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The Myocardium, Second Edition is a comprehensive presentation of cardiac function, including ultrastructure, cellular development and morphogenesis, ion channels, ion transporters, excitation-contraction coupling and calcium compartmentation, mechanics and force production, and energy metabolism. The Second Edition presents the new molecular, subcellular, and cellular developments which have occurred in this rapidly expanding field during the past 22 years. Comprehensive overview of all aspects of heart function at the cellular, subcellular, and molecular level Integrates molecular events to give understanding of global cardiac function Includes basis of important pathological states

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Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases.

* * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins.* Provides a distinctly immunopharmacological approach to the kinin system.* Reviews of the role of kinins in disease and inlcudes data from human studies.* Includes information that is fully up-to-date and comprehensive.

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Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation

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Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Clonal evolution of the metastasis phenotype Cell Cycle regulation Apoptosis in tumour growth and metastasis Angiogenesis in cancer Cell surface glycoproteins and their receptors Proteinases and their inhibitors in cancer invasion Oncogenes and cancer metastasis Developmental genes Tumour suppressor genes Metastasis suppressor genes Dominant metastasis-associated genes

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Among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. They comprise the majority of all experimental mammals and tend to be the model of choice used for research into many diseases/disorders including cancer, heart disease, asthma, Alzheimers, Down syndrome, deafness, osteoporosis, obesity, diabetes and even mental health research. Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project.One of the most time-consuming activities in research laboratories is looking up information specific to the species or strain of animal being used. This book, part of the highly successful Handbook of Experimental Animals series, allows the user quick access to any point of interest on the mouse as an experimental model.

* Edited by Hans Hedrich, Hannover Medical School* Comprehensive reference source written by international experts* Well-illustrated with high quality detailed images* Two-color, user-friendly format combined with color plate sections

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The Many Faces of RNA is the subject for the eighth SmithKline Beecham Pharmaceuticals Research Symposia. It highlights a rapidly developing area of scientific investigation. The style and format are deliberately designed to promote in-depth presentations and discussions and to facilitate the forging of collaborations between academic and industrial partners.This symposium focuses on several of the many fundamental, advancing strategies for exploring RNA and its functions. It emphasizes the interplay between biology, chemistry, genomics, and molecular biology which is leading to exciting new insights and avenues of investigation. The book explores RNA as a therapeutic target, RNA as a tool, RNA and its interactions, along with chemical, computational, and structural investigations.

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D. S. Eggleston, Catherine D. Prescott, Neil D. Pearson

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This is the first compilation of protein lipidation enzymes. This volume summarizes recent dramatic developments regarding enzymes responsible for protein lipidation, a process critical for a number of physiological functions, including cell proliferation and morphology. Inhibitors of protein lipidation have recently been shown to be useful as anticancer drugs. Enzymatic mechanisms, mutational analysis, and structural studies are presented. The enzymatic mechanisms of protein lipidation Three-dimensional structures of protein farnesytransferase, protein geranylgeranytransferase II, and n-myristoryltransferase

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Co- and Posttranslational Proteolysis of Proteins

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This volume examines a number of different proteases, a type of enzyme, that are required in order for the change to a biologically active mature protein to occur. The discussion of these various proteases is rarely undertaken in one volume and will serve as a great resource for scientists studying the group of proteases on signal peptide processing as well as those working on propeptide processing. These areas of research do not normally overlap, and yet they are each of common importance to the same cell processes.

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The clostridia are a group of bacteria of considerable medical and economic importance and include species responsible for generating the most potent toxins known to humans. The Clostridia: Molecular Biology and Pathogenesis is a unique work, comprising the most complete reference on the clostridia for over 20 years, bringing together the results from some of the most innovative and exciting research in the past decade. Using a principle-oriented rather than taxonomic approach, the results from molecular biology research are placed in the context of their clinical significance, and the disease process as a whole. This state-of-the-art work is truly comprehensive, covering and integrating the diverse topics of genetics, physiology, pathogenesis and cell biology. Written and edited by world-renowned authorities, material is presented to give the reader an up-to-date knowledge of the pathogenic species of this important genus. Background information is followed by details of the genetics, molecular biology, biochemistry and disease mechanisms. The structure, function and mode of action of toxins and other virulence determinants is clearly presented. As such, this work will prove essential for students, teachers, research microbiologists, infectious disease clinicians, toxin specialists, and all those working in medical or veterinary bacteriology, microbial genetics and the pharmaceutical industries.
Covers appropriate medical and veterinary topics Contains authoritative contributions by international experts Presents the current state of knowledge and areas for future research Truly comprehensive--covers topics from molecular biology and physiology

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Julian I. Rood, Bruce A. McClane, J. Glenn Songer, Richard W. Titball

