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Statistical Modelling of Molecular Descriptors in QSAR/QSPR

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This handbook and ready reference presents a combination of statistical, information-theoretic, and data analysis methods to meet the challenge of designing empirical models involving molecular descriptors within bioinformatics. The topics range from investigating information processing in chemical and biological networks to studying statistical and information-theoretic techniques for analyzing chemical structures to employing data analysis and machine learning techniques for QSAR/QSPR. The high-profile international author and editor team ensures excellent coverage of the topic, making this a must-have for everyone working in chemoinformatics and structure-oriented drug design.

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Matthias Dehmer, Kurt Varmuza, Danail Bonchev, Frank Emmert-Streib

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Now presented in large format, the new Schmid is the ideal primer in biotechnology. The two-page layout with one page being a full color figure and the opposite page being explanatory text is the ideal combination between rapid visual-based learning with in depth information.

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Rolf D. Schmid, Claudia Schmidt-Dannert, Ruth Hammelehle

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This advanced textbook is tailored for an introductory course in Systems Biology and is well-suited for biologists as well as engineers and computer scientists.  It comes with student-friendly reading lists and a companion website featuring a short exam prep version of the book and educational modeling programs. The text is written in an easily accessible style and includes numerous worked examples and study questions in each chapter. For this edition, a section on medical systems biology has been included.

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Edda Klipp, Wolfram Liebermeister, Christoph Wierling, Axel Kowald

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The Solitary Auditor fills a gap in the available instructional materials for undergraduate and graduate auditing courses.  This innovative text tracks the timeline of an audit from the initial planning session through the completion of the audit as seen through the eyes of Michael Bishop, an audit senior.  Bishop and his colleagues face a series of challenging circumstances as the five-month audit of BRIC Industries, a large public company, unfolds.  Those circumstances include missing client documents, conflicting audit evidence, time pressure, and client personnel intent on subverting the work of the auditors.  Bishop eventually learns that BRICs accounting records are being distorted by a large-scale fraud orchestrated by the companys three top executives.  To salvage the jobs, if not careers, of the senior BRIC accountants who have been browbeaten into participating in the fraud, Bishop agrees to cooperate with a plan developed by those accountants to end the fraud.  But the plan backfires, and Bishop becomes a pawn in a three-handed cat-and-mouse game involving the fraudsters, federal law enforcement authorities, and a shadowy syndicate of inside traders who intend to make a killing in the stock market when the accounting fraud is exposed.  Sound far-fetched?  In fact, the circumstances woven into the entertaining storyline of the BRIC Industries audit were drawn from actual audit failures researched by the author over his 35-year academic career.  The Solitary Auditor will capture students attention while at the same time revealing to them the nature and purpose of an independent audit.  No other available auditing text provides such a realistic, comprehensive, and no-holds-barred view of the challenging work role of the independent auditor.

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Interprofessional Rehabilitation: a Person-Centred Approach is a concise and readable introduction to the principles and practice of a person-centred interprofessional approach to rehabilitation, based upon a firm scientific evidence base. Written by a multi-contributor team of specialists in physiotherapy, occupational therapy, nursing, psychology and rehabilitation medicine, this text draws together common themes that cut across the different professional groups and the spectrum of health conditions requiring rehabilitation, and sets out a model of practice that is tailored to the specific needs of the client. Showing interprofessionalism at work in a range of clinical contexts, the book argues that effective rehabilitation is best conducted by well-integrated teams of specialists working in an interdisciplinary way, with the client or patient actively involved in all stages of the process. This book will be essential reading for students preparing for practice in an increasingly interprofessional environment, and will be of interest to any health care practitioner keen to understand how an integrated approach to rehabilitation can benefit their clients.

