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GET /services/catalog/products?format=api&page=78041
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It also generally describes the technologies typically patented in connection with regenerative medicine.\n\nThis e-book is provided for informational purposes only and should not replace legal advice, which is necessary to anticipate and address the nuances of the patenting process. In addition, there are issues that should be considered and addressed when considering patenting isolated stem cells and associated technologiessuch as the process for obtaining patent rights outside the United States, post-grant procedures for challenging patents, non-patent protection of intellectual property, and enforcement of patents through litigationwhich are beyond the scope of this chapter.", "author": "Antoinette F. Konski", "slug": "patenting-stem-cell-technologies-57523-9781615046232-antoinette-f-konski", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615046232.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57523", "product_url": "/app/ecom/book/57523/patenting-stem-cell-technologies-57523-9781615046232-antoinette-f-konski", "bisac_codes": [ "SCI017000" ], "items_count": null, "identifiers": { "ISBN13": "9781615046225", "EISBN13": "9781615046232", "EISBN10": "1615046232" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216108" } } } }, { "type": "Product", "id": "00010000057522", "attributes": { "name": "Processing of VEGF-C and -D by the Proprotein Convertases", "subtitle": "Importance in Angiogenesis, Lymphangiogenesis, and Tumorigenesis", "description": "The vascular endothelial growth factor (VEGF) family members that include VEGF-A, -B, -C, -D,\nand placental growth factor (PlGF), display distinct binding affinities for their receptors VEGFR-1,\n-2, and/or -3. In addition to their requirements in the initiation, development, and maintenance of\nblood and lymphatic vasculature, VEGFs and VEGFRs are upregulated during neoplasia and are\ninvolved in the remodeling of tumoral blood and lymphatic vasculature. By activating VEGFR-1\nand VEGFR-2, both expressed on blood endothelial cells, VEGF-A promotes the formation of\nnew tumoral blood vessels and thereby accelerates tumor growth. In contrast, upregulation of\nVEGF-C, a ligand for lymphatic endothelial VEGFR-3 as well as for VEGFR-2, induces the\nformation of tumor-associated lymphatic vessels and thus promotes the passive metastatic dissemination\nof tumor cells to regional lymph nodes. Of the VEGF family members, only VEGF-C and\n-D were found to be proteolytically processed by Furin-like enzymes. This processing controls\nthe selective activation of VEGFR-2 and -3 signaling during tumor angiogenesis and lymphangiogenesis.\nHere, we provide an overview of angiogenesis processes and discuss the importance of\nVEGF-C and VEGF-D precursors processing by the proprotein convertases during the activation\nof VEGFR-2 and VEGFR-3 receptors and the mediation of their functions during angiogenesis,\nlymphangiogenesis, and tumorigenesis.", "author": "Abdel-Majid Khatib, Geraldine Siegfried, A. Majid Khatib, Ph.D.", "slug": "processing-of-vegf-c-and-d-by-the-proprotein-convertases-57522-9781615046119-geraldine-siegfried-abdel-majid-khatib", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615046119.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57522", "product_url": "/app/ecom/book/57522/processing-of-vegf-c-and-d-by-the-proprotein-convertases-57522-9781615046119-geraldine-siegfried-abdel-majid-khatib", "bisac_codes": [ "MED008000" ], "items_count": null, "identifiers": { "ISBN13": "9781615046102", "EISBN13": "9781615046119", "EISBN10": "1615046119" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216019" } } } }, { "type": "Product", "id": "00010000057521", "attributes": { "name": "Membrane Nanodomains", "subtitle": "", "description": "Many membranes in eukaryotic cells are inhomogeneous structures in which various membrane components are nonrandomly distributed, forming diverse types of domains. Some membrane domains have long been well known, because they are sufficiently large, long-lived, and morphologically well defined to be characterized using classical microscopic and biochemical approaches. However, new technologies have revealed the presence in membranes of smaller, often highly dynamic nanodomains that also play key roles in membrane function. Our current understanding of the diversity, the properties, and the functions of nanodomains is still very limited and, in some cases, controversial. Nonetheless, it is clear that many important aspects of membrane biology arise from features of membrane organization that play out on spatial and temporal scales that are only now becoming experimentally accessible in living systems. In this book, we will discuss properties and interactions of membrane molecules that lead to nanodomain formation, new and emerging technologies by which nanodomains can be studied, and experimental examples that illustrate both highlights and current limitations of our present knowledge of the properties of membrane nanodomains in various cell types.", "author": "John R. Silvius", "slug": "membrane-nanodomains-57521-9781615046218-john-r-silvius", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615046218.