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The HLA FactsBook presents up-to-date and comprehensive information on the HLA genes in a manner that is accessible to both beginner and expert alike. The focus of the book is on the polymorphic HLA genes (HLA-A, B, C, DP, DQ, and DR) that are typed for in clinical HLA laboratories. Each gene has a dedicated section in which individual entries describe the structure, functions, and population distribution of groups of related allotypes. Fourteen introductory chapters provide a beginner's guide to the basic structure, function, and genetics of the HLA genes, as well as to the nomenclature and methods used for HLA typing. This book will be an invaluable reference for researchers studying the human immune response, for clinicians and laboratory personnel involved in clinical and forensic HLA typing, and for human geneticists, population biologists, and evolutionary biologists interested in HLA genes as markers of human diversity. Introductory chapters provide good general overview of HLA field for novice immunologists and geneticists Up-to-date, complete listing of HLA alleles Invaluable reference resource for immunologists, geneticists, and cell biologists Combines both structural and functional information, which has never been compiled in a single reference book previously Serological specificity of allotypes Identity of material sequenced including ethnic origin Database accession numbers Population distribution Peptide binding specificities T cell epitopes Amino acid sequences of allotypes Key references

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Steven G.E. Marsh, Peter Parham, Linda D. Barber

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The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics. Covers all aspects of the aging skeleton in one comprehensive volume Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton Reviews current therapeutic approaches and methods Written by internationally renowned authors and edited by leaders in the field Is the only book available on this subject

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Clifford Rosen, Julie Glowacki, John P. Bilezikian

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Praise for the Series:"The mainly sharp scientific focus of this set of snapshots is a credit to both the contricutors and the editorial team."--Biotechnology and Applied Biochemistry Techniques in Protein Chemistry VIII is the latest volume in this successful series. As a valuable bench-top reference tool for protein chemists, the ten section sof the book are divided by subject area to show the reader which techniques are currently applied to particular problems in protein science. This approach reflects current trends in which specific instruments and methodologies are used in several different areas.

* * The book features the latest advances in protein chemistry methodologies in the following areas:* Protein sequencing and amino acid analysis* Mass spectral analysis of peptides and proteins* Posttranslational processing* High-sensitivity protein and peptide separations* Protein folding and NMR* Functional domain analysis* Protein design and engineering* Three-dimensional protein structure

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What's on, Who's Watching, and What it Means

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Television: What's On, Who's Watching, and What It Means presents a comprehensive examination of the role of television in one's life. The emphasis is on data collected over the past two decades pointing to an increasing and in some instances a surprising influence of the medium. Television is not only watched but its messages are attended to and well understood. There is no shame in spending hours in front of the set, in fact, people over-estimate the time they spend viewing. Television advertising no longer persuades--it sells by creating a burst of emotional liking for the commercial. The emphases of television news determine not only what voters think about but also the presidential candidate they expect to support on election day. Children and teenagers who watch a great deal of television perform poorly on standardized achievement tests, and among the reasons are the usurpation of time spent learning to read and the discouragement of book reading. Television violence frightens some children and excites others, but its foremost effect is to increase aggressive behavior that sometimes spills over into seriously harmful antisocial behavior. Incorporates social psychology, political science, sociology, child development, and the growing field of communications Presents tables and graphs clarifying theories and linking sets of data Paints concise portraits of the role of television in entertainment, politics, and child-rearing Contains background for dozens of lectures and articles Contains a comprehensive bibliography of more than 1000 citations, many recent

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Techniques in Protein Chemistry VI, an invaluable bench-top reference source for protein chemists, highlights current methods in the following areas:
Protein sequencing and amino acid analysis Mass spectral analysis of peptides and proteins Posttranslational processing High-sensitivity protein and peptide separations Protein folding and NMR Analysis of protein interactions Protein design and engineering
Techniques in Protein Chemistry VI, an invaluable bench-top reference source for protein chemists, highlights current methods in the following areas:
Protein sequencing and amino acid analysis Mass spectral analysis of peptides and proteins Posttranslational processing High-sensitivity protein and peptide separations Protein folding and NMR Analysis of protein interactions Protein design and engineering

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Statistical Methods in the Atmospheric Sciences

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This book introduces and explains the statistical methods used to describe, analyze, test, and forecast atmospheric data. It will be useful to students, scientists, and other professionals who seek to make sense of the scientific literature in meteorology, climatology, or other geophysical disciplines, or to understand and communicate what their atmospheric data sets have to say. The book includes chapters on exploratory data analysis, probability distributions, hypothesis testing, statistical weather forecasting, forecast verification, time(series analysis, and multivariate data analysis. Worked examples, exercises, and illustrations facilitate understanding of the material; an extensive and up-to-date list of references allows the reader to pursue selected topics in greater depth.

