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This book provides comprehensive up-to-date information on the structure and function of immunoglobulins. It describes the basic features of these molecules, which assists the reader in understanding how they function as an integral part of the immune system. The Immunoglobulins describes the localization and structure of different binding sites of immunoglobulin molecules, including the antigen-binding site, on the basis of latest x-ray crystallography studies. It discusses recently developed biotechnological methods that allow scientists to obtain fully active antibody molecules in vitro even without immunization and to construct new variants of immunoglobulins and their fragments by fusing with various other active molecules. A survey of recent knowledge on immunoglobulin-binding molecules other than antigens and on flexibility of immunoglobulin molecules concludes the discussion of functional aspects of the problem. Describes recent reviews on the structure and function of immunoglobulin molecules of various species Summarizes in detail recent findings on the fine structure of the antigen-combining site Presents comparative data on the antigen-recognizing sites of other molecules such as MHC proteins and T-cell receptors Summarizes growing data on immunoglobulin binding sites responsible for the reaction of immunoglobulins with molecules other than antigens Explores the rapid advance of recent biotechnological methods used for the construction of antibody molecules and their fragments with new properties Presents extensive references and is lavishly illustrated

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Immunopharmacology represents the boundary between the immune system and chemical mediators of the inflammatory and neuroendocrine responses. The subject as applied to the respiratory system embraces most of the common non-malignant lung diseases of which asthma and allied disorders are the most prevalent. An understanding of the underlying mechanisms of the disorders provides rationale for prevention and drug treatment as well as creating opportunities for novel drug development. Immunopharmacology of Respiratory System embraces all of these principles and should enable the reader to become rapidly updated in an area of medical importance. Focuses on aspects of disease pathogenesis that are common to a variety of lung disorders Includes coverage of the mechanisms of asthma - origin, progression, and novel therapeutic interventions This volume is another in the "Systems" section of the Handbook of Immunopharmacology

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As this volume demonstrates, immunobiology is a young science which is undergoing explosive growth. Judged by results, it is already an elaborate discipline which cuts across every other area in biomedical research and even has its own vocabolary (e.g., the "veto" effect). Rather than inculcate the habit of superficial learning by having the student go through a maze of details, we have sought to gather together sixteen essays that range from T-cells to psyhoneuroimmunology. This is keeping with the growing understanding that the student is expected to read and think far more for herself/himself.
Next to nothing is known about innate immunity. However, recent evidence suggests that collectins might bridge the gap between innate immunity and specific clonal immune responses. Collectins are soluble effector proteins that include serum mannose-binding protein, and lung surfactants A and D. They are considered to be ante-antibodies.

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Immunoassays are among the most powerful and sensitive technologies now available for patient diagnosis and monitoring. This book is an indispensable guide to information on the theory and practice of immunoassays. It discusses the scientific basis of these technologies in a logical, organized, and heuristic manner and provides protocols for specific assays. The contents of this unique book are balanced among theory, practical issues, quality control, automation, and subspecialty areas, making it ideal for health science students, laboratory scientists, and clinicians. Presents up-to-date information Provides extensive cross-referencing Covers theory and practice in full detail Written by leading authorities

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Eleftherios P. Diamandis, Theodore K. Christopoulos

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The Immune Response is a unique reference work covering the basic and clinical principles of immunology in a modern and comprehensive fashion. Written in an engaging conversational style, the book conveys the broad scope and fascinating appeal of immunology. The book is beautifully illustrated with superb figures as well as many full color plates. This extraordinary work will be an invaluable resource for lecturers and graduate students in immunology, as well as a vital reference for research scientists and clinicians studying related areas in the life and medical sciences. Current and thorough 30 chapter reference reviewed by luminaries in the field Unique single voice' ensures consistency of definitions and concepts Comprehensive and elegant illustrations bring key concepts to life Provides historical context to allow fuller understanding of key issues Introductory chapters 1-4 serve as an Immunology Primer' before topics are discussed in more detail

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Tak W. Mak, Mary E. Saunders, Maya Rani Chaddah, Wendy Lynn Tamminen