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57521", "product_url": "/app/ecom/book/57521/membrane-nanodomains-57521-9781615046218-john-r-silvius", "bisac_codes": [ "SCI017000" ], "items_count": null, "identifiers": { "ISBN13": "9781615046201", "EISBN13": "9781615046218", "EISBN10": "1615046216" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216066" } } } }, { "type": "Product", "id": "00010000057520", "attributes": { "name": "Peripheral Arterial Disease", "subtitle": "Pathophysiology and Therapeutics", "description": "Peripheral arterial disease (PAD) is a cardiovascular disorder of the peripheral vasculature due to progressive atherosclerotic stenosis of conduit arteries restricting blood flow to tissues. PAD is typically a disease of older individuals, and the incidence of PAD continues to rise due to an increase in cardiometabolic disease and an aging population. Importantly, all cause and cardiovascular morbidity and mortality are significantly increased in PAD patients. PAD diagnosis remains a significant challenge, as a large number of patients are asymptomatic. Moreover, PAD results in a significant financial and societal burden with underutilized diagnostics and limited effective therapies. Here we discuss PAD signs and symptoms, pathophysiological mechanisms, current management, and future disease targets and possible therapeutic treatments for PAD.", "author": "Christopher B. Pattillo, Shyamal C. Bir, Christopher G. Kevil", "slug": "peripheral-arterial-disease-57520-9781615045990-christopher-g-kevil-shyamal-c-bir-christopher-b-pattillo", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045990.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57520", "product_url": "/app/ecom/book/57520/peripheral-arterial-disease-57520-9781615045990-christopher-g-kevil-shyamal-c-bir-christopher-b-pattillo", "bisac_codes": [ "SCI036000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045983", "EISBN13": "9781615045990", "EISBN10": "1615045996" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216088" } } } }, { "type": "Product", "id": "00010000057519", "attributes": { "name": "Stroke", "subtitle": "Pathophysiology and Therapy", "description": "Stroke is a major global health problem because of its large contribution to mortality, morbidity, and disability. The most common form of stroke is ischemic stroke which accounts for approximately 80% of all strokes. During the past decade, our knowledge of the molecular and cellular processes that contribute to stroke pathophysiology has increased substantially and offers many targets for future therapeutic strategies. This book provides an overview of the current knowledge of stroke pathophysiology and the mechanisms that interfere with recovery and regeneration. Moreover, this book reviews the latest advances in the development of future therapeutic strategies.", "author": "Christoph Kleinschnitz, Christiane Albert-Weissenberger, Antje Schmidt, Jens Minnerup", "slug": "stroke-57519-9781615045877-jens-minnerup-antje-schmidt-christiane-albert-weissenberger-christoph-kleinschnitz", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045877.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57519", "product_url": "/app/ecom/book/57519/stroke-57519-9781615045877-jens-minnerup-antje-schmidt-christiane-albert-weissenberger-christoph-kleinschnitz", "bisac_codes": [ "SCI036000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045860", "EISBN13": "9781615045877", "EISBN10": "1615045872" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216137" } } } }, { "type": "Product", "id": "00010000057518", "attributes": { "name": "Necrotizing Enterocolitis", "subtitle": "Insights into the Pathogenesis of this Challenging Disease", "description": "Necrotizing enterocolitis is an acute inflammatory necrosis of bowel that primarily afflicts premature infants in the neonatal intensive care unit setting. Although patients who develop this disease have high morbidity and mortality rates, the pathogenesis is poorly understood, and therefore there are no specific preventive or treatment strategies that have been clearly effective. Recent studies have suggested that the pathophysiology of necrotizing enterocolitis includes alterations in the inflammatory response leading to dysregulated pro-inflammatory signaling in premature infants, as well as abnormal intestinal bacterial colonization patterns that can activate these inflammatory pathways, and these factors are discussed in depth in the following chapters. While human milk feedings are currently the standard of care for the prevention of this challenging condition, new approaches will be described based on sound evidence that might have a significant impact for premature infants throughout the world.", "author": "Michael S. Caplan", "slug": "necrotizing-enterocolitis-57518-9781615045914-michael-s-caplan", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045914.