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The Cerebellum and Cognition pulls together a preeminent group of authors. The cerebellum has been previously considered as a highly complex structure involved only with motor control. The cerebellum is essential to nonmotor functions, and recent research has revealed new medically important roles of the cerebellum and cognitive processes. Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries Comprehensive coverage of cerebellum in motor control and cognition New developments regarding the cerebellum and motor systems  Therapeutic implications of cerebellar contributions to cognition Preeminent group of contributors

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International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Key Features* Cell Model Systems in Plant Cytoskeleton Studies* The Structure, Function, and Assembly of Actin Filament Bundles* Nuclear Components with Microtubule-Organizing Properties in Multicellular Eukaryotes: Functional and Evolutionary Considerations* Sialic Acids in Molecular and Cellular Interactions* Embryonic Neural Chimeras in Brain and Head Development

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Discusses various advances in applied microbiology, including: production of acetic acid by Clostridium thermoaceticum; marine microorganisms as a source of new natural products; and stereoselective biotransformations for synthesis of some pharmaceutical intermediates.

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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

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J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle

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Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms theAcademic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

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Jeffrey C. Hall, Jay C. Dunlap, Theodore Friedmann, Francesco Giannelli

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International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Contents Include* Structure of the Insect Head in Ontogeny and Phylogeny: A View from Drosophila* Functional Reconstitution of the Tonoplast Proton-ATPase from Higher Plants* The Role of Molecular Chaperones in Motochondrial Protein Import and Folding* Proteoglycans and Related Components in Plant Cells

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International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. A Model for Flagellar Motility Basement-Membrane Stromal Relationships: Interactions between Collagen Fibrils and the Lamina Densa The Role of Endoxyloglucan Transferase in the Organization of Plant Cell Walls Microtubule-Microfilament Synergy in the Cytoskeleton Insulin Internalization and Other Signaling Pathways in the Plieotropic Effects of Insulin

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Recent findings related to the roles of proteasomes in the MHC class I-restricted antigen processing pathway New observations and insights on V(D)J recombination Structure, function, and mechanisms of regulation of mammalian Ets transcription factors Processes of B2m assembly and peptide loading and the involving molecules Current concepts and enigmas of lymphocyte homing Description of plasmacytomagenesis in mice and insights into the cellular and molecular biology of human plasma cell dyscrasias Summary of the rationale for anti TNF antibody therapy and its clinical effects

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Volume 71 of Advances in Cancer Research begins with Morgan and Kastan presenting data on the roles of p53 and ATM in cell cycle progression and cell death in response to DNA damage and how this information may lead to targets for improved cancer therapies. Kok et all. Review the methodological advantages and limitations to localizing tumor suppressor genes, especially those on the short arm of chromosome 3. Peltomaki and de la Chapelle describe research on mismatch repair genes and their effects on colorectal cancer. McKenna and Cotter present findings on the functions and failures of apoptosis in the hematopoietic system. Ravitz and Wenner review TGF-B and how it controls and affects cell cycle progression in a variety of cell types. Andrew Simpson presents data on the mutation frequencies of microsatellites in human carcinogenesis. Naor and colleagues present research on a multitude of tumors expressing levels of CD44 and discuss how CD44 may be used as a target for cancer therapy. Luisa Villa discusses various aspects of HPV and the potential clinical use of HPV testing in cervical cancer prevention programs. Last, Disis and Cheever review the studies that define HER-2/neu specific immunity in patients with cancer and the current vaccine strategies for generating specific immunity.

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Advances in Genetics continues to present articles that are of interest to both human and molecular geneticists. Volume 37 offers a single chapter, written by I.F. Zhimulev, in which Dr. Zhimulev undertakes thelaborious task of presenting an in-depth and detailed account of the various aspects of heterochromatin organization in the mitotic and interphase polytene chromosomes. It also includes details concerning the organization of heterochromatin at high resolution are also analyzed.

