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Hereditary or genetic diseases featuring involuntary movements constitute a major aspect of the practice of neurology, functional neurosurgery, genetics, and many areas of basic and applied neuroscience research. Describing the current knowledge on these disorders, Genetics of Movement Disorders brings together information essential for clinicians, geneticists, and neuroscientists in one source. Utilizing a convenient and accessible format, the book is designed to allow easy identification of relevant information, with the overall organization of topics following established phenotypic classifications of movement disorders such as Parkinsonian syndromes, chorea, ataxia, and major categories of diseases grouped by gene locus. This book broadly appeals to neurologists, neuroscientists, geneticists, as well as cell and molecular biologists and hematologists. Consistently formatted to present a clinical description of the disorder, followed by an in-depth analysis of the mutation and function of the mutated gene including cellular and animal models Emphasizes the use of DNA tests for each respective disorder Provides up-to-date, easily accessible information for clinicians, geneticists, and neuroscientists

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Gene Expression Systems: Using Nature for the Art of Expression offers detailed information on a wide variety of gene expression systems from an array of organisms. It describes several different types of expression systems including transient, stable, viral, and transgenic systems. Each chapter is written by a leader in the field. The book includes timelines and examples for each expression system, and provides an overview of the future of recombinant protein expression. Provides detailed information on expression systems Covers a variety of promoters and host organisms enabling researchers to tailor protocols to their specific needs Includes timelines and examples Compares pros and cons of each method

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The Gene Knockout Factsbook, Two-Volume Set

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The FactsBooks Series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as "a growing series of excellent manuals" by Molecular Medicine Today, and "essential works of reference" by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. Using an easy-to-follow format and drawing from meticulous research, the Factsbooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity.
The Gene Knockout FactsBook contains entries, grouped into subject disciplines, covering immunology, neurobiology, development, cancer, and other knockouts. It describes more than 600 gene knockouts described and listed in alphabetical order for easy reference.

Key Features
* Entries provide information on:
* general description of the protein and its function
* gene symbol and database accession number
* knockout construct
* mouse phenotype
* key references

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Furunculosis: Multidisciplinary Fish Disease Research presents a fascinating insight into the opinions and the controversies which have led to current knowledge of this disease. It is the first book to cover one single fish disease by presenting not just the reviews, but also critical examination of the progress made by various disciplines. The multidisciplinary approach of the book makes it a valuable guide for veterinarians, fisheries biologists, and fish farm managers, as well as an excellent instructional text for students. The volume explores current research strategies and projects what developments can be expected in each field. Considers the whole disease and not just the pathogen, Aeromonas salmonicida Analyzes the state of modern knowledge on the disease Suggests topics for future research and uses furunculosis as a model for other diseases Highlights and summarizes each section's themes and concepts Presents a unique compendium of research information for all professionals working on furunculosis

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Eva-Maria Bernoth, Anthony E. Ellis, Paul J. Midtlyng, Gilles Olivier, Peter Smith

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The contributors to this text, who are all biochemists who worked during the 1950s and 60s, describe what appears to them to be the conceptually significant developments in biochemistry since the mid 1950s and how these were achieved. Their aim is to make their subjects intelligible to other scientists not expert in their field.

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This fourth volume in the series on biochemistry looks at foundations in modern biochemistry. Topics covered include: the genetic solution; the genetic basis of development; DNA repair; evolution in an RNA world; nitrogen fixation; solute channels; viruses; biochemistry in retrospect and propspect.

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Fluorescent and Luminescent Probes for Biological Activity

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A Practical Guide to Technology for Quantitative Real-Time Analysis

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The use of fluorescent and luminescent probes to measure biological function has increased dramatically since publication of the First Edition due to their improved speed, safety, and power of analytical approach. This eagerly awaited Second Edition, also edited by Bill Mason, contains 19 new chapters and over two thirds new material, and is a must for all life scientists using optical probes.
The contents include discussion of new optical methodologies for detection of proteins, DNA and other molecules, as well as probes for ions, receptors, cellular components, and gene expression. Emerging and advanced technologies for probe detection such as confocal laser scanning microscopy are also covered. This book will be essential for those embarking on work in the field or using new methods to enhance their research.

