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                "name": "Schizophrenia and Comorbid Conditions",
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                "description": "Schizophrenia is one of the most difficult diagnoses to make. And, once made, it was once among the most limited, offering few options in the management of care for schizophrenia patients with comorbid conditions. It was not until 1994, with the publication of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), that diagnostic guidelines first permitted additional diagnoses on Axis I, such as anxiety disorder, in the presence of schizophrenia. Yet remnants of the old hierarchical diagnostic system remain, diverting attention from the pressing issue of managing what appear to be common -- and treatable -- disabling conditions, such as panic disorder and obsessive-compulsive disorder (OCD), that often occur with schizophrenia.Schizophrenia and Comorbid Conditions: Diagnosis and Treatment lays diagnostic oversimplification of schizophrenia to rest once and for all. All schizophrenia patients are not the same. The editors of this groundbreaking work criticize the reductionist view of schizophrenia as a single unitary disorder -- a view that has led many psychiatrists and mental health care professionals to overlook potentially important syndromes.Asserting that these patients should be managed on the basis of their individual clinical presentations, not just their categorical diagnosis, recognized experts in their specialties offer a fascinating array of topics. Chapter 1 goes straight to the heart of this assertion, beginning with epidemiology and showing how hierarchical diagnostic concepts keep associated psychiatric syndromes (APS) hidden from clinical and scientific attention. Also presented are the findings of the few treatment studies of APS in schizophrenia.Additional chapters feature the following topics:   Chapter 2 takes an indepth look at the extensive literature on depression in patients with schizophrenia, including a discussion on differential diagnosis and treatment approaches. Chapters 3 and 4 detail obsessive-compulsive disorder and panic symptoms, using case vignettes to illustrate the clinical management of schizophrenia with these two conditions. Chapters 5 and 6 discuss the recognition and management of medical and surgical illness and the management of pregnancy in patients with schizophrenia, respectively. Chapter 7 reviews cognitive impairment in older patients with schizophrenia, including etiology, assessment, and treatment approaches. Chapter 8 presents old and new approaches to the treatment of aggressive behaviors and violence in patients with schizophrenia. Chapter 9 extensively reviews substance abuse in schizophrenia, with suggested practical approaches to assessing and treating the \"dual-diagnosis\" schizophrenia patient. Intended to help practitioners enhance their recognition of and improve treatment for the large -- and often neglected and clinically challenging -- group of schizophrenia patients with comorbid conditions, this unique collection combines a wealth of clinical and research experience of enduring value to practitioners and researchers alike.",
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                "description": "PTSD is a recently named psychiatric condition that unknown before the publication of DSM-III in 1980. The creation of this diagnosis was intensely controversial, and there continued to be considerable reluctance to apply the term to children. The 1985 landmark volume, Posttraumatic Stress Disorder in Children, edited by Spencer Eth and Robert Pynoos, helped establish the validity of this condition during childhood. Now Spencer Eth has edited PTSD in Children and Adolescents, a work that brings the field of childhood trauma in to the new century by offering fresh insights on five major topic areas in child and adolescent PTSD:   Techniques for comprehensive evaluation -- details recently developed diagnostic instruments and rating scales that measure the variety and severity of traumatic symptoms in children and adolescents. Forensic aspects of traumatized children -- surveys legally pertinent issues, including abuse, reliability of traumatic memories, and credibility of child victims. Juvenile offenders and incarcerated youth -- examines the role of trauma in the lives of juvenile offenders, noting that the victimization of delinquents must be specifically addressed in order for an integrated approach to treatment to achieve effective rehabilitation. Biological treatment strategies -- systematically reviews the important role of medications for PTSD in clinical practice, including such topics as biological dysregulation, target symptoms, and the inclusion of drugs into the biopsychosocial treatment plan. The relationship between exposure to trauma in childhood and the development of psychiatric disorders in adulthood -- presents current research on the long-term prognosis of traumatized children and adolescents by analyzing the association between early traumatic exposure, biological substrates, and subsequent symptomatic morbidity. Mental health practitioners and trainees, as well as attorneys, pediatricians, and school personnel, will find this thoroughly annotated volume an invaluable roadmap in their journey toward understanding PTSD and discovering more effective treatments for traumatized children and adolescents. With its eclectic perspective and interdisciplinary format, this exceptional reference will also enhance courses in developmental psychology, social work, and education.",