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Jeffrey C. Hall, Jay C. Dunlap, Theodore Friedmann, Francesco Giannelli

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The presentation of Foundations in Cancer Research articles has become a focal point of the Advances in Cancer Research series. This volume begins with two such timely reviews, the first of which is by series co-editor George Klein. Dr. Klein evaluates and reviews Leslie Foulds' suggestion that tumors develop in a series of steps and the effect that this 40-year-old hypothesis has had on cancer research. The second Foundations article by L.A. Loeb presents the historical significance of increased mutagenesis and clonal selection on tumor progression. The first regular article, by R. Khosravi-Far and colleagues, analyzes the functional role of Ras in signal transduction and the involvement that Rho family proteins have on Ras. Mark Saville and Roger Watson review supporting evidence that B-Myb may be a critical regulator of the cell cycle. S. Baylin and co-authors compare DNA methylation in normal cells with that in cancerous cells and discuss the specific consequences associated with tumor progression. Last, Steven Grant discusses the use of ara-C as a treatment for various types of cancer and summarizes its cellular metabolism, mode of action and resistance, and the molecular events involved in apoptosis.

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Cell death is one of the fundamental processes by which normal development is modulated, and the importance of both necrosis and apoptosis in a number of pathologies has generated intense interest from researchers in many fields. This timely book covers both the proteins that are produced by dying cells and the proteins that signal cells to initiate cell death.Cell Death Proteins provides an overview of the explosive interest in cellular death. Six review papers, written by researchers at the forefront of this rapidly moving field, focus on proteins that promote, signal, and inhibit cell death. Major players involved in the cell death cascade and its controls are covered, including cell cycle checkpoints, the function of interleukin-1J converting enzyme, the role of IGF-I receptor, the Bcl-2 family of proteins, viral inhibitors of apoptosis, and p53-dependent apoptosis.

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Cellular and Molecular Procedures in Developmental Biology

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This volume incorporates practical methods at the level of molecular, cellular, and whole organism biology in vertebrate and invertebrate models. It presents straightforward protocols written step-by-step for state-of-the-art techniques with the emphasis on single-cell resolution procedures. Provides straightforward, current protocols and critical appraisals Includes diverse analysis of cellular and molecular techniques Presents everything from whole-organ cultures to electrophysiological approaches Details a variety of methods for interfering with gene function in various species Offers multiple illusions of in situ hybridization, immunostaining, and apoptosis

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Roger A. Pedersen, Gerald P. Schatten, Flora de Pablo, Alberto Ferrus, Claudio D. Stern

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Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms the Academic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.This volume of Advances in Genetics continues the series goal to present both human and molecular genetic reviews in a timely fashion. Anderson and Kay investigate CAB gene expression in the regulation of gene transcriptions in plants. Harmon and Allan offer a historical overview of apoptosis and its recent heightened interest. Developments involving four X-linked disorders and their resulting increased susceptibility to infection are presented by Smithand Notarangelo. Dickson and colleagues present research on the role of dystrophin in Duchenne muscular dystrophy and the potential feasibility of gene therapy in curing this disease as well as other diseases involving the heart and central nervous system. The relationship between mice and humans and the ways in which they help each other understand gene function and relationship is presented by Elizabeth Fisher. Timmons and Shearn summarize what information has been learned about prune, Killer of prune, and the prune/Killer of prune lethal interactions: rare genetic phenomena in Drosophila melanogaster. Meiotic recombination, via the breaking and rejoining of DNA and the subsequent reciprocal exchange and the cytological evidence of the exchange, are explored by Ross et al. Last, Coonar and McKenna discuss the four major cardiomyopathies, focusing on recent advances in hypertrophic cardiomyopathy.

