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WTEC Panel Report on Tissue Engineering Research

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WTEC Panel on Tissue Engineering Research is a comparative review of tissue engineering research and development activities in the United States, Japan, and Western Europe conducted by a panel of leading U.S. experts in the field. This book covers biomaterials, cells, biomolecules, non-medical applications, engineering design, informatics, and legal and regulatory issues associated with tissue engineering research and applications.  This document will serve as a basis for continued dialogue within nations' tissue engineering research and development community and with other important stakeholders, providing guidance for future programs. This text highlights the necessity for providing continued and enhanced resources to further the progress in tissue engineering, harness developments, and maintain scientific and economic leadership.

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The Discovery of the Molecular Basis of Life

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Vital Forces tells the history of the 'biochemical revolution', a period of unprecedentedly rapid advance in human knowledge that profoundly affected our view of life and laid the foundation for modern medicine and biotechnology. The story is told in a clear, engaging, and absorbing manner. This delightful work relates the fascinating and staggering advances in concepts and theories over the last 200 years and introduces the major figures of the times.

Vital Forces also describes the discovery of the molecular basis of life through the stories of the scientists involved, including such towering figures as Louis Pasteur, Gregor Mendel, Linus Pauling, and Francis Crick. Combining science and biography into a seamless chronological narrative, the author brings to life the successes and failures, collaborations and feuds, and errors and insights that produced the revolution in biology.
Vividly describes dramatic scientific discoveries, personalities, feuds and rivalries Answers a general readers quest to understand the nature of life, and the relevance of biochemistry/molecular biology to modern medicine, industry and agriculture

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Visions: Artists Living with Epilepsy is the art of epilepsy, captured in a book. You will discover beautiful, insightful, haunting images that reveal the souls of artists touched by epilepsy.

* Contains 200+ high-quality reproductions of works of art* Includes the artists biographies* CD-ROM of the artwork is also available separately or as part of the Deluxe Edition

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In Virus-Insect-Plant Interactions, the world's leading scientists discuss the latest breakthroughs in understanding the biological and ecological factors that define these complex transmission systems and how this knowledge might be used to our advantage in producing innovative, user and environmentally friendly approaches to controlling the spread of plant pathogens by insects. This is an invaluable reference work for researchers, teachers, and students. There are many quick-reference figures and tables, the contents pages include individual chapter abstracts, and each chapter ends with its own bibliography. Presents the most significant research breakthroughs of the past two decades Contains eighteen chapters by forty-two world-renowned researchers Invaluable reference work for researchers, teachers and students Each chapter ends with its own bibliography Contents pages of forematter include individual chapter abstracts Contains many quick-reference figures and tables

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Kerry F. Harris, Oney P. Smith, James E. Duffus

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Viral Ecology defines and explains the ecology of viruses by examining their interactions with their hosting species, including the types of transmission cycles that have evolved, encompassing principal and alternate hosts, vehicles, and vectors. It examines virology from an organismal biology approach, focusing on the concept that viral infections represent areas of overlap in the ecology of viruses, their hosts, and their vectors. The relationship between viruses and their hosting species The concept that viral interactions with their hosts represents a highly evolved aspect of organismal biology The types of transmission cycles which exist for viruses, including their hosts, vectors, and vehicles The concept that viral infections represent areas of overlap in the ecology of the viruses, their hosts, and their vectors

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The Virology Methods Manual is a comprehensive source of methods for the study, manipulation, and detection of viruses. Edited by Brian Mahy and Hillar Kangro, this work describes the most up-to-date, definitive techniques, provided by experts in each area, and presented with easy-to-use, step-by-step protocols. This new manual will satisfy the needs of virologists and all those working with viruses who need a practical guide to methods that work! Provides up-to-date techniques by experts worldwide Presents common, step-by-step protocols in an attractive, easy-to-use fashion Contains useful appendices including virus taxonomy, metabolic inhibitors, and Bio-safety in the virology laboratory

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Molecular and Biological Responses to the Extracellular Matrix

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In the last several years, the development of reagents that recognize smooth muscle-specific proteins has enabled researchers to identify smooth muscle cells (SMC) in tissue undergoing both differentiation and repair. These developments have led to increased research on SMC. The latest volume in the Biology of the Extracellular Matrix Series takes a current and all-encompassing look at this growing area of research. Devoted entirely to the subject of SMC, the book covers a diversity of topics-from SMC architecture and contractility to differentiation and gene expression in development. It also examines the proliferation and replication of SMC and its role in pharmacology and vascular disease. A must for cell, developmental, and molecular biologists, this book also will appeal to cardiologists, pathologists, and biomedical researchers interested in smooth muscle cells. Presents a molecular, genetic, and developmental perspective of the vas smooth muscle cell Overview sections highlight key points of chapters, including the clinical relevance of the research and expectations for future study Appeals to both the basic biologist and to the biomedical researcher of vascular disease

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Gene Therapy and Neuroscience Applications

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Genetic manipulation of the adult mammalian nervous system is one of the most exciting areas in contemporary neurobiology. The explosive growth of this field has been facilitated by harnessing the power of viruses to transfer genetic material into mammalian cells.
Viral Vectors: Gene Therapy and Neuroscience Applications represents the first comprehensive review of viral vector applications to the nervous system by leaders in virology, molecular neurobiology, neuroanatomy, and developmental neurobiology. It serves both as a source of fundamental information for those newly interested in viral vectors and as a compilation of state-of-the-art technologies and applications for more experienced researchers.
This work provides expert background information on viral systems, and the broad range of applications will help readers appreciate the current and future impact of viral vectors in both clinical and basic neuroscience.

