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Notwithstanding widespread studies and even several biological journals devoted to temperature, it is difficult to perceive a field of thermobiology as such. Interest in the effects of temperature of biological systems is fragmented into specific thermal ranges and often connected with particular applications: subzero cryobiology and preservation of cells and tissues or survival of poikilotherms, para-zero cryobiology and preservation of whole organs and survival of whole animals, intermediate ranges and physiological adaption and regulation, high temperatures and use of heat for killing cancer cells, very high temperatures and limits of biological structure. Yet it has not always been so, and there are good reasons why it need not remain so. General and comparative physiologists such as W.J. Crozier, H. Precht, J. Belehradek, F. Johnson, C.L. Prosser, and others have sought throughout this century to lay foundations for unified approaches to temperature in biological systems.Recent findings also serve to suggest principles and processes that span the range of temperatures of biological interest. Microviscosity of membranes is an issue originally of interest to low temperature biologists but with relevance to limiting high temperatures; conversely for protein structure. Certain "heat shock proteins" now appear to be responses to generalized stress, including low temperature.Inevitably, the chapters of this book reflect the "zonal" character of thermobiology: two chapters (by Storey and Raymond) deal with protection against subfreezing temperatures; three (Hazel, membrane structure, Dietrich, microtubular structure, and Kruuv, cell growth) deal with the effects of and modulation to cool-to-moderate superfreezing temperatures, one (Willis) with modulation (of membrane ion transport) to moderate-to-high temperatures and two (Li, heat shock proteins and Lepock, proteins in general) with stressfully high temperatures. Explicit in each of these chapters, however, are principles and issues that transcend the parochialism of the temperature range under consideration.

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Molecular Biology of Receptors and Transporters: Receptors

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This multi-volume set within International Review of Cytology encompasses the recent advances in the understanding of structure-function relationships at the molecular level of receptors, transporters, and membrane proteins. Several diverse families of membrane receptors/proteins are discussed with respect to the molecular and cellular biology of their synthesis, assembly, turnover, and function. Included are such receptor superfamilies as G-proteins, immunoglobulins, ligand-gated receptors, interleukins, and tyrosine kinases as well as such transporter/protein families as pumps, ion channels, and bacterial transporters. Each section of each volume features a "perspectives/commentary" chapter which includes comments on the recent advances and predictions on new directions. Written by acknowledged experts in the field, this volume, 137B, highlights the recent developments in receptors.

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Geoffrey H. Bourne, James F. Danielli, Kwang W. Jeon, M. Friedlander, Michael Mueckler

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International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

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International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

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International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

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International Review of Research in Mental Retardation

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This serial was established under the editorship of Dr. Norman R. Willis in 1966. As a result of his editorial effort and the contributions of many authors, the serial is now recognized as the area's best source of reviews of behavioral research on mental retardation. From its inception, active research scientists and graduate students in mental retardation have looked to this serial as a major source of critical reviews of research and theory in the area. These volumes are required reading for any professional seeking a deeper insight into the behavioral consequences of intellectual and developmental handicaps.

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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. Cell Transformation by the E7 Oncoprotein of HPV Type 16: Interactions with Nuclear and Cytoplasmic Target Proteins Tumor Invasion: Role of Growth Factor-Induced Cell Motility Non-Enzymatic Interactions Between Proteinases and the Cell Surface: Novel Roles in Normal and Malignant Cell Physiology Molecular Pathogenesis of AIDS-Associated Kaposi's Sarcoma: Growth and Apoptosis Perspectives on Cancer Chemoprevention Research and Drug Development

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There are currently 3-5 million cases of leishmaniasis in the world and the prevalence is rising. The first chapter in this volume reviews the cell biology of the parasite and its transmission and survival. The second review addresses the apicomplexan protozoan parasites Theileria anulaga, T. parva and T. sergenti which globally cost agriculture over one billion US dollars annually. Current research in this area aims to produce effective, stable and cheap subunit viruses requiring only a single application and the authors predict that success will eventually be achieved with 'naked DNA' vaccines containing cytokine genes as immunopotentiators.
The next review is the first in over 30 years to discuss the larva of the class Monogenea.The authors cover morphology, behaviour and structure of many examples providing a detailed reference for researchers. The penultimate chapter discusses the distribution of Schistosoma bovis and considers the reported interactions occurring between parasites and snails. The final chapter reviews one of the most serious parasitic diseases in salmonid aquaculture - sealice. In 1998 the costs due to sealice damage in Scotland alone were estimated at 15-30 million pounds. Discussion of biology and control of these ectoparasites emphasizes the need to understand the basic biology of the parasite.
This volume will be essential reading for parasitologists in many branches of the subject.