TOPICS COVERED:
* Single and multiphoton confocal microscopy
* Applications of green fluorescent protein and chemiluminescent reporters to gene expression studies
* Applications of new optical probes for imaging proteins in gels
* Probes and detection technologies for imaging membrane potential in live cells
* Use of optical probes to detect microorganisms
* Raman and confocal raman microspectroscopy
* Fluorescence lifetime imaging microscopy
* Digital CCD cameras and their application in biological microscopy

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Fertilization provides in-depth reviews of individual research topics, while emphasizing key concepts and the significance of findings within other fields. The author identifies essential questions to be answered by future research. Fertilization broadly covers the many molecular and cellular events of animal fertilization and includes a section on unique problems and potential applications of fertilization research. Provides in-depth reviews of individual research topics Emphasizes key concepts and significance of findings to other fields Broadly covers the many molecular and cellular events of animal fertilization Includes a section on unique problems and potential applications of fertilization research Identifies essential questions to be answered by future research

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The thalamus is a group of cells placed centrally in the brain that serve a critical role in controlling how both sensory and motor signals are passed from one part of the cerebral cortex to another. Essentially, all information reaching the cerebral cortex and thus consciousness is relayed through the thalamus. The role of the thalamus in controlling the flow of information (such as visual, auditory, and motor) to the cortex has only recently begun to be understood. This book provides an in-depth look at the function of the thalamus and its role as relayer of information to the cerebral cortex. The authors explore how the thalamus controls messages that are passed to the cortex and they introduce the novel suggestion that the thalamus serves a critical role in controlling how messages pass from one part of the cortex to another. Exploring the Thalamus is a comprehensive, up-to-date reference for researchers. It discusses problems concerning the function and structure of the thalamus and concludes each chapter with thought-provoking questions regarding future research. Focuses on thalamocortical interrelationships Discusses important problems concerning the function and structure of the thalamus Concludes each chapter with thought-provoking questions requiring future research

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Febrile Seizures is written by the most active researchers and clinicians in epilepsy research today. This book presents the latest developments in this field as well as the current state of knowledge in the following: New imaging tools and emerging data, visualizing effects of febrile seizures on the brain; New genetic methodologies; The use of animal models to permit scientific analysis of the electrophysiology and molecular biology of the seizure. First book on febrile seizures in over 20 years! Broad spectrum of approaches, from genetic and epidemiological to bench research using animal models and in vitro single-cell patch-clamp methods Comprehensive update of the topic, written by world leaders in the field Novel and newly discovered information based on up-to the minute methods Engaging style, accessible to the clinician, researcher, and educated parent

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Form, Function and Evolution in Tetrapod Vertebrates

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As the first four-legged vertebrates, called tetrapods, crept up along the shores of ancient primordial seas, feeding was among the most paramount of their concerns. Looking back into the mists of evolutionary time, fish-like ancestors can be seen transformed by natural selection and other evolutionary pressures into animals with feeding habitats as varied as an anteater and a whale. From frog to pheasant and salamander to snake, every lineage of tetrapods has evolved unique feeding anatomy and behavior.Similarities in widely divergent tetrapods vividly illustrate their shared common ancestry. At the same time, numerous differences between and among tetrapods document the power and majesty that comprises organismal evolutionary history.Feeding is a detailed survey of the varied ways that land vertebrates acquire food. The functional anatomy and the control of complex and dynamic structural components are recurrent themes of this volume. Luminaries in the discipline of feeding biology have joined forces to create a book certain to stimulate future studies of animal anatomy and behavior.

