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GET /services/catalog/products?format=api&page=72367
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It presents information on: <br>characteristics of cultured cells; culture vessels; glassware preparation and sterilisation techniques; subculturing; primary cells; cell culture media; techniques; contamination; the cell cycle; cell synchronisation; use of radioactive isotopes in cell culture; cell mutants and cell hybrids; viruses; and differentiation in cell cultures.<p><br>Reviews on the 1st edition:<p> <br>``.. the book provides an excellent insight into the way cell culture techniques can be employed in the analytical study of cellular biology.'' - Trends in Biochemical Sciences <p><br>``It is well written in a concise, easy-to-read style which stimulates the interest of the reader....'' - Science Tools<p> <br>``A useful handbook on principles and practice.'' - Immunology Today<br><br>", "author": "R.L.P. Adams", "slug": "cell-culture-for-biochemists-428061-9780080858777-rlp-adams", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9780080858777.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "428061", "product_url": "/app/ecom/book/428061/cell-culture-for-biochemists-428061-9780080858777-rlp-adams", "bisac_codes": [ "SCI007000", "SCI010000" ], "items_count": null, "identifiers": { "ISBN13": "9780444813060", "EISBN13": "9780080858777", "EISBN10": "0080858775" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010026345266" } } } }, { "type": "Product", "id": "00010000428044", "attributes": { "name": "Advances in Developmental Biology", "subtitle": "", "description": "Volume 4 of Advances in Developmental Biology and Biochemistry consists of five chapters that review specific aspects of fly and mammalian development. In Chapter 1, Y. Mishina and R. Behringer discuss various aspects of Mullerian-inhibiting substance (MIS) in mammals, from a brief history of its discovery to recent studies of the MIS gene in transgenic and knock-out animals. In Chapter 2, C. Rushlow and S. Roth discuss the role of the dpp-group genes in dorsoventral patterning of the Drosophila embryo. In Chapter 3, M. Yip and H. Lipshitz discuss the terminal (asegmental termini) gene hierarchy of Drosophila and the genetic control of tissue specification and morphogenesis. In Chapter 4, R. Bachvarova discusses induction of mesoderm and the origin of anterior-posterior polarity in the mouse embryo, using the frog embryo as a paradigm. In Chapter 5, P. Vogt discusses human Y chromosome function in male germ cell development. <br>", "author": "Paul Wassarman", "slug": "advances-in-developmental-biology-428044-9780080876801", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9780080876801.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "428044", "product_url": "/app/ecom/book/428044/advances-in-developmental-biology-428044-9780080876801", "bisac_codes": [ "SCI049000", "SCI072000" ], "items_count": null, "identifiers": { "ISBN13": "9781559389693", "EISBN13": "9780080876801", "EISBN10": "0080876803" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010026369465" } } } }, { "type": "Product", "id": "00010000428042", "attributes": { "name": "Genetic Aberrancies and Neurodegenerative Disorders", "subtitle": "", "description": "Genetic Aberrancies and Neurodegenerative Disorders presents critical reviews and emerging findings concerning the roles of genetic mutations and polymorphisms in the pathogenesis of a range of neurological disorders including Alzheimer's and Parkinson's diseases, trinucleotide repeat disorders, stroke, epilepsy and others. This volume, written by leading experts, brings together fundamental information concerning the roles of inherited traits in the pathogenesis of different neurodegenerative disorders. In addition to providing a catalogue of the known genetic alterations that are linked to specific neurodegenerative disorders, the chapters detail the current state of understanding of the cellular and biochemical mechanisms whereby the genetic aberrancies lead to neuronal dysfunction and degeneration. The emerging picture of each disorder, painted by pathological, biochemical and molecular brushes, suggests that they share key mechanisms including increased levels of oxidative stress, perturbed ion homeostasis, mitochondrial dysfunction and apoptotic proteolytic cascades. The existence of specific molecular defects provides the opportunity to design experiments that can establish the precise pathogenic mechanism of a specific mutation or genetic risk factor. The value of this approach is exemplified by recent studies of how mutations in Cu/Zn-superoxide dismutase cause amyotrophic lateral sclerosis and how presenilin mutations result in early-onset Alzheimer's disease. A theme developed among the different chapters is that events that occur during aging predispose neurons to genetic aberrancies that promote degenerative cascades, and that specific genetic defects exert their influence on particular populations of neurons in a disorder-specific manner. The chapters in this volume will stimulate readers to generate new hypotheses concerning the pathogenic mechanisms of genetic aberrancies that can be experimentally tested.<br>", "author": "M.P. Mattson", "slug": "genetic-aberrancies-and-neurodegenerative-disorders-428042-9780080876733", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9780080876733.