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Ocular Therapeutics: Eye on New Discovery focuses on emerging areas in ocular research, from new approaches to dry eye to gene therapy in the management of retinal diseases. This comprehensive book features more than 25 chapters of information that will be vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics. It is the intent of this book to provide not only information on current approaches to treatment, but also in giving the reader a greater understanding as to what may become available for treating a number of important eye diseases. Each chapter features some new aspect of treatment that holds great promise for the future. The approach has been to concentrate on those areas of ocular diseases that are more prevalent. It also features new insight for drug delivery and for managing devasting diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States. This book will serve as an important resource as it contains a number of relevant references highlighted for their importance to the field. New investigators will be able to obtain an historical perspective for each of the topics and to develop an understanding of the new research directions that are underway. Ocular Therapeutics: Eye on New Discovery is more than a reference book, as it also provides an important glimpse into the near future.

* Contains information that is vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics.* Provides not only information on current approaches to treatment, but also gives the reader a greater understanding as to what may become available for treating a number of important eye diseases.* Historical perspective for each of the topics as well as an important glimpse into the near future to develop an understanding of the new research directions underway.* New insight for drug delivery and for managing devastating diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States

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Thomas Yorio, Abbott Clark, Martin B Wax

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The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including RUNX Genes in Development and Cancer; The RNA Continent; The c-myc Promoter; Designer Self-Assembling Peptide Nanofiber Scaffolds for Study of 3-D Cell Biology and Beyond; and Dendritic Cells in Cancer. Immunotherapy

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First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies on parasites of major influence, such as Plasmodium falciparum and Trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. Eclectic volumes are supplemented by thematic volumes on various topics including Remote Sensing and Geographical Information Systems in Epidemiology and The Evolution of Parasitism  a phylogenetic persepective.

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Insects have much to offer when it comes to designing engineering solutions to problems, whether for robotics, aeronautics, computing or materials science. Insect Mechanics and Control, the first book ever published on this topic, bringing together world experts working at the interface between entomology, engineering and physics to showcase the exciting research in this rapidly growing field. The authors, applied mathematicians, physicists or quantitative biologists, provide coverage of their subjects in a way that uses the minimum necessary technical detail, making the subject accessible to biologists and their students who are not expert in the field. The book in turn provides a valuable compendium of biological information for physical scientists, thus promoting interchange between the biological and physical sciences.

* Covers important problems in mechanics and control, by reference to extraordinary and fascinating insect examples
* Written by experts, physicists, applied mathematicians and quantitative biologists
* Offers a biological inspiration to physical scientists, from MEMS design to robotics
* Provides a compelling example of integrative biology

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Computer Vision Technology for Food Quality Evaluation

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The first book in this rapidly expanding area, Computer Vision Technology for Food Quality Evaluation thoroughly discusses the latest advances in image processing and analysis. Computer vision has attracted much research and development attention in recent years and, as a result, significant scientific and technological advances have been made in quality inspection, classification and evaluation of a wide range of food and agricultural products. This unique work provides engineers and technologists working in research, development, and operations in the food industry with critical, comprehensive and readily accessible information on the art and science of computer vision technology. Undergraduate and postgraduate students and researchers in universities and research institutions will also find this an essential reference source.

Discusses novel technology for recognizing objects and extracting quantitative information from digital images in order to provide objective, rapid, non-contact and non-destructive quality evaluation. International authors with both academic and professional credentials address in detail one aspect of the relevant technology per chapter making this ideal for textbook use Divided into three parts, it begins with an outline of the fundamentals of the technology, followed by full coverage of the application in the most researched areas of meats and other foods, fruits, vegetables and grains.

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Although the field of Neuro-Oncology has grown considerably in the last 10 to 15 years and has a rather extensive literature, there are no comprehensive, single-source books that summarize the current literature and future trends of neuroimaging in neuro-oncology. This book covers this topic in more comprehensive fashion, making it an important addition to the armamentarium of physicians that care for patients with brain tumors and other neuro-oncological disorders. Well-founded in basic science, it includes chapters that provide an overview of relevant background material in critical areas such as physics, contrast agents, ultra-high field brain MRI, and molecular imaging.

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Multiscale Modeling of Developmental Systems

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Mathematical and computational biology is playing an increasingly important role in the biological sciences. This science brings forward unique challenges, many of which are, at the moment, beyond the theoretical techniques available. Developmental biology, due to its complexity, has lagged somewhat behind its sister disciplines (such as molecular biology and population biology) in making use of quantitative modeling to further biological understanding. This volume comprises work that is among the best developmental modeling available and we feel it will do much to remedy this situation.
This book is aimed at all those with an interest in the interdisciplinary field of computer and mathematical modeling of multi-cellular and developmental systems. It is also a goal of the Editors to attract more developmental biologists to consider integrating modeling components into their research. Most importantly, this book is intended to serve as a portal into this research area for younger scientists especially graduate students and post-docs, from both biological and quantitative backgrounds.