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John R. Baker, Ralph Muller, David Rollinson

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Karl Maramorosch, Frederick A. Murphy, Aaron J. Shatkin

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Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

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When we walk, drive a car, or fly an airplane, visual motion is used to control and guide our movement. Optic flow describes the characteristic pattern of visual motion that arises in these situations. This book is the first to take an in-depth look at the neuronal processing strategies that underlie the brain's ability to analyze and use optic flow for the control of self-motion. It does so in a variety of species which use optic flow in different behavioral contexts. The spectrum ranges from flying insects to birds, higher mammals and man. The contributions cover physiological and behavioral studies as well as computational models. Neuronal Processing of Optic Flow provides an authoritative and comprehensive overview of the current state of research on this topic written by a group of authors who have made essential contributions to shaping this field of research over the last ten years. Provides the first detailed overview of the analysis of complex visual motion patterns in the brain Includes physiological, behavioral, and computational aspects of optic flow processing Highlights similarities and differences between different animal species and behavioral tasks Covers human patients with visual motion deficits Enhances the reader's understanding with many illustrations

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Robert Adron Harris, Ronald J. Bradley, Peter Jenner, Markus Lappe

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Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.

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Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

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Walleye Pollock is one of the world's largest fisheries. In this volume, the first review describes the population biology of walleye Pollock including its life history, population dynamics, genetic structure, and metapopulation structure. The second review discusses pollutants and the marine environment using ecotoxicological bioassays with bivalve embryos and larvae. These tests ascertain the effects of pure chemicals and determine the quality of effluents, coastal waters, and sediments sampled in the field.

Advances in Marine Biology has always offered marine biologists an in-depth and up-to-date review on a variety of topics. As well as many volumes that provide a selection of important topics, the series also includes thematic volumes that examine a particular field in detail.

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Alan J. Southward, Paul A. Tyler, Craig M. Young

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The six reviews in this latest issue of Advances in Ecological Research cover a broad spectrum of ecology, from micro-patterns and processes, to the ecophysiology of the individual organism, to forest-scale processes. Topics covered include the possible evolutionary forces that have shaped particular strategies, and the potential and limitations for techniques in ecology, such as fractal geometry, field experiments and eddy co-variance measures. Despite this diversity of topics, there are plenty of points of contact and cross-reference.

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Drosophila melanogaster: Practical Uses in Cell and Molecular Biology

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Drosophila melanogaster: Practical Uses in Cell and Molecular Biology is a compendium of mostly short technical chapters designed to provide state-of-the art methods to the broad community of cell biologists, and to put molecular and cell biological studies of flies into perspective. The book makes the baroque aspects of genetic nomenclature and procedure accessible to cell biologists. It also contains a wealth of technical information for beginning or advanced Drosophila workers. Chapters, written within a year of publication, make this topical volume a valuable laboratory guide today and an excellent general reference for the future.

Key Features* Collection of ready-to-use, state-of-the art methods for modern cell biological and related research using Drosophila melanogaster* Accessible to both experienced Drosophila researchers and to others who wish to join in at the cutting edge of this system * Drosophila offers an easily managed life cycle, inexpensive lifestyle, extraordinarily manipulable molecular and classical genetics, now combined with powerful new cell biology techniques * Introduction and overview sections orient the user to the Drosophila literature and lore * Six full-color plates and over 100 figures and tables enhance the understanding of these cell biology techniques

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Leslie Wilson, Paul T. Matsudaira, Lawrence S.B. Goldstein, Eric A. Fyrberg

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Antibodies in Cell Biology focuses on a new generation of protocols aimed at the cell biologist. This laboratory manual features systems and techniques that are especially relevant for modern problems. The contributing authors have been carefully chosen for their specific expertise, and have provided detailed protocols, recipes, and troubleshooting guides in each chapter. The book is designed for any researcher or student who needs to use antibodies in cell biology and related research areas.
Practical applications and future emphases of antibodies, including:
Light microscopic immunolocalization of antigens Gold particles in immunoelectron microscopy Special methods of fixation and permeabilization Microinjection of antibodies into living cells Antibodies to identify cDNA clones Antisense antibody strategies

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Leslie Wilson, Paul T. Matsudaira, David J. Asai

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Progress in Nucleic Acid Research and Molecular Biology

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From the Reviews of Previous Volumes"In perusing these chapters, I found much of interest. It is worth investigating."-P. BRICKNELL"Full of interest not only for the molecular biologist - for whom the numerous references will be invaluable - but will also appeal to a much wider circle of biologists, and in fact to all those who are ocncerned with the living cell."BRITISH MEDICAL JOURNAL

Key Features* Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology * Contributions from leaders in their fields * Abundant references

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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental. This volume includes reviews on some of the hottest topics in pharmacology, including:   Multidrug resistance and the MDR1 gene in gene therapy Regulation of calcium channels in epithelial cells Gene therapy and vascular disease Potential therapeutic applications for Heparin Calcium channel blockers Antithrombotic agents Regulation of potassium channels in epithelial cells

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J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle

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Progress in Nucleic Acid Research and Molecular Biology

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FROM THE REVIEWS OF THE PREVIOUS VOLUMES:
"In perusing these chapters, I found much of interest. It is worth investigating."
- P. Bricknell in BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY.
"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."
-BRITISH MEDICAL JOURNAL.

*
* Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology
* Contributions from leaders in their fields
* Abundant references