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "428042", "product_url": "/app/ecom/book/428042/genetic-aberrancies-and-neurodegenerative-disorders-428042-9780080876733", "bisac_codes": [ "MED057000", "SCI007000" ], "items_count": null, "identifiers": { "ISBN13": "9780762304059", "EISBN13": "9780080876733", "EISBN10": "0080876730" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010026345337" } } } }, { "type": "Product", "id": "00010000428041", "attributes": { "name": "Cell Adhesion", "subtitle": "", "description": "<p>One prerequisite for the evolution of multicellular organisms was the invention of mechanisms by which cells could adhere to one another. At some point in our history, dividing cells no longer went their separate protozoic ways in the primordial oceans, but instead found that by maintaining an association, by sticking together but not fusing, numerous evolutionary advantages became possible. The subsequent development of specialized tissues and organs depended on the elaboration of incredibly sophisticated, regulatable cell-to-cell adhesion mechanisms which are known to operate in biological processes as diverse as the growth of the embryo, the immune response, the establishment of connections between nerve cells, and arteriosclerosis, to name just a few. Although we can only guess at the ancestral mechanisms that fostered the first primitive intercellular unions, some one billion years ago, we now recognize contemporary molecular \"themes\" with presumably ancient origins that mediate cell-cell interactions.</p> <p>The chapters in this book serve as useful, thought-provoking, but not exhaustive, commentaries on contemporary topics within the broad field of cell adhesion. If the reader detects a slight tilt toward those adhesion molecules that function in the nervous system, this is merely a reflection of this editor's interests, biases, and of course, limitations. </p>", "author": "D.R. Colman", "slug": "cell-adhesion-428041-9780080876993", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9780080876993.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "428041", "product_url": "/app/ecom/book/428041/cell-adhesion-428041-9780080876993", "bisac_codes": [ "SCI049000", "SCI072000" ], "items_count": null, "identifiers": { "ISBN13": "9780762301430", "EISBN13": "9780080876993", "EISBN10": "0080876994" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010026359098" } } } }, { "type": "Product", "id": "00010000428040", "attributes": { "name": "The Adhesive Interaction of Cells", "subtitle": "", "description": "The aim of \"The Adhesive Interaction of Cells\" has been to assemble a series of reviews by leading international experts embracing many of the most important recent developments in this rapidly expanding field. The purpose of all biological research is to understand the form and function of living organisms and, by comprehending the normal, to find explanations and remedies for the abnormal and for disease conditions. The molecules involved in cell adhesion are of fundamental importance to the structure and function of all multicellular organisms. In this book, the contributors focus on the systems of vertebrates, especially mammals, since these are most relevant to human disease. It would have been equally possible to concentrate on developmental processes and adhesion in lower organisms. <br>A major function of adhesion molecules is to bind cells to each other or to the extracellular matrix, but they are much more than \"glue\". Adhesions in animal tissues must be dynamic-forming, persisting, or declining in regulated fashion- to facilitate the mobility and turnover of tissue cells. Moreover, the majority of adhesion molecules are transmembrane molecules and thus provide links between the cells and their surroundings. This gives rise to another major function of adhesion molecules, the capacity to transduce signals across the hydrophobic barrier imposed by the plasma membrane. Such signal transduction is crucially important to many aspects of cellular function including the regulation of cell motility, gene expression, and differentiation. <br>The work in this book progresses through four sections. Part I discusses the four major families of adhesion molecules themselves, the integrins (Green and Humphries), the cadherins (Stappert and Kemler), the selectins (Tedder et al.) and the immunoglobulin superfamily (Simmons); part 2 considers junctional complexes involved in cell interactions: focal adhesions and adherens junctions (Ben Ze'ev), desmosomes (Garrod et al.), and tight junctions (Citi and Cordenonsi). The signaling role of adhesion molecules is the focus of part 3, through integrins and the extracellular matrix (Edwards and Streuli), through platelet adhesion (Du and Ginsberg), and in the nervous system (Hemperley). In part 4, the aim is to show how adhesive phenomena contribute to important aspects of cell behavior and human health. Leukocyte trafficking (Haskard et al.), cancer metastasis (Marshall and Hart), cell migration (Paleck et al.), and implantation and placentation (Damsky et al.) are the topics considered in depth. <br>The different sections are, of course, not mutually exclusive: it is both undesirable and impossible to separate structure from function when considering cell adhesion. Each chapter has its unique features, but some overlap is both invevitable and valuable since it provides different perspectives on closely related topics. We hope that the whole contributes a valuable and stimulating consideration of this important topic. <br>", "author": "David Garrod, A.J. North, M.A.J. Chidgey", "slug": "the-adhesive-interaction-of-cells-428040-9780080877136", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9780080877136.