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International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

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Challenging and provocative overviews are presented in Volume 40 of Current Topics in Membranes. Topics on cell lipids vary from basic themes such as biosynthesis and membrane distribution to the role of lipids in intracellular signaling and membrane flow. This single volume also highlights the roles of lipids in eukaryotic cells and discusses organization of lipids in microdomains.

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Arnost Kleinzeller, Dale J. Benos, Dick Hoekstra

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Praise for the Series:
"This serial... is well known to virologists. It is a valuable aid in maintaining an overview of various facets of the rapidly expanding fields of virology... Timely, informative, and useful to student, teacher, and research scientist."
--American Scientist
"A mandatory purchase for all types of comprehensive libraries, both public and university, as well as for those interested in or doing research in the field of virology."
--Military Medicine Among the topics covered are: Virus-induced immunopathology Filoviruses Molecular characterization of pestiviruses Transactivation of cellular genes by hepatitus B virus proteins Principles of molecular organization, expression, and evolution of closteroviruses Primate T lymphotropic oncoretroviruses Replication of positive-stranded RNA viruses of plants and animals

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Karl Maramorosch, Frederick A. Murphy, Aaron J. Shatkin

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This Series provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. This year marks a major milestone for the Series as it completes its thirtieth year of publication, making it the longest-running forum for contemporary issues in developmental biology.

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The cytoskeleton is central to cell biology and is instrumental in developmental events. Volume 31 is divided into two major sections: nonchordate development and chordate development. Summaries of each section compare evolutionary conservation among organisms.

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Roger A. Pedersen, Gerald P. Schatten, David G. Capco

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Current Topics in Developmental Biology, Volume 29 surveys the major issues at the forefront of developmental biology. This volume, like others in the serial, is valuable to researchers in the fields of animal and plant development, and to students and other professionals who want an introduction to current topics in cellular and molecular approaches to developmental biology. Volume 29s chapters on the nervous system, reproductive system, and flowering introduce new models and concepts for understanding these processes.
Essential reading for anyone interested in:
Development of the nervous system Development of the reproductive system Flowering in plants Roles of homeobox-related transcription factors, and growth factors in axis and organ development

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Among the topics covered are:   Poliovirus assembly and incapsidation of genomic RNA HIV type 1 reverse transcriptase Mechanisms of persistence and associated disease Genome rearrangements of rotaviruses Luteoviruses Hepadnaviruses Iridoviruses

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Karl Maramorosch, Frederick A. Murphy, Aaron J. Shatkin

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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

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J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle

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Praise for the Series:
"The series which all immunologists need."
--The Pharmaceutical Journal
"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions."
--Science
"Deserves a permanent place in biomedical libraries as an aid in research and in teaching."
--Journal of Immunological Methods

Key Features:
* The role of CD40 and its ligand, gp39, as central players in the regulation of B cell growth and differentiation
* Prolactin, growth hormone and insulin-like growth factor-I as full-fledged immunological growth and differentiation factors
* Transcription factors of functionally mutant mice are highly relevant to understanding hemopoiesis and B cell genesis in vivo
HIV infection of xenotransplanted mice compared with natural HIV and SIV infections
* The expression and role of cytokines in Rheumatoid Arthritis and in seronegative arthritis
* The functions of the surrogate light chain in B cell development
* Mechanisms that regulate cytokine activity and the generation and function of sCR as cytokine anatogonists and/or cytokine "carriers" in vivo
* Potential transducing molecules involved in signaling processes and which mark the difference between signaling through IL-2R and IL-4R

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Karl Maramorosch, Frederick A. Murphy, Aaron J. Shatkin