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Volume 6 of Biomembranes covers transmembrane receptors and channels. A particularly important role for the membrane is that of passing messages between a cell and its environment. Part I of this volume covers receptors for hormones and growth factors. Here, as in so many other areas of cell biology, the application of the methods of molecular biology have led to the recognition of a number of families of receptors. Typically, such receptors contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular catalytic domain whose activation, as a result of ligand binding, leads to generation of second messengers within the cell and stimulation of a range of cytosolic enzymes. An alternative signaling strategy, exploited in particular in the nervous system, is to use ion channels to allow controlled movement of monovalent (Na+, K+) or divalent (Ca2+) cations in or out of the cell, resulting in changes in membrane potential or alterations in the intracellular concentration of Ca2+. Part II of this volume is concerned with these ion channels and with other, often simpler, ion channel systems whose study can throw light on channel mechanism.<br>

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Tropical Mariculture takes an in-depth look at developmental activities in a growing industry striving towards sustainability and environmental integrity. All of the contributors to this book have considerable experience and expertise in the field of tropical mariculture, and this is the first book to bring expert contributions together. The topics covered are wide and varied, ranging from general issues such as the impact of mariculture on coastal ecosystems to genetic improvement of cultured marine species, as well as the specifics of breeding selected marine species of current importance, such as groupers and sea bass. Significant coverage is also given to the problems of larval rearing in inland aquaculture as well as the demands of water- and land-based resources in a tropical environment. This book will be essential for everyone working in and researching tropical mariculture. Looks at developmental activities in tropical mariculture All of the contributors are experts in the field Covers specific breeding problems and larval rearing Studies the environmental impact of inland aquacultural activities Provides detailed examples of cultivated species in the tropics Compiles mariculture strategies and discusses example species First book to give an overview of tropical mariculture

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The Wisdom of the Eye is a survey of the major concepts underlying many of the basic sciences related to the human eye and visual brain in one volume, using anecdotes and a minimum of highly technical language to emphasize the important points. This book presents an up-to-date treatment on how the eye and visual system work to help us see, interpret what we see, and communicate what we feel. It also examines how this description of the visual system teaches us more about ourselves. Written in a user-friendly style, absent of jargon Humanizes vision research using anecdotes Uses many original illustrations and examples to demonstrate concepts Provides a synthesis of many disciplines including ophthalmology, optometry, and basic science Presents the visual system consistently in the context of its survival advantages Covers a wide variety of topics including infant vision, adult retinal image, animal vision, eye injuries, refractive areas, the eye as a transmitter and receiver of information, optical illusions, color, visual awareness, and more

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Toxicology of Organophosphate and Carbamate Compounds

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This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs.

In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides.
Describes everything you need to know about Organophosphates and Carbamates Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis Provides in vitro and in vivo models for neurotoxicity testing Integrates knowledge of studies in lab animals and humans Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues Describes management of Anticholinesterase poisoning in humans

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Toxicology is a comprehensive text for researchers and graduate students in toxicology and public health. It addresses every aspect of the field, starting with the fundamentals and incorporating such areas as organ toxicology, applications, and environmental toxicology. In addition to covering the traditional subject matter of toxicology, special emphasis has been placed on recent areas of interest, such as risk assessment, apoptosis, and methodical developments.

Key Features
* Comprehensive text, covering all aspects of the field of toxicology
* Analyzes the importance of toxicokinetics and metabolism as well as cellular targets for the mechanisms of toxic effects
* Identifies the various classes of chemical compounds responsible for the toxic effects
* Describes the approaches and methods used by various disciplines which investigate toxic effects and their prevention
* Adapted from a very successful German text, this edition is completely revised and expanded
* The text is well illustrated with diagrams, charts, and tables

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Hans Marquardt, Siegfried G. Schäfer, Roger O. McClellan, Frank Welsch

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This third edition of the standard reference on the nervous system of the rat is a complete and updated revision of the 1994 second edition. All chapters have been extensively updated, and new chapters added covering early segmentation, growth factors, and glia. The book is now aligned with the data available in the Rat Brain in Stereotaxic Coordinates, making it an excellent companion to this bestselling atlas. Physiological data, functional concepts, and correlates to human anatomy and function round out the new edition. Designed to be used in conjunction with the bestselling Rat Brain in Stereotaxic Coordinates New to this edition is inclusion of physiological data, functional concepts, and correlates to human anatomy and function in each chapter Contains new chapters on early segmentation of the central nervous system, growth factors and glia

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The Vaccine Book provides comprehensive information on the current and future world of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases such as AIDS, tuberculosis, and malaria. The Vaccine Book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines.