Key Features* Presents and explains techniques used in atmospheric data summarization, analysis, testing, and forecasting* Includes extensive and up-to-date references* Features numerous worked examples and exercises* Contains over 130 illustrations

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Tasting and Smelling presents a comprehensive overview to research on these two important modes of perception. The book offers a review of research findings on the biophysics, neurophysiology, and psychophysicsof both senses, as well as discussing the emotional component associated with taste and smell, and clinical disorders affecting each of these two senses. Tasting and Smelling answers how odors and flavors are perceived, why we have favorites, and what happens when our senses go awry. This book is of interest to the researcher in perception, cognition, or neurophysiology.

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Sturkie's Avian Physiology is the classic comprehensive single volume on the physiology of domestic as well as wild birds. The Fifth Edition is thoroughly revised and updated, and includes new chapters on the physiology of incubation and growth. Chapters on the nervous system and sensory organs have been greatly expanded due to the many recent advances in the field. The text also covers the physiology of flight, reproduction in both male and female birds, and the immunophysiology of birds.

The Fifth Edition, like the earlier editions, is a must for anyone interested in comparative physiology, poultry science, veterinary medicine, and related fields. This volume establishes the standard for those who need the latest and best information on the physiology of birds.
Thoroughly updated and revised Coverage of both domestic and wild birds New larger format Only comprehensive, single volume devoted to birds

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Stem cells are relatively undifferentiated cells which are the permanent lineage ancestor cells of tissues. Newly developed molecular biological techniques and probes have made possible dramatic advances in our ability to study the lineage development of stem cells. A major impetus to develop these techniques has been to identify specific stem cells for gene therapy purposes. The role that stem cells play in the development of cancer is also an important area. This book provides up-to-date reviews on a wide variety of stem cell systems by world experts. Chapters range from descriptions of the current knowledge of the biology of stem cells, to current molecular biological approaches and clinical implications. Oncologists and cell biologists will find this book of particular interest. It will also be usefule to radiobiologist, biotechnologists, and gene therapists. Provides reviews of stem cell systems by world experts Covers stem cell biology in plants, invertebrates, and mammals Presents clinical implications of stem cell differentiation

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With the recent changes in the health care industry, surgeons face increasing pressure to devote their time to their clinical activities, thus limiting their research efforts. It is essential that young and creative individuals are encouraged to perform research and are given incentives to participate in research under the mentorship of more experienced research investigators.

Surgical Research is the first book to include all the information necessary for the surgical scientist to perform a research experiment. The editors have assembled outstanding, expert investigators in multiple surgical fields and asked them to describe how they achieve their research accomplishments. In Surgical Research, these experts in the field have outlined everything involved in preparing and conducting a research project. Some of the topics covered in the book include how to state a research question, how to review the available information, how to write research protocol, how to obtain grant money for the experiment, how to analyze the data, and how to present the findings. Also discussed are the ethics of animal and human experimentation along with the history and philosophy of surgical research.

To continue to advance technologies and surgical methods, research must continually be performed. Potentially great discoveries are being missed because would-be researchers do not know where to start or how to conduct research, and therefore do not even try. This book provides prospective researchers with all the basic steps needed to perform a research experiment in the surgical field. No student, resident, or fellow should start a research project without this book and no senior surgical scientist should be without it occupying a prominent position in the library.

Key Features
* The first complete compendium detailing the process and procedures to perform surgical research
* Provides details on and compares various methodologies
* A "must have" resource for the surgical resident, fellow, or scientist
* Includes a listing of resources and web sites to help the researcher even further

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This volume of the treatise deals with structural aspects of the cytoskeleton: the characteristics of the filaments and their components; the organization of the genes; motor proteins; interactions with membranes.

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Sperm Competition and Sexual Selection presents the intricate ways in which sperm compete to fertilize eggs and how this has prompted reinterpretations of breeding behavior. This book provides a theoretical framework for the study of sperm competition, which is a central part of sexual selection. It also discusses the roles of females and the relationships between paternal care in sperm competition. The chapters focusing on taxonomic development are diverse and cover all the major animal groups, both vertebrate and invertebrate, and plants. The final chapter provides an overview discussing the relationship between sperm competition and sexual selection in terms of both function and mechanism and how these translate into species fitness. This book will be of prime interest to behaviorists, ecologists and evolutionary biologists, suggesting new avenues of research and new ways of approaching old problems. The only up-to-date summary of a central and popular subject Well known editors and authors Provides a theoretical framework for the study of sperm competition Covers all major animal groups Includes a chapter on plants