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                "description": "Suicide remains all too common in the United States. As the ninth leading cause of death -- responsible for 30,000 deaths annually -- it is also one of the more preventable causes of deathIncreasingly, mental health clinicians must care for suicidal patients within managed care systems. Managed care's cost-driven focus on rapid assessment and triage, narrowly restrictive hospital admission criteria, and abbreviated inpatient stays have resulted in poorer clinical care and increased opportunities both for adverse outcomes such as suicide and for clinician liability.Bringing together a unique mix of clinicians, authorities, and administrators from private practice and managed care, Treatment of Suicidal Patients in Managed Care offers practical guidance on how to improve care and reduce risk for suicidal patients. Contributors explore a wide range of topics:   Hospitalization -- Emphasizes the increased importance of the initial assessment when managed care systems shorten or deny hospitalization for suicidal patients and of knowing whom to call within the managed care system. Includes alternative programs from acute residential care to cognitive-behavioral strategies and dialectical behavior therapy for the suicidal patient in crisis Suicide risk among adolescents and the elderly -- For adolescents, emphasizes the value of multiple levels of care when admissions are too short and too often followed by distressing and costly readmissions. For the elderly, offers preventive interventions for primary care physicians who are uncomfortable discussing depression and suicidal ideation and intention with their elderly patients Suicide and substance abuse -- Details the role of case managers in providing continuity of care in a disorder known to be chronic and relapsing Pharmacotherapy of depression and suicidality -- Discusses the effects of managed care and raises questions about the expertise of the prescriber, especially relevant now that more primary care physicians are treating patients with uncomplicated unipolar depression Risk management issues -- To counter the perception that managed care companies profit from withholding care, emphasizes the crucial importance today of documenting the reasons for treatment decisions Helping those affected by the aftermath of a suicide -- A step-by-step process: 1) anticipating a suicide, 2) announcing or sharing the news of a suicide, 3) assessing those affected by a suicide, and 4) seeing what can be learned from reviewing the patient's treatment This clinical guide will aid understanding of clinical, administrative, and risk management issues relevant to the care of suicidal patients. Psychiatrists, psychologists, nurse clinical specialists, social workers, administrators, and primary care physicians will also rely on it as they cope with the mounting pressures of managed care while maintaining the quality of their care for these vulnerable and patients.",
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                "description": "The past decade has witnessed tremendous progress in psychiatric neuroimaging research. Investigators have developed, in tandem with significant advances in imaging technology, innovative strategies for exploiting the awesome potential of these new tools.This volume brings you up to date on the latest developments by providing insight into the methodology of experimental design of the numerous neuroimaging articles being published in today's peer-reviewed journals. Revealing the remarkable wealth of neuroimaging's potential contributions to psychiatry, 49 distinguished contributors use accounts of their own research to illustrate the power of particular paradigmatic techniques. These techniques hold promise not only for delineating pathophysiology and advancing neuroscience, but also for yielding discoveries of direct clinical significance, such as diagnostic testing, predictors of treatment response, and new medications. Focused specifically on applications in psychiatry, these chapters are uniquely organized around experimental paradigms rather than psychiatric disorders:   Using magnetic resonance imaging (MRI) to detect and characterize subtle, easily overlooked abnormalities in schizophrenia and schizotypal personality disorder. Testing specific hypotheses regarding the functional integrity of implicated neural systems within the brain as part of cognitive activation studies of schizophrenia and obsessive-compulsive disorder (OCD). Assessing the roles of the amygdala and striatum in anxiety disorders, including masked stimuli and other task manipulation methods to assay nonconscious brain activity.  