Topics unique to this book:* Ethics * Economics * Diseases that could be prevented* Clinical trial designs* Ideas about the future of vaccines* Challenges facing research scientists in the vaccine area* Burden of vaccine-preventable illness and the impact of vaccines* Scientific obstacles to be overcome by existing and new vaccines* Basic mechanisms of host immunity and pathogen interaction with host tissues* New approaches to future vaccines against challenging diseases* Real and perceived safety issues which dominate vaccine development and vaccination policies* Microbial pathogenesis as a basis for vaccine design* Planning vaccine trials* Introducing new vaccines into the healthcare system * Future challenges for vaccines and immunizations

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Barry R. Bloom, Barry R. Bloom, Paul-Henri Lambert

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Everyman's Guide to Infection and Immunity

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Infectious diseases are the leading cause of death worldwide. In The War Within Us, well-known author and infectious disease specialist Cedric Mims makes the intricacies of the immune system and infectious diseases less baffling for the general reader and answers the questions of how things work and why. The story is told in terms of the ancient conflict between the invader (the infectious disease) and the defender (the body's immune system) and the strategies and counter-strategies used by both sides, making it a book that is both informative and interesting to read. <br>The War Within Us is an ideal introduction to the basics of immunity and infection for general readers and students. It also serves as a quick reference book for physicians, researchers, and other health workers. Parasite versus host The conflict: how we defend ourselves The microbe's response to our defence How microbes cause diseas Thumbnail sketches of seven selected diseases:  The threat of new diseases

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How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, and structure? Are you tired of scanning review articles, primary papers, and databases to locate that elusive fact? The Academic Press FactsBook Series has established itself as the best source of easily-accessible and accurate facts about protein groups. Described as "a growing series of excellent manuals" by Molecular Medicine Today and "essential works of reference" by Trends in Biochemical Sciences, the FactsBooks have become the most popular comprehensive data resources available. Using an easy-to-follow format, the FactsBooks will keep you up-to-date with the latest advances in structure, amino acid sequences, physicochemical properties, and biological activity. Meticulously researched and compiled by experts in the field, keeping abreast of developments has never been so easy!The Transporter FactsBook contains entries covering almost 800 transporters. Organized into 55 families of structurally related transporters, this volume includes ATPases, ABC transporters, H+-dependent antiporters and symporters, Na+-dependent antiporters and symporters, and other transporters such as mitochondrial transporters. Nomenclature, biological sources and substrates Phylogenetic relationships Predicted structures Physical and genetic characteristics Multiple amino acid sequence alignments Database accession numbers Key references

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This second edition of The Ovary incorporates the dramatic research developments regarding the ovarian life cycle within the past decade. It looks at ovarian function from a detailed molecular and cellular level. The updated chapters, along with the new material, represent an unparalleled compilation of chapters relevant to contemporary ovarian physiology. The book is divided into 8 sections: The Ovarian Follicular Apparatus: Operational Characteristics; Oocyte Maturation and Ovulation; The Corpus Luteum; Putative Intraovarian Regulators; Cyclic Ovarian Cell Death; Novel Experimental Models; Human Ovarian Pathophysiology: Select Aspects; and Human Ovarian Surface Epithelium and Neoplasia.

* Addresses all phases of the ovarian life cycle* New information includes the latest developments in ovarian surface epithelium * Contains 38 in-depth chapters

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Peter C.K. Leung, Peter C.K. Leung, Eli Y. Adashi

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The T Cell Receptor FactsBook contains entries on all the 176 functional variable, diversity, joining, and constant regions of the human T cell receptor, including alpha, beta, gamma, and delta loci. Introductory chapters summarize information of T cell receptor chain synthesis, chromosomal location, and an overview of the human T cell receptor loci.

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Metabolic bone degeneration (osteoporosis) affects millions of people--primarily postmenopausal women--and is directly responsible for debilitating hip, vertebral, and limb fractures in the elderly. Incorporating advances made within just the past five years, The Osteoporotic Syndrome: Detection, Prevention, and Treatment serves as an up-to-date, practical guide to the major clinical aspects of osteoporosis. The text is liberally illustrated with detailed figures. As a resource for the clinician dealing with metabolic bone degeneration, this book represents an excellent source of information on the diagnosis and day-to-day management of osteoporosis. Topics covered include:   Therapy with Vitamin D metabolites, sodium fluoride, thiazides, and isoflavones Biochemical markers of bone turnover Calcium, Vitamin D, and bone metabolism Estrogens and tissue selective estrogens for prevention and treatment of osteoporosis The effects of osteoporosis on orthopaedic surgery The therapy of glucocorticoid bone disease Effects of aging on bone structure and metabolism Management of osteoporotic patients in our health care delivery system The genetics of osteoporosis Bisphosphonate therapy for osteoporosis Calcitonin Bone mass measurement techniques in clinical practice Osteoporosis and the bone biopsy