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Multicellular organisms must be able to adapt to cellular events to accommodate prevailing conditions. Sensory-response circuits operate by making use of a phosphorylation control mechanism known as the "two-component system."

Sections in Two-Component Signaling Systems, Part B include:
Structural Approaches Reconstitution of Heterogeneous Systems Intracellular Methods and Assays Genome-Wide Analyses of Two-Component Systems Presents detailed protocols Includes troubleshooting tips

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Melvin I. Simon, Brian Crane, Alexandrine Crane

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First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

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This fifth volume of the successful series Advances in Atomic Spectroscopy continues to discuss and investigate the area of atomic spectroscopy.
It begins with a description of the use of various atomic spectroscopic methods and applications of speciation studies in atomic spectroscopy. The emphasis is on combining atomic spectroscopy with gas and liquid chromatography.
In chapter two the authors describe new developments in tunable lasers and the impact they will have on atomic spectroscopy. The traditional methods of detection, such as photography and the photomultiplier, and how they are being replaced by new detectors is discussed in chapter three. The very active area of glow discharge atomic spectrometry is presented in chapter four where, after a brief introduction and historical review, the use of glow discharge lamps for atomic spectroscopy and mass spectrometry are discussed. Included in this discussion is geometry and radiofrequency power. The future of this source in atomic spectroscopy is also discussed.
This comprehensive book is then completed with a look at the use of a laser-induced or laser-ablated plasma as a spectrochemical source for atomic emission spectrometry.

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This is the third edition of an established and successful university textbook. The original structure and philosophy of the book continue in this new edition, providing a genuine synthesis of modern ecological and physiological thinking, while entirely updating the detailed content. New features include a fresh, unified treatment of toxicity, emphasizing common features of plant response to ionic, gaseous, and other toxins, explicit treatment of issues relating to global change, and a section on the role of fire in plant physiology and communities. The illustrations in the text are improved over previous editions, including color plates for the first time, and the authors' continuing commitment to providing wide citation of the relevant literature has further improved the reference list. This revision of Environmental Physiology of Plants will ensure the reputation of this title as a useful and relevant text well into the 21st century. Includes enhanced illustrations, now with color plates Examines new molecular approaches which can be harnessed to solve problems in physiology Features new topics such as the unified treatment of toxicity, an explicit treatment of the issues relating to global change, and a section on the role of fire

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Primitive fishes are a relatively untapped resource in the scientific search for insights into the evolution of physiological systems in fishes and higher vertebrates. Volume 26 in the Fish Physiology series presents what is known about the physiology of these fish in comparison with the two fish groups that dominate today, the modern elasmobranchs and the teleosts. Chapters include reviews on what is known about cardiovascular, nervous and ventilatory systems, gas exchange, ion and nitrogenous waste regulation, muscles and locomotion, endocrine systems, and reproduction. Editors provide a thorough understanding of how these systems have evolved through piscine and vertebrate evolutionary history.

Primitive Fishes includes ground-breaking information in the field, including highlighs of the most unusual characteristics amongst the various species, which might have allowed these fishes to persist virtually unchanged through evolutionary time. This volume is essential for all comparative physiologists, fish biologists, and paleontologists.
Provides an analysis of the evolutionary significance of physiological adaptations in "ancient fishes" Offers insights on the evolution of higher vertebrates The only single source that presents an in-depth discussion of topics related to the physiology of ancient fishes

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David J. McKenzie, Anthony Farrell, Colin Brauner

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This book addresses herbicides and their use as an important aspect of modern weed management, and strives to place them in an ecological framework. Many weed scientists believe agriculture is a continuing struggle with weeds - without good weed control, good and profitable agriculture is impossible. Each agricultural discipline sees itself as central to agriculture's success and continued progress, and weed science is no exception. While not denying the importance of weed management to successful agriculture, this book places it in a larger ecological context. The roles of culture, economics, and politics in weed management are also discussed, enabling scientists and students to understand the larger effects on society.
NEW TO THIS EDITION:
Information on New herbicides included, along with the old herbicides that are important for understanding the history New section on weed resistance to herbicides and genetic engineering New information on invasive plants Expanded chapters on Biological Control, Pesticide Legislation and Regulation, Weed Management Systems, and more