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Identifying Marine Phytoplankton is an accurate and authoritative guide to the identification of marine diatoms and dinoflagellates, meant to be used with tools as simple as a light microscope. The book compiles the latest taxonomic names, an extensive bibliography (referencing historical as well as up-to-date literature), synthesis and criteria in one indispensable source. Techniques for preparing samples and containing are included as well as hundreds of detailed, helpful information. Identifying Marine Phytoplankton is a combined paperback edition made available by popular demand of two influential books published earlier--Marine Phytoplankton and Identifying Marine Diatoms and Dinoflagellates. Contains hundreds of illustrations showing critical characteristics necessary for proper identification, plus keys and other guides Provides up-to-date taxonomic revisions Includes species from around the world Updates synthesis of modern and historical literature presented by active researchers in the field Compiles literature from around the world into one handy source

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The Recurrence of Similarity in Evolution

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Why do unrelated organisms sometimes appear almost identical in details of the anatomy, behavior, physiology, and ecology? Homoplasy assembles leaders in evolutionary biology to explore issues of parallelism, convergence, and reversals. This innovative book is certain to provoke discussion of homoplasy compelling evidence for particular theories of evolutionary change The first book on this increasingly interesting subject Includes authoritative treatments from leading experts expressing a variety of viewpoints

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Human Performance and Ergonomics brings together a comprehensive and modern account of how the context of performance is crucial to understanding behavior. Environment provides both constraints and opportunities to individuals, such that external conditions may have reciprocal or interactive effects on behavior.The book begins with an account of research in human factors and engineering, with application of research to real world environments, methodological concerns, and rumination on current and future trends. The book proceeds to how technology has moved from being designed to help human physical survival to helping humans achieve "quality of life" improvements. Real world examples are explored in detail including hearing technology, driving, and aviation. Issues of control, maneuvering, and planning are discussed in conjunction with how intention and expectancy affect behavior. The fit between human and environment is examined as a dynamic interaction, and many chapters address the all important human-machine communication, particularly that between humans and computers.The book closes with a reminder that even our technological environment is filled with other people, with whom we must interact personally or via technology, to achieve our larger goals. Teamwork is thus discussed for its integration of cognitive, behavioral, and affective components toward our achieving desired aims.

* Includes the application of research in human factors in engineering to real world environments* Discussion of both current and future trends is included* Real-world examples of how technology is now helping humans to achieve "quality of life" improvements are explored in detail including hearing technology, driving and aviation* Many chapters examine the all important human/machine communication, particularly human-computer interaction (HCI)

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Hormones and Signaling focuses on the mechanism of gene regulation at the cellular level. It also covers the way hormones act to modulate gene regulation and animal development.
Includes information on:
Nuclear receptors, coactivators, and corepressors Membrane receptors, kinases, and phosphorylation on cascades Hormonal regulation of development Calcium channels and neurotransmitters Chromatin, transcription factors, and regulation of gene expression JAK/STAT pathways Hormone-regulated development and gene "knock-out"

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Ronald Evans, Lutz Birnbaumer, James Darnell, Vale Wylie, Tony Hunter, Anthony R. Means, Bert W. O'Malley

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HIV and the New Viruses presents cutting-edge reviews of persistent human virus infections as a coherent collection for the first time. These cover recently discovered viruses such as HHV-6, HHV-8 and HCV, as well as the latest research on HIV.

This comprehensive and updated reference includes an in-depth study of the major issues in the epidemiology, pathogenicity, molecular virology, host responses and management of conditions associated with those viruses. Information on new pharmaceuticals and vaccine developments is also included.

Edited by the leading experts in the field, HIV and the New Viruses will be essential reading for postgraduates, clinicians and researchers in virology, immunology, cancer, molecular biology and the pharmaceutical industry.
Presents cutting-edge reviews of persistent human virus infections as a coherent collection for the first time Includes an in-depth study of the major issues in the epidemiology, pathogenicity, molecular virology, host responses, and management of conditions associated with those viruses

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The anticipated encore volume of the Biomedical Research Reports Series, Hepatitis C is the first book that offers comprehensive and up-to-date coverage of this "silent epidemic." The subject matter ranges from basic science to clinical medicine, with contributions from more than 30 international experts in the field. This important new book details the hepatitis C virus and the disease that it causes, including its prevalence, means of spread, symptoms, complications, natural history, prevention, and therapy.The editors, T. Jake Liang, M.D., and Jay H. Hoofnagle, M.D., are both hepatologists and clinical and laboratory researchers who are well known leaders in the hepatitis field. Their team of authors provide the latest information on key issues such as the role of hepatitis C in liver cancer and evolving therapy for hepatitis C, including special subgroups of patients such as children, patients with renal failure, patients undergoing liver transplantation, and patients with HIV coinfection. The book also addresses future directions in antiviral therapy of hepatitis C and the real challenges of developing a vaccine. Hepatitis C is the integrated reference book for all researchers, clinicians, and students dealing with this troubling virus.