Investigating the neural correlates of psychiatric symptoms in anxiety disorders, using script-driven imagery and in vivo exposure to experimentally manipulate study conditions. Capturing the often elusive symptoms of hallucinations and psychomotor tics using innovative imaging techniques. Using transcranial magnetic stimulation (TMS) to investigate how the brain regulates mood. Other fascinating topics include using positron emission tomography (PET) and single photon emission computed tomography (SPECT) to discern the therapeutic mechanisms of psychotropic medications and enhance the development of new medications; integrating structural and functional imaging to treat major depression; using magnetic resonance spectroscopy (MRS) to quantify brain concentrations of exogenous compounds; using MRI to visualize circuits implicated in developmental disorders such as attention-deficit/hyperactivity disorder (ADHD) and anxiety, including ground-breaking studies of children; using functional MRI in animals and its applications in psychiatric research; and exploring the use of neuroimaging methods to investigate genetic contributions to normal cognitive function. Specialists and general clinicians alike will find much of interest in this definitive look at the exciting developments in neuroimaging today and how they can enhance our understanding and treatment of psychiatric disorders. This comprehensive text with its extensive illustrations and annotations will also prove a welcome addition to any course in the neurosciences.",
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                "name": "The Difficult-to-Treat Psychiatric Patient",
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                "description": "Why do some psychiatric patients fail to get better, even when in the care of competent clinicians?Treatment-refractory conditions are all too common in everyday clinical practice. Treatment resistance occurs across the full spectrum of psychiatric disorders, incurring enormous emotional, economic, and social costs. In the United States, treatment of depression alone costs more than $40 billion annually, and as many as 40% of patients with depression have a treatment-refractory form of the illness.This groundbreaking clinical guide starts where standard textbooks end, focusing on clinical strategies to be used after all basic treatment options, such as medication and psychotherapy, have failed. In this book expert contributors address the sequential clinical steps in treating difficult-to-treat psychiatric patients by offering a blend of evidence-based clinical recommendations, detailed case vignettes, treatment algorithms, and -- when necessary to go beyond the reach of evidence -- the clinical wisdom of leaders in the field. The chapters in this user-friendly, practical guide are organized by major disorder. Each chapter offers concrete recommendations on what to do when the usual first steps in therapy are ineffective, including evidence for biopsychosocial treatments alone versus in combination, generic versus specific therapies, and literature reviews and the latest expert wisdom. A sampling includes   The management of the complex and often refractory bipolar disorder, which involves replacing or combining lithium treatment with anticonvulsants or atypical antipsychotic agents with adjuncts such as benzodiazepines, thyroid hormone, and electroconvulsive therapy, but also -- above all -- with careful attention to the therapeutic alliance. The importance of combined therapeutic modalities for patients with schizophrenia -- especially given managed care's cost-cutting strategies, which deprive many schizophrenic patients of effective treatment modalities such as family therapy or early use of an atypical antipsychotic. Combination treatments for anxiety, with medications adjusted over time as symptoms wax and wane, and early and appropriate interventions to mitigate internal and external environmental stressors. The emphasis on common sense, optimism, a sense of humor, and an iron constitution as the most important tools for clinicians wishing to work with the most severely ill patients with borderline personality disorder. The importance of individual differences in biological vulnerability, emotionality and expressiveness, cognitive schemas and beliefs, prior traumatic experience, resilience, and coping strategies for successful treatment of posttraumatic stress disorder. Packed with up-to-date information of immediate relevance, this volume will prove invaluable in both classroom and clinical practice, for everyone from beginning interns and residents to experienced psychiatric and medical practitioners and social workers.",
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                "name": "Treating Mental Illness and Behavior Disorders in Children and Adults With Mental Retardation",