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57518", "product_url": "/app/ecom/book/57518/necrotizing-enterocolitis-57518-9781615045914-michael-s-caplan", "bisac_codes": [ "MED075000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045907", "EISBN13": "9781615045914", "EISBN10": "1615045910" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216115" } } } }, { "type": "Product", "id": "00010000057517", "attributes": { "name": "The Molecular Biology of Chronic Heart Failure", "subtitle": "", "description": "The clinical syndrome of chronic heart failure (CHF) is the hallmark of progressive cardiac decompensation, one of the most common chronic medical conditions that affect around 2% of the adult population worldwide irrespective of ethnic and geographic origin (Anonymous). Apart from ischemic heart disease, hypertension, infection, and inflammation, several other etiologic factors account for irreparable and irreversible myocardial damage leading to heart failure (HF). Genetic and genomic factors are now increasingly identified as one of the leading underlying factors (Arab and Liu 2005). These factors may be related to pathogenic alterations (mutation or polymorphism) within specific cardiac genes, mutations in genes incorporating single or multiple molecular pathways (protein families) relevant to cardiac structure and/or function, genetic or genomic polymorphisms of uncertain significance (gene variants, single-nucleotide polymorphisms (SNPs), and copy number variations (CNVs)), and epigenetic or epigenomic changes that influence cardiac gene functions scattered across the human genome. Recent genetic and genomic studies in both systolic and diastolic ventricular dysfunction, the hallmark of CHF, have revealed a number of mutations in genes belonging to specific cardiac protein families. For example, around 200 mutations are now known to exist in around 15 genes coding for several different types of sarcomere proteins (Liew and Dzau 2004). The sarcomere protein family, alone, accounts for the bulk of inherited cardiomyopathies including hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), restrictive cardiomyopathy (RCM), and left ventricular (LV) non-compaction (LVNC). In addition, there are several other potentially relevant factors involving different genes and genome-level elements. This article presents a systematic account on the available factual information and interpretations based on genetic and genomic studies in CHF (Liew and Dzau 2004). Genomic and molecular approaches have opened the way for a renewed debate for taxonomy of CHF (Ashrafian and Watkins 2007). The review draws attention to the potential diagnostic and therapeutic implications of genomic and transcriptional profiling in HF and translational genomics research that is likely to permit greater personalization of prevention and treatment strategies to address the complexities of managing clinical HF (Creemers, Wilde et al. 2011).", "author": "Dhavendra Kumar", "slug": "the-molecular-biology-of-chronic-heart-failure-57517-9781615045570-dhavendra-kumar", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045570.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57517", "product_url": "/app/ecom/book/57517/the-molecular-biology-of-chronic-heart-failure-57517-9781615045570-dhavendra-kumar", "bisac_codes": [ "SCI029000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045563", "EISBN13": "9781615045570", "EISBN10": "1615045570" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216072" } } } }, { "type": "Product", "id": "00010000057516", "attributes": { "name": "Immune Mechanisms of Hypertension", "subtitle": "", "description": "In the vast majority of patients, hypertension has no identifiable cause. Moreover, despite decades of discovery and therapeutic development, approximately only half of the hypertensive patients are achieving clinically recommended blood pressure control. For these reasons, there has been continued interest in studying the factors that underlie the pathogenesis of hypertension. One area of research that has garnered significant attention is the potential link between immune system activation and blood pressure. Several lines of evidence, dating back several decades, support the concept for this association. This monograph gives a history of the early studies linking immune system function with hypertension and an overview of the large number of studies published in the past decade. The major focus is on the components of the innate and adaptive immune systems for which there is considerable evidence of their contributions to blood pressure control.", "author": "Michael J. Ryan", "slug": "immune-mechanisms-of-hypertension-57516-9781615045839-michael-j-ryan", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045839.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57516", "product_url": "/app/ecom/book/57516/immune-mechanisms-of-hypertension-57516-9781615045839-michael-j-ryan", "bisac_codes": [ "SCI036000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045822", "EISBN13": "9781615045839", "EISBN10": "161504583X" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015215969" } } } }, { "type": "Product", "id": "00010000057515", "attributes": { "name": "Cell Survival Programs and Ischemia/Reperfusion", "subtitle": "Hormesis, Preconditioning, and Cardioprotection", "description": "The major purpose of this book is to review the evidence supporting the concept that intrinsic cell survival programs can be activated by a variety of mildly noxious stimuli or pharmacologic agents to confer protection against the deleterious effects of ischemia/reperfusion (I/R). We begin with a discussion of the concept of hormesis (a term used most extensively in the toxicologic literature which refers to biphasic cellular responses that depend on concentration or