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Jeffrey C. Hall, Jay C. Dunlap, Theodore Friedmann, Francesco Giannelli

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The Eye's Aqueous Humor: From Secretion to Glaucoma

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This volume presents a basic consensus of how the aqueous humor is formed and exits through the trabecular meshwork and canal of Schlemm. It presents a timely update to current knowledge of the molecular transport mechanisms which underlie aqueous humor dynamics. In addition, it provides a concise description of the clinical approaches used for assessing these basic transport processes. The book emphasizes the phenomenon of the diurnal rhythm of aqueous humor formation, from both the clinical and molecular points of view. This phenomenon provides the major indication that aqueous humor secretion is regulated. Introduces the mechanisms of aqueous humor formation and outflow Describes the clinical study of aqueous humor dynamics Exposes the research approaches currently applied Emphasizes the diurnal rhythm of aqueous humor secretion Provides awareness of unanswered questions

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Arnost Kleineller, Douglas M. Fambrough, Dale J. Benos, Mortimer M. Civan

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In spite of the fact that the process of meiosis is fundamental to inheritance, surprisingly little is understood about how it actually occurs. There has recently been a flurry of research activity in this area and this volume summarizes the advances coming from this work. All authors are recognized and respected research scientists at the forefront of research in meiosis. Of particular interest is the emphasis in this volume on meiosis in the context of gametogenesis in higher eukaryotic organisms, backed up by chapters on meiotic mechanisms in other model organisms. The focus is on modern molecular and cytological techniques and how these have elucidated fundamental mechanisms of meiosis. Authors provide easy access to the literature for those who want to pursue topics in greater depth, but reviews are comprehensive so that this book may become a standard reference.

Key Features* Comprehensive reviews that, taken together, provide up-to-date coverage of a rapidly moving field* Features new and unpublished information* Integrates research in diverse organisms to present an overview of common threads in mechanisms of meiosis* Includes thoughtful consideration of areas for future investigation

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Roger A. Pedersen, Gerald P. Schatten, Mary Ann Handel

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This volume is a comprehensive guide to the methodologies used in the study of structural domains of cell nuclei. The text covers chromatin, the karyoskeleton, the soluble domain, and the nucleolus. It details methods that are used to isolate components from these domains and techniques used to assemble and disassemble nuclear elements. There is also coverage of three-dimensional mapping and localization of nuclear processes.

Key Features
* Provides a practical laboratory guide for studying cell nuclei
* Includes comprehensive and easy-to-follow protocols

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Leslie Wilson, Paul T. Matsudaira, Miguel Berrios

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Ig A Deficiency
The Role of Cellular Immunity in Protection against HIV Infection
Mouse Mammary Tumour Virus: Immunological Interplays between Virus and Host
The Transporter Associated with Antigen Processing
NF-kB in cytokine gene expression
NF-kB as a target for immunosuppressive and anti-inflammatory molecules The Role of Cellular Immunity in Protection against HIV Infection Mouse Mammary Tumor Virus: Immunological Interplays between Virus and Host The Transporter Associated with Antigen Processing NF-kB in cytokine gene expression NF-kB as a target for immunosuppressive and anti-inflammatory molecules

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Volume 55 in Methods in Cell Biology is a concise laboratory book that emphasizes the methods and technologies needed to use single polarized laser light source that functions simultaneously as an optical trap and a dual-beam interferometer.

* * Provides a practical laboratory guide for methods and technologies used with laser tweezers* Includes comprehensive and easy-to-follow protocols

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Leslie Wilson, Paul T. Matsudaira, Michael P. Sheetz

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This volume presents the physiological and biochemical aspects of storage carbohydrates, or starch granules, in plants. This up-to-date and thorough resource carefully integrates fundamental knowledge with the most recent information on the starch granule. It discusses the chemistry of the starch granule and the biochemistry, molecular biology, plant physiology, and genetics of plant starch synthesis. The books also describes the implications of these studies for theseed, biotechnology, and modified starch industries. Written for a broad readership Emphasizes the recent findings on the properties of starch biosynthetic enzymes and on studies describing their localization Details the implications these studies have on the seed, biotechnology, and modified starch industries Includes numerous references to the original literature Introduces the reader to the most important individuals and discoveries in the field

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Steve Taylor, Mirta Noemi Sivak, Jack Preiss