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "428040", "product_url": "/app/ecom/book/428040/the-adhesive-interaction-of-cells-428040-9780080877136", "bisac_codes": [ "SCI049000", "SCI072000" ], "items_count": null, "identifiers": { "ISBN13": "9780762304950", "EISBN13": "9780080877136", "EISBN10": "0080877133" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010026369370" } } } }, { "type": "Product", "id": "00010000428038", "attributes": { "name": "Myocardial Preservation and Cellular Adaptation", "subtitle": "", "description": "<p>Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alteration including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses.</p> <p>The heart possesses remarkable ability to adapt itself against any stressful situation by increasing resistance to the adverse consequences. Stress composes the foundation of many degenerative heart diseases including atherosclerosis, spasm, thrombosis, cardiomyopathy, and congestive heart failure. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for preventing of myocardial injury. Creation of stress reactions by repeated ischemia and reperfusion or subjecting the hearts to heat or oxidative stress enables them to meet the future stress challenge. Repeated stress exposures adapt the heart to withstand more severe stress reactions probably by upregulating the cellular defense and direct accumulation of intracellular mediators, which presumably constitute the material basis of increased adaptation to stress. Thus, the powerful cardioprotective effect of adaptation is likely to originate at the cellular and molecular levels that compose fundamental processes in the prophylaxis of such diseases.</p> <p>Volume six of the Advances in Organ Biology series contains state-of-the-art reviews on myocardial preservation and cellular adaptation from the leading authorities in this subject. </p>", "author": "D.K. Das", "slug": "myocardial-preservation-and-cellular-adaptation-428038-9780080877235", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9780080877235.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "428038", "product_url": "/app/ecom/book/428038/myocardial-preservation-and-cellular-adaptation-428038-9780080877235", "bisac_codes": [ "SCI049000", "900" ], "items_count": null, "identifiers": { "ISBN13": "9780762303915", "EISBN13": "9780080877235", "EISBN10": "0080877230" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010026358395" } } } }, { "type": "Product", "id": "00010000428037", "attributes": { "name": "Advances in Developmental Biochemistry", "subtitle": "", "description": "Volume 3 of Advances in Developmental Biology and Biochemistry consists of five chapters that review specific aspects of mammalian and fly development. In Chapter 1, D. Chapman and D. Wolgemuth discuss the role of protein kinases, especially tyrosine-and serine/threonine kinases, in regulating cell cycle events during mammalian gametogenesis. IN Chapter 2, M. Lundell and J. Hirsh discuss the regulation of the DOPA decarboxylase gene during Drosophila development. DO PA decarboxylase is a key enzyme in biogenic amine biosynthesis and its expression is subject to both transcriptional and post-transcriptional regulation. In Chapter 3, S. Potter discusses the role of homeobox genes as master switches determining the developmental destinies of groups of cells during murine development. In Chapter 4, G. Cooper discusses the expression and function of the c-mos proto-oncogene in mammalian germ cells where it plays a central role in regulating the meiotic cell cycle. In Chapter 5, F. Beermann, R. Gan, and G. Schutz discuss the regulation of pigmentation during mammalian development, with emphasis on the production of melanin in mouse melanocytes.", "author": "Paul Wassarman", "slug": "advances-in-developmental-biochemistry-428037-9780080876795", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9780080876795.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "428037", "product_url": "/app/ecom/book/428037/advances-in-developmental-biochemistry-428037-9780080876795", "bisac_codes": [ "SCI072000", "SCI008000" ], "items_count": null, "identifiers": { "ISBN13": "9781559388658", "EISBN13": "9780080876795", "EISBN10": "008087679X" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010026354913" } } } }, { "type": "Product", "id": "00010000428035", "attributes": { "name": "Cell Polarity", "subtitle": "", "description": "Few cells conform to the stereotype of the spherical blob hastily scribbled on chalkboards and, regrettably, sometimes even displayed prominently in textbooks. Instead, real cells display a remarkable degree of structural and functional asymmetry. In modern cell biological parlance, this asymmetry has come to be lumped under the general heading of \"cell polarity\". Cell polarity is by no means restricted to the cells of tissues and organs, but can also be displayed by cells that lead a more solitary existence. The amazing extent to which cell morphology is correlated with function has long been a source of inspiration for biologists. Today the fascination continues unabated in the field of cell polarity, where it is fueled by an ever-deepening appreciation for the ways that fundamental cellular processes, such as membrane trafficking and cytoskeleton assembly, contribute to the establishment and maintenance of cell polarity. In the ensuing chapters, a collection of experts will summarize and interpret the findings obtained from basic research on cell polarity in a diverse array of experimental systems. <br>", "author": "J.R. Bartles", "slug": "cell-polarity-428035-9780080877112", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9780080877112.