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                "description": "Since the 1970s, the development of normalization philosophy and the implementation of community care policies have highlighted the nature and treatment of psychiatric and behavior disorders in people with mental retardation and rekindled the interest of scientists, psychiatric practitioners, and service providers. With these changes has grown a substantial body of new research and information on the phenomenology, epidemiology, classification, and clinical features of mental illness and behavior disorders in mentally retarded persons.In response to this growing interest and awareness, the editors, together with internationally renowned contributors from the United States and Europe, have compiled the first comprehensive handbook of the current theory and practice of mental health treatment and care in mentally retarded children and adults.Both contemporary and in-depth, this multidisciplinary, multidimensional volume covers all available therapeutic methods, including psychopharmacotherapy, psychotherapy, behavior therapies, cognitive therapy, and the systems approach for all the main diagnostic disorders in people with mental retardation.Parts I and II present an overview of epidemiology and clinical presentation, including research trends, and therapeutic methods, including psychotherapy, psychopharmacology, behavioral therapies, cognitive and social learning treatments, and working with families and caregivers.Parts III and IV focus on psychotherapeutic interventions, such as rational emotive group treatment with dually diagnosed adults, pre-therapy for persons with mental retardation who are also psychotic, and systemic therapy, and how to apply these methods to the treatment of specific mental illnesses, such as schizophrenia, epilepsy, and mood and anxiety disorders.Parts V and VI discuss how to treat behavior disorders such as aggression/self-aggression (pharmacotherapy and strategic behavioral interventions) and self-injurious behaviors (multimodal contextual approach), including group therapy for sex offenders and a pedagogical approach to behavior problems, and which treatment methods, such as psychodynamically oriented psychotherapy and pharmacotherapy, are most effective with children, including developmental-dynamic relationship therapy with more severely mentally retarded children.Parts VII and VIII provide guidance on mental health services and staff training, including psychiatric treatment in community care and a model for inpatient services for mentally ill persons with mental retardation, and the editors final chapter, which draws together all the various therapeutic approaches described in previous chapters to provide a practical framework for an integrative approach.Filling a major gap in the literature, this indispensable resource for psychiatrists, psychologists, and educators working with mentally retarded persons is also intended for general practitioners, doctors, social workers, and therapists working in the same or related fields.",
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                "name": "The Early Stages of Schizophrenia",
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                "description": "In sharp contrast to the prevailing belief during the past century that schizophrenia inevitably results in a progressive deteriorating clinical course, research since the early 1980s shows that early intervention can significantly improve the long-term outcome of this complex illness. With very early treatment, many affected individuals can achieve an excellent recovery.This research has set off an explosion of interest in -- and optimism about -- early intervention in what was once thought to be an intractable illness. The work of 19 top experts in the field of schizophrenia research is available in this single, powerful volume that introduces the concept of early intervention and describes the clinical approaches most likely to facilitate the fullest degree of recovery. Contributors review the clinical and epidemiological evidence that supports the importance of comprehensive and optimal treatment during the early stages of schizophrenia -- treatment that must encompass emotional, family, and vocational as well as pharmacological needs of affected individuals. This rich overview is organized into three major parts:   Early Intervention, Epidemiology, and Natural History of Schizophrenia, which presents an overview of important concepts in early intervention and reviews our current understanding of the outcome from a first episode of schizophrenia, including which features predict the onset of first-episode psychosis Management of the Early Stages of Schizophrenia, which reviews the critical management issues in providing specialized and optimal care to this complex patient group and their families, including meeting the patient's emotional needs Neurobiological Investigations of the Early Stages of Schizophrenia, which describes important specialized topics that contribute to our understanding of the first episode of schizophrenia, including schizophrenia in childhood and adolescence and cognitive dysfunction in the early stages of schizophrenia This ground-breaking volume provides reason for new optimism about the treatment and outcome of schizophrenia. With its dramatically different perspective on the potential long-term outcome of a still-baffling illness, this volume is a must-read for mental health practitioners and educators, psychiatry residents, and family members of affected individuals.",
