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Quantitative Functional Brain Imaging with Positron Emission Tomography

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This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain. Authored by international authorities in PET Provides the latest up-to-date techniques and applications Covers all fundamental disciplines of PET in one volume A comprehensive resource for students, clinicians, and new PET researchers

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Richard E. Carson, Peter Herscovitch, Margaret E. Daube-Witherspoon

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Quantification of Brain Function Using PET

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Functional imaging of the brain is one of the most rapidly advancing areas of neuroscience and Positron Emission Tomography (PET) plays a major role in this progress. This book provides a comprehensive overview of the current status of PET and state-of-the-art neuroimaging. It is comprised of summaries of the presentations by experts in the field. Topics covered include radiotracer selection, advances in instrumentation, image reconstruction and data analysis, and statistical mapping of brain activity. This book focuses on the accuracy of the functional image and the strategies for addressing clinical, scientific, and diagnostic questions.

Covers the PET imaging process from tracer selection to analysis and interpretation
Contains 79 concise reports with abundant illustrations
The definitive state-of-the-art book for functional neuroscience with PET

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Ralph Myers, Vin Cunningham, Dale Bailey

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This newly revised and updated edition of Radiation Biophysics provides an in-depth description of the physics and chemistry of radiation and its effects on biological systems. Coverage begins with fundamental concepts of the physics of radiation and radioactivity, then progresses through the chemistry and biology of the interaction of radiation with living systems. The Second Edition of this highly praised text includes major revisions which reflect the rapid advances in the field. New material covers recent developments in the fields of carcinogenesis, DNA repair, molecular genetics, and the molecular biology of oncogenes and tumor suppressor genes. The book also includes extensive discussion of the practical impact of radiation on everyday life. Covers the fundamentals of radiation physics in a manner that is understandable to students and professionals with a limited physics background Includes problem sets and exercises to aid both teachers and students Discusses radioactivity, internally deposited radionuclides, and dosimetry Analyzes the risks for occupational and non-occupational workers exposed to radiation sources

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This volume covers such quantum leaps in the field of biochemistry as the coding properties of DNA and the central dogma, manipulating DNA, extranuclear DNA, protein synthesis and the ribosome, and cell cycles.

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The field of psychological assessment has been undergoing rapid change. The second edition of this Handbook, published in 1990, appeared at the beginning of a decade marked by extensive advances in assessment in essentially all of its specialized areas. There are many new tests, new applications of established tests, and new test systems. Major revisions have appeared of established tests, notably the Wechsler intelligence scales. The time seemed right for a third edition, since even over the relatively brief period of ten years, many tests described in the second edition have been replaced, and are no longer commonly used. Furthermore, much new research in such areas as neuropsychology, cognitive science, and psychopathology have made major impacts on how many tests and other assessment procedures are used and interpreted. This third edition represents an effort to give the reader an overview of the many new developments in assessment, while still maintaining material on basic psychometric concepts in order for it to continue to serve as a comprehensive handbook for the student and professional.<br>

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Proteins: Analysis and Design focuses solely on individual experimental approaches, rather than on specific classes of proteins. The book provides insight into the important issues in protein science and how one can cope with them. These include all issues which explore the detailed relationship of protein structure to function. Provides problems and technical solutions Includes posttranslational modifications Uses synthetic peptides as biological models Details mutagenesis and protein engineering Covers design of protein structure and function

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The design and production of novel peptides and proteins occupy pivotal positions in science and technology and will continue to do so in the 21st century. Protein Engineering and Design outlines the rapid advances in computer-based modeling, protein engineering, and methods needed for protein and peptide preparation and characterization. This indispensable reference lays the groundwork for understanding this multidisciplinary activity while providing an introduction for researchers and students to the field of protein design. Introduces and defines the techniques involved in protein engineering and design Provides a concise overview of key technologies involved and demonstrates their contributions to the specialized design and production of novel proteins and peptides

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The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field.

Key Features* Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves* Essential to anyone working in the field* Educates and directs both the novice and advanced researcher* Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves* Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell* Considered the definitive reference in the field* List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others

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Robert Lanza, Robert Langer, Joseph P. Vacanti

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Principles and Practice of Clinical Research

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Principles and Practice of Clinical Research is a comprehensive text which addresses the theoretical and practical issues involved in conducting clinical research.

This book is divided into three parts: ethical, regulatory, and legal issues; biostatistics and epidemiology; technology transfer, protocol development and funding. It is designed to fill a void in clinical research education and provides the necessary fundamentals for clinical investigators. It should be of particular benefit to all individuals engaged in clinical research, whether as physician or dental investigators, Ph.D. basic scientists, or members of the allied health professions, as well as both students and those actively participating in clinical research.