Key Features* Provides comprehensive coverage of hepatitis C, ranging from basic science to clinical application* Includes contributions from more than 30 international experts in the field* Supplies current recommendations on management of hepatitis C* Designed in an easy-to-use format with consistent organization* Includes extensive illustrations

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John I. Gallin, Anthony S. Fauci, T. Jake Liang, Jay H. Hoofnagle

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Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students.

Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology

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Yoshihisa Kurachi, Andre Terzic, Michael V. Cohen, Nicholas Sperelakis

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Histidine Kinases in Signal Transduction

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Living cells are constantly sensing environmental changes, and their abilities to sense these changes and adapt to them are essential for their survival. In bacteria, histidine kinases are the major sensors for these environmental stresses, enabling cells to adapt to new growth conditions.

Written by leading experts in the field, this book provides an up-to-date and comprehensive review on the structure and function of histidine kinases. It also provides extensive information on the physiological roles of histidine kinases in bacteria and eukaryotes.

An an essential reference for cell biologists, microbiologists, molecular biologists, and biochemists interested in signal transduction. Experimental biologists and pharmacologists studying signal transduction systems in living organisms will also find it a valuable research tool.
The first comprehensive book on the roles of histidine kinases in cells 23 in-depth chapters written by leading experts in the field Describes the most recent advances in the field of signal transduction

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This book describes the complex structures of heparins and heparan sulfates (heparinoids) and how they are generated by their biosynthetic pathways. The book also details the methodologies for studying these structures and their cellular metabolism. Heparin-Binding Proteins introduces the general nature of interactions between heparinoids and proteins, and presents the role for these structures in their interactions with the proteins of the hemostatic mechanisms, fibroblasts growth factors, superoxide dismutase, and lipoproteins. Covers cellular metabolism of heparinoid proteoglycans Written by a distinguished expert in the field of carbohydrate biochemistry Describes the roles of heparan sulfate proteoglycans in   Blood coagulation and fibrinolysis Lipoprotein metabolism Superoxide dismutase activity Fibroblast growth factor responses of cells

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A Practical Handbook A Volume in the EDUCATIONAL PSYCHOLOGY Series

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The Handbook of Psychoeducational Assessment is a practical guide for educational and psychological professionals using norm-referenced tests in the ability, achievement, and behavioral assessment of children. Written by key individuals involved in the construction and evolution of the most widely used tests, this book provides critical information on the nature and scope of commonly used tests, their reliability and validity, administration, scoring and interpretation, and on how the tests may differ and complement each other in their utility with specific populations.

Part 1 of the Handbook of Psychoeducational Assessment focuses on ability assessment and the use of full battery intelligence tests as well as brief scales and short forms. Part 2 discusses achievement and the expanded role of psychologists in consultation with educators. Part 3 covers behavior assessment with special attention given to discussion of which tests are most suitable for assessing specific behavioral problems such as ADHD, anxiety, and depression. The final section recognizes the importance of context and person sensitive assessment practices, discussing cross-cultural assessment, neuropsychological assessment, and the usefulness of dynamic assessment for program planning and intervention delivery.

Key Features:
Covers the most commonly used and newest assessment instruments Describes the nature, scope, reliability, and validity of each test Discusses the administration, scoring, and interpretation of tests Provides empirical findings on patterns of performance with tested populations Includes case studies to highlight the utility of specific tests for specific populations Illustrates new developments in instrumentation and unique features Covers the most commonly used and newest assessment instruments Describes the nature, scope, reliability, and validity of each test Discusses the administration, scoring, and interpretation of tests Provides empirical findings on patterns of performance with tested populations Includes case studies to highlight the utility of specific tests for specific populations Illustrates new developments in instrumentation and unique features

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Gary D. Phye, Donald H. Saklofske, Jac J.W. Andrews, Henry L. Janzen