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                "description": "In questions of psychiatric ethics, simple \"yes\" or \"no\" answers are rare, yet questions arise frequently in the clinical setting. \"Should I accept a patient's invitation to a party?\" \"Is it OK to tell a patient that I, too, have had a depression?\" \"Can I release sensitive information about my patient without the patient's consent?\" \"Can I give a psychiatric opinion about someone I've never examined?\"A shortage of ethics instruction from medical school through residency has left many psychiatrists facing the increasingly complex field of ethics without a clear guide to ethical decision making and conductuntil now.Informed by some of the formal proceedings of the APA Ethics Committee, Ethics Primer of the American Psychiatric Association presents today's ethical dilemmas in eleven informative chapters -- brought to life by the clinical vignettes based on actual cases seen by this primer's distinguished contributors.    Boundary violations between the doctor -- patient relationship and any other relationship (e.g., social, sexual/romantic, business) Issues such as informed consent, psychopharmacology, hospitalization, and psychotherapy with children, adolescents, and families Issues such as confidentiality, competence and consent, quality of life, abuse and neglect, and use of restraints with geriatric populations  Involuntary hospitalization rife with conflict and controversy where many ethical principles clash (e.g., beneficence, autonomy, informed consent) Reconciling ethical conduct (as delineated in guidelines of the AMA, APA, and Sabin) with managed care's cost containment and rationing of medical services Confidentiality, how this fundamental ethics principle can clash with the business ethics of managed care and insurance companies Gifts from patients and industry when and why they are or are not acceptable The often uncomfortable duty to report colleagues who engage in fraud or deception, from speaking privately with a colleague to referring a concern to a departmental committee, supervisor, or local APA ethics committee (and applicable legal mandates) Emergency care ethics how to ensure proper treatment for psychiatric patients who come to the emergency room with physical illnesses forensic psychiatry, including codes of ethics, boundary issues, and management of allegations of ethical misconduct When consultations and second opinions are needed Including an appendix with selected material from The Principles of Medical Ethics With Annotations Especially Applicable to Psychiatry, this clinical guide and reference is sure to stimulate the discussion so integral to maintaining the dynamic tradition of ethics. As such, it is essential reading for every psychiatrist -- whether in training or in established clinical practice -- who aspires to a richer appreciation for the wisdom and subtleties of the guidelines and principles of medical ethics.",
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                "description": "Psychiatric patients have an increased rate of morbidity and mortality due to physical illnesses. Distressingly, psychiatrists fail to recognize these comorbid medical illnesses in nearly half of all cases. All too often, the physical illness may be causing or exacerbating the psychiatric symptoms. Furthermore, the psychiatric condition itself and iatrogenic complications of medication or other treatments can result in serious medical pathology.Until now, most psychiatrists have deferred the general medical care of their patients to other practitioners. Yet because psychiatrists are uniquely positioned to provide health care that bridges somatic and mental conditions, they are increasingly being called on to ensure that their patients also receive adequate medical care. This breakthrough text responds to that call to action from a perspective unique in the literature: It focuses on the medical complications of psychiatric illnesses, rather than the more typical psychiatric complications of medical illnesses.This concise yet comprehensive book is intended for practitioners who treat adult medical patients. It is divided into two main sections:    Health Care of Psychiatric Patients, organized by recommendations for routine medical management and reproductive health, focuses on the general health care maintenance of psychiatric patients with medical illnesses. Also discussed are the unique reproductive health needs of psychiatric patients, who are often at increased risk of coercive or abusive sexual relationships, rape and other sexual assaults, unplanned pregnancy, pregnancy complications, and sexually transmitted diseases. Psychiatric Disorders, organized by diagnostic groupings, focuses on those psychiatric disorders -- affective, anxiety, and somatoform disorders and dementia; schizophrenia and other psychotic disorders; Munchausen's syndrome and other factitious disorders; self-injurious behavior; eating disorders; and alcohol and drug abuse -- that most clearly can have medical complications. Using extensive notes and tables throughout, these distinguished contributors have created far more than just another compendium of medical illnesses that can present with psychiatric symptoms. Here you'll find a practical, detailed roadmap that will be welcomed not only by students, residents, and clinicians working with adult psychiatric patients who develop medical complications, but also by practitioners who manage psychiatric patients in a general medical practice.",