intensity of a stimulus), review the seminal studies that led to the discovery of the cardioprotective effects of ischemic preconditioning, and outline its therapeutic potential (Chapter 1). This is followed by a summary of our current understanding of the mechanisms of I/R injury (Chapter 2), as this provides several points of intervention in limiting postischemic tissue injury that may be targeted by the adaptive programs invoked by conditioning stimuli. Chapters 3 and 4 focus on the mechanisms underlying ischemic pre-, post-, and remote conditioning, which establishes the mechanistic rationale for development of pharmacologic conditioning strategies that may mimic the remarkably powerful effects of ischemic conditioning (and are covered in Chapter 5). Lifestyle interventions, including exercise, caloric restriction, and consumption of alcoholic beverages and/or phytochemicals, that may induce hormetic responses will also be reviewed in this chapter. While the promise for conditioning as a therapeutic approach is enormous, there are obstacles to its practical application in patients, which are covered in Chapter 6. The final chapter (Chapter 7) examines the extension of our mechanistic understanding of the signaling pathways invoked by conditioning stimuli into the realm of gene therapy and to the preservation of stem cell viability in the harsh ischemic environment as natural translational outgrowths of preconditioning into therapeutics.", "author": "Ronald Korthuis, Theodore Kalogeris, Christopher Baines, Maike Krenz", "slug": "cell-survival-programs-and-ischemiareperfusion-57515-9781615045853-maike-krenz-christopher-baines-theodore-kalogeris-ronald-korthuis", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045853.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57515", "product_url": "/app/ecom/book/57515/cell-survival-programs-and-ischemiareperfusion-57515-9781615045853-maike-krenz-christopher-baines-theodore-kalogeris-ronald-korthuis", "bisac_codes": [ "SCI036000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045846", "EISBN13": "9781615045853", "EISBN10": "1615045856" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216052" } } } }, { "type": "Product", "id": "00010000057514", "attributes": { "name": "Ascites", "subtitle": "", "description": "This volume deals with the history, aetiology, pathophysiology, symptoms, signs, prognosis, and rational treatment of ascites. During the past decade, our knowledge of the pathophysiology of ascites has increased substantially and more specific therapies are now based on aetiology and pathophysiology. It is the intention of this book to review recent progress in pathophysiology of ascites and therapies based on pathophysiology. Although the different types of ascites have a different aetiology and very different pathophysiology, the development of fluid in the peritoneal cavity is always a bad clinical sign. It has a severe prognosis, which is mainly dependent on the aetiology and progression of the underlying disease. However, among patients with ascites, the prognosis may be very different, mainly owing to the presence of portal venous hypertension, malignancy in the abdominal cavity, and end-stage congestive heart failure. The addition of complications like the hepatorenal syndrome and bacterial peritonitis, whether spontaneous or secondary, adds heavily to the bad prognosis. Since hepatic ascites are by far the most complex with respect to pathophysiology, complications, and treatment, emphasis is put on the description of this entity. Ascites of other aetiologies are mentioned along with hepatic ascites, in particular, if the pathophysiology differs from ascites of hepatic origin.", "author": "Søren Møller, Jens H. Henriksen", "slug": "ascites-57514-9781615045679-jens-h-henriksen-sren-mller", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045679.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57514", "product_url": "/app/ecom/book/57514/ascites-57514-9781615045679-jens-h-henriksen-sren-mller", "bisac_codes": [ "SCI036000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045662", "EISBN13": "9781615045679", "EISBN10": "1615045678" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216091" } } } }, { "type": "Product", "id": "00010000057513", "attributes": { "name": "Genetics of Epilepsy and Refractory Epilepsy", "subtitle": "", "description": "Epilepsy affects approximately 3% of the population, and is usually defined as a tendency to experience recurrent seizures arising from periodic neuronal hyperexcitability of unknown causes. Different genetic factors, through various mechanisms, can cause this abnormal neuronal behavior. The etiology of epilepsy is a major determinant of clinical course and prognosis. Many of the genes that have been implicated in idiopathic epilepsies code for ion channels, whereas a wide spectrum of syndromes where epilepsy is a main clinical feature are caused by mutated genes that are involved in functions as diverse as cortical development, brain malformations, mitochondrial function, and cell metabolism. Similarly, different conditions as hypoxia, trauma, infections, or metabolic unbalances can develop epileptic syndromes where upregulation of several genes could be related to the epileptogenic mechanisms. The most common human genetic epilepsies display a complex pattern of inheritance, and