has been identified and their structural properties have been characterized.  These studies have provided novel insights into how methylation regulates a variety of biological functions including DNA and RNA metabolism, protein synthesis and signal transduction.  Methylation also plays important roles in aging.  This volume is intended to capture these recent developments concerning protein methyltransferases.

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Advances in Microbial Physiology is one of the most successful and prestigious series from Academic Press, an imprint of Elsevier. It publishes topical and important reviews, interpreting physiology to include all material that contributes to our understanding of how microorganisms and their component parts work.First published in 1967, it is now in its 50th volume. The Editors have always striven to interpret microbial physiology in the broadest context and have never restricted the contents to traditional views of whole cell physiology. Now edited by Professor Robert Poole, University of Sheffield, Advances in Microbial Physiology continues to be an influential and very well reviewed series. In 2004, the Institute for Scientific Information released figures showing that the series had an Impact Factor of 8.947, with a half-life of 6.3 years, placing it 5th in the highly competitive category of Microbiology.

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DNA Microarrays, Part A: Array Platforms and Wet-Bench Protocols

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Modern DNA microarray technologies have evolved over the past 25 years to the point where it is now possible to take many million measurements from a single experiment. These two volumes, Parts A & B in the Methods in Enzymology series provide methods that will shepard any molecular biologist through the process of planning, performing, and publishing microarray results.

Part A starts with an overview of a number of microarray platforms, both commercial and academically produced and includes wet bench protocols for performing traditional expression analysis and derivative techniques such as detection of transcription factor occupancy and chromatin status. Wet-bench protocols and troubleshooting techniques continue into Part B. These techniques are well rooted in traditional molecular biology and while they require traditional care, a researcher that can reproducibly generate beautiful Northern or Southern blots should have no difficulty generating beautiful array hybridizations.

Data management is a more recent problem for most biologists. The bulk of Part B provides a range of techniques for data handling. This includes critical issues, from normalization within and between arrays, to uploading your results to the public repositories for array data, and how to integrate data from multiple sources. There are chapters in Part B for both the debutant and the expert bioinformatician.
Provides an overview of platforms Includes experimental design and wet bench protocols Presents statistical and data analysis methods, array databases, data visualization and meta-analysis

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The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

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P. Michael Conn, Stephen A. Benjamin, Caleb E. Finch, John C. Guerin, James F. Nelson, S. Jay Olshansky, George Roth, Roy G. Smith

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Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. In 2004, the Institute for Scientific Information released figures showing that the series has an Impact Factor of 2.576, with a half-life of 7.1 years, placing it 11th in the highly competitive category of Virology.

* Edited by an experienced plant pathologist who has over 50 years experience in plant virus epidemiology* Covers topics such as Evolutionary epidemiology of plant virus disease, The control of tropical plant virus diseases, and Control of plant virus diseases* A valuable resource for students and researchers alike

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Handbook of Biologically Active Peptides

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Peptides play a crucial role in many physiological processes including actions as neurotransmitters, hormones, and antibiotics. Research has shown their importance in such fields as neuroscience, immunology, pharmacology, and cell biology. The Handbook of Biologically Active Peptides presents, for the first time, this tremendous body of knowledge in the field of biologically active peptides in one single reference. The section editors and contributors represent some of the most sophisticated and distinguished scientists working in basic sciences and clinical medicine. The Handbook of Biologically Active Peptides is a definitive, all-encompassing reference that will be indispensable for individuals ranging from peptide researchers, to biochemists, cell and molecular biologists, neuroscientists, pharmacologists, and to endocrinologists. Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas with which they would not ordinarily be familiar.

*Chapters are designed to be a source for workers in the field and will enable researchers working in a specific area to examine other related areas that they would not ordinarily be familiar.*Fascinating relationships described in the book include the presence of some peptides originally found in frog skin that persist in the human human and brain where they can affect food intake and obesity.

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Analysis & Interpretation in the Diagnosis and Treatment of Neurological Disease

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The analysis of the protein content of the Cerebrospinal Fluid (CSF) is a central tool in the diagnosis of a number of diseases, including Multiple Sclerosis and Encephalitis. Proteins of the Cerebrospinal Fluid is a complete revision of the first edition published 16 years ago and reflects the advances in the field in that period. Containing the most comprehensive reference list available today with over 1300 references cross-indexed according to topics, it also includes many classical works that cannot be easily found through the public literature database (like PubMed). This book covers new areas of research such as the use of the analysis of protein content in the CSF to guide the prognosis of patients with severe head injury and/or stroke (currently being tested using technology which can be applied at the bedside to yield results within 15 minutes).

With many new or completely revised illustrations, this book serves as not only a reference on the topic, but also a lab manual for bench work with recipes, and a clinical reference on individual diseases.
Introduces the Eastern blotting, the technique considered the "gold standard" by the US Food & Drug Administration (FDA) for the demonstration of IgG by immunofixation following isoelectric focusing Provides numerous tables for ease-of-use Extensively cross-referenced with over 1300 references

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First published in 1943, VITAMINS AND HORMONES is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, VITAMINS AND HORMONES continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

*Includes color illustrations*Available on ScienceDirect*Longest running series published by Academic Press *Contributions by leading international authorities

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Crime Scene Photography is a book wrought from years of experience, with material carefully selected for ease of use and effectiveness in training, and field tested by the author in his role as a Forensic Services Supervisor for the Baltimore County Police Department.

While there are many books on non-forensic photography, none of them adequately adapt standard image-taking to crime scene photography. The forensic photographer, or more specifically the crime scene photographer, must know how to create an acceptable image that is capable of withstanding challenges in court. This book blends the practical functions of crime scene processing with theories of photography to guide the reader in acquiring the skills, knowledge and ability to render reliable evidence. Required reading by the IAI Crime Scene Certification Board for all levels of certification Contains over 500 photographs Covers the concepts and principles of photography as well as the "how to" of creating a final product Includes end-of-chapter exercises

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Provides a coherent and comprehensive account of the theory and practice of real-time human disease outbreak detection, explicitly recognizing the revolution in practices of infection control and public health surveillance. Reviews the current mathematical, statistical, and computer science systems for early detection of disease outbreaks Provides extensive coverage of existing surveillance data Discusses experimental methods for data measurement and evaluation Addresses engineering and practical implementation of effective early detection systems Includes real case studies

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Michael M. Wagner, Andrew W. Moore, Ron M. Aryel

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Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.

Volume 68, the most recent publication in Current Topics in Developmental Biology, not only discusses the most up-to-date discoveries, it includes 46 figures and 7 tables, all in full color. This volume touches upon topics such as Prolactin and Growth Hormone Signaling; Corpus Luteum Development: Lessons from Genetic Models in Mice; Comparative Developmental Biology of the Mammalian Uterus; Sarcopenia of Aging and its Metabolic Impact; and even a chapter on Initial failure in Myoblast Transplantation Therapy has led the way towards the isolation of muscle stem cells: Potential for tissue regeneration.

* Most recent volume series that offers 11 chapters of the latest studies of developmental biology
* Discusses various subjects such as tissue regeneration, the role of proteins, and a comparative analysis of the mammalian uterus
* Full color figures and tables with detailed illustrations