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After presenting an overview of a particular area, the articles summarize work from the authors' own laboratories and include new, unpublished material. Emphasis is on the more dynamic aspects of the subject rather than on detailed descriptions. The contributions range from descriptions of the organization of the centrosome at the molecular level to speculations on how the centrosome may affect the behavior of entire cells. Experimental studies are complemented by theoretical considerations to provide added insight into the structure and function of this organelle and by speculations on directions which appear most profitable for future studies. Controversial ideas and conflicting hypotheses, which often provide the driving force for new advances, have also been included.", "author": "Vitauts I. 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The book begins with a discussion of the role of hormones in the control of cell differentiation and biochemical control over the life of an organism. This is followed by separate chapters on an intracellular control problem, namely, the proper reproduction of cellular organelles and their apportionment between daughter cells at cell mitosis; cell mutants with different temporal order for macromolecular synthesis; and the control of a plant enzyme that converts triglycerides into carbohydrate during the early stages of postgerminative growth within seed cotyledon. Subsequent chapters deal with the possible role of mitochondria in changing the control mechanism of cells to that associated with carcinogenesis; the possibility of transforming genes being detectable in the genome after the transformation to neoplastic cell; the correlation between viruses and tumor cells; and whether viruses can originate from cells rather than coming before cells.", "author": "G. H. Bourne, J. F. 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The first volume, Human Judgment and Decision Processes (Academic Press, 1975) was concerned with formal and mathematical approaches to the problems of judgment and decision making. The major theoretical orientations (information integration theory, signal detection theory, portfolio theory, and multiattribute-utility measurement) were presented and their rationales discussed. The present volume is concerned with the application of these theories, and the various techniques derived from them, to the problems of decision making in the everyday world. The chapters reflect the many modifications and adjustments that must be made to mathematical rules in order to apply decision theory models in the real world. The tools described serve a broad variety of interests: those of the urban health or social planner, the organizational manager, the researcher, the educator, and, in fact, all of those who must weight evidence to reach decisions. Planner, manager, researcher, teacher, policymakerall will find assistance in overcoming the commonly encountered roadblocks when one must choose between alternatives in what remains an uncertain world.", "author": "Martin F. 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The book is organized into three sections. Section I contains studies on pathology induced by inflammatory cytokines. Topics covered include the biological effects of interferon-?, tumor necrosis factor- a (TNF), interleukin-8, transforming growth factor-, and leukemia inhibitory factor on experimental animals; TNF-induced pathophysiologic alterations; and the biological activity of leukemia inhibitory factor (LIF). The papers in Section II examine cytokine receptors, including their structure and signal transduction; interferon-? (IFN-?) activity; and immunoregulatory role of TNF-a. Section III is devoted to cytokine receptors, including studies on TNF properties relevant to tissue injury and its role in T cell-mediated immunopathological reactions in vivo; the role of cytokines in experimental pulmonary fibrosis induced in mice; and the role of cytokines in bacterial meningitis.", "author": "G. W. 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Szent-Gyorgyi, born in Budapest on September 16, 1893, established the Institute for Muscle Research at the Marine Biological Laboratory in 1947. His influence and impact extend beyond the confines of the laboratory. Throughout his life he was intensely concerned with the serious problems of mankind. He opposed Hitler and Stalin, and was outspoken against the involvement of the U.S. Government in the Vietnam War. Starting with recollections of Albert Szent-Gyorgyi by John T. Edsall of Harvard University, the remainder of the text is organized into six parts that cover the fields of Szent-Gyorgyis major contributions and interests: metabolism, vitamin C, molecular mechanisms of muscle contraction, submolecular biology and cell growth, and cancer; the social interrelations of science were also not neglected. These milestones form the basis of this volume.", "author": "Benjamin Kaminer", "slug": "search-and-discovery-294794-9781483274553", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9781483274553.