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Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters. Coverage of the field of excitatory amino acids from synaptic function to preclinical and clinical pharmacology Description of the development of NMDA (Nmethyl-d-aspartate) and non-NMDA antagonists Reports of potential drugs in early and late clinical stages of development

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Extracellular Matrix of the Liver addresses the basic science of the extracellular matrix and discussesnew strategies for the treatment of cirrhosis of the liver, with a primary focus on possible gene therapyapproaches.

The chapters are divided into six sections as follows:
Basic Science of Extracellular Matrix Cells Responsible for Extracellular Matrix Production Activation Mechanism of Hepatic Cells and Signal Transduction Basic Science for Extracellular Matrix Metabolism including Enzymes and their Inhibitors Matrix Mettaloproteinases and Tissue Inhibitors for Matrix Mettaloproteinases New Strategies for the treatment of Liver Cirrhosis Discusses the possibility of gene therapy for liver cirrhosis Includes information on new aspects of hepatic stellate cells Written by top experts in basic science and clinical hepatology

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Isao Okazaki, Yosifumi Ninomiya, Tanikawa Kyuichi, Scott I. Friedman

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The Second Edition of The Extracellular Matrix FactsBook has been completely revised, updated and expanded by over 50 percent. It contains over 85 entries on the diverse group of macromolecules that assemble toform the extracellular matrix. Entries provide information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and key references.

Key Features
* Compiled by members of one of the foremost centers of matrix biochemistry in the world
* Contains over 30 new entries, with all previous entries being revised and updated
* Includes new entries on proteinases involved in the deposition of the extracellular matrix
* Presents 3D ribbon diagrams in cases where the protein structure is now known

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Shirley Ayad, Ray Boot-Handford, Martin Humphries, Karl Kadler, Adrian Shuttleworth

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Enzymology Primer for Recombinant DNA Technology

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Enzymes are indispensable tools in recombinant DNA technology and genetic engineering. This book not only provides information for enzymologists, but does so in a manner that will also aid nonenymologists in making proper use of these biocatalysts in their research. The Enzymology Primer for Recombinant DNA Technology includes information not usually found in the brief descriptions given in most books on recombinant DNA methodology and gene cloning. Provides essential basics as well as up-to-date information on enzymes most commonly used in recombinant DNA technology Presents information in an easily accessible format to serve as a quick reference source Leads to a better understanding of the role of biocatalysts in recombinant DNA techniques

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Cellular Organelles and the Extracellular Matrix

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This volume is in two parts. The first contains the remaining chapters on cellular organelles and several chapters relating to organelle disorders. An account of mitochondriopathis is given in the chapter on the mitochondrion rather than in a separate one. The subject matter of this part of the volume shows quite clearly that the interdisciplinary approach to the study of organelles has shed considerable light on the nature of the mechanisms underlying the etiology and pathobiology of many of these disorders. As an example, mutations in the genes encoding integral membrane proteins are found to lead to disturbances in peroxisome assembly. It is also interesting and significant that mistargeting of protein is now thought to be another cause. It will be revealing to see whether mistargeting is the result of mutations in the genes encoding chaperones.
The second part of the volume is concerned with the extracellular matrix. It sets out to show that a vast body of new knowledge of the extracellular matrix is available to us. Take for example the integrin family of cell adhesion receptors. It turns out that integrins play a key role not only in adhesion but also in coupling signals to the nucleus via the cytoskeleton. As for fibronectins, they seem to link the matrix with the cytoskeleton by interacting with integrins.
Collagen molecules are dealt with in the last two chapters. The boundaries of collagen in disease are defined by drawing a clear line of demarcation between systemic connective tissue disorders (e.g., scleroderma), better known as autoimmune diseases, and the heritable, and the heritable diseases such as osteogenesis imperfect and the Marfan syndrome. This classification takes into account a second group of acquired disorders of collagen forming tissues in which regional fibrosis is the hallmark. Liver cirrhosis and pulmonary fibrosis are prime examples.
The decision to place Volumes 2 and 3 before those dealing with cell chemistry was not easily made. It was based on the view that most students will have had an undergraduate course in biochemistry of cell biology or both courses, and that they could go to Volumes 4-7 in which the subject of cell chemistry is covered, and then return to Volumes 2 and 3.