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Sarah G. Dean, Richard J. Siegert, William J. Taylor

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The telecommunications industry has advanced in rapid, significant and unpredictable ways into the 21st century. Global Networks: Design, Engineering and Operation guides the global industry and academia even further by providing an in-depth look at the current and developing trends, as well as examining the complex issues of developing, introducing, and managing cutting-edge telecommunications technologies. The author draws upon his considerable experience in the telecommunications industry to educate engineers designing equipment and systems on the hardware and software features essential to fault tolerant operation.A  He describes how to design networks that are fault tolerant and global in scope; how to identify best engineering and operations practices; and examines the role of technology labs in carrier networks. Software and hardware engineering practices are covered in depth. Hardware and software designs are explained with an emphasis on application and interaction of craft and operators with equipment and systems. The author proposes that equipment, systems and network designs should be integrated with the engineering and operations teams that run them. Practice, experience and a historical background are used to describe which designs and technologies fit which network services and applications. Global Networks is a complete and thorough assessment of the communications industry today, written by an author of international renown. Key features:  Comprehensive treatment of the key theories and technologies associated with the design of modern communications networks, including equipment, systems and network design Coverage of equipment and software design, mobile networks, integration and the characteristics of large network outages Written in an accessible style and fully illustrated, it offers a complete and up-to-date picture of communications technologies from initial design through to application Includes a section on future challenges such as the Exabyte traffic growth and an assessment of the dual roles of IPV4 and IPV6

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From reviews of previous editions: 'This excellent book provides useful guidance on the use of reflection in practice.... a helpful addition to any nursing library.a Primary Health Care 'aan excellent investment in any nursesa library portfolio.' Journal of Advanced Nursing 'An extremely welcome addition to nursing's literature on thoughtful, knowledgeable practice.' Nursing Times 'This is an excellent practical guide to reflective practiceaI would highly recommend this book to all practice teachers and students.' Journal of Practice Nursing The ability to reflect on practice has become a competency demanded of every healthcare professional in recent years. It can be a daunting prospect- but this practical and accessible text guides the way, using the latest research and evidence to support the development of skills in reflective practice and provides help and advice on how to get started, how to write reflectively and how to continue to use reflective practice in everyday situations. This fifth edition of Reflective Practice in Nursing is an indispensable guide for students and practitioners alike who wish to learn more about reflective practice, as well as containing essential information for teachers and lecturers.

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Dit is Ierland aan die einde van die agtiende eeu: n Ierland onder die hiel van die Engelse heerser, sy volk onderdruk, magteloos, sonder regte. Die opstandsgevoel neem toe, ook onder invloed van die Franse Rewolusie en Napoleon se opkoms. Teen hierdie agtergrond maak David, jonger broer van sir Arthur, heer van Donore, onverwags kennis met die Ierse volk. Hy raak bevriend met die skoolmeester Liam O Neill, die verarmde Seamas Ban, die priester O Floinn, met die meisies Nora en Eilis . . . en hy bevind hom in n posisie waar n keuse aan hom opgedwing word, teen sy sin. Een ding het hy egter besef, dat niks hierna meer dieselfde kan wees nie . . . Soos op n golf is hy voortgespoel deur die gang van sake, en die gety sou nie bly staan in sy stroming of hom terugkeer nie.
	David weier om hom by enige groep te skaar  hy wil alleen homself bly en met sy vriende verkeer  maar dit is nie moontlik nie en onverbiddelik beweeg omstandighede hom om tog daadwerklik die Iere te probeer help. Die uiteinde is vir David tragies en ironies: Geen mens wat begryp nie, en na sy dood ook geen mens wat sal weet hoe dit was nie; indien daar n beeld van hom bly voortbestaan, sal dit iets wees wat geen verband hou met die werklikheid nie. 
	By fakkellig is n ontroerende roman waarin die Ierse landskap, die rustige leefwyse van die adel, die verbitterde bestaan van die boerevolk en die vertwyfeling van Arthur uitgebeeld word op n wyse wat herinner aan Yeats se woorde van byna twee eeue later: A terrible beauty is born.