Key Features
* Comprehensive review ranging from a historical perspective to the current ethical, legal and social issues and an introduction to biostatistics and epidemiology
* Practical guide to writing a protocol, getting funding for clinical research, preparing images for publication and display
* Cohesive and clear presentation by authors carefully selected to teach a very popular course at NIH
* Excellent companion text for courses on clinical research

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There is a need in small group teaching for a readable module that provides a balanced treatment of the four main areas of medical microbiology-bacteriology, mycology, virology and parasistology. It need not be encyclopedic in scope nor didactic, but it should emphasise principles and concepts. Any existing gaps in this type of presentation are, of course, left for the student to fill.Some subject material has been excluded. An example is a chapter on laboratory procedures including PCR for rapid bacterial and viral diagnosis. The discussion of bacterial sexually transmitted diseases does not cover goncoccal infections. This is not a serious matter because the tutor can assign the topic to the students. Moreover, we have reluctantly omitted a separate chapter on anaerobic bacteria. The subject of nosocomial pathogens is touched upon but not in sufficient detail (e.g., control). These bacteria (e.g., S. aureus, E. coli and pseudomonas) are found in hospitals and are resistant to disinfectants and antibiotics. A new but serious problem is the emergence of resistance to antiviral agents.Without question, molecular biology owes more to the study of viruses than bacteria. The fact remains, however, that effective therapy against most viral diseases is not yet available. Perhaps one of the most dramatic examples of this situation is the fight against the AIDS virus and the search for a vaccine. The public health challenge of AIDS remains formidable in spite of the recent encouraging results obtained with protease inhibitor therapy. At the moment at least six receptors for HIV are known to be present in human cells. One of them is the CCR5 receptor in the absence of which cells fail to get infected with the virus. Drugs that can interrupt CCR5 binding sites on the virus envelope are being vigorously sought. Thus, Volume 9B gives a large place to HIV disease.The last group of chapters highlight several features of microbiology which are also of clinical importance and heuristic value. The chapter on fever of unknown origin provides fertile soil for problem based learning.

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Principles of Bacterial Pathogenesis presents a molecular perspective on a select group of bacterial pathogens by having the leaders of the field present their perspective in a clear and authoritative manner. Each chapter contains a comprehensive review devoted to a single pathogen. Several chapters include work from authors outside the pathogenesis field, providing general perspectives on the evolution, regulation, and secretion of virulence and determinants. Explains the basic principles of bacterial pathogenesis Covers diverse aspects integrating regulation, cellular microbiology and evolution of microbial disease of humans Discusses current strategies for the identification of virulence determinants and the methods used by microbes to deliver virulence factors Presents authoritative treatises of the major disease microorganisms

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Primer on Cerebrovascular Diseases is a handy reference source for scientists, students, and physicians needing reliable, up-to-date information on basic mechanisms, physiology, pathophysiology, and medical issues related to brain vasculature. The book consists of short, specific chapters written by international experts on cerebral vasculature, and presents the information in a comprehensive and easily accessible manner. The book also contains valuable information on practical applications of basic research. Presents topics in a comprehensive and accessible format Written by international authorities on cerebral vasculature Provides practical applications for researchers

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Louis R. Caplan, Bo K. Siesjo, Bruce Weir, K. Michael Welch, Louis R. Caplan, Donald J. Reis

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This comprehensive work discusses novel biomolecular surfaces that have been engineered to either control or measure cell function at the atomic, molecular, and cellular levels. Each chapter presents real results, concepts, and expert perspectives of how cells interact with biomolecular surfaces, with particular emphasis on interactions within complex mechanical environments such as in the cardiovascular system. In addition, the book provides detailed coverage of inflammation and cellular immune response as a useful model for how engineering concepts and tools may be effectively applied to complex systems in biomedicine.

-Accessible to biologists looking for new ways to model their results and engineers interested in biomedical applications
-Useful to researchers in biomaterials, inflammation, and vascular biology
-Excellent resource for graduate students as a textbook in cell & tissue engineering or cell mechanics courses

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Designed for easy use by both beginning and experienced protein crystallographers, the second edition of Practical Protein Crystallography is an essential handbook for any scientist interested in solving a protein structure. The book includes examples of actual experiments and data, electron density maps, and computer methods. This second edition has new material covering CCP4, SHELX, cryocrystallography, MAD and automated fitting. In-depth coverage of every aspect of crystallography Coverage of the small details that can make or break projects Strongly application-oriented Exceptionally well illustrated Simple and easy-to-follow robust methods Tutorials with actual data available on the Web Useful for a broad spectrum of scientists

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An understanding of the dynamics of populations is critically important to ecologists, evolutionary biologists, wildlife managers, foresters, and many other biologists. This edited treatise brings together the latest research on how populations fluctuate in size, the factors that drive these changes, and the theories explaining how populations are regulated. The book also includes specific chapters dealing with insects of economic importance.