the susceptible genes are largely unknown. However, major advances have recently been made in our understanding of the genetic basis of monogenic inherited epilepsies. As we continue to unravel the molecular genetic basis for epilepsies, it will increasingly influence their classification and diagnosis. A majority of epileptic patients may control their crisis with anticonvulsant drugs, however 30%40% became refractory to pharmacological therapies and require surgical treatment. The challenge of the molecular revolution will be the design of the best treatment protocols based on genetic profiles that include both the specific mechanistic etiology of the epilepsies, as well as their potential refractory behavior to current medications. This includes also the design of new therapeutic agents and targets, so as to reduce the number of cases with refractory epilepsy and epileptogenesis, and perhaps avoid the current surgical treatment (a procedure that was first described more than 4000 years ago) except as a last option.", "author": "Liliana Czornyj, Alberto Lazarowski", "slug": "genetics-of-epilepsy-and-refractory-epilepsy-57513-9781615045334-alberto-lazarowski-liliana-czornyj", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045334.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57513", "product_url": "/app/ecom/book/57513/genetics-of-epilepsy-and-refractory-epilepsy-57513-9781615045334-alberto-lazarowski-liliana-czornyj", "bisac_codes": [ "SCI029000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045327", "EISBN13": "9781615045334", "EISBN10": "1615045333" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216144" } } } }, { "type": "Product", "id": "00010000057512", "attributes": { "name": "Apoptosis", "subtitle": "", "description": "Multi-cellular organisms eliminate individual cells through a self-destruct process known as apoptosis. Apoptosis is critical for proper development and maintenance of tissue homeostasis. The importance of this process is highlighted by the fact that too much or too little apoptosis is the underlying cause of pathologies such as cancer, autoimmune diseases (e.g., lupus, arthritis), and neurodegenerative disorders (e.g., Parkinson's, Alzheimer's). In the early days, apoptotic cells were identified strictly by cell morphology. Now we know that biochemical signatures define a number of death programs, of which apoptosis is the most widely understood. In this review, we discuss genetic insights gained from C. elegans, the importance of caspases, engulfment of apoptotic cells, apoptotic signals, the role of mitochondria, the Bcl-2 family, and the link between dysfunctional apoptosis and disease. Within each topic, we highlight landmark studies that contributed to our current understanding of apoptosis. All together, this research exemplifies tremendous scientific synergy between the disciplines of genetics, biochemistry, developmental cell biology, and structural biology. Continued exploration into mechanisms that regulate apoptosis will undoubtedly lead to insights into disease processes with potential therapeutic strategies.", "author": "Inge Swie Goping, Ning Yang", "slug": "apoptosis-57512-9781615045396-ning-yang-inge-swie-goping", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045396.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57512", "product_url": "/app/ecom/book/57512/apoptosis-57512-9781615045396-ning-yang-inge-swie-goping", "bisac_codes": [ "SCI017000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045389", "EISBN13": "9781615045396", "EISBN10": "1615045392" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015215986" } } } }, { "type": "Product", "id": "00010000057511", "attributes": { "name": "Dengue", "subtitle": "", "description": "Dengue is a major public health concern throughout the tropical and sub-tropical regions of the world. It is the most rapidly spreading mosquito-borne viral disease, with a 30-fold increase in global incidence over the past 50 years. Infection with any of the Dengue virus serotypes can be asymptomatic, cause the classic dengue fever, or evolve to severe disease, which leads to hypovolemic shock and death if untreated. There is no approved specific treatment, prognostic markers, or vaccines for dengue, in part because there is insufficient knowledge of dengue pathogenesis. In this e-book, we will focus on what we believe to be a true challenge in dengue research: to understand hostpathogen interactions. Disease development results from the interaction between host and viral factors, in which the host immune response is critical. Recent advances in dengue experimental models together with clinical data have provided useful information indicating that severe dengue hallmarks (excessive production of pro-inflammatory cytokines, endothelial activation, and plasma leakage) are immune-mediated events. We hope to present readers with a comprehensive description of the immune response to the Dengue virus, detailing how DENV unbalances host homeostasis.", "author": "Mauro M. Teixeira, Daniel Cisalpino, Rodrigo Guabiraba, Rafael Elias Marques", "slug": "dengue-57511-9781615045754-rafael-elias-marques-rodrigo-guabiraba-daniel-cisalpino-mauro-m-teixeira", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045754.