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Een van die ergste vorms van die Swart Dood in die 14de eeu het sy slagoffers binne vyf dae uitgewis. Maar dat daar ander, subtiele, moderne en ewe dodelike vorme bestaan van die Pes wat in die donker wandel, ontdek die bruin Kaapse meisie Andrea Malgas gedurende die vyf dae wat sy na n jarelange verblyf in Europa in Provence deurbring. 
	Sy staan tussen twee mans: Paul, die welvarende, middeljarige blanke esteet wat haar al die gerief en sekuriteit van n lewe in Europa aanbied; en Mandla, die jong swart aktivis wat haar opnuut blootstel aan die gevaarlike teenwoordigheid van Afrika, waarvan sy haar so lank al vry gewaan het. Onder andere moet sy besluit of vryheid ook mag beteken dat jy kan klaarkom sonder die land, die samelewing, die mense wat jou gevorm het.
	Op soek na lokaliteite vir Paul se film oor die Swart Dood kom Andrea en Mandla uit by die oorblyfsels van n Muur van die Pes wat eeue gelede gebou is om die plaag te probeer keer. Vir haar is dit die kulminasie van al die baie mure waardeur sy in haar lewe voorgekeer is en wat mense apart van mekaar probeer hou: mure tussen ras en ras, tussen generasie en generasie, tussen man en vrou, tussen hede en herinnering, tussen werklikheid en droom, uiteindelik tussen lewe en dood. Wat sy egter ontdek in die skokkende ontknoping van n lewe, herleef in vyf dae, is nie iets negatiefs nie, maar die ontroerende besef dat mure ook afgebreek kan word. 
	In die laaste instansie is dit die skrywer Paul wat in een van die oorspronklikste verteltegnieke wat nog in n roman gebruik is, antwoorde moet gee op die baie vrae wat die verhaal se opset bepaal. Wat daardie antwoorde is, en of hy daarby uitkom, kan die lesers eers aflei wanneer hy die hele sirkel van die roman voltooi het. 
	Die muur van die pes, wat in baie opsigte n bedoelde tweeluik met Kennis van die aand vorm, is n ryker en ryper werk as enigiets want Andre P. Brink nog geskryf het.

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Stefan vry graag in die bondel. Hy is definitief nie 'n ou vir commitment nie. Maar sy suster se vriendin, Ciska, is nie soos ander meisies nie. Haar rooi hare is net so rebels soos sy en as sy vir hom kyk, kry hy 'n snaakse pyn oor sy hart. As n dokter hom sou vra, sou hy moes erken hy het hierdie gevoel al van Desember af toe Ciska Rossouw in sy lewe ingestap het. Maar vir die rekord: Hy is nie verlief nie en hy sal ook nooit verlief raak nie.
Ciska wil nooit van 'n man afhanklik wees nie. Sy het 'n sewe-jaar-plan om haar studies klaar te maak en te begin werk, en sy is trots daarop. Dan eers sal sy weer 'n verhouding oorweeg.  Geen man sal ooit weer oor haar hart dans nie, daarvoor sal sy sorg. Want ouens soos Stefan Bruwer is gevaarlik. Veral met sy ondeunde glimlag en die aantreklike kuiltjie in sy ken . . .
Elke verhaal in die Tienerharte-reeks is propvol aksie, hartstog en drama wat jou vasgevang sal hou tot die laaste bladsy!

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Jy sit op n brander en dink jy gaan in een rigting, dan stoot die onderste oseaan en slaan die branders n ander rigting in. Jy verloor jou bewussyn. Die volgende oggend, jare later, word jy wakker op n vreemde strand. Jy staan verdwaas op en wil dieselfde rigting in stap wat jy van vroeer onthou, maar die pad is weg, die deur is toe, die een wat jy onthou is nie daar nie, jy kan nie terug nie. Jy staan verdwaas op. Jy het verdwaal, hy het verdwyn. Ek kan nie onthou hoe ek hier beland het nie. Of hoekom. Hoe kyk n mens terug na jou lewe en wens jy het n ander vurk in die pad geneem? Wat sou gebeur het as? As? In die diep ontroerende novelle toor die skrywer soos n alchemis van ouds met verdriet en spyt. Dit is n liefdesroman, n elegie aan die verlore liefde. Die verteller verlang terug na Anders, na Jena, na Duitsland. Maar die verlede spoel n mens rond soos die see. Nou is dit te laat. Vir altyd te laat. n Uitsonderlike debuutroman deur Valda Jansen.