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Practical Guide to Occupational Health and Safety

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Written with corporate regulatory compliance officers, health and safety managers, loss control managers, and human resource specialists in mind, this book offers workplace-tested strategies for meeting the health and safety needs of a modern corporation. Emphasizing the practical means of achieving compliance with OSHA regulations, this book also provides a unique assessment of the more extensive factors that influence the management of workplace health and safety. The integration of practical regulation strategies with corporate objectives is particularly relevant to graduate curricula in business management, public policy, and occupational medicine. Provides practical guidelines for industrial compliance with major OSHA regulations Presents concise explanations of technical and scientific concepts underlying regulatory requirements Integrates specific examples of the global economy's influence on the design and implementation of workplace health and safety Elucidates the effects of health and safety programs on financial and legal risk management practices in industry Includes explanations of practical alternative compliance strategies for company health and safety officers

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Polysaccharides are the subject of heightened interest today, and this book is a concise and fully up-to-date study of the properties of food polysaccharides, describing their interaction with water, the mass-volume-pressure-relationship, various types of mathematical modeling, and the common phenomenology under different combinations of stimuli. New empirical and theoretical equations, which are not often identified with food technologies, are used to support the findings.  Polysaccharide Dispersions: Chemistry and Technology in Food is written in a simple, nontechnical style and should be equally comprehensible to the student, the researcher, the plant manager, and the casual observer with only a modest technical background. Contains fundamental principles, practical applications, and new discoveries regarding polysaccharides Presents material in a simple, easy to understand style Focuses exclusively on the food industry

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Stems, of various sizes and shapes, are involved in most of the organic processes and interactions of plants, ranging from support, transport, and storage to development and protection. The stem itself is a crucially important intermediary: it links above- and below ground organs-connecting roots to leaves. An international team of leading researchers vividly illustrate that stems are more than pipes, more than simple connecting and supporting structures; rather stems are critical, anatomically distinct structures of enormous variability. It is, to an unappreciated extent, this variability that underpins both the diversity and the success of plants in myriad ecosystems.

Plant Stems will be a valuable resource on form/function relationships for researchers and graduate-level students in ecology, evolutionary biology, physiology, development, genetics, agricultural sciences, and horticulture as they unravel the mechanisms and processes that allow organisms and ecosystems to function.
Syntheses of structural, physiological, and ecological functions of stems Multiple viewpoints on how stem structure relates to performance Highlights of major areas of plant biology long neglected

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Play Therapy Treatment Planning and Interventions

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Play Therapy Treatment Planning and Interventions: The Ecosystemic Model and Workbook contains key information on one of the most rapidly developing and growing areas of therapy. The book is designed to help play therapists develop specific treatment goals and develop focused treatment plans, as now required by many regulating agencies and third party payers.

The text includes descriptions of 25 actual play therapy activities. Any preparation the therapist may need to complete before the session is identified as is the outcome the therapist may expect. Each activity description ends with a suggestion as to how the therapists might follow up on the content and experience in future sessions. The activity descriptions are very practical and are geared to the child clients specific developmental level.

Play Therapy Treatment Planning and Interventions presents guidelines for interviewing clients and their parents as well as pretreatment assessment. The book provides guidance on data gathering for the intake process and case conceptualization. Case examples and completed sections of the workbook, quotes, and lists increase the text's comprehension. The entire workbook is provided in text format and on disk. It provides the therapist with an easy-to-use format for recording critical case information, specific treatment goals, and the overall treatment plan.
Presents a comprehensive theory of play therapy and a comprehensive model of play therapy intervention Clearly relates the theoretical model to the interventions Provides examples of the application of both the theory and the intervention model to specific cases Provides a structure by which the reader can apply the theory and intervention model to his or her own cases Describes actual play therapy activities and identifies how therapists can prepare for the session, implement the activity, and the outcome they may expect Describes play activities clustered according to the developmental level of the children to which they are best suited Workbook format provides the reader with a method for obtaining comprehensive intake and assessment data, organizing that data into a case formulation and treatment goals, and then developing a comprehensive treatment plan Provides a blank copy of the workbook, as well as the workbook on disk, for use in ones own practice

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Research and Clinical Laboratory Procedures

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Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. Scientists have made great strides in recent years in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has a direct effect on millions of people who deal with cardiovascular disease, strokes, surgery, physical trauma, and other conditions. While references to platelet function have been included in some large texts, there has not been a basic reference manual that researchers and clinicians can use in their daily work until now.
Platelet Protocols fills the need for a straightforward and comprehensive laboratory manual on current procedures for evaluating and analyzing platelet function and abnormalities. It is an easy-to-read, understandable resource which can be kept at the bench and referred to frequently by scientists, clinicians, and laboratory staff involved in platelet related areas. Topics range from the basics of anticoagulants to the latest developments in platelet testing.
Includes:
A basic introduction to platelet anatomy and physiology Testing procedures for new anti-platelet therapies Descriptions of platelet function abnormalities Therapeutic approaches to inhibition of platelet function Step-by-step methodologies with clear explanations Helpful appendixes of recipes, instructions, sources of reagents, and more