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Forensic Neuropathology provides superior visual examples of the more commonly encountered conditions in forensic neuropathology and answers questions that arise regarding neuropathological findings. The work includes values for frequently-encountered clinical assessments, and contains a more comprehensive summary of aging/dating of various neuropathological processes than is available in any other single current source. General pathology residents, forensic pathology and neuropathology fellows, and general pathologists and clinicians involved in referred cases will find this book extremely useful, as will individuals in allied fields such as law enforcement officers and attorneys.

Forensic Neuropathology aims to: (1) provide a concise summary of practical information frequently needed in forensic neuropathology cases; (2) include selected material previously known but perhaps not significantly emphasized in current literature; and (3) where possible, to suggest aging/dating parameters for certain neuropathological findings relevant to forensic neuropathology testimony. As a selective reference, the volume emphasizes practical issues and focuses on the most commonly encountered issues among neuropathology and medical examiner professionals.
Over 800 high-quality full-color photographs, gross and microscopic as well as illustrative line drawings Use of actual cases, briefly summarized and illustrated to emphasize key principles Focuses on the most-commonly encountered cases as relate to forensic incident and covers these aspects in depth and detail

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Hideo H. Itabashi MD, John M. Andrews MD, Uwamie Tomiyasu MD, Stephanie S. Erlich MD, Lakshmanan Sathyavagiswaran

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Objective Approaches and Case Applications

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In Bloodstain Pattern Evidence, the concepts introduced in the author's first book, Blood Dynamics, are updated and applied to provide essential answers in the resolution of actual crimes. The book is accessible to all levels of investigators, regardless of academic background, and allows readers to develop a fundamental understanding of the underlying scientific principles behind bloodstain pattern evidence.

Bloodstain Pattern Evidence builds on the fundamental ideas brought about by an understanding of Non-Newtonian dynamics, and illustrates through case work the practical forensic science applications of these principles to the analysis of bloodstain patterns.
Extensive case examples provide practical application of essential pattern analysis principles Extensively illustrated with over 350 photos and line drawings Takes a unique and scientific approach to bloodstain pattern analysis by exploring the fundamentals of fluid behavior

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Scientific Basis of the Disease and Its Management

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Rabies is the most current and comprehensive account of one of the oldest diseases known that remains a significant public health threat despite the efforts of many who have endeavored to control it in wildlife and domestic animals. During the past five years since publication of the first edition there have been new developments in many areas on the rabies landscape. This edition takes on a more global perspective with many new authors offering fresh outlooks on each topic. Clinical features of rabies in humans and animals are discussed as well as basic science aspects, molecular biology, pathology, and pathogenesis of this disease. Current methods used in defining geographic origins and animal species infected in wildlife are presented, along with diagnostic methods for identifying the strain of virus based on its genomic sequence and antigenic structure. This multidisciplinary account is essential for clinicians as well as public health advisors, epidemiologists, wildlife biologists, and research scientists wanting to know more about the virus and the disease it causes. Offers a unique global perspective on rabies where dog rabies is responsible for killing more people than yellow More than 7 million people are potentially exposed to the virus annually and about 50,000 people, half of them children, die of rabies each year New edition includes greatly expanded coverage of bat rabies which is now the most prominent source of human rabies in the New World and Western Europe, where dog rabies has been controlled Recent successes of controlling wildlife rabies with an emphasis on prevention is discussed Approximately 40% updated material incorporates recent knowledge on new approaches to therapy of human rabies as well as issues involving organ and tissue transplantation Includes an increase in illustrations to more accurately represent this diseases unique horror

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Advances in Food and Nutrition Research recognizes the integral relationship between the food and nutritional sciences and brings together outstanding and comprehensive reviews that highlight this relationship.