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EPUB and EPDF available Open Access under CC-BY-NC-ND licence. How do education systems shape educational inequalities and differences in educational outcomes? And how do advantages and disadvantages in educational attainment translate into privileges and shortcomings in labour market and general life chances? Education systems and inequalities compares different education systems and their impact on creating and sustaining social inequalities. 
The book considers key questions such as how  education systems impact educational inequalities along such variables as social origin, gender, ethnicity, migration background or ability and what social mechanisms are behind the links between education system and educational inequalities and provides vital evidence to inform debates in policy and reform.

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WINNER OF THE BRITISH ACADEMY PETER TOWNSEND PRIZE 2017
Welcome to Foodbank Britain, where emergency food provision is an increasingly visible and controversial feature of ongoing austerity. We know the statistics, but what does it feel like to be forced to turn to foodbanks for help? What does it take to get emergency food, and what's in the food parcel?
Kayleigh Garthwaite conducted hundreds of hours of interviews while working in a Trussell Trust foodbank. She spoke to people like Anna and her 11 year old daughter Daisy who were eating out of date food since Anna left her job due to mental health problems. Glen explained the shame he felt using the foodbank having taken on a zero hours contract. Pregnant Jessica walked two miles to the foodbank because she couldn't afford public transport.
This provocative book provides a much needed voice for foodbank users and volunteers in the UK, and a powerful insight into the realities of foodbank use from the inside.

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Convict criminology is the study of criminology by those who have first-hand experience of imprisonment. This is the first single-authored book to trace the emergence of convict criminology and explore its relevance beyond the USA to the UK and other parts of Europe. 
Addressing epistemological issues of insider research, it presents uniquely reflexive scholarship combining personal experience with critical perspectives on contemporary penality. Taking a gendered approach and focusing explicitly on men, it covers: 
	the way prisoners, ex-prisoners and prison research contribute to criminological knowledge
	historical figures in criminology whose prison experiences are rarely recognised 
	the way racism, colonialism and class shape penal  experience and social worlds 
Drawing from his own experience of imprisonment, prison research and criminology, the author demonstrates how this experience can expand the criminological imagination. It is a novel and compelling account for students, teachers, academics and penal practitioners. It will inform, educate and entertain anyone working in criminal justice, the legal and para-legal professions and those with an interest in social justice.

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Since second-wave feminism of the 1970s, women's rights and opportunities in education and employment have increased across the globe, but has equality, whether social, political or legal, really been achieved? 
In this fascinating book, Miriam E. David, a well-known and influential feminist in higher education, celebrates the achievements of international feminists as activists and scholars. She provides a critique of the expansion of global higher education masking their pioneering zeal and zest for knowledge. 
Looking at the changing zeitgeist,  David contends that feminism has yet to have an enduring influence, despite how generations of women  have felt empowered. She illustrates the power of patriarchal social relations and how everyday sexism or misogyny is keenly felt.  
This impassioned book asks whether a feminist-friendly future is possible, or indeed, desirable.

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Introduction to Pharmaceutical Chemical Analysis

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This textbook is the first to present a systematic introduction to chemical analysis of pharmaceutical raw materials, finished pharmaceutical products, and of drugs in biological fluids, which are carried out in pharmaceutical laboratories worldwide.  In addition, this textbook teaches the fundamentals of all the major analytical techniques used in the pharmaceutical laboratory, and teaches the international pharmacopoeias and guidelines of importance for the field. It is primarily intended for the pharmacy student, to teach the requirements in aanalytical chemistrya for the 5 years pharmacy curriculum, but the textbook is also intended for analytical chemists moving into the field of pharmaceutical analysis.   Addresses the basic concepts, then establishes the foundations for the common analytical methods that are currently used in the quantitative and qualitative chemical analysis of pharmaceutical drugs   Provides an understanding of common analytical techniques used in all areas of pharmaceutical development   Suitable for a foundation course in chemical and pharmaceutical sciences   Aimed at undergraduate students of degrees in Pharmaceutical Science/Chemistry Analytical Science/Chemistry, Forensic analysis   Includes many illustrative examples