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57511", "product_url": "/app/ecom/book/57511/dengue-57511-9781615045754-rafael-elias-marques-rodrigo-guabiraba-daniel-cisalpino-mauro-m-teixeira", "bisac_codes": [ "MED075000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045747", "EISBN13": "9781615045754", "EISBN10": "1615045759" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015215966" } } } }, { "type": "Product", "id": "00010000057510", "attributes": { "name": "X-linked Adrenoleukodystrophy", "subtitle": "", "description": "X-linked adrenoleukodystrophy (X-ALD) is the most common leukodystrophy and the most frequent peroxisomal disorder, with an estimated incidence of 1:17,000. This complex neurodegenerative disorder is characterized by a huge clinical variability both in the age of onset and in symptoms. The two main forms are the childhood cerebral ALD (ccALD) characterized by inflammatory demyelination of the central nervous system, and the adult form called adrenomyeloneuropathy (AMN), characterized by a non-inflammatory slowly progressive demyelination affecting spinal cord and peripheral nerves. Adrenal insufficiency is usually associated with the nervous symptoms, X-ALD being the main cause of Addison's disease. The main biochemical defect is the accumulation of very-long-chain fatty acids (VLCFA, fatty acids with a chain length of more than 22 carbon atoms), particularly in the cholesterol ester fraction of the adrenal gland and brain white matter. X-ALD is associated with mutations in the ABCD1 gene, which encodes for a peroxisomal ATPBinding Cassette (ABC) transporter predicted to allow VLCFA-CoA to enter into the peroxisome for their -oxidation. In spite of animal models, the physiopathogenesis of the disease remains poorly understood. However, several therapeutic strategies have been investigated. Among them, allogeneic bone marrow transplantation has proven effective and, more recently, the first gene therapy trial ended with a resounding success.", "author": "Stéphane Savary, Doriane Trompier", "slug": "x-linked-adrenoleukodystrophy-57510-9781615045556-doriane-trompier-stephane-savary", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045556.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57510", "product_url": "/app/ecom/book/57510/x-linked-adrenoleukodystrophy-57510-9781615045556-doriane-trompier-stephane-savary", "bisac_codes": [ "SCI029000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045549", "EISBN13": "9781615045556", "EISBN10": "1615045554" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216136" } } } }, { "type": "Product", "id": "00010000057509", "attributes": { "name": "Intermediate Filaments", "subtitle": "", "description": "Intermediate filaments (IFs), in concert with microfilaments (MFs) and microtubules (MTs), form the cytoskeleton, and each of these fibrillar networks exhibits rather unique structural and functional characteristics. Intermediate filaments were discovered in eukaryotic cells in the late 1960s, and their name comes from the fact that their diameter is intermediate between MFs and MTs. In contrast to the latter, IFs constitute a network that extends from the nuclear envelope throughout the cytoplasm, and in many cases, interact with cell surface domains involved in cell-cell and cell- matrix interactions. Several key features of their expression, assembly, structure and dynamics are highlighted in this eBook. For instance, IF proteins are encoded by several genes, which are classified into six types reflecting the tissues (cells) of origin. Moreover, IF proteins contain a conserved central -helical (rod) domain flanked by N-terminal (head) and C-terminal (tail) globular domains that enables assembly of fibrous IFs exhibiting a tripartite structure. Although the rod domain is responsible for the formation of the coiled-coil framework and yields the main driving force during the IF protein assembly, the head and tail domains contribute to most of the structural heterogeneity of IF organization and undergo several types of post-translational modifications. Furthermore, the development of gene targeting methods to genetically knockout the expression of the IF genes in mice has uncovered the mechanical versus non-mechanical features of the IF networks, namely, their involvement in cell response to diverse forms of stress, growth stimulation, migration, or death insults. Finally, there is accumulating evidence revealing that the tissue and cell-type expression of IF genes reflects itself in the presence of causal or predisposition mutations responsible for numerous human tissue-specific diseases, known as IF-pathies.\n\nTable of Contents: List of Abbreviations / Introduction / IFs as a Multigene Family of Filamentous Proteins / Nuclear Lamina / IF Functional Interplay with Cell Surface Domains and Organelles / IFs and Cell Specialization / IF Relevance to Human Diseases / Conclusion / References / Author Biographies", "author": "Stéphane Gilbert, Anne Loranger, Normand Marceau", "slug": "intermediate-filaments-57509-9781615045419-normand-marceau-anne-loranger-stephane-gilbert", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045419.