Contributions detail the scientific developments in the broad areas of food science and nutrition are intended to ensure that food scientists in academia and industry as well as professional nutritionists and dieticians are kept informed concerning emerging research and developments in these important disciplines.
Series established since 1948 Advisory Board consists of 8 respected scientists Unique series as it combines food science and nutrition research

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HIV I: Molecular Biology and Pathogenesis: Clinical Applications

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The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.<br>The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia. Detailed insights into viral packaging, expression, and assembly Mechanistic understanding of how HIV interacts with receptors and infects cells Delineation of virally encoded regulatory processes unique to HIV Clinical Applications:   An updated review of current chemotherapeutics for HIV New concepts in the discovery and design of novel anti-HIV drugs The latest developments in HIV-vaccine research

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J. Thomas August, Ferid Murad, Kuan-Teh Jeang

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For anyone who treats postmenopausal women, this latest edition of Rogerio Lobo's classic work combines the best from two well-known references: Menopause, and the second edition of Treatment of the Postmenopausal Woman. By adding significant discussions of the basic science behind menopause, it is possible to objectively assess the clinical value and limitations of current approaches to treatment and provide a basis and rationale for strategies that will result in better individualized and specialized care. Not only does the third edition discuss diagnosis and treatment of menopause but it covers biological, anatomical, physiological, pathobiological, and pharmacological aspects as well bringing together, in one source, all of the information needed to understand and treat postmenopausal conditions. Over 50% new material representing the vast amount of information available since the Women's Health Initiative (WHI) clinical trials were completed making this the most up-to-date reference on postmenopausal women Includes several new sections on comparisons between clinical trials and observational data, urology, and pelvic support Each section is preceded by a preface to put the area into context with many chapters having suggested treatment regimens

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Translation Initiation: Cell Biology, High-throughput and Chemical-based Approaches

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For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the third of three on the topic of Translation Initiation includes articles written by leaders in the field.

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Translation Initiation: Reconstituted Systems and Biophysical Methods

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For over fifty years the Methods in Enzymology series has been the critically aclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume, the second of three on the topic of Translation Initiation includes articles written by leaders in the field.

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With cancer-related deaths projected to rise to 10.3 million people by 2020, the need to prevent, diagnose, and cure cancer is greater than ever. Cancer Imaging presents readers with the most up-to-date imaging instrumentation, general and diagnostic applications for various cancers, with an emphasis on lung and breast carcinomas--the two major worldwide malignancy types. This book discusses the various imaging techniques used to locate and diagnose tumors, including ultrasound, X-ray, color Doppler sonography, PET, CT, PET/CT, MRI, SPECT, diffusion tensor imaging, dynamic infrared imaging, and magnetic resonance spectroscopy. It also details strategies for imaging cancer, emphasizing the importance of the use of this technology for clinical diagnosis. Imaging techniques that predict the malignant potential of cancers, response to chemotherapy and other treatments, recurrence, and prognosis are also detailed. Concentrates on the application of imaging technology to the diagnosis and prognosis of lung and breast carcinomas, the two major worldwide malignancies Addresses the relationship between radiation dose and image quality Discusses the role of molecular imaging in identifying changes for the emergence and progression of cancer at the cellular and/or molecular levels

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Advances in Marine Biology was first published in 1963. Now edited by David W. Sims (Marine Biological Association, UK), the serial publishes in-depth and up-to-date reviews on a wide range of topics which will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, oceanography. Eclectic volumes in the series are supplemented by thematic volumes on such topics as The Biology of Calanoid Copepods and Restocking and Stock Enhancement of Marine Invertebrate Fisheries.

* New information on the offspring size in marine invertebrates
* Discusses important information on the social structure and strategies of delphinids
* More than 250 pages of the latest discoveries in marine science

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This second of two volumes on Cancer Imaging covers the three major topics of imaging instrumentation, general imaging applications, and imaging of a number of human cancer types. Where the first volume emphasized lung and breast carcinomas, Volume 2 focuses on prostate, colorectal, ovarian, gastrointestinal, and bone cancers. Although cancer therapy is not the main subject of this series, the crucial role of imaging in selecting the type of therapy and its post-treatment assessment are discussed. The major emphasis in this volume is on cancer imaging; however, differentiation between benign tumors and malignant tumors is also discussed. This volume is sold individually, and Cancer Imaging, Volume 1 [ISBN: 978-0-12-370468-9] sells separately for $189 and also as part of a two volume set [ISBN: 978-0-12-374212-4] for $299.