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                "description": "Countless studies have demonstrated the power of early intervention to permanently alter the course of a child's life. Yet -- heightened by the past decade's research breakthroughs in genetics -- the nature vs. nurture controversy rages on.This volume dispels some of the persistent myths surrounding this controversy. Unlike largely theoretical texts that describe infant behavioral and emotional difficulties and other psychosocial challenges affecting young children, this eminently practical guide illustrates what to do in numerous clinical situations with actual patients. Written by clinicians who work with infants and children and their families every day, this reality-based approach addresses the most common and important problems in infant psychopathology (e.g., trauma, sleep, feeding, excessive crying, attachment disruptions), covering models of intervention from pregnancy through infancy, attachment issues, and transgenerational themes. Here, you'll find topics rarely addressed elsewhere:   The theoretical and clinical implications of trauma during early childhood and its effects on emotional regulation, cognition, and attachment, including potential disruptions of attachment -- a topic widely overlooked in the life of young children, perhaps because of the distress it produces in adults to think that infants can be subject to violence, witness major traumatic events, and experience consequences from such events Techniques, such as multimodal parent-infant psychotherapy, for working effectively with families -- once considered \"unreachable\" -- who are under severe stress and have endured multiple disruptions, disappointments, and marginalization A timely discussion of a rarely addressed problem on the importance of early intervention and the effects of day care for infants, from the point of view of the infant exposed to multiple caretakers, addressing the very difficult questions of the effects on infants of changes in caretakers How young children use their bodies and its functions to manifest their difficulties, focusing on sleeping, crying, and eating with practical suggestions that can be widely applied by health care professionals Unique commentaries on two case examples by a diverse international panel of clinicians and researchers -- from countries such as Argentina, Canada, France, Japan, Mexico, Switzerland, the UK, and the U.S. -- illustrating the differences of opinion, approaches, and perspectives that together generate more effective assessment and treatment This thought-provoking clinical reference is a \"must read\" for developmental, child, and adolescent psychiatry educators and practitioners -- and nurses, pediatricians, occupational therapists, and clinical social workers -- as they help the youngest members of our community through theoretical understanding and practical intervention.",
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                "description": "For most of its history, medicine has been male oriented. Doctors, research subjects, and patients were nearly all men, and medication dosages were considered to be \"one size fits all.That orientation has changed dramatically. The medical profession now recognizes that women's physiology is different and realizes that women's health is one of its leading issues. Our relatively recent efforts to understand sex differences in the onset, presentation, course, and treatment of mental illnesses are yielding sometimes striking results. Why is schizophrenia so much more common in men, and why does it have an earlier onset and a more malignant course? Do estrogens protect against schizophrenia? Why do women have higher rates of mood disorders and increasing rates of substance abuse? Representing the work of 60 distinguished contributors, this comprehensive summary answers these and many other questions concerning the psychological and pharmacological treatment of psychiatric illnesses in women, including useful information about recent developments in psychopharmacology, physiology, course and manifestation, and the interaction between social and biological factors. This eye-opening book is divided into five parts:   Anxiety disorders and other related disorders -- Panic, agoraphobia, obsessive-compulsive disorder, posttraumatic stress disorder (PTSD), and substance abuse disorder associated with PTSD, featuring research that continues to uncover promising hypotheses to explain gender differences in prevalence and treatment rates Major depressive disorder and related disorders -- The role of women's reproductive cycle in precipitating or exacerbating mood instability; psychopharmacology of antidepressants; effects of hormones (especially estrogen); sex differences in brain structure and function; and pharmacokinetic differences in rates of drug absorption, distribution, metabolism, and elimination