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Volume 4 of Biomembranes covers endocytosis, exocytosis and related processes. A major role of the plasma membrane is as a permeability barrier, keeping the inside of the cell inside and the outside, outside. Mechanisms must then exist to allow movement of material between the cell and its environment. One mechanism for export from the cell is by exocytosis, a process in which the membranes of secretory vesicles fuse with the plasma membrane releasing the contents of the vesicle into the extracellular medium. The process has been studied in particular depth for the release of neurotransmitters at the synapse. Import into the cell is possible by the process of receptor-mediated endocytosis in which selected plasma membrane proteins are internalizes; when these proteins are receptors for macromolecules, the result is uptake of the macromolecule. Transferring, the low-density lipoprotein, and asialoglycoproteins are all taken up into cells in this way. Phagocytosis, the ingestion of cells and cell fragments by neutrophils and macrophages, also involves receptors - on the phagocytic membrane - of which the best studied are those for the Fc domain of IgG, for the third component of complement, and for the mannose/fructose carbohydrates. Protection of a host against infection can also be achieved by damaging the integrity of the plasma membrane of the invading organism. This is the strategy evolved by the cytotoxic T lymphocytes, which produce a pore-forming toxin, perforin. Volume 4 of Biomembranes explores the structures and mechanisms involved in these biologically and medically important processes.

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Emerging Infections is the first volume of the new Biomedical Research Reports Series, which will provide annual updates on hot topics of interest to a broad spectrum of the biomedical research community. This book provides state-of-the-art reviews of new and reemerging bacterial, viral, and parasitic infections, their life cycles, host defense evasion strategies, and clinical features. It includes the history of infectious disease outbreaks, population and evolutionary biology of human pathogens, and current epidemiological models that describe how ecological and demographic changes produce new epidemics. Provides reviews on hot topics of interest to the biomedical research community Editor and contributors are renowned international experts Covers the major established pathogens as well as the new and sensational--such as mad cow disease, hantavirus pulmonary syndrome, pathogenic E. Coli, and flesh-eating bacteria

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John I. Gallin, Anthony S. Fauci, Richard M. Krause

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Endocrine Methods contains descriptions of contemporary and cutting-edge methodologies in various areas of endocrinology, including receptor theory and immunologic techniques for endocrine research. The book presents step-by-step procedures easily available to study the endocrine system and includes experts in their respective fields as contributors. The book presents step-by-step procedures for many important areas of endocrine target organs.Endocrine Methods serves as a valuable methodological resource for investigators using endocrine methods.

Includes comprehensive, yet rapid methodical proceduresOffers a wide spectrum of assays including both in vivo and in vitro systems important to the several areas of hormone researchDescribes several techniques for studying receptors, examining osteoblast activity, and measuring parathyroid hormonesEncompasses a host of important research tools that can be utilized by the toxicologist and other biomedical scientists

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Agricultural crops are prominent features of an increasing number of variously perturbed ecosystems and the landscapes occupied by these ecosystems. Yet the ecology of agricultural-dominated landscapes is only now receiving the scientific attention it has long deserved. This attention has been stimulated by the realization that all agriculture must become sustainable year after year while leaving nearby ecosystems unaffected.

Ecology in Agriculture focuses exclusively on the ecology of agricultural ecosystems. The book is divided into four major sections. An introduction establishes the unique ties between agricultural and ecological sciences. The second section describes the community ecology of these sorts of ecosystems, while the final section focuses on the processes that operate throughout these agricultural landscapes.
Contains an ecological perspective on agricultural production and resource utilization Includes in-depth reviews of major issues in crop ecology by active researchers Covers a range of topics in agricultural ecophysiology, community ecology, and ecosystems ecology Provides examples of ecological approaches to solving problems in crop management and environmental quality