* Articles written by leading exponents in the field
* Provides techniques to address multiscale modeling
* Coverage includes a wide spectrum of modeling approaches
* Includes descriptions of the most recent advances in the field

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Gerald P. Schatten, Santiago Schnell, Philip Maini, Stuart A. Newman, Timothy Newman

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The Skeptics vs the Preponderance of Evidence

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Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. The Cholesterol Wars chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future. Dr. Steinberg and his colleagues have published over 400 papers relating to lipid and lipoprotein metabolism and atherosclerosis reflecting the prominence these authors have in the community Chronicles the miraculous power of the statins to prevent heart attacks and save lives, of great interest to the many manufacturers of these drugs Discusses new targets for intervention based on a better understanding of the molecular basis of atherosclerosis

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This work is the first book-length publication on the topic of insect immunology since 1991, complementing earlier works by offering a fresh perspective on current research. Interactions of host immune systems with both parasites and pathogens are presented in detail, as well as the genomics and proteomics, approaches which have been lacking in other publications. Beckage provides comprehensive coverage of topics important to medical researchers, including Drosophila as a model for studying cellular and humoral immune mechanisms, biochemical mediators of immunity, and insect blood cells and their functions. Encompasses the most important topics of insect immunology including mechanisms, genes, proteins, evolution and phylogeny Provides comprehensive coverage of topics important to medical researchers including Drosophila as a model for studying cellular and humoral immune mechanisms, biochemical mediators of immunity, and insect blood cells and their functions Most up-to-date information published with contributions from international leaders in the field

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Recent advances in molecular and cellular biology have markedly changed our understanding of the heart, and this is having tremendous ramifications for the clinician. This unique reference offers a comprehensive and critical evaluation of this contribution in the field of cardiovascular molecular medicine providing the reader with a sense of new directions in which molecular medicine might be applied. It begins with a detailed primer that makes readily accessible recent molecular, genetic and cellular techniques. Rounding out the coverage of this exciting field are critical and comprenhesive discussions on the use of molecular, genetic and cellular techniques used to identify the etiology and pathophysiology of specific cardiac diseases.

* Discusses diagnostic and therapeutic options available not only in the adult and aging individuals but also in infants/children* Numerous illustrations and flow-charts* Explans cutting-edge molecular techniques, including analysis of mitochondria, their role in cardiac dysfunction and updated analysis of Cardioprotection and Metabolic Syndrome* Presentation of recent translational studies for the treatment of cardiovascular diseases is included (e.g., gene therapy, pharmacological treatments and stem cell transplantation)

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This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Up-to-date reviews on a large and very important group of natural products from both a chemical and biological perspective Comprehensive dynamic reviews written by the leading authors in their respective fields Broader coverage than before on the biological aspects

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Biosensors have captured the imagination of the world's scientific and commercial communities by combining interdisciplinary skills of biologists, physicists, chemists and engineers to provide innovative solutions to analytical problems. Biosensors are applicable to clinical diagnostics, food analysis, cell culture monitoring, environmental control and various military situations. Ever increasing demands for rapid and convenient analyses of a wide variety of materials in diverse locations has led to intense interest in the fusion of biology and electronics which mimics our principal concern: the effect of materials and environments on living systems. This series, "Advances in Biosensors", presents a compendium of research papers, in which authorities in the field of biosensors provide an up-to-date overview of their laboratory's contribution, summarizing the primary research as it has appeared, possibly scattered, in the journal and conference literature, and reflecting on their findings. The net result will be intense, yet highly readable accounts of the state of the art at this leading edge of analytical technology.

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The series Advances in Dendritic Macromolecules aims to cover the synthetic, as well as chemical, aspects of this expanding field: the chemistry to and supramolecular chemistry of dendritic or cascade supermolecular compounds.   In Chapter 1 of this volume, Hawker and Wooley delineate the convergent growth approach to dendrimers, then relate their three-dimensional architectures to different block polymers. In Chapter 2, Moors and Vogtle describe Professor Vogtle's initial cascade molecules via the repetitive strategy, then expand his original concepts of its application by others, and lastly delineate the synthesis of a new series of tosylamide cascades. They also demonstrate the utility of his original Michael addition/reduction procedure by its application to differ cores. Chapter 3, composed by Professor Engel, describes ionic dendrimers which incorporated an internal transition metal center as well as his work based on ammonium and phosphonium centers. In Chapter 4, Mathias and Carothers review recent studies on silicon-based dendrimers and hyperbranched polymers. Chapter 5, by Kim, describes the preparation and utility of hyperbranched aromatic polymers. Lastly in Chapter 6, Escamilla reviews the historical as well as recent examples of ionic and nonionic bolaamphiphiles.