Schizophrenia and related disorders -- Origins and progression; neurocognition and symptom expression, with the central role of gonadal hormones; the effect of estrogen (menopause coincides with worsening symptoms); neuroleptic-induced hyperprolactinemia; quality-of-life considerations and systems of care; and schizophrenia's impact on the family in our post-institutionalization age Dementia and related disorders -- Overview of Alzheimer's disease (AD) research from the National Institute on Aging, recent clinical trials that suggest the treatment efficacy of estrogen replacement, the central role of gonadal steroids in preventing and treating AD, and the challenges faced by women caregivers Other psychiatric illnesses and special topics -- Epidemiology of substance abuse disorders, victimization, and PTSD; dissociative disorders (by far more prevalent in women than men); factors in the pathogenesis of anorexia nervosa and bulimia nervosa; treatment challenges during pregnancy; and women, ethnicity, and psychopharmacology Clinicians and laypersons alike will welcome this clearly written, definitive guide on the most recent developments in our understanding of the major differences in the brain anatomy, physiology, and epidemiology of psychiatric illnesses between women and men.",
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                "name": "Brain Circuitry and Signaling in Psychiatry",
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                "description": "The 1990s, appropriately termed \"the decade of the brain,\" witnessed unprecedented advances in our knowledge of psychiatric neuroscience. Yet with every advance, we realized afresh that we were still in the beginning stages of a much longer journey.This text chronicles the next step of that journey. Structured around a proven teaching methodology that uniquely integrates the clinical aspects of psychiatric disorders with their neurobiology, this volume begins with two introductory chapters on functional neural circuitry and neural signaling pathways. The remaining six chapters present current knowledge on the neuroanatomic and neurochemical mechanisms underlying schizophrenia, addiction, anxiety, depression, bipolar disorder, and dementia/Alzheimer's disease. For clarity and consistency, each chapter features the same four divisions -- clinical presentation, neural circuitry, signaling pathways, and psychopharmacology -- as they relate to   Schizophrenia, which reviews studies of the neural basis of schizophrenia and describes how the cortex, the thalamus, the basal ganglia, and the medial temporal lobe work together during normal brain function and then how each is perturbed in psychosis.  Addiction, which focuses on the consequences of psychoactive substance use, including compulsive practices (e.g., eating, sex, Internet browsing) that might also involve the same brain circuits and signaling pathways. Of exceptional value are two unique illustrations that capture -- for the first time -- much of what we know about the anatomy and neurochemistry underlying the behavioral symptoms of addiction. Anxiety, which presents current hypotheses regarding neurocircuitry and signaling pathways for the three best-studied (from a neurobiologic perspective) anxiety disorders: panic disorder, posttraumatic stress disorder, and obsessive-compulsive disorder. Depression, which offers evidence for the involvement of highly interconnected cortical and limbic structures such as the prefrontal cortex, medial thalamus, amygdala, ventral striatum, hippocampus, and the hypothalamic-pituitary-adrenal axis in unipolar major depression, and suggests target areas (such as the cAMP pathway) for study in the development of new antidepressants. Bipolar disorder, which shows that specific abnormalities in signal transduction pathways, including protein kinase activity, G protein levels, and gene expression, are unique to bipolar patients, concluding that the actions of lithium and anticonvulsants on intracellular signaling pathways provide a new paradigm for novel pharmacological interventions.  Dementia and Alzheimer's disease, which details current findings on neurofibrillary degeneration, relevant genes and proteins, pathogenesis (metabolic decline, defective cell repair, and A toxicity), and treatment strategies (neurotransmitter replacement, and neuroprotective and regenerative approaches). Discusses frontotemporal dementia, dementia with Lewy bodies, Parkinson's disease, and vascular dementia. Meticulously researched and clearly written by 15 contributors -- all recognized experts from leading research and teaching institutions in the United States -- this compact and extensively illustrated volume stands out in the literature because it combines readability and practicality with the breadth and depth typically found only in far lengthier works. Psychiatric practitioners, residents, and students alike will welcome this informative, easy-to-read text, which will also be of special interest to mental health and pharmaceutical industry professionals, and of general interest to anyone who wants to know more about the biology of psychiatric illness.",
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