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"The series which all immunologists need."--The Pharmaceutical Journal"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions."--Science"Deserves a permanent place in biomedical libraries as an aid in research and in teaching"--Journal of Immunological Methods"A provocative and scholarly review of research"--Journal of the American Medical Association"Provides an extremely valuable source of reference and many stimulating ideas...the main repository of information in a rapidly devloping subject"--The Lancet"Provides unrivalled value in both academic and fiscal terms and should be purchased by hard pressed librarians as a major priority to be jealously defended."--Journal of Medical Microbiology"A very valuable serial publication...no serious student of immunology can afford to be without it."--Archives of Biochemistry and Biophysics Focus on components of the V(D)J recombination machinery that might be related to diseases in humans and animals Control of the complement system by control of C3/C5 convertase on host cells, control of fluid phase C3/C5 convertases, control of fluid phase MAC, and control of deposited MAC Immunodeficiency resulting from a complete absence of MHC class II expression and two trans-acting factors controlling transcription Current knowledge of IL-2R signaling, highlighting IL-2 signaling, and T-cell growth regulation Functional role of CD40 in cells, the in vivo significance of CD40-CD40-L interactions, and the signal transduction machinery activated following crosslinking of the CD40 antigen Integrative approach to better understand the observed heterogeneity of an individual response to allergens Regulation of isotype specificity, switch recombination regulation, and the mechanism of switching Two lymphocyte-specific proteins, RAG1 and RAG2, initiate V(D)J recombination of antigen receptor genes

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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

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J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle

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With contributions from Steven A. Porcelli and other internationally recognized leaders in the field, this volume continues the tradition of indispensable reviews. Papers on the CD1 family, positive selection of thymocytes, and molecular and cellular aspects of XLA highlight the latest volume.

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Karl Maramorosch, Frederick A. Murphy, Aaron J. Shatkin

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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

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J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle

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This text should be a useful guide for researchers in immunology, cell and molecular biology and development biology.

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Insect physiology is currently undergoing a revolution with the increased application of molecular biological techniques to investigate the molecular mechanisms underlying the physiological responses to insect cells.Advances in Insect Physiology is commited to publishing high quality reviews on molecular biology and molecular genetics in areas where they provide an increased understanding of physiological processes in insects. Volume 26 of this classic seriescontinues to provide up-to-date reviews on topical subjects of importance to all invertebrate physiologists and neurobiologists and contains increased coverage on the molecular biology of insect physiology.

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Key Features* Organizational and structural overview of the human IgH* RAG-2 deficient blastocyst complementation assay to germline mutation* Review of IFN-g`s biological function* Interaction of cell surface molecules and soluble mediators* Comparisons of structural and kinetic properties of PGHS-1 and 2* Tumor antigens and their role in immunogenicity* Mechanisms caused by lung damage during pulmonary inflammation

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This volume highlights the latest reviews of mechanisms and actions of the immune system and the host response to infection and inflammation.

Key Features
* Covers cytokine functioning as influenced by the Janus protein tyrosine kinase family
* Explores immunodeficiencies, including:
* Immunoglobulin deficiencies and B cells development
* Glycosyl Phosphatidylinositol (GPI)-anchor and Paroxysmal Nocturnal Hemoglobinuria (PNH)
* Investigates the links molecular pathology established between deficiencies in GPI-anchor synthesis and PNH
* Includes the use of Multiple Antigen Peptides (MAPs) to induce protective immune response
* Offers a timely update on Eosinophils' role in disease
* Covers histology of Germinal center reaction of a spleen twelve days after primary immunization
* Includes new research on cytotoxic T-lymphocytes
* Presents the multiple roles of Nitric oxide (NO) in the inflammatory response

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From the Reviews of Previous Volumes
"Provides unrivalled value in both academic and fiscal terms and should be purchased by hard pressed librarians as a major priority to be jealously defended."
-JOURNAL OF MEDICAL MICROBIOLOGY
"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions."
-SCIENCE
"A provocative and scholarly review of research."
-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
"Deserves a permanent place in biomedical libraries as an aid in research and in teaching."
-JOURNAL OF IMMUNOLOGIC METHODS