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By detailing experimental and basic research, from premalignancy to fully invasive tumors, this book has wide applicability to all human carcinomas. No other group of human cancers is better positioned for the application of recently developed novel and targeted therapies, and this book uniquely presents the unusual opportunities tumors of the head and neck provide for clinical, translational, and basic science research. Cutting-edge and experimental treatment approaches are presented, along with future strategies and an evaluation of emerging technologies. Presents a multi-disciplinary perspective from authorities in diverse fields Addresses state-of-the art approaches in cancer research as well as other scientific opportunities in this field Provides comprehensive yet easily comprehendible source of information

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John Frederick Ensley, Silvio Gutkind, John A. Jacobs, Scott Lippman

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This unique book provides a comprehensive and comparative guide to the immune systems of major vertebrate species, including domestic and wild animals of veterinary or medical interest, fish and amphibia. Data in this essential reference work has been compiled by world-renowned editors and an international group of authors. For each species, the information is presented in a structured 'user-friendly' format allowing easy cross reference and comparison between the various species.
This book will be considered the definitive reference work on vertebrate immunology and will be essential for scientists and professionals working in Immunology, Vaccinology or with Animal Models, for students of Veterinary or Human Medicine, Biology and researchers in Comparative Medicine and Physiology.
Each section, devoted to a major animal group covers:
Lymphoid organs and their anatomical disposition Leukocytes and their markers Leukocyte traffic and associated molecules Cytokines T cell receptors Immunoglobulins MHC antigens Ontogeny of the immune system Passive transfer of immunity Neonatal immune responses Non-specific immunity Complement system Mucosal immunity Immunodeficiencies Tumours of the immune system Autoimmunity

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Paul-Pierre Pastoret, Philip Griebel, Hervé Bazin, André Govaerts

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Landmark Papers of the Twentieth Century

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This book is a centennial volume celebrating the enormous progress made in hematology in the 20th century. It is edited by Marshall Lichtman, a distinguished senior hematologist, past president of the American Society of Hematology, and co-editor of the leading text in the field. Hematology is a compendium, with commentaries, of the most important papers published in the field from 1900-1999. The book will be useful for reference--many of the older papers can no longer be found in most libraries, yet are still referred to in current publications, especially review articles--as well as teaching.The Editor and a team of associate editors have included the most important papers covering eight categories: anemia; phagocytic cells; platelets; coagulation and thrombosis; lymphocytes and immune disorders; transfusion medicine; hematologic malignancies and therapeutics; and laboratory developments. Each paper is accompanied by a 1-2 page commentary explaining its impact, and references to the developments that resulted.

Key Features* Contains 86 landmark articles from the last 100 years of research in clinical hematology* Includes expert commentaries discussing the impact of each article* Cites approximately 1000 preceding or subsequent articles of consequence in the commentaries* Includes the English translations of nine articles originally published in other languages* Provides easy access to several papers that may no longer be found in libraries

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Marshall A. Lichtman, Laurence A. Boxer, Edward Henderson, Sanford J. Shattil, Jerry L. Spivak

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This volume combines the classical fields of perception research with the major theoretical attitudes of today's research, distinguishing between experience- versus performance-related approaches, transformational versus interactional approaches, and approaches that rely on the processing versus discovery of information. Perception is separated into two parts. The first part deals with basic processes and mechanisms, and discusses early vision and later, yet still basic, vision. The second covers complex achievements with accounts of perceptual constancies and the perception of patterns, objects, events, and actions. Gives an overview of the current status of research in classical areas and of current approaches to perception Covers research areas and theoretical approaches Combines American and European research Emphasizes complex achievements of perception: auditory patterns, object identification, event perception, and perception of action

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Handbook of Secondary Fungal Metabolites, 3-Volume Set

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This three-volume set is a desirable reference for a wide range of specialists who study secondary fungal metabolites ranging from pharmaceutical house researchers, agricultural researchers, those involved in food and feed control regulation, and veterinary researchers. It discusses in depth the molecular formula of, the molecular weights of, and fungal/plant source indexes of secondary fungal metabolites.

* Includes all major groups of secondary fungal metabolites
* Covers various methods used to isolate and purify metabolites are present
* Each metabolite is supported by appropriate references
* Secondary metabolite molecular formula, molecular weights and fungal/plant source indexes are included

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Richard J. Cole, Milbra A. Schweikert, Bruce B. Jarvis