Concentrates on the application of imaging technology to the diagnosis and prognosis of prostate, colorectal, ovarian, gastrointestinal, and bone cancers Addresses relationship between radiation dose and image quality Discusses the role of molecular imaging in identifying changes for the emergence and progression of cancer at the cellular and/or molecular levels

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The Psychology of Learning and Motivation

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The view of memory use as skilled performance embraces the interactive nature of memory and higher order cognition. In considering the contexts in which memory is used, this book helps to answer such questions as:
If asked where I live, how do I decide on a street address or city name? What influences my selection in a criminal lineup besides actual memory of the perpetrator? Why do expert golfers better remember courses they've played than amateur golfers?
Chapters in this volume discuss strategies people use in responding to memory queries- whether and how to access memory and how to translate retrieved products into responses. Coverage includes memory for ongoing events and memory for prospective events-how we remember to do future intended actions. Individual differences in memory skill is explored across people and situations, with special consideration given to the elderly population and how strategies at encoding and retrieval can offset what would otherwise be declining memory.
An intergrative view of memory, metamemory, judgment and decision-making, and individual differences Relevant to both applied concerns and basic research Articles written by expert contributors

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HIV: Molecular Biology and Pathogenesis: Viral Mechanisms

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The cumulative death toll from AIDS has reached 16.3 million individuals, and more than 33 million persons are currently living with HIV-1. Although it is one of the most-widely studied viruses, many mysteries remain about this pathogen. In this comprehensive two-volume set, HIV-1: Molecular Biology and Pathogenesis, leading investigators in HIV research present a timely picture of the molecular mechanisms which guide HIV-1 expression and replication and provide the most current clinical strategies for combating this virus. Twenty-six teams of experts unravel structure-function interactions of HIV-1 with host cells and the resulting pathological consequences, review strategies fo treatment, and describe ongoing progress in developing animal models and prophylactic vaccines.The two volumes, covering viral mechanisms and clinical applications, respectively, are written by an international collection of AIDS expers from North America, Europe, Australia, and Asia. Detailed insights into viral packaging, expression, and assembly Mechanistic understanding of how HIV interacts with receptors and infects cells Delineation of virally encoded regulatory processes unique to HIV Clinical Applications:   An updated review of current chemotherapeutics for HIV New concepts in the discovery and design of novel anti-HIV drugs The latest developments in HIV-vaccine research

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J. Thomas August, Ferid Murad, Kuan-Teh Jeang

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Lipidomics and Bioactive Lipids: Lipids and Cell Signaling

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This volume in the well-established Methods in Enzymology series features methods for the study of lipids using mass spectrometry techniques. Articles in this volume cover topics such as Phospholipase A1 assays using a radio-labeled substrate and mass spectrometry; Real-time Cell Assays of Phospholipases A2 Using Fluorogenic Phospholipids; Analysis and Pharmacological Targeting of Phospholipase C a interactions with G proteins; Biochemical Analysis of Phospholipase D.; Measurement of Autotaxin/Lysophospholipase D Activity; Platelet-Activating Factor; Quantitative measurement of PtdIns(3,4,5)P3; Measuring Phosphorylated Akt And Other Phosphoinositide 3-Kinase-Regulated Phosphoproteins In Primary Lymphocytes; Regulation of Phosphatidylinositol 4-Phosphate 5-Kinase activity by partner proteins; Biochemical Analysis of Inositol Phosphate Kinases; Analysis of the phosphoinositides and their aqueous metabolites; Combination of C17-sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism; Measurement of mammalian sphingosine-1-phosphate phosphohydrolase activity in vitro and in vivo; A rapid and sensitive method to measure secretion of sphingosine-1-phosphate; Ceramide Kinase and Ceramide-1-Phosphate; Measurement of Mammalian Diacylglycerol Kinase Activity in vitro and in Cells; Lipid Phosphate Phosphatases from Saccharomyces cerevisiae.