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Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure.

* Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology* The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine* New discoveries from leading researchers on restoration of diseased tissues and organs

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Anthony Atala, Robert Lanza, Robert Nerem, James A. Thomson

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The series Advances in Dendritic Macromolecules aims to cover the synthesis and supramolecular chemistry of dendritic or cascade super-molecules as well as their less perfect hyperbranched cousins.This volume demonstrates the novel and varied growth in this topic and certainly pushes the supramolecular concepts of Lehn into the budding "supramacro-molecular" frontier.   In Chapter 1, Villavicenio and McGrath present their pivotal work in the creation of azobenzene-containing dendrimers; their Chapter describes the fundamental underpinnings to this interesting family.  As they state in their summation, "A continuing combination of fundamental studies on the photomodulation of dendrimer properties in azobenzene-containing dendrimers and the new developments in the application of these materials to new and existing technologies is anticipated."  The field of linear - dendritic block copolymers is summarized inChapter 2 from the eyes of Ivan Gitsov, who along with Professor Frechet were the initiators of this variety of macromolecules.In Chapter 3, Astruc and colleagues present the recent advances in metallodendrimers, which incorporate ferrocenyl and/or other transition metal sandwich components; their Chapter capitalizes on the importance of supramolecular chemistry in these dendritic constructs.Finally, in Chapter 4, Wiener and Narayanan describe the practical applications of dendrimers to the area of magnetic resonance imaging contrast agents.  Each of these unique chapters covers a different perspective of this versatile group of macromolecules.

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Advances in Strained and Interesting Organic Molecules

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The eighth volume of this series comprises six chapters and describes a variety of interesting strained and not so strained molecules and their use - or abuse - in the widest sense. This volume contains a position summary of planar carbon networks, the field of strained allenesis addressed by considering the five- to- nine-membered ring derivatives and this is followed by an introduction to the nature of carbene geometry and the use of ESR spectroscopy in deducing carbene structure. The use of strained molecules in the synthesis of important new compounds of a natural and non-natural nature is a main theme in the volume. Other areas that are discussed are strained carbohydrates, stereocontrolled access to natural products and polymer systems as well as a much sought after contribution to the series on small-ring nitrogen heterocycles.

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Advances in Amino Acid Mimetics and Peptidomimetics

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Peptidomimetics have found wide application as bioavailable, and often potent mimetics of natural peptides. They form the basis of important classes of enzyme inhibitors, they act as receptor agonists and antagonists, and they have even been used to mimic DNA structure. Recent advances in the use of solid-phase organic synthesis have paved the way for the preparation of libraries of these structures to allow the rapid optimization of theri biological properties and hence therapeutic potential. We are also beginning to gain a greater understanding of the structural features of this class of compounds that influence their ability to permeate membranes, and their rate of clearance and metabolism. This volume brings together many of these critical issues by highlighting recent advances in a number of core peptidomimetic-based research.<br>

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The aim of this series is to provide authoritative reviews in the rapidly expanding area of bioinorganic chemistry. The series will present "state of the art" reviews covering the whole field of bioinorganic chemistry.
The present volume is the fourth in the series and covers the topics: lithium in biology, the structure and function of ceroplasmin, rhenium complexes in nuclear medicine, the anti-HIV activity of macrocyclic polyamines and their metal complexes for dinuclear phosphoesterase enzymes.

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Advances in Amino Acid Mimetics and Peptidomimetics

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Peptidomimetics are compounds which mimic the biological activity of peptides while offering the advantages of increased bioavailability, biostability, bioefficiency, and bioselectivity against the natural biological target of the parent peptide. Examples of peptidomimetics have been isolated as natural products, synthesized as libraries from novel subunits, and designed on the basis of X-ray crystallographic studies and through an intricate knowledge of the biological mode of action of natural peptides. They offer challenging synthetic targets and are increasingly important medicinal agents and biological probes. As a consequence, peptidomimetics embrace much of what is modern medicinal and organic chemistry. This volume highlights some recent and exciting developments in the area.

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The aim of this text is to provide reviews and monographs on topics involving molecular similarity, ranging from the fundamental physical properties underlying molecular behaviour to applications in industrially important fields such as pharmaceutical drug design and molecular engineering. The editors hope that this series will encourage new ideas and approaches, help to systematize the rapidly accumulating new chemical information, and make chemistry better understood and better applied.