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57509", "product_url": "/app/ecom/book/57509/intermediate-filaments-57509-9781615045419-normand-marceau-anne-loranger-stephane-gilbert", "bisac_codes": [ "SCI049000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045402", "EISBN13": "9781615045419", "EISBN10": "1615045414" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216147" } } } }, { "type": "Product", "id": "00010000057508", "attributes": { "name": "Stress and the Developing Brain", "subtitle": "", "description": "The human brain does not develop in a vacuum according to a set of predetermined blueprintsit is involved in a dynamic interplay with the environment that influences gene expression and ultimately structure and function. Some cortical regions, such as the prefrontal cortex (PFC) undergo structural changes throughout the adolescent period and into early adulthood, making their structure and functions particularly interesting to study with respect to gene-environment interactions. Repeated exposure to stress is a predisposing factor in the emergence of various mental illnesses, such as anxiety and depression, although this is by no means an absolute relationship. While some people appear to be vulnerable to the effects of repeated stressors, others are resilient, and this individual variability is partly due to developmental programming of brain regions involved in modulating stress responding, such as the PFC. In the present book, we will discuss features of adolescent brain development that may provide a basis for neural plasticity in stress responding: the highly protracted development of the PFC, the profound change in interconnectedness among cortical and subcortical brain regions, and the characteristic rise and fall pattern for many of the late-developing aspects of neural architecture in PFC and other stress-related brain regions.", "author": "Tara Perrot, Lisa Wright", "slug": "stress-and-the-developing-brain-57508-9781615045280-lisa-wright-tara-perrot", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045280.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57508", "product_url": "/app/ecom/book/57508/stress-and-the-developing-brain-57508-9781615045280-lisa-wright-tara-perrot", "bisac_codes": [ "SCI089000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045273", "EISBN13": "9781615045280", "EISBN10": "1615045287" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015215990" } } } }, { "type": "Product", "id": "00010000057507", "attributes": { "name": "Development of the Hypothalamus", "subtitle": "", "description": "The involvement of key factors operating independently or in cooperation with others contributes to physical and physiological mechanisms to help engineer a vertebrate hypothalamus. The actions of these key factors influence developmental mechanisms including neurogenesis, cell migration, cell differentiation, cell death, axon guidance, and synaptogenesis. On a molecular level, there are several ways to categorize the actions of factors that drive brain development. These range from the actions of transcription factors in cell nuclei that regulate the expression of developmental genes, to external factors in the cellular environment that mediate interactions and cell placements, and to effector molecules that contribute to signaling from one cell to another. Sexual dimorphism is a hallmark of the vertebrate hypothalamus that may arise as a direct consequence of hormone actions or gene actions. These actions may work through any of the mechanisms outlined above. Given the arrangement of cells in groups within the hypothalamus, cell migration may be one particularly important target for early molecular actions that help build the bases for appropriate functions.", "author": "Kristy McClellan, Stuart A. Tobet", "slug": "development-of-the-hypothalamus-57507-9781615045136-stuart-a-tobet-kristy-mcclellan", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045136.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57507", "product_url": "/app/ecom/book/57507/development-of-the-hypothalamus-57507-9781615045136-stuart-a-tobet-kristy-mcclellan", "bisac_codes": [ "SCI089000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045129", "EISBN13": "9781615045136", "EISBN10": "1615045139" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216093" } } } }, { "type": "Product", "id": "00010000057506", "attributes": { "name": "Neuropeptides and Other Bioactive Peptides", "subtitle": "From Discovery to Function", "description": "Neuropeptides and peptide hormones represent the largest class of chemical messengers that transmit information from one cell to another. In this review, several decades of research on peptides in cell-cell signaling are summarized, with a focus on neuropeptide discovery, biosynthesis, and function. In addition to covering the well-studied aspects of neuropeptides, emerging concepts are discussed, including classical versus non-classical neuropeptides and direct versus indirect neuropeptides. Other potential functions for peptides in intercellular and intracellular signaling are also discussed.", "author": "Lloyd D. Fricker", "slug": "neuropeptides-and-other-bioactive-peptides-57506-9781615045075-lloyd-d-fricker", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045075.