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "294794", "product_url": "/app/ecom/book/294794/search-and-discovery-294794-9781483274553", "bisac_codes": [ "NAT019000", "SCI070030" ], "items_count": null, "identifiers": { "ISBN13": "9780123951502", "EISBN13": "9781483274553", "EISBN10": "1483274551" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010026357449" } } } }, { "type": "Product", "id": "00010000294793", "attributes": { "name": "New Trends in Genetic Risk Assessment", "subtitle": "", "description": "New Trends in Genetic Risk Assessment is based on the Fifth International Round Table of the Rhone-Poulenc Sante Foundation, held in Nice 1987. The conference was an attempt to review the latest theories and mechanisms stipulated for the various aspects of genotoxicity; it was above all an open forum to discuss the new trends, the new tests, and the new battery of tests for assessing the genetic risk of chemicals and especially drugs. This volume is actually not a proceedings of the meeting but a monograph specially edited to report the reviews which were presented and the discussions which took place; it was designed to provide a better understanding of the knowledge obtained in the most recent years and to help in the practical choice of approaches or tests for the prediction of the various forms of genotoxicity. The main subjects of this review concern molecular analysis of mutagenesis, detection of DNA damage, gene mutation, clastogenesis, aneuploidy, and germ cells. Each theme is preceded by a short overview summarizing the state of the art and the contributions of each author. Finally, special attention was given to the personal views of some leading toxicologists as to the battery of tests presently available or recommended.", "author": "G. Jolles, A. 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The central theme of the volume is membranes. The diversity of topics ranges from the biogenesis of membranes and their components, to the use of optical and lectin probes as a means to study the structure, physiology, and interactions of cell components and organelles in plant and animal systems. The book begins with a study on the cell surface of the mammalian embryo and the events associated with the formation of the differentiated blastocyst. This is followed by separate chapters on the structural associations between the inner and outer bacterial membrane; the interactions of cell wall and membrane in plant cells; the morphological and functional aspects of membranes; and methods for studying the physiology of cell and organelles at the membrane level. Subsequent chapters deal with the synthesis of cellular proteins and glycoproteins; techniques for fixing and preserving the ultrastructure of the membrane; the synthesis of artificial organelles; and the effects of drugs and chemicals on membrane transport utilizing kidney tissue and vesicles. This book provides an outstanding reference source for all scientific researchers and teachers.", "author": "A. L. 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This book presents the basic mathematical and computational approaches to problems in the artificial intelligence field. Organized into four parts encompassing 16 chapters, this book begins with an overview of the various fields of artificial intelligence. This text then attempts to connect artificial intelligence problems to some of the notions of computability and abstract computing devices. Other chapters consider the general notion of computability, with focus on the interaction between computability theory and artificial intelligence. This book discusses as well the concepts of pattern recognition, problem solving, and machine comprehension. The final chapter deals with the study of machine comprehension and reviews the fundamental mathematical and computing techniques underlying artificial intelligence research. This book is a valuable resource for seniors and graduate students in any of the computer-related sciences, or in experimental psychology. 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This book introduces the tools of generating functions and matrix theory to facilitate a detailed study of such models. Organized into five chapters, this volume begins with an overview of the elementary theory of probability for discrete random variables. This text then reviews the concepts of convergence, absolute convergence, uniform convergence, continuity, differentiation, and integration. Other chapters consider the occurrence of general patterns of successes and failures in Bernoulli trials. This book discusses as well the matrix theory, which is used in the study of stochastic processes, particularly in the analysis of the behavior of Markov chains. The final chapter deals with the properties of a special class of discrete time chains. This book is a valuable resource for students and teachers.", "author": "Jeffrey J. Hunter, J. 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The collection discusses the political dimension of stratification, the results of observation of first-graders in their reading group assignments against their social background, and stereotyping practices held by dominant groups of society. Anther papers use a causal model to analyze occupational status and earnings of Cuban exiles in the U.S.; other authors discuss the effects of institutionalization of formal employment in Brazil, and propose a revision of the Duncan Scale by a more comprehensive set of occupational prestige scale. The book also analyzes measurements of ranked preferences using a single latent factor behind the ranked items. One authors points that some sociological terms can be misleading in propounding a sound theory when these terms themselves confound what they are supposed to correlate. The text also addresses the fundamental problems concerning welfare that include order, collective action, and consensus. 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This book covers a variety of topics that range from mathematical numerical analysis to numerical methods applied to problems in mechanics, meteorology, and fluid dynamics. Organized into 18 chapters, this book begins with an overview of the methods of the RayleighRitzGalerkin type for the approximation of boundary value problems using spline basis functions and Sobolev spaces. This text then analyzes a special approach aimed at solving elliptical equations. Other chapters consider the approximation theoretic study of special sets of approximating functions. This book discusses as well combining the alternating-direction methods with Galerkin methods to obtain highly efficient procedures for the numerical solution of second order parabolic and hyperbolic problems. The final chapter deals with the results concerning Chebyshev rational approximations of reciprocals of certain entire functions. 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