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "428035", "product_url": "/app/ecom/book/428035/cell-polarity-428035-9780080877112", "bisac_codes": [ "SCI072000", "SCI049000" ], "items_count": null, "identifiers": { "ISBN13": "9780762303816", "EISBN13": "9780080877112", "EISBN10": "0080877117" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010026346334" } } } }, { "type": "Product", "id": "00010000428034", "attributes": { "name": "Cell Cycle", "subtitle": "", "description": "There has been an enormous advance in our understanding of the regulation of the cell division cycle in the last five years. The leap in understanding has centered on the cell cycle control protein p34cdc2 and its congeners and on the cyclins. The most important insight to emerge has been that cell cycle control mechanisms and their participating proteins are very well-conserved through evolution. This has created a spectacular growth in knowledge as data from one organism have been readily applied to another. In this volume, there are sea urchin and frog eggs, as well as mammalian cells and yeast. There is also an illustration of how fruitful the genetic approach can be in other organisms than yeast with a chapter on Aspergillus nidulans. The cell cycle kinase has been well-characterized and has also been well-exposed in numerous proceedings volumes and collections. In this issue of Advances in Molecular Cell Biology, the cell cycle kinase is ever present, but in the early chapters it has a supporting role. Center stage are the regulatory mechanisms that control the kinase. The contribution that the centrosome (the organelle of cell division) makes to cell cycle regulation are described. The part played by calcium and calcium-controlled regulatory proteins is emphasized. The importance of phosphatase as well as kinase activity to cell cycle regulation is stressed. The last words are reserved for the mitotic kinase: the last chapters describe its effects and its regulation in cell-free systems.", "author": "Michael Whitaker", "slug": "cell-cycle-428034-9780080876955-michael-whitaker", "thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/9780080876955.jpg", "default_thumbnail_image": "//redshelf-images.s3-external-1.amazonaws.com/thumbnail/default_book_thumbnail.jpg", "product_type": "book", "product_id": "428034", "product_url": "/app/ecom/book/428034/cell-cycle-428034-9780080876955-michael-whitaker", "bisac_codes": [ "SCI049000", "900" ], "items_count": null, "identifiers": { "ISBN13": "9781559389495", "EISBN13": "9780080876955", "EISBN10": "0080876951" }, "drm": null, "cover_image": null, "default_cover_image": null, "book_type": null }, "relationships": { "lowest_offering": { "data": { "type": "offerings", "id": "00010026358646" } } } }, { "type": "Product", "id": "00010000428032", "attributes": { "name": "Thermobiology", "subtitle": "", "description": "Notwithstanding widespread studies and even several biological journals devoted to temperature, it is difficult to perceive a field of thermobiology as such. Interest in the effects of temperature of biological systems is fragmented into specific thermal ranges and often connected with particular applications: subzero cryobiology and preservation of cells and tissues or survival of poikilotherms, para-zero cryobiology and preservation of whole organs and survival of whole animals, intermediate ranges and physiological adaption and regulation, high temperatures and use of heat for killing cancer cells, very high temperatures and limits of biological structure. Yet it has not always been so, and there are good reasons why it need not remain so. General and comparative physiologists such as W.J. Crozier, H. Precht, J. Belehradek, F. Johnson, C.L. Prosser, and others have sought throughout this century to lay foundations for unified approaches to temperature in biological systems.Recent findings also serve to suggest principles and processes that span the range of temperatures of biological interest. Microviscosity of membranes is an issue originally of interest to low temperature biologists but with relevance to limiting high temperatures; conversely for protein structure. Certain \"heat shock proteins\" now appear to be responses to generalized stress, including low temperature.Inevitably, the chapters of this book reflect the \"zonal\" character of thermobiology: two chapters (by Storey and Raymond) deal with protection against subfreezing temperatures; three (Hazel, membrane structure, Dietrich, microtubular structure, and Kruuv, cell growth) deal with the effects of and modulation to cool-to-moderate superfreezing temperatures, one (Willis) with modulation (of membrane ion transport) to moderate-to-high temperatures and two (Li, heat shock proteins and Lepock, proteins in general) with stressfully high temperatures. Explicit in each of these chapters, however, are principles and issues that transcend the parochialism of the temperature range under consideration.", "author": "J.S. 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Several diverse families of membrane receptors/proteins are discussed with respect to the molecular and cellular biology of their synthesis, assembly, turnover, and function. Included are such receptor superfamilies as G-proteins, immunoglobulins, ligand-gated receptors, interleukins, and tyrosine kinases as well as such transporter/protein families as pumps, ion channels, and bacterial transporters. Each section of each volume features a \"perspectives/commentary\" chapter which includes comments on the recent advances and predictions on new directions. Written by acknowledged experts in the field, this volume, 137B, highlights the recent developments in receptors.", "author": "Geoffrey H. Bourne, James F. Danielli, Kwang W. Jeon, M. 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