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Steen HonorÃ© Hansen, Stig Pedersen-Bjergaard, Knut Rasmussen

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A recent construction project in Singapore involved a Russian plant, a Japanese management team, Australian and Italian engineers, Thai steel workers and a labour force from throughout Asia ... The recent growth explosion of multi-nationals and the lowering of trade barriers is pushing the globalization of construction at a startling pace. Mark Mawhinney has brought together for the first time, advice, information and evidence on this developing arena from a wide range of sources. This book offers a clear understanding of the international construction market and an explanation of what knowledge is required to operate successfully in it. It also helps readers become familiar with some of the analytical tools available. Drawing on both contractor and consultant case studies and including a practical 'hints and signposts' section, International Construction provides a lively and informed introduction for construction professionals moving into international work.

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Historians of political thought have argued that the real Machiavelli is the republican thinker and theorist of civic virtu. Machiavellian Rhetoric argues in contrast that Renaissance readers were right to see Machiavelli as a Machiavel, a figure of force and fraud, rhetorical cunning and deception. Taking the rhetorical Machiavel as a point of departure, Victoria Kahn argues that this figure is not simply the result of a naive misreading of Machiavelli but is attuned to the rhetorical dimension of his political theory in a way that later thematic readings of Machiavelli are not. Her aim is to provide a revised history of Renaissance Machiavellism, particularly in England: one that sees the Machiavel and the republican as equally valid--and related--readings of Machiavelli's work.

In this revised history, Machiavelli offers a rhetoric for dealing with the realm of de facto political power, rather than a political theory with a coherent thematic content; and Renaissance Machiavellism includes a variety of rhetorically sophisticated appreciations and appropriations of Machiavelli's own rhetorical approach to politics. Part I offers readings of The Prince, The Discourses, and Counter-Reformation responses to Machiavelli. Part II discusses the reception of Machiavelli in sixteenth-and seventeenth-century England. Part III focuses on Milton, especially Areopagitica, Comus, and Paradise Lost.

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This is the first English translation of selected poems by one of the most important and unusual modern poets of South Korea. In contrast to the strident political protests found in the poetry of many of his contemporaries, Pak Chaesam's work is characterized by intimate portraits of place, nature, childhood, and human relationships, and by indirection, nostalgia, and reflectiveness.

Often focused upon the border of this world and some other, Pak writes with a spareness of presentation but a cornucopia of imagery, meticulously exploring objective and subjective realms of existence and memory. Encouraging the reader to see and listen, and to allow the sensory to reshape the analytical, Pak's poetry opens up new realms of experience. A fellow Korean poet described Pak's poetry as being "the most exquisite expression of the Korean sense of han," or melancholy.

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Chaesam Pak, David R. McCann, Jiwon Shin

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This is the first comprehensive English-language collection of verse by the most celebrated Slovenian poet of modern times and one of Europe's most notable postwar poets, Edvard Kocbek (1904-1981).

The selections introduce the reader to the full spectrum of Kocbek's long and distinguished career, starting with the pantheist and expressionist nature poems of his early period and continuing through the politically engaged poetry written during and after World War II, to the philosophical and metaphysical meditations of his fecund late period.

Readers will be struck by the originality and freshness of Kocbek's sinewy and intense vision, rendered into fluid and idiomatic English by two experienced translators. The Slovenian texts appear on the facing pages.

The opening stanza of "Moon with a Halo"

The man beside me was killed.
He had a mother who bore him
and a father who made him toys,
he had a brother and a playful uncle
and a little girl with blond braids,
he had a wooden cart and a wooden horse,
a trunkful of colored dreams
and a brook where he used to fish.

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Edvard Kocbek, Charles Simic, Michael Scammell, Veno Taufer