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57506", "product_url": "/app/ecom/book/57506/neuropeptides-and-other-bioactive-peptides-57506-9781615045075-lloyd-d-fricker", "bisac_codes": [ "SCI036000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045068", "EISBN13": "9781615045075", "EISBN10": "1615045074" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216051" } } } }, { "type": "Product", "id": "00010000057505", "attributes": { "name": "The Role of Proprotein Convertases in Animal Models of Skin Carcinogenesis", "subtitle": "", "description": "<p>Many proprotein convertases (PC), especially furin and PACE4, are involved in pathological processes such as viral infection, inflammation, hypercholesterolemia, and cancer, and have been postulated as therapeutic targets for some of these diseases. In this chapter, we review mostly our work using animal models of squamous cancers that have been induced by chemical or UV carcinogenesis protocols to highlight the role of PCs in the development and progression of experimental tumors. After demonstrating in wild type mice the role of PACE4 in tumor progression as well as detecting the expression of PACE4 and furin in human non-melanoma skin cancers, we developed transgenic mice that over-express either PACE4 or furin in squamous epithelia, including the epidermis. This was accomplished by targeting the expression of the corresponding PC by using the promoter of the bovine keratin 5. Both K5-PACE4 and K5-Furin transgenic mice showed increased susceptibility to a two-stage carcinogenesis protocol of chemical carcinogenesis. Similar studies conducted in K5-PACE4 mice also showed an increased sensitivity to ultraviolet B radiation carcinogenesis. In most of these experiments, we were able to demonstrate that compared to the control wild type mice, the over-expression of the transgene in the epidermis increased the number of benign and malignant skin tumors and also had an effect on tumor progression as evidenced by the presence of less differentiated tumors and more frequent local and distant metastases in many of the transgenic lines. Interestingly, double transgenic mice in which PACE4 and furin are targeted to the epidermis did not show any additive effect, pointing to a probable in vivo overlap of functions at least in cutaneous tissues.</p><p>The tumor-enhancing effects of PACE4 and furin further support their possible role as therapeutic targets. Furthermore, a proof of principle for PC inhibition as a therapeutic tool has been substantiated by an in vivo experiment in which the PC-inhibitor, decanoyl-RVKRchloromethylketone, was topically administrated to the skin of wild type and transgenic mice treated with chemical carcinogenesis protocols, resulting in a significant decrease of tumor development and progression.</p>", "author": "Andres J.P. Klein-Szanto, Jirong Zhang, Jian Fu, Daniel Bassi, A. Majid Khatib, Ph.D.", "slug": "the-role-of-proprotein-convertases-in-animal-models-of-skin-carcinogenesis-57505-9781615045099-daniel-bassi-jian-fu-jirong-zhang-andres-jp-klein-szanto", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045099.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57505", "product_url": "/app/ecom/book/57505/the-role-of-proprotein-convertases-in-animal-models-of-skin-carcinogenesis-57505-9781615045099-daniel-bassi-jian-fu-jirong-zhang-andres-jp-klein-szanto", "bisac_codes": [ "SCI086000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045082", "EISBN13": "9781615045099", "EISBN10": "1615045090" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015215987" } } } }, { "type": "Product", "id": "00010000057504", "attributes": { "name": "Alveolar Structure and Function", "subtitle": "", "description": "In the distal regions of the human lung, one of the most challenging problems facing a large multicellular organism is solvedensuring an adequate supply of oxygen for aerobic tissue metabolism while removing associated waste products. Conduits for both air and blood converge at the alveolar level to match ventilation with perfusion and thus assure the free diffusion of oxygen and carbon dioxide. Despite their thin walls and their intimate relationship to the pulmonary capillary bed, the alveolus must present a barrier function robust enough to resist alveolar flooding from the hydrostatic pressures generated by the weight of the lungs and the volume of blood in the pulmonary circuit. The strategic position of the alveolar region and its vast associated capillary network ensure its importance in the synthesis and degradation of a wide range of molecules. Finally, the alveoli have evolved important immune functions vital to protecting the host from a variety of inhaled pollutants and microorganisms. Understanding alveolar structure and function is essential not only to appreciate the elegance of the human lung in its pristine state but also to understand the perturbations that underlay many lung diseases.", "author": "Adam Wellikoff, D. Keith Payne", "slug": "alveolar-structure-and-function-57504-9781615045051-d-keith-payne-adam-wellikoff", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781615045051.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "57504", "product_url": "/app/ecom/book/57504/alveolar-structure-and-function-57504-9781615045051-d-keith-payne-adam-wellikoff", "bisac_codes": [ "MED075000" ], "items_count": null, "identifiers": { "ISBN13": "9781615045044", "EISBN13": "9781615045051", "EISBN10": "1615045058" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010015216085" } } } } ], "meta": { "pagination": { "page": 78041, "pages": 78533, "count": 1570660 } } }
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